Pediatric Sepsis Program Research Publications

Physicians and researchers from the Pediatric Sepsis Program at Children's Hospital of Philadelphia are regular contributors to clinical publications and frequent speakers at national conferences. Here, we highlight some of their publications, abstracts and presentations.

Publications

2019

Fitzgerald JC, Zane NR, Himebauch AS, Reedy MD, Downes KJ, Topjian AA, Furth SL, Thomas NJ, Scheetz MH, Zuppa AF: Vancomycin prescribing and therapeutic drug monitoring in children with and without acute kidney injury after cardiac arrest. Pediatric Drugs Epub ahead of print 2019.

Randolph AG, Xu R, Novak T, Newhams MM, Bubeck Wardenburg J, Weiss SL, Sanders RC, Thomas NJ, Hall MW, Tarquinio KM, Cvijanovich N, Gedeit RG, Truemper EJ, Markovitz B, Hartman ME, Ackerman KG, Giuliano JS Jr, Shein SL, Moffitt KL for the Pediatric Intensive Care Influenza Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network. Vancomycin monotherapy bay be insufficient to treat methicillin-resistant staphylococcus aureus coinfection in children with influenza-related critical illness. Clinical Infectious Diseases 2019;68(3):365-372.

Pais GM, Avedissian SN, O'Donnell JN, Rhodes NJ, Lodise TP, Prozialeck WC, Lamar PC, Cluff C, Gulati A, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH: Comparative performance of urinary biomarkers for vancomycin induced kidney injury according to timeline of injury. Antimicrob Agents Chemotherapy Epub ahead of print 2019.

Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL. Major Adverse Kidney Events in Pediatric Sepsis. Clinical Journal of American Society of Nephrology 2019; doi: 10.2215/CJN.12201018. [Epub ahead of print].

Thakkar RK, Weiss SL, Fitzgerald JC, Thomas NJ, Nadkarni VM, Muszynski JA. Hall MW for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Risk factors for mortality in pediatric post-surgical versus medical severe sepsis. Journal of Surgical Research 2019, In Press.

Saffaran S, Das A, Hardman JG, Yehya N, Bates DG: High-fidelity computational simulation to refine strategies for lung protective ventilation in paediatric acute respiratory distress syndrome. Intensive Care Med Epub ahed of print 2019.

Levy ER, Yip W, Super M, Ferdinands JN, Anushay M, Su HC, Zhang Y, McLaughlin G, Sapru A, Loftis L, Weiss SL, Hall MW, Cvijanovich N, Schwarz A, Tarquinio K, Randolph A for for the PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators. Mannose binding lectin is associated with pediatric influenza-related critical illness susceptibility and mortality. Submitted to Clinical Infectious Diseases 2019.

Levy E, Yip W, Super M, Ferdinands J, Mistry AJ, Newhams MN, Zhang Y, Su HC, McLaughlin GE, Sapru A, Loftis LL, Weiss SL, Hall MW, Cvijanovich N, Schwarz A, Tarquinio KM, Mourani PM, Randolph AG. Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. Frontiers Immunology 2019, In Press.

Gollomp K, Poncz M. Gp1ba-Cre or Pf4-Cre: pick your poison. Blood. 2019;133(4):287-288.[PMID30679234]

Weiss SL, Zhang D, Bush J, Graham K, Starr J, Tuluc F, Henrickson S, Kilbaugh T, Deutschman CS, Murdock D, McGowan FX, Becker L, Wallace DC. Persistent mitochondrial dysfunction linked to prolonged organ dysfunction in pediatric sepsis. Submitted to Critical Care Medicine 2019

Matehuala S, Pasala S, Goudie A, Fiser R, Weiss SL, Irby K, Crary S, Wang A, Sanders R. Red blood cell distribution width values are associated with multiorgan dysfunction and outcomes in children admitted to the pediatric intensive care unit. Submitted to Intensive Care Medicine 2019.

Han M, Roberts AL, Migliore BA, Cardenas AM, Weiss SL. Reactivation viremia in pediatric sepsis. Submitted to Pediatric Critical Care Medicine 2019.

Weiss SL, Blowey B, Keele L, Ganetskey R, Murali CN, Fitzgerald JC, Sutton RM, Berg RA. Matched retrospective cohort study of thiamine to treat persistent hyperlactatemia in pediatric septic shock. Submitted to Pediatric Critical Care Medicine 2019.

Glau CL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A. Diaphragm atrophy during pediatric acute respiratory failure is associated with prolonged noninvasive ventilation requirement following extubation. Submitted to Pediatric Critical Care Medicine 2019.

