Robert B. Wilson, MD, PhD

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Robert B. Wilson, MD, PhD, is Co-Director of the Friedreich's Ataxia Center of Excellence at Penn Medicine and Children's Hospital of Philadelphia and Senior Scientist in the Center for Mitochondrial and Epigenomic Medicine at CHOP.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Wilson is an experienced molecular biologist and a co-inventor of the first shRNA-expressing libraries. These libraries have been used in a pooled approach to identify and optimize shRNA sequences that induce selected phenotypes (as shRNAs or as siRNAs) in cell-culture models. Dr. Wilson also has experience in more conventional drug development, specifically for Friedreich Ataxia (FA).

Dr. Wilson is a practicing, board-certified molecular genetic pathologist with more than 20 years’ experience.

During a sabbatical in 2012-2013, Dr. Wilson studied advanced computational statistics at the University of Pennsylvania, culminating in graduate-level courses in Machine Learning and Advanced Bayesian Data Analysis.

Education and Training

Medical School

MD - University of Pennsylvania, Philadelphia, PA

Residency

Residency in Clinical Pathology - Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Fellowship in Transfusion Medicine - Hospital of the University of Pennsylvania, Philadelphia, PA

Post-doctoral Research - Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA

 

Board Certification

American Board of Pathology/Molecular Genetics
Clinical Pathology

Graduate Degree

PhD in Genetics - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Co-Director, Friedreich's Ataxia Center of Excellence

Senior Scientist, Center for Mitochondrial and Epigenomic Medicine

Professor of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Professor of Pathology and Laboratory Medicine in Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2016

Rufini A, Wilson RB, Testi R. Drug Discovery and Emerging Therapeutic Strategies. Journal of Rare Diseases. 2016;4(1):19-23.

2015

Cotticelli MG, Acquaviva F, Xia S, Kaur A, Wang Y, Wilson RB. Phenotypic Screening for Friedreich Ataxia Using Random shRNA Selection. J Biomol Screen. 2015 Oct;20(9):1084-90.

Seyer L, Greeley N, Foerster D, Strawser C, Gelbard S, Dong Y, Schadt K, Cotticelli MG, Brocht A, Farmer J, Wilson RB, Lynch DR. Open label pilot study of interferon gamma-1b in Friedreich ataxia. Acta Neurol Scand. 2015 Jul;132(1):7-15.

Lazaropolous M, Dong Y, Clark E, Greeley NR, Seyer LA, Brigatti KW, Christie C, Perlman SL, Wilmot GR, Gomez CM, Mathews KD, Yoon G, Zesiewicz T, Hoyle C, Subramony SH, Brocht AF, Farmer JM, Wilson RB, Deutsch EC, Lynch DR. Frataxin levels in peripheral tissue in Friedreich ataxia. Ann Clin Transl Neurol. 2015 Aug;2(8):831-42.

Cotticelli MG, Acquaviva F, Xia S, Kaur A, Wang Y, Wilson RB. Phenotypic screening for Friedreich ataxia using random shRNA selection. J Biomol Screen. 2015 Oct;20(9):1084-90

2014

Wang Y, Speier JS, Engram-Pearl J, Wilson RB. Introduction of mismatches in a random shRNA-encoding library improves potency for phenotypic selection. PLoS One. 2014;9(2):e87390.

Books

Chapters

2007

Ogino, S. and Wilson, R.B.: Bayesian analysis. Molecular Pathology in Clinical Practice. Leonard, D.G., et al. (eds.). Springer, 2007.

2006

Wilson, R.B.: Experimental Therapeutics for Friedreich Ataxia. Genetic Instabilities and Neurological Diseases. Wells, R.D. and Ashizawa, T. (eds.). Elsevier-Academic Press, 2006

Wilson, R.B.: Iron Dysregulation in Friedreich Ataxia. Seminars in Pediatric Neurology: Disorders of Brain Iron. Hayflick, S.J. and Bodensteiner, J.B. (eds.). Elsevier-Academic Press, 2006.

Posters and Presentations

Lectures by Invitation

2016

Wilson RB. "Phenotypic drug screening using random shRNA selection." Sixth International Ataxia Investigators Meeting, National Ataxia Foundation, Orlando, FL, April 2016

Wilson RB. "p38 MAPK inhibitors for the Treatment of Friedreich's Ataxia." GlaxoSmithKline, King of Prussia, PA, March 2016

2015

Wilson RB. "Friedreich's Ataxia Drug Discovery and Treatment Pipeline." Eighth Annual Children's Hospital of Philadelphia Friedreich's Ataxia Symposium, King of Prussia, PA, October 2015

Wilson RB. "Random shRNA Selection." New York Genome Center, New York, NY, September 2015

Wilson RB. "Therapeutic Discovery Using Random shRNA Selection." Columbia University College of Physicians and Surgeons, New York, NY, August 2015

2014

Wilson RB. "Drug Discovery for Friedreich's Ataxia." Seventh Annual Children's Hospital of Philadelphia Friedreich's Ataxia Symposium, King of Prussia, PA, October 2014

Awards and Honors

2016, Top Doctor, Philadelphia, Castle Connolly

2013, Harrington Discovery Institute Scholar-Innovator Award

2011, 2011 Kevin E. Salhany Award for Excellence in Clinical Teaching, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania2010, Distinguished Investigator Award, Friedreich's Ataxia Research Alliance

2009, NIH Director's Transformative Research Award

2009, Best Small Group Leader Teaching Award, University of Pennsylvania School of Medicine Class of 2012

2005, Basic Science Teaching Award, University of Pennsylvania School of Medicine Class of 2008

2004, Leonard Berwick Memorial Teaching Award, University of Pennsylvania School of Medicine

2003, Peter C. Nowell Teaching Award, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania

2002, 2002 Kevin E. Salhany Award for Excellence in Clinical Teaching, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania

2002, John Morgan Society, University of Pennsylvania

2001, The Outstanding Group Discussion Leader Teaching Award, University of Pennsylvania School of Medicine Class of 2003

1992, Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists

1989, Roy G. Williams Research Award, University of Pennsylvania School of Medicine

1982, Sigma Xi, Brown University

1982, Brand Musical Premium, Brown University

1982, Magna Cum Laude, Brown University

1982, Honors in Biochemistry, Brown University

1982, Honors in Music, Brown University

1980, Phi Beta Kappa, Brown University

Editorial and Academic Positions

Editorial positions

Reviewer

1997-present, Ad Hoc Reviewer for Nature Genetics, Science, Neurology, Journal of Human Molecular Genetics, American Journal of Medical Genetics, European Journal of Human Genetics, Journal of Molecular Diagnostics, Leukemia and Lymphoma

Academic committees

2013-present, Committee on Appointments and Promotions, Perelman School of Medicine at the University of Pennsylvania

2010-present, Academic Appointments and Promotions Committee, Department of Pathology and Laboratory Medicine

2001-present, Selection Committees for Residents, Fellows, and Faculty, Department of Pathology and Laboratory Medicine

1998-present, Thesis Committees, Cell and Molecular Biology and Neuroscience Graduate Groups

Leadership and Memberships

International

2005-present, Friedreich's Ataxia Research Alliance (Scientific advisor)

1997-present, Association for Molecular Pathology (Clinical Practices Committee, 1997)

National

2002-present, National Ataxia Foundation (Medical Research Advisory Board)