Research News from CHOP
New Research from Children’s Hospital of Philadelphia and St. Jude Poised to Transform Approach to Diagnosing and Treating Acute Leukemia in Children
Researchers at Children’s Hospital of Philadelphia (CHOP), St. Jude Children’s Research Hospital (St. Jude) and the Children’s Oncology Group (COG) today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA. The collaborative study, supported by the Gabriella Miller Kids First Pediatric Research Program (Kids First) and National Institutes of Health (NIH) Common Fund, was published today in the journal Nature.
Children’s Hospital of Philadelphia Researchers Find Possible Inaccuracies in Crash-Reported Child Passenger Injuries
Improvements needed to better guide policy and best practice recommendations.
Children’s Hospital of Philadelphia Researchers Reveal New Hope for Chemotherapy-Resistant Neuroblastoma Patients
Researchers at Children’s Hospital of Philadelphia (CHOP) announced a significant breakthrough in understanding chemotherapy resistance in high-risk neuroblastoma, a common and potentially deadly childhood cancer arising within the peripheral nervous system.
Breaking the Deadly Link Between Suicide Ideation and Accessible Guns
Youth suicidality can be fleeting, but not if a loaded firearm is easily accessible in the home. Counseling families about safe gun storage can save lives.
Children’s Hospital of Philadelphia Researchers Use AI-Powered Method to Identify Genetic Epilepsies Much Earlier than Current Genetic Diagnosis
New method, bolstered by a study of 89 million points of data, could help patients receive precision care months or years earlier
Pioneering Single Cell Kidney Atlas Developed by Children’s Hospital of Philadelphia and Penn Medicine Researchers Sheds Light on Potential Treatments
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania revealed the most extensive single cell atlas of the human kidney, capturing the complexity of healthy and diseased kidneys at an unprecedented level and predicting chronic kidney disease (CKD) progression earlier in its course. The findings were published today in the journal Nature Genetics.
Antibiotic Use in Extremely Low Birth Weight Infants Decreased Over Time, according to a New Study from Children’s Hospital of Philadelphia
In a new study, researchers at Children’s Hospital of Philadelphia found that the total amount of antibiotics prescribed to extremely low birth weight (ELBW) infants admitted to neonatal intensive care units (NICUs) decreased over time. The findings were published today in the journal Archives of Disease in Childhood Fetal and Neonatal Edition.
Children’s Hospital of Philadelphia, Penn Medicine Researchers Report High-Throughput Variant Re-Classification for Alagille Syndrome Disease Gene
Findings will help provide more accurate diagnoses to families.
Children’s Hospital of Philadelphia Researchers Implement Successful Virtual Driving Assessment for Teens in Healthcare Settings
Study results, the culmination of two years worth of expansion, offer strategies for providers to empower teen driving safety.
Children’s Hospital of Philadelphia Researchers Develop Antioxidant Strategy to Address Mitochondrial Dysfunction Caused by SARS-COV-2 Virus
Preclinical data suggests a new strategy for treating complex cases of COVID-19 independent of mutations and variants.