Balamuth F, Kittick M, McBride P, Woodford AL, Vestal N, Casper TC, Metheney M, Smith K, Atkin NK, Baren J, Dean JM, Kuppermann N, Weiss SL. Pragmatic pediatric trial of balanced versus normal saline fluid in sepsis: the PRoMPT BOLUS pilot feasibility study. Submitted to Academic Emergency Medicine 2019

Lockman JL, Yehya N, Schwartz AJ, Cronholm PF: Professionalism in Pediatric Anesthesiology: Affirmation of a definition based on results of a nationally-administered survey of pediatric anesthesiologists. Paediatr Anaesth 29(4): 345-352, Apr 2019.

Schlapbach LJ, Weiss SL, Wolf J. Primum non nocere:  Reducing Collateral Damage from Mandates for Time to Antibiotics. JAMA Pediatrics. doi: 10.1001/jamapediatrics.2019.0174. [Epub ahead of print]

Weiss SL, Babl FE, Dalziel SR, Balamuth F. Is chloride worth its salt? [Invited editorial]. Intensive Care Medicine 2019;45(2):275-277.

Imber DA, Thomas NJ, Yehya N: Association between tidal volumes adjusted for ideal body weight and outcomes in pediatric acute respiratory distress syndrome. Pediatr Crit Care Med 20(3): e145-e153, Mar 2019.

Maulden Alexandra B, Garro Aris C, Balamuth Fran, Levas Michael N, Bennett Jonathan E, Neville Desiree N, Branda John A, Nigrovic Lise E: Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. Journal of the Pediatric Infectious Diseases Society Feb 2019.

Yehya N, Thomas NJ, Wong HR: Evidence of endotypes in pediatric acute hypoxemic respiratory failure caused by sepsis. Pediatr Crit Care Med 20(2): 110-112, Feb 2019.

Masino Aaron J, Harris Mary Catherine, Forsyth Daniel, Ostapenko Svetlana, Srinivasan Lakshmi, Bonafide Christopher P, Balamuth Fran, Schmatz Melissa, Grundmeier Robert W: Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PloS one 14(2): e0212665, February 2019.

Lindell Robert B, Nishisaki Akira, Weiss Scott L, Balamuth Fran, Traynor Danielle M, Chilutti Marianne R, Grundmeier Robert W, Fitzgerald Julie C: Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database. Critical care medicine 47(2): e129-e135, Feb 2019. PMCID: PMC6336511

Yehya N, Song MJ, Lawrence GG, Margulies SS: HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch. Int J Mol Sci 20(4): E948, Feb 2019.

Khemani RG, Smith L, Lopez-Fernandez YM, Kwok J, Morzov R, Klein MJ, Yehya N, Willson D, Kneyber MCJ, Lillie J, Fernandez A, Newth CJL, Jouvet P, Thomas NJ: Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir Med 7(2): 115-128, Feb 2019.

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Srinivasan L, Bonafide CP, Balamuth F, Schmatz M, Grundmeier RW. Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PLoS One. 2019 Feb 22; 14(2):e0212665. doi: 10.1371/journal.pone.0212665. eCollection 2019. PMID: 30794638

Pruitt Christopher M, Neuman Mark I, Shah Samir S, Shabanova Veronika, Woll Christopher, Wang Marie E, Alpern Elizabeth R, Williams Derek J, Sartori Laura, Desai Sanyukta, Leazer Rianna C, Marble Richard D, McCulloh Russell J, DePorre Adrienne G, Rooholamini Sahar N, Lumb Catherine E, Balamuth Fran, Shin Sarah, Aronson Paul L: Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal of pediatrics 204: 177-182.e1, Jan 2019. PMCID: PMC6309646

Mahadeo K, Khazal S, Abdel-Azim H, Fitzgerald JC, Taraseviciute A, Bollard C, Tewari P, Duncan C, Traube C, McCall D, Steiner M, Cheifetz I, Lehmann L, Mejia R, Slopis J, Bajwa R, Kebriaei P, Martin P, Moffet J, McArthur J, Petropoulos D, Curry JO, Featherston S, Foglesong J, Shoberu B, Glubis A, Mireles M, Hafemeister L, Nguyen C, Kapoor N, Rezvani K, Neelapu SS, Shpall E, PALISI Network: Guidelines for Chimeric Antigen Recepter T-Cell (CAR-T) therapy management of pediatric patients. Nat Rev Clin Oncol 16(1): 45-63, January 2019.

Yehya N, Thomas NJ: Sepsis and Pediatric Acute Respiratory Distress Syndrome. J Pediatr Intensive Care 8(1): 32-41, Jan 2019.

2018

Thomson Joanna, Sucharew Heidi, Cruz Andrea T, Nigrovic Lise E, Freedman Stephen B, Garro Aris C, Balamuth Fran, Mistry Rakesh D, Arms Joseph L, Ishimine Paul T, Kulik Dina M, Neuman Mark I, Shah Samir S: Cerebrospinal Fluid Reference Values for Young Infants Undergoing Lumbar Puncture. Pediatrics Page:  doi: 10.1542, February 2018 Notes: epub ahead of print.

