Drew H. Scoles, MD, PhD

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Drew H. Scoles, MD, PhD, is an attending physician with the Division of Ophthalmology at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Rochester, Rochester, NY

Internship

Medicine - Lankenau Hospital, Wynnewood, PA

Residency

Ophthalmology - University of Pennsylvania Scheie Eye Institute, Philadelphia, PA

Fellowship

Vitreoretinal Surgery - Associated Retinal Consultants PC, Novi, MI

Board Certification

Ophthalmology – American Board of Ophthalmology

Undergraduate Degree

BS - University of Rochester, Rochester, NY

Graduate Degree

PhD in Biomedical Engineering - University of Rochester, Rochester, NY

Titles and Academic Titles

Attending Physician

Assistant Professor of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2023

Saleem, Z., Scoles, D., Capone, A., & Mahmoud, T. H. (2023). Iatrogenic macular hole due to Nd:YAG-SLT laser: Case report and management. Retin Cases Brief Rep. In Press. 

Tsui, J. C., Wong, M. B., Kim, B. J., Maguire, A. M., Scoles, D.,VanderBeek, B. L., & Brucker, A. J. (2023). Appropriateness of ophthalmic symptoms triage by a popular online artificial intelligence chatbot. Eye. https://doi.org/10.1038/s41433-02302556-2 

Rao, N., Tsui, J.C., Trese, M. G. J., Randhawa, S., Scoles, D. (2023). Posterior Retinal Breaks Secondary to Closed Globe Blunt Ocular Trauma – A Case Series and Review of the Literature. JVRD. In Press 

Pontarelli MK, Zeiger JS, Vempuluru VS, Scoles D, Shields CL. Multifocal White Retinal Lesions in a Young Boy. J Pediatr Ophthalmol Strabismus. Published online December 19, 2023. doi:10.3928/01913913-20231026-03 

Ramirez DA, Anninger WV, Scoles D. Optic nerve hypoplasia and bilateral persistent fetal vasculature due to TUBA1A tubulinopathy. Retin Cases Brief Rep. Published online December 15, 2023. doi:10.1097/ICB.0000000000001540 

Liu, T., Schwartz, T., Chebolu, A. P., Tsui, J. C., Bhatt, N., & Scoles, D. (2023). Teclistamab-Associated Sclerouveitis with Hypopyon. Retin Cases Brief Rep. https://doi.org/10.1097/ICB.0000000000001449 

Cohen, D., Binenbaum, G., El-Jack, K., Spiller, A., Yu, Y., Ying, G. S., Jensen, A., & Scoles, D. (2023). Incidence and Risk Factors for Exudative Retinal Detachment Following Laser Photocoagulation for ROP. Retina. https://doi.org/10.1097/IAE.0000000000003983  

Gupta, A. S., & Scoles, D. (2023). Macular Hole Retinal Detachment in the Setting of a Regressed Choroidal Metastasis. Ophthalmology Retina. https://doi.org/https://doi.org/10.1016/j.oret.2023.09.009 

Dass, S., Scoles, D., Trese, M. G. J., & Drenser, K. A. (2023). Retinal detachment in a pediatric patient with enhanced S-cone syndrome. J AAPOS, 27(4), 229-231. https://doi.org/10.1016/j.jaapos.2023.04.014  

Cohen, D. C., Tsui, J. C., & Scoles, D. (2023). Congenital Retinal Macrovessel and Cavernous Hemangioma in Cowden Syndrome - A Case Report and Review of Literature. Retin Cases Brief Rep. https://doi.org/10.1097/ICB.0000000000001477

Tsui, J.C., Wong, M.B., Kim, B.J., Maguire, A.M., Scoles, D., VanderBeek, B.L., Brucker, A.J. (2023). Appropriateness of ophthalmic symptoms triage by a popular online artificial intelligence chatbot. Eye. https://doi.org/10.1038/s41433-02302556-2

2022

Moussa M.T., Scoles D., Branham K., Fahim A.T., Capone A. (2022). Clinical and imaging findings of choroideremia in a pediatric patient due to a novel frameshift mutation. American Journal of Ophthalmology Case Reports. doi: 10.1016/j.ajoc.2022.101718

Begaj, T., Scoles, D., Randhawa, S. Bilateral Simultaneous Rhegmatogenous Retinal Detachments. Retinal Physician. In Press.

