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Children’s Hospital of Philadelphia Researchers Discover that Acute Myeloid Leukemia Can Permanently Reprogram Stem Cells Through Inflammation
New research from Children’s Hospital of Philadelphia (CHOP) uncovered a previously unknown side effect of Acute Myeloid leukemia (AML), the second most common blood cancer in children, that leaves a long-lasting imprint on healthy blood-forming stem cells, influencing immune responses long after the disease has entered remission. The results were published recently in the journal Cancer Letters.
Children’s Hospital of Philadelphia Preclinical Study Unveils Promising New Treatment Approach for Fanconi Anemia Patients
In a preclinical study, researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a novel treatment strategy for patients with Fanconi anemia (FA), a rare genetic disease resulting in loss of blood-forming stem cells in the bone marrow. The researchers successfully used in situ mRNA delivered directly into the body by lipid nanoparticles (LNPs) to target bone marrow cells and transiently restore stem cell function in patients with FA.
Overcoming Fears and Empowering Other Kids
Inspired by her own journey, a CHOP patient helps other children deal with the stress of managing an illness.
Researchers Determine Underlying Mechanisms of Inherited Disorder that Causes Bone Marrow Failure
Study also found that a readily available bile salt could be used as a treatment to restore proper function.
Q&A with Dr. Cassandra Ligh
Meet pediatric plastic surgeon Cassandra Ligh, MD, FACS, the new Director of CHOP’s Pediatric and Adolescent Breast and Chest Program.
CHOP Researchers Improve Fitness of Cells Used in Cell Transplants
CHOP researchers find exposing cells to a small molecule drug improves cell fitness during hematopoietic stem cell transplants, which could improve ex vivo gene therapy.
Joe Oved, MD, Joins the Comprehensive Bone Marrow Failure Center at CHOP
Dr. Oved brings deep expertise to the group, having completed scientific and clinical training that included tenures as a Fulbright Fellow with the Weizmann Institute in Israel, the NYU School of Medicine with two years as a Howard Hughes Medical Fellow, followed by a residency in Pediatrics at NYP Weill Cornell Medical College.
Millicent — a Mentor and an Inspiration
Millicent, a dedicated BMFC staff member, was selected as a Spark Most Valuable Person (MVP) for the Mentor All Star Awards.
Scott Bartlett, MD, Honored for Work in Craniofacial Surgery
Award honors surgeon’s contributions to the field of reconstructive surgery.