Aronson Paul L, Wang Marie E, Shapiro Eugene D, Shah Samir S, DePorre Adrienne G, McCulloh Russell J, Pruitt Christopher M, Desai Sanyukta, Nigrovic Lise E, Marble Richard D, Leazer Rianna C, Rooholamini Sahar N, Sartori Laura F, Balamuth Fran, Woll Christopher, Neuman Mark I: Risk Stratification of Febrile Infants u880460 Days Old Without Routine Lumbar Puncture. Pediatrics 142(6), Dec 2018. PMCID: PMC6317769

Nigrovic Lise E, Lipsett Susan C, Molins Claudia R, Wormser Gary P, Bennett Jonathan E, Garro Aris C, Levas Michael N, Balamuth Fran, Neville Desiree, Lingampalli Nithya, Robinson William H, Branda John A: Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagnostic microbiology and infectious disease Dec 2018.

Balamuth M.D. Ph.D. MSCE,1 Andrea T. Cruz M.D. M.P.H.,2 Stephen B. Freedman M.D. M.P.H.,3 Paul T. Ishimine M.D.,4 Aris C. Garro M.D. M.P.H.,5 Sarah Curtis M.D.,6 Kendra L. Grether-Jones M.D.,7 Aaron S. Miller M.D. M.P.H.,8 Neil G. Uspal M.D.,9 Suzanne M. Schmidt M.D.,10 Samir S. Shah M.D. M.P.H.,11 Lise E. Nigrovic M.D. M.P.H.12 for the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC) HSV Study Group.  : Test Characteristics of cerebrospinal fluid Gram stain to identify bacterial meningitis in infants less than 60 days old. Pediatric Emergency Care 204: 177-182, November 2018.

Himebauch AS, Yehya N, Yan W, Conlon TW, Kilbuagh TJ, McGowan FX, Mercer-Rosa L: Early right ventricular systolic dysfunction and pulmonary hypertension are associated with worse outcomes in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): e1055-e1062, Nov 2018.

Keim G, Watson RS, Thomas NJ, Yehya N: New morbidity and discharge disposition of pediatric acute respiratory distress syndrome survivors. Crit Care Med 46(11): 1731-1738, Nov 2018.

Gollomp K, Kim M, Johnston I, Hayes V, Welsh JD, Arepallly GW, Kahn ML, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska AM, Poncz M. Neutrophil accumulation and NET release contribute to thrombosis in HIT. JCI Insight 2018;3(18).pii:99446 [PMID30232279]

Dowell JC, Parvathaneni K, Thomas NJ, Khemani RG, Yehya N: Epidemiology of cause of death in pediatric acute respiratory distress syndrome. Crit Care Med 46(11): 1811-1819, Nov 2018.

Bhalla AK, Yehya N, Mack WJ, Wilson ML, Khemani RG, Newth CJL: The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 46(11): 1803-1810, Nov 2018.

Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin SS, Aronson PL for the Febrile Young Infant Research Collaborative: Factors associated with adverse outcomes among febrile young infants with invasive bacterial infections. Journal of Pediatrics 204:177-182.e1.: doi: 10.1016, October 2018.

Rowan CM, McArthur J, Hsing DD, Gertz SJ, Smith LS, Loomis A, Fitzgerald JC, Nitu ME, Moser EAS, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM; Investigators of the Pediatric Acute Lung Injury and Sepsis Network: Acute respiratory failure in pediatric hematopoietic cell transplantation - A Multicenter Study. Critical Care Medicine 46(10): e967-e974, October 2018.

Cornell TT, Selewski DT, Alten JA, Askenazi D, Fitzgerald JC, Topjian AA, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Moler FW: Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131: 63-38, October 2018.

Christopher Wall, Mark Neuman, Christopher Pruitt, Marie Wang, Eugene Shapiro, Samir Shah, Russell McCulloh, Lise Nigrovic, Sanyukta Desai, Adrienne DePorre, Rianna Leazer, Richard Marble, Frances Balamuth, Elana Feldman, Laura Sartori, Whitney Browning, Paul Aronson: Epidemiology and Etiology of Invasive Bacterial Infection in Infants u880460 Days Old Treated in Emergency Departments. Journal of Pediatrics 200(2): 210-217, September 2018.

Gollomp K, Friedman D, Poncz M. Platelets can soak it up and then spit it out: Lessons for a novel therapy in TTP and beyond. Athero Thromb Vasc Biol. 2018;38(11):2544-2545. [PMID30354233]

Stenson EK, Cvijanovich NZ, Anas N, Allen GL, MD, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Raj SS, Gertz S, Grunwell JR, Wong HR.  Hyperchloremia is associated with complicated course and mortality in pediatric patients with septic shock. Pediatric Critical Care Medicine 2018:19(2):155-160.

