Research News from CHOP

Multicenter Study Finds Treatment Omalizumab May Help Patients With Certain Food Allergies
A 16-week course could increase the threshold of peanut, tree nuts, egg, milk and wheat that would trigger an allergic reaction.
The Wyss Foundation provides $5 Million in funding for Children’s Hospital of Philadelphia’s Wyss/Campbell Center for Thoracic Insufficiency Syndrome
Children’s Hospital of Philadelphia (CHOP) is thrilled to announce a gift of $5 million from the Wyss Foundation to support innovations that improve the lives of patients with thoracic insufficiency syndrome (TIS).
CHOP Researchers Successfully Employ New Method for Treating Pediatric Patients with Common Heart Valve Disease
This new method, typically used in adult patients, may spare patients from having to undergo open heart surgery.
Web-Based Resource Provides Precise Classification of Dual Genome Variants of Primary Mitochondrial Disease
Quick-Mitome, developed by an international consortium of mitochondrial disease specialists, is available for non-commercial, non-clinical research.
The PUSH Study: Patterns of Polysubstance Use and Its Association with Sexual Partnership Factors
Researchers from Children’s Hospital of Philadelphia (CHOP) and Johns Hopkins University School of Medicine studied how high levels of substance and polysubstance use are associated with sexual practices, and partner characteristics that can reinforce risk for HIV acquisition or transmission among Black and Latinx sexual youth as well as gender minority youth.

Children’s Hospital of Philadelphia Performs First in U.S. Gene Therapy Procedure to Treat Genetic Hearing Loss
Children’s Hospital of Philadelphia is proud to announce the initial results of an experimental gene therapy treatment of a patient with hereditary hearing loss in the United States. Findings to date indicate that the treatment was successful.
COVID-19 Vaccine Reduces Long COVID in Children
Vaccination associated with moderate protection in large, diverse cohort.
CHOP Researchers Develop Algorithm to Determine How Cellular “Neighborhoods” Function in Tissues
Data from this method could be used to discover how cancers are able to evade therapy and provide better insight into underlying tumor mechanisms.
Researchers from CHOP, Drexel Find Disparities in Rates of Certain Preterm Births
Medically indicated preterm births, like cesarean sections and induced births, can be a sign of other negative health issues affecting patients at neighborhood levels.
CHOP Researchers Find About a Quarter of Mitochondrial Disease Patients Suffer from Malnutrition
The study also found that increased fat and protein intake may improve muscle strength and quality of life in patients with mitochondrial disease.