Scoles, D., Mahmoud, T.H. (2022). Inaccurate Measurements Confound the Study of Myopic Macular Hole. Ophthalmology Retina 6, 95-96, doi:10.1016/j.oret.2021.10.009

Meer, E., Scoles, D., Hua, P., McGeehan, B., VanderBeek, B.L. (2022). Recent Practice Patterns in Acute Retinal Artery Occlusions in the United States. Ophthalmic Epidemiololgy. doi: 10.1080/09286586.2021.2020297

Scoles, D.,  McGeehan, B., VanderBeek, B.L. (2022).  The association of stroke with central and branch retinal arterial occlusion. Eye. doi: 10.1038/s41433-021-01546-6

2021

Scoles, D., Bracha, P., Aleman, T.S., Bhatt, N. (2021). Diagnostic and Therapeutic Challenge: Unilateral panuveitis. Retina. doi: 10.1097/IAE.0000000000003042.

2020

Cherayil, N.R., Scoles, D., Moran, A. M., Elder, D. E., Tamhankar, M. A. (2020). Gazing Into the Crystal Ball, Journal of Neuro-Ophthalmology. doi: 10.1097/WNO.0000000000001090

Bedoukian, E. C., Zhou, X., Serrano, L. W., Scoles, D., Aleman, T. S. (2020). NMNAT1-Associated Cone Rod Dystrophy: Evidence for Foveal Maldevelopment and Treatment Potential. Retina Cases and Brief Reports, In press. doi: 10.1097/ICB.0000000000000992. Epub ahead of print.

Scoles, D., Ammar, M.J., Carroll, R.O., Orlin, S.E., Addis, V., Maguire, A. M. (2020). Cytomegalovirus retinitis in an immunocompetent host after complicated cataract surgery. American Journal of Ophthalmology Case Reports. 18:100702. doi: 10.1016/j.ajoc.2020.100702.

Scoles, D., Massaro-Giordano, M., Maguire, A. M., Lee, V.  (2020). Scleral depression saves lives. American Journal of Ophthalmology Case Reports 18:100656. doi: 10.1016/j.ajoc.2020.100656.

Scoles, D.,  Ying, G. S., Pan, W., Hua, P., Grunwald, J. E., Daniel, E., Jaffe, G. J., Toth, C. A., Martin, D. F., Maguire, M. G. (2020). Characteristics of Eyes With Good Visual Acuity at 5 Years After Initiation of Treatment for Age-Related Macular Degeneration but Not Receiving Treatment From Years 3 to 5: Post Hoc Analysis of the CATT Randomized Clinical Trial. JAMA Ophthalmology,138(3):276-284. doi: 10.1001/jamaophthalmol.2019.5831.

2019

Scoles, D., Tapino, P. J. (2019). Separation Anxiety. Ophthalmology Retina, 3(6), 499.

O’Neil, E., Serrano, L., Scoles, D., Cunningham, K. E., Han, G., Chiang, J., Bennett, J., Aleman, T. S., (2019). Detailed retinal phenotype of Boucher- Neuhäuser syndrome associated with mutations in PNPLA6 mimicking choroideremia, Ophthalmic Genet, doi: 10.1080/13816810.2019.1605392

2017

Vogel, R. N., Langlo, C. S., Scoles, D., Carroll, J., Weinberg, D. V, Kim, J. E. (2017). High-Resolution Imaging of Intraretinal Structures in Active and Resolved Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 58(1), 42-49. doi: 10.1167/iovs.16-20351.