Yehya N, Keim G, Thomas NJ: Subtypes of pediatric acute respiratory distress syndrome have different predictors of mortality. Intensive Care Med 44(8): 1230-1239, Aug 2018.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ. Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Critical Care Medicine 2018:46(3):e242-e249.

Michelson KN, Reubenson G, Weiss SL, Fitzgerald JC, Ackerman K, Christie L, Bush JL, Nadkarni VM, Thomas NJ, Schreiner MS for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Site variability in regulatory oversight for an international study of pediatric sepsis.  Pediatric Critical Care Medicine 2018;19(4):e180-e188.

Khemani RG, Parvathaneni K, Yehya N, Bhalla AK, Thomas NJ, Newth CJL: PEEP Lower Than the ARDS Network Protocol is Associated with Higher Pediatric ARDS Mortality. Am J Respir Crit Care Med 198(1): 77-89, Jul 2018.

Garro A, Bennett J, Balamuth F, Levas MN, Neville D, Branda JC, Maulden AB, Lantos PM, Nigrovic LE for the Pedi Lyme Net. : Positive Two-tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the U.S. Pediatric Infectious Disease Journal Page: doi: 10.1097, July 2018 Notes: epub ahead of print.

Carrie Daymont, Fran Balamuth, Halden Scott, Patrick Brady, Chris Bonafide, Holly Depinet, and Elizabeth Alpern: Elevated heart rate and risk of revisit with admission in pediatric emergency patients. Pediatric Emergency Care Page: e-pub ahead of print, July 2018.

Stewart CA, Yehya N, Fei L, Chima RS: High frequency oscillatory ventilation in a cohort of children with respiratory failure. Pediatr Pulmonol 53(6): 816-823, Jun 2018.

Glau DL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A. Progressive diaphragm atrophy in pediatric acute respiratory failure. Pediatric Critical Care Medicine 2018;19(5):406-411.

Fitzgerald JC, Li Y, Fisher BT, Huang YS, Miller TP, Bagatell R, Seif AE, Aplenc R, Thomas NJ: Hospital variation in intensive care resource utilization and mortality in newly diagnosed pediatric leukemia. Pediatric Critical Care 19(6): e312-e320, June 2018.

Aronson Paul L, McCulloh Russell J, Tieder Joel S, Nigrovic Lise E, Leazer Rianna C, Alpern Elizabeth R, Feldman Elana A, Balamuth Fran, Browning Whitney L, Neuman Mark I: Application of the Rochester Criteria to Identify Febrile Infants With Bacteremia and Meningitis. Pediatric emergency care Page: doi: 10.1097, February 2018 Notes: epub ahead of print.

Aronson PL, Wang ME, Nigrovic LE, Shah SS, Desai S, Pruitt CM, Balamuth F, Sartori L, Marble RD, Rooholamini SN, Leazer RC, Woll C, DePorre AG, Neuman MI; for the Febrile Young Infant Research Collaborative. : Time to pathogen detection for non-ill vs. ill-appearing infants u880460 days old with bacteremia and meningitis. Hospital Pediatrics 8(7): 379-384, July 2018.

Ross RK, Keele K, Kubis S, Lautz AJ, Dziorny AC, DensonAR, O’Connor KA, Chilutti MR, Weiss SL, Gerber JS. Effect of the procalcitonin assay on antibiotic use in critically ill children. Journal of the Pediatric Infectious Diseases Society 2018;7)2):e43-e46.

Nelson CE, Ostapenko S, Zorc JJ, Balamuth F.: Utilization of Antipyretics for Nonurgent Fever in a Pediatric Emergency Department. Clinical Pediatrics 57(6): 722-726, June 2018.

Nelson CE, Chen A, McAndrew L, Tay KY, Balamuth F.: Management of Skin and Soft-Tissue Infections Before and After Clinical Pathway Implementation. Clinical Pediatrics 57(6): 660-666, June 2018.

Signoff JK, Fitzgerald JC, Teachey DT, Balamuth F, Weiss SL. Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis. Pediatric Critical Care Medicine 2018;19(5):397-405.

Idris I, Alpern E, Angus D, Friedrich M, Kissoon N, Lemeshow S, Levy M, Parker M, Terry K, Watson S, Weiss SL, Zimmerman J, Seymour C. One-hour bundle and mortality during mandated care for pediatric sepsis. JAMA 2018;320(4):358-367.

Fitzgerald JC, Ross ME, Thomas NJ, Weiss SL, Balamuth F, Hyre Anderson A. Risk factors and inpatient outcomes associated with acute kidney injury at pediatric severe sepsis presentation. Pediatric Nephrology 2018;33(10):1781-1790.

Irving SY, Daly B, Verger J, Typpo KV, Brown A, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V for the SPROUT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The association of nutrition status and nutrition support with outcomes in children with severe sepsis: a secondary analysis from the Sepsis, Prevalence, Outcomes, and Therapies (SPROUT) study. Critical Care Medicine 2018;46(11):e1029-e1039.

