Research News from CHOP

CHOP Research Offers Key New Insights in the Treatment of Patellar Sleeve Fractures in Youth
Researchers in the Division of Orthopedics and Sports Medicine and Performance Center at Children’s Hospital of Philadelphia (CHOP) announced results from a large retrospective study of patients surgically treated for Patellar Sleeve Fractures (PSFs), rare knee fractures that occur when a piece of bone and cartilage separates from kneecap. They found that in most pediatric patients with displaced fractures, surgery was effective in restoring full range of motion (ROM) and enabled them to return to their regular activities.
Children’s Hospital of Philadelphia Researchers Discover Molecule’s Ability to Suppress Negative Effects of Type 2 Diabetes, Obesity
Discovery could one day serve as the basis for a non-insulin based therapeutic
Children’s Hospital of Philadelphia Researchers Find Elementary Age Children Experience More Concussions During Activities Unrelated to Sports
Children between 5 and 12 are more likely to experience worse symptoms and delays in specialist care if injured during recreation or other non-sport activities.
Children’s Hospital of Philadelphia Researchers Find Some Patients with Aicardi Goutières Syndrome Have Normal IQ
While unable to speak, patients can understand parents and caregivers, paving the way for future clinical trial design
Expanding Access to Omics-enabled Care in the CHOP ICUs
Rapid diagnosis in the neonatal and cardiac intensive care units (NICU, CICU) is essential to provide care and treatment to critically ill infants.
Children’s Hospital of Philadelphia Study Reveals Novel Immune-Based Biomarker Helps Detect Ovarian Cancer Two to Four Years Before Conventional Diagnosis
Researchers at Children’s Hospital of Philadelphia (CHOP) announced the discovery of a novel immune-based biomarker that could pave the way for potential lifesaving early detection of high-grade ovarian cancer (HGOC). The findings were published today in the journal Cell Reports Medicine.
Researchers Develop New Tool for Better Classification of Inherited Disease-Causing Variants
Tool is freely available for researchers and conforms to evolving research guidelines
CHOP Evaluates Strategies in the Pediatric Intensive Care Unit (PICU) to Enhance Communication and Ensure Equitable Participation in Research
In a new retrospective cohort study, researchers at Children’s Hospital of Philadelphia (CHOP) discuss disparities in race and ethnicity when enrolling families to participate in research conducted in its Pediatric Intensive Care Unit (PICU).
CHOP Researchers Develop Safer, Alternative Conditioning Regimen for the Treatment of Beta-Thalassemia
Innovative model highlights bone marrow transplantation without toxic side effects.

New CHOP Research Links Genetics, Environment and Health Disparities to Increased Stress and Mental Health Challenges During Adolescence
Study is the first to validate allostatic load as measurable in teens.