Cardiac Center Researchers from Children’s Hospital of Philadelphia Present Findings at the Virtual 2020 AHA Scientific Sessions

Physician-researchers from the Cardiac Center at Children’s Hospital of Philadelphia (CHOP) had a very strong presence at the American Heart Association’s Scientific Sessions, held virtually for 2020. From the use of telemedicine in monitoring infants with palliated congenital heart disease, to the relationship between mental health disorders and the use of ventricular assist devices, the CHOP team covered a variety of topics and themes aimed at advancing diagnostics and care for pediatric cardiac patients.

Presentations and participants

Incidence of Mortality and Morbidity in a Cohort of Congenital Complete Heart Block Patients Followed for Over 40 Years
Scott Weinreb, Heather Griffis, Timmy Okunowo and Victoria Vetter

Novel Three-dimensional Principal Strain Analysis for Global Function of Right Ventricle After Repair of Tetralogy of Fallot: Can It Predict Need for Pulmonary Valve Replacement?
Daisuke Matsubara, Alessandro Satriano, Nowell M. Fine, James A. White, Gianni Pedrizzetti and Anirban Banerjee

Longitudinal Assessment of Electrical-Mechanical Interactions in Children and Young Adults with Repaired Tetralogy of Fallot
Suellen Moli Yin, Laura M. Mercer-Rosa, Jungwon Min, Elizabeth Goldmuntz and Victoria L. Vetter

Fully Automated 'Hands-off' Evaluation of Left Atrial Volume in Children
Hunter Kauffman, Kevin Whitehead, Michael Convery, Matthew O’Connor, Michael Quartermain and Anirban Banerjee

Unintended Consequences of Pediatric Catheterization Guidelines
Michael O’Byrne

Association of Weight with Ablation Outcomes in Pediatric Wolff-Parkinson-White Syndrome: Analysis of the NCDR® IMPACT Registry
Christopher M. Janson, Maully J. Shah, Kevin Kennedy, Ramesh Iyer, Shashank P. Behere, Tammy Sweeten and Michael L. O’Byrne

Impact of Device Miniaturization on Implantable Loop Recorder Utilization in the Pediatric Population: An Analysis of the Marketscan Database
Dustin Nash, Hannah Katcoff, Jennifer Faerber, Ramesh Iyer, Michael L. O'Byrne, Maully Shah and Christopher Janson

Comparison of Treatment Strategies for Neonates with Tetralogy of Fallot and Pulmonary Atresia: A Report from the Congenital Catheterization Research Collaborative
Holly Bauser Heaton, Christopher Mascio, Andrew C. Glatz and Jeffery J. Meadows, et al.

On the Mechanisms of Accelerated Calcification of Bioprosthetic Heart Valve Biomaterials in Juvenile Animal Models
Yingfei Xue, Alexander Kossar, Gaetano Theine, Robert Levy and Giovanni Ferrari

Relationship Between Brain-type Natriuretic Peptide and Serum Growth Factors in Infants with Single Ventricle Heart Disease and Shunt- or Ductal-dependent Pulmonary Blood Flow
Monique Gardner, Jen Faerber, Tamar J Preminger, Catherine M Avitabile, Somya Shankar, Susan Schachtner, Andrew C Glatz, Chitra Ravishankar and David J Goldberg

Pro-inflammatory Urinary CXCL10 and VCAM Are Elevated After Infant Cardiac Surgery-associated Acute Kidney Injury (AKI)
Daniella Levy- Erez, Lokesh Shah, Kathryn D Howarth, Sherin Meloni, Benjamin Laskin, Kathleen E. Sullivan and Joshua J. Blinder

Initial Experience with Telemedicine for Interstage Monitoring in Infants with Palliated Congenital Heart Disease
Alyson Stagg, Therese M. Giglia, Monique Gardner, Bonnie F. Offit, Kate M. Fuller, Shobha S. Natarajan, David A. Hehir, Anita L. Szwast, Jonathan J. Rome, Chitra Ravishankar and Tamar J. Preminger

Serotonin Transporter (SERT) Knockout Leads to Increased Myocardial and Mitral Valvular Fibrosis in a Murine Model
Alex D'Angelo, Estibaliz Castillero, Robert Levy and Giovanni Ferrari

Gabapentin as a Novel Adjunct for Postoperative Management After Superior Cavopulmonary Connection Operation in Children
Evan Z. Ramsey, Hailey Collier, Deepthi Gunturi, Jen Faerber, Celine Thibault, Emily Schwartz, Jonathan Chen, David J. Goldberg and Monique M. Gardner

Trends in Discharge Prescription of Digoxin After Norwood Operation: An Analysis of Data from the Pediatric Health Information Systems Database (PHIS)
Michael L. O’Byrne, Lihai Song, Jing Huang, David J. Goldberg, Monique A. Gardner, Chitra Ravishankar, Jonathan J. Rome and Andrew C. Glatz

Development of a Reliable Means of Assessment of Liver Function After the Fontan Operation: Dual Cholate Clearance Assay
Yuli Y. Kim, Greg Everson, Steve Helmke, Jessica Carducci, Andrew C. Glatz, Sara L. Partington, Emily Ruckdeschel, Jack Rychik and Maarouf Hoteit

Prevalent Pharmacotherapy in United States Children and Adolescents After Fontan Completion
Michael L. O’Byrne, Jen Faerber, Hannah Katcoff, Jing Huang, Jonathan Edelson, David Finkelstein, Catherine Avitabile, Andrew C. Glatz and David J. Goldberg

Impact of Udenafil on Vascular Function in Fontan Circulation: Results from the FUEL Trial
Bryan H. Goldstein, David J. Goldberg, Stephen Paridon and Elaine M. Urbina, et al.

