Pavle S. Milutinovic, MD, PhD

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Pavle S. Milutinovic, MD, PhD, is an attending physician with the Division of Allergy and Immunology at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA


Internal Medicine/Pediatrics - Duke University Medical Center (DUMC), Durham, NC


Allergy-Immunology - National Institutes of Health (NIH), Bethesda, MD

Board Certification

Allergy and Immunology – American Board of Allergy and Immunology
Internal Medicine – American Board of Internal Medicine
Pediatrics – American Board of Pediatrics

Graduate Degree

MS in Chemistry - Dartmouth College, Hanover, NH
PhD in Pathology - University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA

Titles and Academic Titles

Attending Physician

Conditions Treated

Departments and Services




VanBlargan LA, Milutinovic PS, Goo L, DeMaso CR, Durbin AP, Whitehead SS, Pierson TC, Dowd KA. Dengue virus serotype 1 conformational dynamics confers virus strain-dependent patterns of neutralization by polyclonal sera. J Virol. 2021 Nov 9;95(23): e0095621.


Perkins TN, Oczypok EA, Milutinovic PS, Dutz RE, Oury TD. RAGE-dependent VCAM-1 expression in the lung endothelium mediates IL-33 induced allergic airway inflammation. Allergy. 2018 Jun 14. doi: 10.1111/all.13500.


Oczypok EA*, Milutinovic PS*, Alcorn JF, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol. 2015 Sep;136(3):747-756.e4. * Co-first authors


Milutinovic PS, Englert JM, Crum LT, Mason NS, Ramsgaard L, Enghild JJ, Sparvero LJ, Lotze MT, Oury TD. Clearance Kinetics and Matrix Binding Partners of the Receptor for Advanced Glycation End Products. PLOS One. 2014 Mar; 9(3): e88259.


Milutinovic PS, Alcorn J, Englert J, Crum L, Oury T. The Receptor For Advanced Glycation End- Products Is A Central Mediator Of Asthma Pathogenesis. Am J Pathol. 2012 Oct; 181(4): 1215-25.


Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011 Mar; 4(3): 241-54.

Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. Lack of the Receptor for Advanced Glycation End-Products Attenuates E. coli Pneumonia in Mice. PLOS One. 2011; 6(5): e20132.


Milutinovic PS, Zhao J, Sonner JM. Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Anesth Analg. 2009 Jan; 108(1): 176-80.

Cantor RS, Twyman KS, Milutinovic PS, Haseneder R. A kinetic model of ion channel electrophysiology: bilayer-mediated effects of agonists and anesthetics on protein conformational transitions. Soft Matter. 2009 Sep; 5(17): 3266-78.


Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner JM. Ammonia has anesthetic properties. Anesth Analg. 2007 Jun; 104(6): 1430-3.

Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM. Anesthetic-like modulation of a gammaaminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug; 105(2): 386-92.

Yang L, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function. Anesth Analg. 2007 Aug; 105(2): 393-6.

Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Eger EI 2nd, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone. Anesth Analg. 2007 Sep; 105(3): 673-9.




Morabito K. M., Milutinovic P. S., Graham B. S., Pierson T. C. (2021) Zika Virus Vaccines (In Press). In Plotkin S. A., Orenstein W., Offit P. A., Edwards K. M. Plotkin’s Vaccines (8th Edition). Philadelphia: Elsevier.

Posters and Presentations


Milutinovic PS, Maciejewski S, Dowd KA, Graham BS, Pierson TC. Impact of residues in the Zika virus E protein stem and transmembrane region on the antigenic structure of virus particles. American Society for Virology (ASV) 39th Annual Meeting, Fort Collins, CO, USA, 2020. (Conference canceled).

Awards and Honors

2019, 2020, 2022, Annual Meeting Travel Award, American Academy of Allergy Asthma and Immunology
2015-2018, The Robert J. Lefkowitz Society (Duke University)
2013, Chrysalis Project participant, with Travel Award, American Academy of Allergy Asthma and Immunology
2012, PhD awarded with honors
2010-2012, Angiopathy Training Program, NIH T32-HL094295, trainee