Research News from CHOP

Antibiotic Use in Extremely Low Birth Weight Infants Decreased Over Time, according to a New Study from Children’s Hospital of Philadelphia
In a new study, researchers at Children’s Hospital of Philadelphia found that the total amount of antibiotics prescribed to extremely low birth weight (ELBW) infants admitted to neonatal intensive care units (NICUs) decreased over time. The findings were published today in the journal Archives of Disease in Childhood Fetal and Neonatal Edition.
Children’s Hospital of Philadelphia, Penn Medicine Researchers Report High-Throughput Variant Re-Classification for Alagille Syndrome Disease Gene
Findings will help provide more accurate diagnoses to families.
Children’s Hospital of Philadelphia Researchers Implement Successful Virtual Driving Assessment for Teens in Healthcare Settings
Study results, the culmination of two years worth of expansion, offer strategies for providers to empower teen driving safety.
Children’s Hospital of Philadelphia Researchers Develop Antioxidant Strategy to Address Mitochondrial Dysfunction Caused by SARS-COV-2 Virus
Preclinical data suggests a new strategy for treating complex cases of COVID-19 independent of mutations and variants.
Many Youths Continue to Take Opioids Months After Surgical Procedures
1 in 6 also filled an opioid prescription two weeks prior to the actual surgery, increasing risk of persistent opioid use
Children’s Hospital of Philadelphia Researchers Find Parent and Caregiver Support Linked to Decreased Depression and Suicidal Thoughts in LGBTQ+ and non-LGBTQ+ Youth
Authors highlight urgent need to tailor health interventions and educate caregivers.
Researchers at Children’s Hospital of Philadelphia Find Lentiviral Gene Transfer Improves Human Alpha Globin Production for the Treatment of Alpha Thalassemia
Researchers at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania Perelman School of Medicine pioneered a new model that offers a potential platform for developing novel therapies to treat Alpha Thalassemia (AT), a severe blood disorder. The findings were published in the journal Blood.
Researchers Publish Final Results of Key Clinical Trial for Monoclonal Antibody in Young Children with Eosinophilic Esophagitis
Results led to expanded FDA approval in January 2024.
CHOP Research Offers Key New Insights in the Treatment of Patellar Sleeve Fractures in Youth
Researchers in the Division of Orthopedics and Sports Medicine and Performance Center at Children’s Hospital of Philadelphia (CHOP) announced results from a large retrospective study of patients surgically treated for Patellar Sleeve Fractures (PSFs), rare knee fractures that occur when a piece of bone and cartilage separates from kneecap. They found that in most pediatric patients with displaced fractures, surgery was effective in restoring full range of motion (ROM) and enabled them to return to their regular activities.
Children’s Hospital of Philadelphia Researchers Discover Molecule’s Ability to Suppress Negative Effects of Type 2 Diabetes, Obesity
Discovery could one day serve as the basis for a non-insulin based therapeutic