The Fontan Udenafil Exercise Longitudinal Trial Subgroup Analysis
David J. Goldberg, Michael G. McBride and Stephen M. Paridon, et al.

Comparison of Management Strategies for the Neonate with Symptomatic Tetralogy of Fallot and Hypoplastic Branch Pulmonary Arteries: Results from the Congenital Catheterization Research Collaborative
Christopher J. Petit, Andrew C. Glatz, Christopher Mascio and Bryan H. Goldstein, et al.

The Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among Five Centers
Francesca Sperotto, Joshua J. Blinder and John N. Kheir, et al.

Trends in Utilization and Outcomes of Mechanical Circulatory Support for Patients with Myocarditis
Jonathan B. Edelson, Alicia Kamesh, Jen Faerber, Antara Mondal, Heather M. Griffis, Danielle S. Burstein, Carol A. Wittlieb-Weber, Kimberly Y. Lin, Christopher Mascio, James W. Gaynor, Jonathan Chen, Stephanie Fuller, Matthew J. O'Connor, Edo Birati, and Joseph W. Rossano

What’s New in the Genetics of Neurodevelopment in CHD?
J. William Gaynor

Early Life Stress: Biophysical and Neurodevelopmental Impact
Amy Jo Lisanti

Trends in Primary Payer Status and Association with Outcomes in Pediatric Heart Transplantation
Kathryn M. Restaino, Xuemei Zhang, Joseph W. Rossano, Kimerly Y. Lin, Danielle S. Burstein, Christopher E. Mascio, Carol Wittlieb-Weber and Matthew J. O’Conner

The Natural History of Asymptomatic and Mildly Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights from the Share Registry
Monica Ahluwalia, Joseph W. Rossano and Neal K. Lakdawala, et al.

Impact of Mental Health Disorders on Ventricular Assist Device Supported Patients Emergency Resource Use and Outcomes
Jonathan J. Edwards, Jonathan Edelson, Hannah Katcoff, Antara Mondal, Debra Lefkowitz, Nosheen Reza, Thomas Hanff, Heather M. Griffis, Jeremy Mazurek, Anjali T. Owens, Carol Wittlieb-Weber, Danielle Burstein, Pavan Atluri, Matthew O’Connor, Lee R. Goldberg, Payman Zamani, Peter W. Groeneveld, Joseph Rossano, Kimberly Y. Lin and Edo Birati

A Novel Risk Model to Predict Emergency Department Associated Mortality for Patients Supported with a Ventricular Assist Device: The Ed-vad Risk Score
Jonathan B. Edelson, Jonathan J. Edwards, Hannah Katcoff, Antara Mondal, Feiyan Chen, Nosheen Reza, Thomas C. Hanff, Heather M. Griffis, Jeremy A. Mazurek, Joyce Wald, Danielle Burstein, Pavan Alturi, Matthew J. O'Connor, Carol Wittlieb-Weber, Lee R. Goldberg, Payman Zamani, Peter W. Groeneveld, Joseph Rossano, Kimberly Y. Lin and Edo Birati

Ischemic Mitral Regurgitation is Associated with Impaired Transforming Growth Factor/Bone Morphogenic Protein Signaling and Increased CD45+ Cell Presence in the Mitral Valve Interstitial Cell Population
Estibaliz Castillero, Robert Levy and Giovanni Ferrari, et al.

Primary Prevention Implantable Cardioverter Defibrillator Utilization for Hypertrophic Cardiomyopathy in US vs Non-US: Findings from the Share Registry
Victor Nauffal, Joseph Rossano and Carolyn Ho, et al.

Cardiopulmonary Exercise Testing in Pediatric Patients with Hypertrophic Cardiomyopathy
Jonathan B. Edelson, Danielle Burstein, Helen Stanley, Maully Shah, Michael W. McBride, Paul Stephens Jr., Jungwon Min, Heather M. Griffis, Carol Wittlieb-Weber, Matthew J. O'Connor, Joseph W. Rossano, Kimberly Y. Lin and Stephen Paridon

Physical Activity in Individuals With the Long Qt Syndrome: Baseline Data From the Lifestyle and Exercise in Long Qt Study (live Lqts)
Rachel J. Lampert, Maully Shah and Michael John Ackerman, et al.

Resilience in Young Adults with CHD: Predictors and Impact on Quality of Life
Alana Cianciulli, Richard F. Ittenbach, Gabrielle Combs, Isabel Randazzo, Daniel J. Licht, Lyla Hampton, Marsha Gerdes, Judy C. Bernbaum, Nancy Burnham and J. William Gaynor