Lindell, RB, Nishisaki A, Weiss SL, Balamuth F, Traynor DM, Chilutti MR, Grundmeier RW, Fitzgerald JF. Comparison of methods for identification of pediatric severe sepsis and septic shock in the Virtual Pediatric Systems database. Critical Care Medicine 2018;47(2):e129-e135.

Stenson EK, Cvijanovich NZ, Allen GL, MD, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak N, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N.  Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock. Intensive Care Medicine 2018;44(11):2004-2005.

Rowan CM, Loomis A, McArthur J, Smith LS, Gertz SJ, Fitzgerald JC, Nitu ME, Moser EA, Hsing DD, Duncan CN, Mahadeo KM, Moffet J, Hall MW, Pinos EL, Tamburro RF, Cheifetz IM: High-frequency oscillatory ventilation use and severe pediatric ARDS in the pediatric hematopoietic cell transplant recipient. Respiratory Care 63(4): 404-411, April 2018.

Yehya N, Thomas NJ, Khemani RG: Risk stratification using oxygenation in the first 24 hours of pediatric acute respiratory distress syndrome. Critical Care Medicine 46(4):619-624, Apr 2018.

Downes, KJ, Fitzgerald JC, Schriver E, Boge C, Russo M, Weiss SL, Balamuth F, Kubis SE, Tolomeo P, Bilker W, Han JH, Lautenbach E, Coffin SE, Gerber JS, for the CDC Prevention Epicenters Program. Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II study. Journal of the Pediatric Infectious Diseases Society 2018 Nov 22. doi: 10.1093/jpids/piy113. [Epub ahead of print].

Fitzgerald JC, Weiss SL. Taking meaning from numbers in regional epidemiologic data [Invited editorial]. The Lancet Child & Adolescent Health 2018 In Press.

Weiss SL, Watson RS. Measuring hospital performance in pediatric sepsis:  without reliable risk there is no reward [Invited editorial]. Pediatric Critical Care Medicine 2018;19(5)489-490.

Weiss SL, Deutschman CS. Are septic children really just “septic little adults”? [Invited editorial on Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit]. Intensive Care Medicine 2018;44(3):392-394.

Weiss SL, Peters M. Focus on Paediatrics: 2017. Intensive Care Medicine 2018;44(2):235-237.

P Gala, R Scarfone, A Murray, and F Balamuth: Eliminating lumbar puncture for low-risk febrile infants: A quality improvement initiative. Pediatric Emergency Care in press 2018.

Andrea T. Cruz, MD, MPH,1 Stephen B. Freedman, MDCM, MSc,2 Dina M. Kulik, MD,3 Pamela J. Okada, MD,4 Alesia H. Fleming, MD, MPH,5 Rakesh D. Mistry, MD, MS,6 Joanna E. Thomson, MD, MPH,7 David Schnadower, MD, MPH,8 Joseph L. Arms, MD,9 Prashant Mahajan, MD, MPH, MBA,10 Aris C. Garro, MD, MPH,11 Christopher M. Pruitt, MD,12 Fran Balamuth, MD, PhD,13 Neil G. Uspal, MD,14  Paul L. Aronson, MD,15 Todd W. Lyons, MD,16 Amy D. Thompson, MD,17 Sarah J. Curtis, MD, MSc,18 Paul T. Ishimine, MD,19 Suzanne M. Schmidt, MD,20 Stuart A. Bradin, DO,21 Kendra L. Grether-Jones, MD,22 Aaron S. Miller, MD, MSPH,23 Jeffrey Louie, MD,24 Samir S. Shah, MD, MSCE,7 Lise E. Nigrovic, MD, MPH,16 and the HSV Study Group of the Pediatric Emergency Medicine Collaborative Research Committee: Herpes Simplex Virus Infection in Infants u8804 60-days-old Undergoing Evaluation for Meningitis. Pediatrics 141(2): 1688, February 2018.

Zubrow ME, Thomas NJ, Friedman DF, Yehya N: RBC transfusions are associated with prolonged mechanical ventilation in pediatric acute respiratory distress syndrome. Pediatric Critical Care Medicine 19(2):e88-e96, Feb 2018.

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC: Elevations of novel cytokines in bacterial meningitis in infants. PLoS One 13(2), February 2018 Notes: e0181449. doi: 10.1371/journal.pone.0181449. eCollection 2018

Yehya N, Wong HR: Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 46(1): e9-e16, Jan 2018.

2017

Srinivasan L, Page G, Kirpalani H, Murray JC, Das A, Higgins RD, Carlo WA, Bell EF, Goldberg RN, Schibler K, Sood BG, Stevenson DK, Stoll BJ, Van Meurs KP, Johnson KJ, Levy J, McDonald SA, Zaterka-Baxter KM, Kennedy KA, Sánchez PJ, Duara S, Walsh MC, Shankaran S, Wynn JL, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Genome-wide association study of sepsis in extremely premature infants. Arch Dis Child Fetal Neonatal Ed. 2017 Sep; 102(5):F439-F445.

Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. New or Progressive Multiple Organ Dysfunction Syndrome (NPMODS) in Pediatric Severe Sepsis: A Sepsis Phenotype with Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017 Jan;18(1):8-16.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid Fluid Choice and Clinical Outcomes in Pediatric Sepsis: A Matched Retrospective Cohort Study. J Pediatr. 2017 Mar;182:304-310.e10.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL. Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock. 2017 Jul;48(1):29-35.

Gordon SM, Srinivasan L, Harris MC: Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Frontiers in Pediatrics 5: 139, June 2017 Notes: doi: 10.3389/fped.2017.00139. eCollection 2017.

Weiss SL, Asaro LA, Flori HR, Allen GL, Wypij D, Curley MAQ. Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure. Pediatr Crit Care Med. 2017 Apr;18(4):319-329.

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign Based Electronic Alert and Bedside Clinician Identification. Ann Emerg Med. 2017 Jun 2. pii: S0196-0644(17)30315-3.

Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die. Pediatr Crit Care Med. 2017 May 25.

2016

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris M C: Cerebrospinal Fluid Cytokines in the Diagnosis of Bacterial Meningitis in Infants. Pediatr Res. 2016 Oct; 80(4):566-72.

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol. 2016 Apr;37(4):483-5.

Giuliano JS, Jr, Markovitz BP, Brierley J, Levin R, Williams G,  Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs.  Pediatr Crit Care Med. 2016 Jun;17(6):522-30.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized Treatment Is Associated With Decreased Organ Dysfunction in Pediatric Severe Sepsis. Pediatr Crit Care Med. 2016 Sep;17(9):817-22.

Lautz AJ, Dziorny AC, Denson AR, O’Connor KA, Chilutti MR, Ross RK, Gerber JS, Weiss SL. Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit. J Pediatr. 2016 Dec;179:74-81.e2.

Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) NetworkAcute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. Crit Care Med. 2016 Dec;44(12):2241-2250.

2015

Weiss SL, Selak MA, Tuluc F, Perales-Villarroel JP, Nadkarni VM, Deutschman CS, Becker, LB. Mitochondrial Dysfunction in Peripheral Mononuclear Cells in Pediatric Septic Shock. Pediatr Crit Care Med. 2015 Jan;16(1):e4-e12.

Weiss SL*, Fitzgerald JC*, PappacHan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A, Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57.  (*contributed equally)

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Acad Emerg Med. 2015 Nov;22(11):1298-306.

Weiss SL, Fitzgerald JC, Maffei F, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Ying Kee S, Bush JL, Roy JA, Thomas, NJ, Nadkarnin VM for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Discordant Identification of Pediatric Severe Sepsis by Research and Clinical Definitions in the SPROUT International Point Prevalence Study. Crit Care. 2015 Sep 16;19:325

Balamuth F, Weiss SL, Hall M, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Centkowski S, Baumer S, Weiser J, Hayes K, Shah SS, Alpern ER. Identifying pediatric severe sepsis and septic shock: accuracy of diagnosis codes. J Pediatr. 2015 Dec;167(6):1295-300.e4.

2014

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ. Understanding the Global Epidemiology of Pediatric Critical Illness: The Power, Pitfalls, and Practicalities of Point Prevalence Studies. Pediatr Crit Care Med. 2014 Sep;15(7):660-666.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med. 2014 Nov;42(11):2409-17.

Balamuth F, Weiss SL, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Hayes K, Gaieski D, Hall M, Shah SS, Alpern ER. Pediatric Severe Sepsis in US Children's Hospitals. Pediatr Crit Care Med. 2014 Nov;15(9):798-805.

Abstracts and presentations

2019

Balamuth F, Kittick M, McBride P, Woodford AL, Vestal N, Casper TC, Metheney M, Smith K, Atkin NK, Baren J, Dean JM, Kuppermann N, Weiss SL. Pragmatic pediatric trial of balanced versus normal saline fluid in sepsis: the PRoMPT BOLUS pilot feasibility study. Poster Presentation at the Pediatric Academic Societies’ Annual Meeting, 2019 April 27-30, Baltimore, MD.

Balamuth F, Scott H, Weiss SL, Webb M, Chamberlain J, Bajaj L, Depinet H, Grundmeier R, Deakyne-Davies S, Simon NJ, Cook L, Alpern E. Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Sepsis-3 Definitions in the Pediatric Emergency Department. Platform Presentation at the Pediatric Academic Societies’ Annual Meeting, 2019 April 27-30, Baltimore, MD.

