Zhe Zhang, PhD, MS
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
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PhD in Biomedical Informatics - University of North Carolina at Chapel Hill, Chapel Hill, NC
MS in Cell and Molecular Biology - Texas Tech University, Lubbock, TX
Principal Bioinformatics Scientist
Integrative analysis and clinical applications of different types of genomic data
Zhang Z, Shi L, Song L, Maurer K, Petri MA, Sullivan KE. Overall Downregulation of mRNAs and Enrichment of H3K4me3 Change Near Genome-Wide Association Study Signals in Systemic Lupus Erythematosus: Cell-Specific Effects. Frontiers in immunology. 2018. PMID: 29593737
*Zhang Z, Zhang Y, Evans P, Chinwalla A, Taylor D. RNA-Seq 2G: online analysis of differential gene expression with comprehensive options of statistical methods. bioRxiv Preprint. 2017. doi: https://doi.org/10.1101/122747. (* Corresponding author)
*Zhang Z, Shi L, Dawany N, Kelsen J, Petri MA, Sullivan KE. H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus. Clinical epigenetics. 2016. PMID: 26839600. (* Corresponding author)
Chapman KA, Bush WS, Zhang Z. Gene expression in cell lines from propionic acidemia patients, carrier parents, and controls. Molecular genetics and metabolism. 2015. PMID:25963861.
Izumi K, Nakato R, Zhang Z, et.al. Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin. Nature genetics. 2015PMID: 25730767.
Zhang Z, Shi L, Song L, et.al. Interferon regulatory factor 1 marks activated genes and can induce target gene expression in systemic lupus erythematosus. Arthritis & rheumatology. 2015. PMID: 25418955.
Zhang Z, Hailat Z, Falk MJ, Chen XW. Integrative analysis of independent transcriptome data for rare diseases. Methods. 2014. PMID: 24981076.
Zhang Z, Falk MJ. Integrated transcriptome analysis across mitochondrial disease etiologies and tissues improves understanding of common cellular adaptations to respiratory chain dysfunction. The international journal of biochemistry & cell biology. 2014. PMID: 24569120.
Zhang Z, Tsukikawa M, Peng M, et.al. Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PloS one. 2013. PMID: 23894440.
*Zhang Z, Leipzig J, Sasson A, et.al. Efficient digest of high-throughput sequencing data in a reproducible report. BMC bioinformatics. 2013. PMID: 24564231. (* Corresponding author)
*Zhang Z, Liu J, Kaur M, Krantz ID. Characterization of DNA methylation and its association with other biological systems in lymphoblastoid cell lines. Genomics. 2012. PMID: 22269447. (* Corresponding author)
Zhang Z, Song L, Maurer K, Bagashev A, Sullivan KE. Monocyte polarization: the relationship of genome-wide changes in H4 acetylation with polarization. Genes and immunity. 2011. PMID: 21451557.
Liu J, Zhang Z, Bando M, et.al. Genome-wide DNA methylation analysis in cohesin mutant human cell lines. Nucleic acids research. 2010. PMID: 20448023.
Zhang Z, Song L, Maurer K, Petri MA, Sullivan KE. Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes. Genes and immunity. 2010. PMID: 19710693.
Zhang Z, Gasser DL, Rappaport EF, Falk MJ. Cross-platform expression microarray performance in a mouse model of mitochondrial disease therapy. Molecular genetics and metabolism. 2010. PMID: 19944634.
Zhang Z, Maurer K, Perin JC, Song L, Sullivan KE. Cytokine-induced monocyte characteristics in SLE. Journal of biomedicine & biotechnology. 2010. PMID: 20625490.
Liu J, Zhang Z, Bando M, et.al. Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PloS biology. 2009. PMID: 19468298.
Zhang Z, Chen D, Fenstermacher DA. Integrated analysis of independent gene expression microarray datasets improves the predictability of breast cancer outcome. BMC genomics. 2007. PMID: 17883867.
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