Research News from CHOP
Mapping Tumor Neighborhoods: A New Spatial Framework to Guide Cancer Treatment
CHOP researchers offer a practical roadmap to identify tumor microenvironments that predict prognosis and guide targeted therapies.
Children’s Hospital of Philadelphia Researchers Demonstrate that Survival in Newborns with Congenital Diaphragmatic Hernia Improved Over Time with Specialized Interventions
Researchers from the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment at Children’s Hospital of Philadelphia found that survival rates in infants with congenital diaphragmatic hernia improved over time even in the most serious cases due to ongoing experience and continuous review of outcomes.
New Guidance Urges Care in How Population Descriptors are Used in Genetic Risk Research
A Nature Genetics report from the Polygenic Risk Methods Development (PRIMED) Consortium and Children’s Hospital of Philadelphia (CHOP) calls for rethinking how researchers label human populations when developing polygenic risk scores (PRS), or the risk of developing certain diseases based on variations in a person’s genome.
Braden’s Hope Awards $1.8 million in Grants to Four Children’s Hospital of Philadelphia Researchers
Children’s Hospital of Philadelphia is pleased to announce that four of its Cancer Center clinicians and researchers were awarded $1.8 million in research grants from Braden’s Hope for Childhood Cancer, a Kansas City-based nonprofit that funds cutting-edge pediatric cancer research and raises community awareness.
Researchers Report No Long-Term Benefits or Harm for Preterm-Born Children Treated with Hydrocortisone
In a new study, researchers at Children’s Hospital of Philadelphia found that hydrocortisone treatment did not improve or harm functional outcomes at school age in preterm infants at high risk for bronchopulmonary dysplasia.
Children’s Hospital of Philadelphia Researchers Identify Concerning Increase in Newborns Not Receiving Preventative Vitamin K Shots
In a new study, researchers at Children’s Hospital of Philadelphia (CHOP) uncovered an alarming trend – the proportion of newborn infants not receiving preventative vitamin K shots has increased by 77% since 2017. The findings were reported in the Journal of the American Medical Association (JAMA).
Children’s Hospital of Philadelphia Study Links Smartphone Ownership in Childhood to Increased Risk of Depression and Obesity in Youth
Owning a smartphone in early adolescence is linked to higher risks of depression, obesity, and poor sleep, according to a CHOP study with Berkeley and Columbia.
Researchers Highlight Genetic Factors in Pediatric Brain and Spinal Cord Tumors
Researchers at Children’s Hospital of Philadelphia (CHOP) and Children’s National Hospital in Washington D.C. are uncovering how rare inherited genetic variants contribute to the development of brain and spinal cord tumors in children.
Enhancing CPR: Key Updates in the 2025 American Heart Association Guidelines
The recently released 2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) mark the first comprehensive update since 2020.
Children’s Hospital of Philadelphia Researchers Find EoE Patients Can Reintroduce Trigger Foods into Diet after Treatment with Dupilumab
Researchers from Children’s Hospital of Philadelphia (CHOP) found that patients with the inflammatory disease eosinophilic esophagitis (EoE) who were treated with the monoclonal antibody dupilumab were able to safely reintroduce foods that would otherwise trigger their symptoms into their diet, with some patients able to reintroduce those foods earlier than others.