Wildenhain P, Oliver A, Kaminski S, Weiss SL, Bird G, Woods-Hill C, Biedron L. The alert that cried wolf: mitigating alert fatigue in critical care areas. Poster Presentation at the Improving Pediatric Sepsis Outcomes Workshop, 2018 December 6-7, Dallas, TX. Published in Pediatric Quality and Safety 2019.

Finnegan L, Harris M, Coggins S, Schmatz M, Tremoglie-Barkowski M, Srinivasan S. Suspected Sepsis in the NICU: Leveraging Staff Perceptions of Delays in Antibiotic Administration to Drive Improvement.  ESPR (podium presentation), SPR (poster) 2019. Platform presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Sivakumar N, Srinivasan L, Grundmeier R, Schmatz M, Harris MC.  Demystifying “Culture-negative sepsis”: Reasons for prolonged antibiotic administration in the NICU. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Coggins S, Harris MC, Grundmeier R, Nawab U, Srinivasan L. Pediatric SIRS and organ dysfunction criteria in late-onset sepsis in a quaternary NICU: a case-control study. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Karavite D, Muthu N, Shaeffer G, Balamuth F, Harris MC, Grundmeier, R.  Lessons Learned from Knowledge Elicitation in Complex Clinical Environments: Iteration is not just for Design. Workshop presentation, Human Factors and Ergonomic Society (HFES) Healthcare Symposium. Chicago, Illinois, March, 2019.

Kharayat P, Conway J, Sanders R, Nett S, Zeqo J, Weiss SL, Edwards L, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner D, Nadkarni V, Nishisaki A. Dose effect of ketamine on hemodynamic outcomes among critically ill children with and without shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Conway J, Kharayat P, Sanders R, Nett S, Weiss SL, Edwards L, Page-Goertz C, Zeqo J, Kirby A, Krawiec C, Polikoff L, Turner D, Nadkarni V, Nishisaki A. Ketamine use in tracheal intubation and adverse hemodynamic events. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Morgan R, Yeung T, Landis WP, Nadkarni VM, Berg RA, Weiss SL, Kilbaugh TJ, Topjian AA, Sutton RM. Post-arrest inflammatory markers and outcomes from pediatric in-hospital cardiac arrest. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Ginsburg S, Conlon T, Himebach A, Glau C, Weiss SL, O’Connor M, Nishisaki A. Prevalence of LV diastolic dysfunction and association with outcomes in septic pediatric patients. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Becker A, Fitzgerald J, Kubis S, Traynor D, Vossough A, Weiss SL, Topjian A, Kirschen M. MRI abnormalities in pediatric sepsis. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Chiotos K, Biedron L, Fitzgerald J, Robbins-Tighe S, Weiss SL, Woods-Hill C. Sepsis huddles in the PICU: Understanding the impact on timely antibiotics, perceptions, and barriers. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Matehuala S, Pasala S, Goudi A, Fiser R, Weiss SL, Irby K, Crary S, Wang A, Sanders R. Red blood cell distribution width values predict multiorgan failure in children admitted to the PICU. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Nishisaki A, Weiss SL, Traynor D, Fitzgerald JC. Risk of mortality in immunocompromised children with severe sepsis and septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Lindell R, Fitzgerald JC, Nishisaki A, Traynor D, Weiss SL. Predictive validity of mortality prediction scores in pediatric severe sepsis and septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Glau GL, Conlon TW, Yehya N, Weiss SL, Himebach AD, Nishisaki A. Pediatric diaphragm atrophy is associated with prolonged non-invasive support following extubation. Star Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Whitney J, Bush J, Graham K, Chen F, Kengle N, Lacey S, Melenhorst JJ, Yehya N, Weiss SL. Endothelial activation is more prominent in indirect versus direct pediatric ARDS. Star Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

Walker S, Conlon T, Zhang B, Mensinger J, Fitzgerald J, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni V, Weiss SL. Targeting vasoactives to warm versus cold pediatric septic shock. Research Presentation at the 48th Society of Critical Care Medicine Annual Congress, 2019 February 17-20, San Diego, CA.

2018

Kaminski S, Morris K, Weiss SL, Wildenhain P, Abbadess MK, Digerolamo K, Fitzgerald JC, Hadley S, Keren R. Measuring the continuum of sepsis care: development of new metrics for sepsis screening. Poster Presentation at the Improving Pediatric Sepsis Outcomes Workshop, 2018 December 6-7, Dallas, TX.

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Grundmeier RW. Machine Learning Models for Infant Sepsis Prediction. Podium presentation, AMIA Annual Symposium. San Francisco, CA November, 2018.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Whitney J, Yehya N, Weiss SL. IL-6 at sepsis recognition is associated with poor functional outcome. Oral presentation, 25th Pediatric Critical Care Colloquium, 2018 October 5-7, Baltimore, MD.

