Research News from CHOP

CHOP Researchers Awarded Crazy 8 Grant from Alex’s Lemonade Stand Foundation
CHOP researchers will receive funds to discover a new drug that targets MYCN, a transcription factor involved in some pediatric cancers.
Researchers Identify Head Impact Rates in Four Major High School Sports
Large study provides head impact sensor analysis across four sports and both genders, a first for basketball and field hockey.
CHOP Researchers Find Ribosome Assembly Essential for Stem Cell Regeneration
The findings identify possible targets for future therapies for ribosomopathies, childhood disorders that lead to bone marrow failure (BMF).
Researchers Identify RNA Editing Events that Impact Gene Expression and Phenotype
CHOP researchers have identified RNA editing events that influence gene expression and phenotype, showing that a single nucleotide change can have large downstream effects.
Using Digital Health Tools to Screen Children for Suicide Risk
CHOP expert leading the effort to develop a chatbot to screen children for suicide risk in a more efficient and scalable manner.

Deep Immune Profiling Shows Significant Immune Activation in Children with MIS-C
Using deep immune profiling, CHOP researchers have found children with MIS-C are extremely immune activated, more like adults with severe COVID-19.
Study Finds Benefits to Both Strategies Used to Treat Symptomatic Tetralogy of Fallot
A study involving CHOP researchers has found the two strategies used for treating infants with symptomatic tetralogy of Fallot both have potential benefits for patients.
Oxygen Therapy in Newborns May Impact Influenza Susceptibility Via Lung Circadian Clock
CHOP researchers have found mice exposed to neonatal hyperoxia have increased influenza susceptibility and disrupted lung circadian clocks.
CHOP Researchers Find Effective Combination of Therapies for Managing Mitochondrial Disease
Study is first to demonstrate how one specific combinational therapy may provide measurable benefits to patients with mitochondrial respiratory chain disorders, which currently lack FDA-approved therapies.
Experts at Children’s Hospital of Philadelphia Describe Types of Rashes Associated with MIS-C
CHOP researchers describe different types of rashes they have seen in patients diagnosed with the COVID-19-related inflammatory syndrome.