Research News from CHOP

Children’s Hospital of Philadelphia Receives $10 Million Grant from the Gilbert Family Foundation to Accelerate Neurofibromatosis Research
Children’s Hospital of Philadelphia (CHOP) today announced that it has received more than $10 million in a series of gifts to fund critical neurofibromatosis research from the Gilbert Family Foundation, a private foundation established by Dan and Jennifer Gilbert to accelerate a cure for neurofibromatosis type 1 (NF1).

CHOP Researchers Reveal Complex Assembly Process Involved in DNA Virus Replication
CHOP researchers have shown that adenovirus proteins use a process called phase separation to coordinate production of viral progeny, which could have broad implications.
CHOP-led Study Identifies Two Different Regulatory T Cell Populations
A CHOP-led study has shown that a regulatory class of T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity.
Two CHOP Teams Awarded Funds to Study Single Ventricle Congenital Heart Disease
Two research teams in CHOP’s Cardiac Center have been awarded research grants to study single ventricle congenital heart disease.
Oxygen Readings May Be Affected by Darker Skin Tones
Researchers found higher rates of false positives in African American children in preliminary data.
CHOP Researchers Find Strong Adolescent-Parent Relationships Lead to Better Long-term Health Outcomes in Young Adults
Based on thousands of adolescents who were followed over a period of more than a decade, this new work represents one of the largest studies on parent-adolescent relationships.
CHOP Researchers Develop First-Of-Its-Kind Prediction Model for Newborn Seizures
The model could predict which newborns would receive the most benefit from monitoring with continuous EEG to detect seizures.

New Study Shows Peanut Patch Effective in Young Toddlers
A new study involving CHOP researchers found that daily use of a “peanut patch” for one year was effective in desensitizing a majority of peanut-allergic toddlers.
CHOP Researchers Find Rate of Fatal Opioid Poisonings Among Children More Than Doubled Over 13-Year Span
Over-the-counter drugs also continue to pose fatal risks to young children despite measures to reduce exposure.
CHOP Selected As New Center for Turning Research Results Into Clinical Practice
CHOP is one of 42 institutions selected by the Patient-Centered Outcomes Research Institute (PCORI) as part of the $50 million initiative.