A research team in the Cardiac Center at Children’s Hospital of Philadelphia (CHOP) in collaboration with Boston Children’s Hospital and the Perelman School of Medicine at the University of Pennsylvania was awarded a $660,000 grant over three years by Additional Ventures through its Single Ventricle Research Fund to accelerate research and develop therapies for fetuses with hypoplastic left heart syndrome (HLHS).

Researchers in the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia (CHOP) developed a new tool called the Methylation Screening Array (MSA) to better understand how changes in DNA methylation-mediated regulation of genes, rather than changes in the genes themselves, affect complex human traits like aging and disease risk. This is the first data set to dissect the two forms of DNA methylation---5-methylcytosine and 5-hydroxymethylcytosine---to associate characteristics such as cell composition, gene regulatory mechanism, and epigenetic age in diverse human cell lines and tissues.

CHOP and Penn researchers have developed a gene therapy that significantly slowed motor function loss in preclinical models of amyotrophic lateral sclerosis (ALS), offering new hope for treating the devastating neurodegenerative disease.

Investigators at Children’s Hospital of Philadelphia, St. Jude Children’s Research Hospital, Dana Farber Cancer Institute, and the Children’s Oncology Group, unveiled for the first time that changes in certain genes affect an aggressive cancer, T-cell acute lymphoblastic leukemia, differently depending on genetic ancestry.

In a new study, researchers at Children’s Hospital of Philadelphia (CHOP) showed that partnering with doulas and midwives to support mothers with newborns in the Neonatal Intensive Care Unit (NICU) significantly improves access to timely, essential health services during a critical period of care.

Children’s Hospital of Philadelphia (CHOP) hosted the Cure Sickle Cell Walk & Family Fun Day presented by West Pharmaceutical Services on Saturday, June7. It was a morning of walking, cheering and celebrating sickle cell warriors and their families at Citizens Bank Park. The event, which included a ceremonial walk to honor those with sickle cell disease, along with fun activities for the whole family, raised more than $242,000 for sickle cell disease research and patient care.

CHOP researchers reported long-term clinical outcomes for the largest single center cohort of individuals who underwent complex reconstructive surgery for hypoplastic left heart syndrome as newborns. In this cohort, more than 30% survived without a transplant to at least 35 years of age.

Researchers at Children’s Hospital of Philadelphia (CHOP) found that the artificial intelligence (AI) chatbot, CHATGPT-4, showed promise as a viable tool to enhance ultrasound image analysis, effectively differentiating liver pathologies.

Earlier this month, Children’s Hospital of Philadelphia (CHOP) hosted its 16th annual Walk for Hope benefiting the Center for Pediatric Inflammatory Bowel Disease (IBD) at CHOP, raising more than $215,000 and sparking hope for a cure to IBD.

Researchers at Children’s Hospital of Philadelphia (CHOP) found compelling preclinical evidence that a molecule called tumor necrosis factor alpha (TNFα), typically known for promoting inflammation, also plays a helpful role in recovery from anemia that is caused by ongoing immune disturbances.