Scoles, D., Sulai, Y. N., Cooper, F. C., Higgins, B. P., Johnson, R. D., Carroll, J., Dubra, A., Stepien, K. E. (2017). Photoreceptor inner segment morphology  in Best vitelliform macular dystrophy. Retina, 37(4), 741-748. doi: 10.1097/IAE.00000000000001203.

2015

Abozaid, M. A., Scoles, D., Goldberg, M., Carroll, J. & Han, D. P. (2015). En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema. JAMA Ophthalmology, 133(8), 961-963. doi: 10.1001/jamaophthalmol.2015.1485

Scoles, D., Flatter, J. A., Cooper, R. F., Langlo, C. S., Robison, S., Neitz, M., Weinberg, D. V., Pennesi, M. E., Han, D. P., Dubra, A., & Carroll, J. (2015) Assessing photoreceptor structure associated with ellipsoid zone disruptions visualized with optical coherence tomography. Retina, 36(1), 91-103. doi: 10.1097/IAE.0000000000000618.

Hansen, S., Batson, S., Weinlander, K. M., Cooper, R. F., Scoles, D., Karth, P. A., . . . Wirostko, W. J. (2015). Assessing photoreceptor structure after macular hole closure. Retin Cases Brief Rep, 9(1), 15-20. doi: 10.1097/ICB.0000000000000117

2014

Scoles, D., Sulai, Y. N., Langlo, C. S., Fishman, G. A., Curcio, C. A., Carroll, J., & Dubra, A. (2014). In vivo imaging of human cone photoreceptor inner segments. Invest Ophthalmol Vis Sci, 55(7), 4244-4251. doi: 10.1167/iovs.14-14542

Scoles, D., Higgins, B. P., Cooper, R. F., Dubis, A. M., Summerfelt, P., Weinberg, D. V., . . . Dubra, A. (2014). Microscopic inner retinal hyper-reflective phenotypes in retinal and neurologic disease. Invest Ophthalmol Vis Sci, 55(7), 4015-4029. doi: 10.1167/iovs.14-14668

Sulai, Y. N., Scoles, D., Harvey, Z., & Dubra, A. (2014). Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope. J. Opt. Soc. Am. A, 31(3), 569-579. doi: 10.1364/JOSAA.31.000569

2013

Scoles, D., Sulai, Y. N., & Dubra, A. (2013). In vivo dark-field imaging of the retinal pigment epithelium cell mosaic. Biomed Opt Express, 4(9), 1710-1723. doi: 10.1364/BOE.4.001710

Carroll, J., Kay, D. B., Scoles, D., Dubra, A., & Lombardo, M. (2013). Adaptive optics retinal imaging--clinical opportunities and challenges. Curr Eye Res, 38(7), 709-721. doi: 10.3109/02713683.2013.784792

Pinhas, A., Dubow, M., Shah, N., Chui, T. Y., Scoles, D., Sulai, Y. N., . . . Rosen, R. B. (2013). In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography. Biomed Opt Express, 4(8), 1305-1317. doi: 10.1364/BOE.4.001305

2009

Scoles, D., Gray, D. C., Hunter, J. J., Wolfe, R., Gee, B. P., Geng, Y., . . . Merigan, W. H. (2009). In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison. BMC Ophthalmol, 9(9), doi: 10.1186/1471-2415-9-9

2008

Gray, D. C., Wolfe, R., Gee, B. P., Scoles, D., Geng, Y., Masella, B. D., . . . Merigan, W. H. (2008). In vivo imaging of the fine structure of rhodamine-labeled macaque retinal ganglion cells. Invest Ophthalmol Vis Sci, 49(1), 467-473. doi: 10.1167/iovs.07-0605

Posters and Presentations

2023

Scoles, D. Mystery Case. Atlantic Coast Retina Club 2023. Boston, MA, USA. 

Scoles, D. CTNNB1-related eye diseases: screening and treatment. 1st International CTNNB1 Syndrome Conference. Madrid, Spain. Delivered virtually.

