Maria C. Lopez, MD

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Maria C. Lopez, MD, is an attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Central University of Venezuela (UCV), Caracas, Venezuela



Pediatrics - Downstate Medical Center, Brooklyn, NY (Chief Resident)



Allergy & Immunology - Johns Hopkins All Children's Hospital, St. Petersburg, FL (Chief Fellow)


Board Certification

Allergy and Immunology – American Board of Allergy and Immunology

Titles and Academic Titles

Attending Physician

Conditions Treated

Departments and Services




Chitty-Lopez M, Duff C, Vaughn G, Trotter J, Monforte H, Lindsay D, Haddad E, Keller MD, Oshrine BR, Leiding JW. Unmanipulated Matched Sibling Donor Hematopoietic Cell Transplantation in TBX1Congenital Athymia: A Lifesaving Therapeutic Approach When Facing a Systemic Viral Infection. Front Immunol. 2021 (in press)

Chitty Lopez M, Diaz-Cabrera N, Saco T, Bindernagel C, Ujhazi B, Danziger R, Csomos, Illes P, Patel KN, Dimitrova D, Kanakry J, Notarangelo L, Walter JE. Separating the wheat from the chaff in asthma and bronchiectasis: the saga trajectory of a patient with adult-onset RAG1 deficiency. The Journal of Clinical Immunology: In Practice. 2021 (in press)

Buchbinder D, Walter JE, Butte MJ, Chan WY, Chitty Lopez M, Dimitriades VR, Dorsey MJ, Nugent DJ, Puck JM, Singh J, Collins CA. When Screening for Severe Combined Immunodeficiency (SCID) with T Cell Receptor Excision Circles Is Not SCID: a Case-Based Review. J Clin Immunol. 2021 Feb;41(2):294-302. doi: 10.1007/s10875-020-00931-2. Epub 2021 Jan 7. PMID: 33411155; PMCID: PMC8179373.


Chitty-Lopez M, Westermann-Clark E, Dawson I, Ujhazi B, Csomos K, Dobbs K, Le K, Yamazaki Y, Sadighi Akha AA, Chellapandian D, Oshrine B, Notarangelo LD, Sunkersett G, Leiding JW, Walter JE. Asymptomatic Infant with Atypical SCID and Novel Hypomorphic RAG Variant Identified by Newborn Screening: A Diagnostic and Treatment Dilemma. Front Immunol. 2020 Sep 29;11:1954. doi: 10.3389/fimmu.2020.01954. PMID: 33117328

Chellapandian D, Chitty-Lopez M, Leiding JW. Precision Therapy for the Treatment of Primary Immunodysregulatory Diseases. Immunol Allergy Clin North Am. 2020;40(3):511-526. 2020, April; Pub PMID: 32654696


Chitty-Lopez M., Pollak-Christian E., Keenaghan M. Pulmonary air leak syndrome associated with traumatic nasopharyngeal suctioning. BMJ Case Reports. 2016, October; Pub PMID: 27793871




Chitty Lopez M. Balanoposthitis. Photography Contribution. Author B. R. Shah (Ed.) The Atlas of Pediatric Emergency Medicine, 3rd Edition. (2019) Brooklyn, NY. Mc Graw Hill Education

Posters and Presentations


Booth C., Kohn DB., Sevilla J., Rao G., Terrazas D., Nicoletti E., Chitty Lopez M., Fernandes A., Kuo C., Oliviera S., Moore T., Choi G., Zeini M., Mesa-Nunez C., Trasher AJ., Bueren J., Schwartz JD. (October 2021) A Phase 1/2 Study of Lentivirus Mediated Ex-vivo Gene Therapy for Pediatric Patients with Severe Leukocyte Adhesion Deficiency-I (LAD-I): Interim Result. European Society of Gene and Cell Therapy 28th Annual Meeting.

Chitty Lopez M., Mhaskar R., Wright H., Marsh R., Garabedian E., Fuleihan R., Sullivan KE., Leiding JW. (April 2021) "The other side of the coin: immunodysregulation in primary immunodeficiency. Analysis of the United States Immunodeficiency Network (USIDNET) database". Poster presented at the CIS Virtual Annual Scientific Meeting.

Chitty Lopez M., Trotter J, Vaughn G, Oshrine B, Sunkersett G, Leiding JW. (February 2021) Omenn Syndrome with Autoreactive T-cell development after viral infections in two patients with Leaky Severe Combined Immunodeficiency (SCID). Poster presented at the AAAAI Virtual Annual Scientific Meeting.

Miranda M, Dasso JF, Ellison M, Trotter J, Timothy P, Chitty Lopez M, Duff C, Nieves-Munoz D, Westermann-Clark E, Tang N, Sher MR, Ballow M, Leiding JW, Sriaroon P, Walter JE. (February 2021) Clinical Characteristics of SARS-CoV2 Infected and Exposed Patients at a Tertiary Care Allergy/Immunology Program in Florida. Poster presented at the AAAAI Virtual Annual Scientific Meeting.


Chitty Lopez M, Dawson I, Sriaroon P. (October 2020) Characteristics of Fish and shellfish allergy – Single Center Experience. Poster presented at Johns Hopkins All Children’s Hospital 9th Annual Research Symposium

Chitty Lopez M., (July 2020). Exercise-induced anaphylaxis. Oral presentation at the annual meeting of the Florida Allergy, Asthma & Immunology Society (FAAIS). Selected as the 2020 guest fellow lecturer; Tampa, Florida.

Chitty Lopez M., Duff C., Leiding JW. (April 2020). Jakinibs: a bridge to immune reconstitution in gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. Oral presentation accepted at the PIDTC Annual Meeting; Pacific Grove, California.

Chitty Lopez M., Walter JE. (April 2020). Dual NFKB1 loss-of-function and CXCR4 missense variant presents as hypogammaglobinemia, neutropenia, and HPV susceptibility. Poster accepted at CIS Annual Meeting; Denver, Colorado.


Chitty Lopez M., Leiding J., Walter J., Westerman-Clark E. (November 2019). Mosaic X-Linked Chronic Granulomatous Disease (CGD) in a septuagenarian male. Poster presented at the ACAAI Annual Scientific Meeting; Houston, TX.

Chitty Lopez M., Dehghani A., Zhang Y., Vastardi M. (July 2019). Systemic Lupus Erythematosus and vasculitic rash in a patient with Ras-associated autoimmune leukoproliferative disorder (RALD). Poster presented at the FAAIS Annual Meeting, Orlando, FL.

Awards and Honors

2019, Fellow-in-Training Annual Bowl, 3rd Place, ACAAI Annual Meeting
2018, Resident of the Year, NYC HH Kings County Hospital
2008-2011, Immunology Medical Student Tutor, Central University of Venezuela

Leadership and Memberships

Memberships in Professional Organizations

2019-present, American College of Allergy, Asthma and Immunology
2019-present,Clinical Immunology Society
2018-present, American Academy of Allergy, Asthma & Immunology
 - 2019-present, Primary Immunodeficiency Committee
2018-present, European Academy of Allergy and Clinical Immunology, Junior Member
2015-present, American Academy of Pediatrics
2015-present, American Medical Association