Research News from CHOP

Children’s Hospital of Philadelphia Study Shows Innovative “Food Pharmacy” Program Benefits Families Living with Food Insecurity
Researchers at Children’s Hospital of Philadelphia (CHOP) found that most patients and their families who reported experiencing food insecurity benefitted from consistent delivery of fresh produce and prepared healthy meals post-hospitalization. The study, recently published in Pediatrics, underscores the need for hospital systems to partner with community-based organizations to address food insecurity throughout the United States.
Children’s Hospital of Philadelphia Researchers Announce New AI Model for Cell Segmentation and Classification
Researchers at Children’s Hospital of Philadelphia (CHOP) announced the creation of a new AI technology called CelloType, a comprehensive model designed to more accurately identify and classify cells in high-content tissue images. The findings were published today in the journal Nature Methods.
CHOP Announces Role in Nationwide NIH Study to Better Understand Escalating Type 2 Diabetes Diagnoses in Children and Teens
Researchers at Children’s Hospital of Philadelphia (CHOP) announced the launch of the initial phase of DISCOVERY of Risk Factors for Type 2 Diabetes in Youth, a nationwide National Institute of Health (NIH) study to address the surge in youth diagnosed with type 2 diabetes over the past two decades.

Children’s Hospital of Philadelphia Researchers Announce Promising Results from First-of-its-Kind, Multicenter, Phase 1 Gene Therapy Trial for Danon Disease
Researchers at Children’s Hospital of Philadelphia (CHOP) announced encouraging results from the first ever gene therapy trial for Danon disease (DD), a rare, X-linked heart condition caused by a single gene mutation. The data on the results of the RP-A501 Phase 1 trial, presented at a late breaking session today at the American Heart Association Scientific Sessions 2024 in Chicago, were also published in the New England Journal of Medicine.
New Research from Children’s Hospital of Philadelphia and St. Jude Poised to Transform Approach to Diagnosing and Treating Acute Leukemia in Children
Researchers at Children’s Hospital of Philadelphia (CHOP), St. Jude Children’s Research Hospital (St. Jude) and the Children’s Oncology Group (COG) today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA. The collaborative study, supported by the Gabriella Miller Kids First Pediatric Research Program (Kids First) and National Institutes of Health (NIH) Common Fund, was published today in the journal Nature.
Children’s Hospital of Philadelphia Researchers Find Possible Inaccuracies in Crash-Reported Child Passenger Injuries
Improvements needed to better guide policy and best practice recommendations.
Children’s Hospital of Philadelphia Researchers Reveal New Hope for Chemotherapy-Resistant Neuroblastoma Patients
Researchers at Children’s Hospital of Philadelphia (CHOP) announced a significant breakthrough in understanding chemotherapy resistance in high-risk neuroblastoma, a common and potentially deadly childhood cancer arising within the peripheral nervous system.
Breaking the Deadly Link Between Suicide Ideation and Accessible Guns
Youth suicidality can be fleeting, but not if a loaded firearm is easily accessible in the home. Counseling families about safe gun storage can save lives.
Children’s Hospital of Philadelphia Researchers Use AI-Powered Method to Identify Genetic Epilepsies Much Earlier than Current Genetic Diagnosis
New method, bolstered by a study of 89 million points of data, could help patients receive precision care months or years earlier

Pioneering Single Cell Kidney Atlas Developed by Children’s Hospital of Philadelphia and Penn Medicine Researchers Sheds Light on Potential Treatments
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania revealed the most extensive single cell atlas of the human kidney, capturing the complexity of healthy and diseased kidneys at an unprecedented level and predicting chronic kidney disease (CKD) progression earlier in its course. The findings were published today in the journal Nature Genetics.