Researchers at Children’s Hospital of Philadelphia (CHOP), in partnership with academic institutions across the country, will lead a pioneering initiative as part of a national collaboration to establish the Whole Person Physiome Research and Coordination Center (WPP-RCC). The project, funded by the National Institutes of Health (NIH), aims to construct the first comprehensive digital map of the human body.
The WPP-RCC map will integrate clinical data, computational models and physiological processes, creating an AI-ready resource that provides visual tools to understand how diseases or treatment impact overall physiology. Digital mapping enables the analysis of complex physiological interactions, prediction of outcomes and development of personalized treatments, resulting in more effective healthcare solutions and innovative therapies.
The center offers a unique opportunity to enhance the understanding of human biology through interdisciplinary collaboration from diverse experts, including physiology, precision medicine, and computational biology. Katalin Susztak, MD, PhD, Co-Director of the Penn-CHOP Kidney Innovation Center, and Liming Pei, PhD, Director of Fundamental Discovery at the CHOP Cardiovascular Institute and a core member of the Center for Mitochondrial and Epigenomic Medicine at CHOP, are two of the principal investigators of the WPP-RCC. Together they will help create a collaborative network of scientists, engineers, clinicians, and data specialists to design maps and models of human physiology. Researchers will also align with the NIH, supporting the NIH Whole Person Initiative to holistically understand health, improve well-being, and reduce illness and disability.
“This initiative marks a groundbreaking leap in the study and modeling of human physiology,” said Susztak. “Our goal is to provide a comprehensive resource that empowers researchers and clinicians to gain deeper insights into health and disease.”
The national collaboration includes institutions such as the Perelman School of Medicine at the University of Pennsylvania, Stanford University, and the Luddy School of Informatics, Computing and Engineering at Indiana University.
Read the full release here.
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Researchers at Children’s Hospital of Philadelphia (CHOP), in partnership with academic institutions across the country, will lead a pioneering initiative as part of a national collaboration to establish the Whole Person Physiome Research and Coordination Center (WPP-RCC). The project, funded by the National Institutes of Health (NIH), aims to construct the first comprehensive digital map of the human body.
The WPP-RCC map will integrate clinical data, computational models and physiological processes, creating an AI-ready resource that provides visual tools to understand how diseases or treatment impact overall physiology. Digital mapping enables the analysis of complex physiological interactions, prediction of outcomes and development of personalized treatments, resulting in more effective healthcare solutions and innovative therapies.
The center offers a unique opportunity to enhance the understanding of human biology through interdisciplinary collaboration from diverse experts, including physiology, precision medicine, and computational biology. Katalin Susztak, MD, PhD, Co-Director of the Penn-CHOP Kidney Innovation Center, and Liming Pei, PhD, Director of Fundamental Discovery at the CHOP Cardiovascular Institute and a core member of the Center for Mitochondrial and Epigenomic Medicine at CHOP, are two of the principal investigators of the WPP-RCC. Together they will help create a collaborative network of scientists, engineers, clinicians, and data specialists to design maps and models of human physiology. Researchers will also align with the NIH, supporting the NIH Whole Person Initiative to holistically understand health, improve well-being, and reduce illness and disability.
“This initiative marks a groundbreaking leap in the study and modeling of human physiology,” said Susztak. “Our goal is to provide a comprehensive resource that empowers researchers and clinicians to gain deeper insights into health and disease.”
The national collaboration includes institutions such as the Perelman School of Medicine at the University of Pennsylvania, Stanford University, and the Luddy School of Informatics, Computing and Engineering at Indiana University.
Read the full release here.
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