Scoles, D., … Aleman, T. Spectrum of disease and management of vitreoretinopathy associated with CTNNB1 mutation. Poster Presentation at ARVO Annual Meeting 2023, New Orleans, LA, USA. 

2022

Scoles, D. Advances in Retinal Detachmnet Surgery for ROP. ROP update 2022 meeting. Cleveland, OH, USA. Invited talk and panelist.

Scoles, D., Mahmoud, T.H. Innacurate Measurements of Macular Holes. Poster presentation at Retina Society Annual Meeting 2022.

Scoles, D., Mahmoud, T.H. Innacurate Measurements of Macular Holes. Paper presentation at ASRS Annual Meeting 2022, Published Online.

2020

Scoles, D., … VanderBeek, B. L. Recent practice patterns in acute retinal artery occlusions in the United States. Paper Presentation at ARVO Annual Meeting 2020, Published Online.

2019

Scoles, D., … Aleman, T. Structural Correlates of Short-wavelength and Normalized Near-infrared Fundus Autofluorescence Imaging in Choroideremia. Poster Presentation at ARVO Annual Meeting 2019, Vancouver, Canada.

2014

Scoles, D., Goldberg, M. R., Langlo, C. S., Sulai, Y. N., Stepien, K. E., Weinberg, D. V., . . . Blodi, B. A. Non-invasive evaluation of microscopic retinal pathology in macular telangiectasia type 2. Poster presentation at ARVO Annual Meeting 2014, Orlando, FL.

2013

coles, D., Sulai, Y. N., & Dubra, A. (2013). In vivo imaging of the retinal pigment epithelium using dark-field AOSLO. Poster presentation at National MD PhD Student Conference, Keystone, CO.

Scoles, D., Cooper, R., Dubis, A., Higgins, B. P., Carroll, J., & Dubra, A. In vivo microscopic inner retinal phenotypes of retinal and neurologic disease. Poster presentation at ARVO Annual Meeting 2013, Seattle, WA. 

Scoles, D., Sulai, Y. N., & Dubra, A. In vivo imaging of the retinal pigment epithelium using dark-field AOSLO. Poster presentation at ISIE Annual Meeting 2013, Seattle, WA. 

2012

Scoles, D., Sulai, Y. N., Manguikian, A. D., Shareef, S., & Dubra, A. Reflectance adaptive optics nerve fiber layer imaging in primary open angle glaucoma. Oral presentaion at ARVO Annual Meeting 2012, Ft. Lauderdale, FL. 

Invited Lectures

2022

Scoles, D. Advances in Retinal Detachmnet Surgery for ROP. ROP update 2022 meeting. Cleveland, OH, USA. Invited talk.

Awards and Honors

2019, Heed Ophthalmic Foundation Residents Retreat Invitee
2016, Biomedical Engineering Department Outstanding PhD Thesis Award
2009, Letter of achievement Mind, Brain, Behavior
2008, Cum laude, with high distinction in Biomedical Engineering
2008, Alpha Eta Mu Beta – Biomedical Engineering Honor Society
2006, Burton Scholarship
2006, Modern Languages and Cultures Department – Sophomore Book Award recipient

Editorial and Academic Positions

Editorial Positions

Reviewer

2022-present, International Journal of Environmental Research and Public Health
2022-present, Retina Cases and Brief Reports
2020-present, American Journal of Ophthalmology
2020-present, Translational Vision Science and Technology
2020-present, Retina
2018-present, Ophthalmic Epidemiology
2013-present, Biomedical Optics Express
2013-present, Investigative Ophthalmology & Visual Science

Leadership and Memberships

Memberships in Professional Organizations

2022-present, DRCR.net Investigator
2021-present, International Retinal Imaging Society
2020-present, American Society of Retina Specialists
2017, American Academy of Ophthalmology
2007-present, Association for Research in Vision and Ophthalmology