Weiss SL, Zhang D, Bush J, Star J, Kilbaugh T, Deutschman CS, Becker L, McGowan FX, Wallace D. Decreased immune cell mitochondrial respiration is not associated with organ dysfunction or early death in pediatric sepsis. Shock 2018;49(Suppl 1):131 [Poster presentation, Shock Society 2018 Annual Meeting, 2018 June 9-12, Scottsdale, AZ].

Walker S, Conlon T, Zhang B, Mensinger J, Fitzgerald J, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni V, Weiss SL. Application of Clinical Signs to Differentiate Warm versus Cold Pediatric Septic Shock. Poster presentation, Pediatric Academic Societies’ Annual Meeting, 2018 May 5-8, Toronto, Canada.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Coggins S, Kalb, E, Harris MC, Nawab U, Grudmeier R, Srinivasan L: Factors Associated with Delayed Recognition of Sepsis in a Quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Whitney J, Yehya N, Weiss SL. Increased endothelial activation is evident if pediatric extrapulmonary sepsis complicated by ARDS. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

Han M, Roberts A, Allen B, Cardenas AM, Weiss SL. Cytomegalovirus reactivation viremia in pediatric sepsis. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

Dziorny A, Fitzgerald J, Weiss SL. A data-driven quality improvement initiative to reduce unnecessary laboratory testing in the PICU. Research Presentation at the 47th Society of Critical Care Medicine Annual Congress, 2018 February 25-28, San Antonio, Texas.

2018

Kalb E, Coggins S, Harris MC, Ursula Nawab, Grundmeier R, Srinivasan L. "Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU." (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilutti M, Harris MC. "Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes." (Poster presentations at Society for Pediatric Research, Toronto, Canada 2018 and Eastern Society for Pediatric Research, Philadelphia 2018).

Coggins S, Kalb E, Harris MC, Nawab U, Grundmeier R, Srinivasan L. "Factors associated with delayed recognition of sepsis in a quarternary NICU." (Poster presentation at Eastern Society for Pediatric Research, Philadelphia 2018).

2017

Skraban C, Herrick H, Medne L, Harris MC, Santani A, Zackai E: Acinar Dysplasia, Tbx4 and Lung Branching Morphogenesis. Platform presentation by collaborator, poster presentation, 38th Annual David W. Smith Workshop on Malformations and Morphogenesis, Stowe, VT August 2017.

Weiss SL, Zhang D, Graham K, Deutschman CS, Kilbaugh T, McGowan F, Becker L,  Wallace D. Reduced Mitochondrial Mass Underlays Decreased Respiration in Septic Immune Cells. Star Research Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Weiss SL, Balamuth F, Fitzgerald J, Hensley J, Bush J, Thomas N, Hall M, Muszynski J. Epidemiology of Death Following Pediatric Sepsis: When, Why, and How Septic Kids Die. Research Snapshot Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Gu H, Keele L, Hayes K, Fitzgerald J, Weiss SL, Balamuth F. Machine Learning Predictive Modeling for Organ Dysfunction In Children with Suspected Sepsis in the Emergency Department. Oral presentation at the American Academy of Pediatrics Annual Meeting, September 2017, Chicago, Illinois.

Downes KJ, Schriver E, Russo M, Weiss SL, Fitzgerald JC, Balamuth F, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS for the CDC Prevention Epicenters Program. Implementation of a Pragmatic Biomarker-driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study. Poster presentation at the IDWeek 2017 Conference, Oct 4-8, 2017, San Diego, CA.

2016

Signoff J, Fitzgerald F, Teachey D, Balamuth F, Weiss SL. Hypofibrinogenemia Is Associated with Poor Outcome and Secondary HLH in Pediatric Severe Sepsis. Critical Care Medicine. 2015;43(12) Suppl:A260 [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

Han M, Fitzgerald J, Balamuth F, Chilutti M, Grundmeier R, Nadkarni V, Thomas N, Weiss SL. Hourly Delays to Antimicrobial Therapy Do Not Increase One-year Mortality in Pediatric Severe Sepsis. Critical Care Medicine. 2015;43(12) Suppl:A272-273. [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

Abaya R, Weiss SL, Fitzgerald JC, Balamuth F. Utility of Procalcitonin to Predict Intensive Care Unit Admission and Identify Bacterial Illness in the ED Resuscitation of Pediatric Sepsis. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 30-May 3, 2016, Baltimore, Maryland.

Ballantine A, DiTaranto S, Roberts K, Balamuth F, Weiss SL, Fitzgerald J, Hadley S, Minich C, Rigby V, Keren R. Improving Response to Suspected Sepsis: Results of a Hospital-wide Quality Improvement Initiative. Poster presentation, American Academy of Pediatrics National Conference & Exhibition, October 22-25, 2016, San Francisco, CA.

2015

Balamuth F, Caplan I, Scott H, Weiss SL, Fitzgerald J, Kubis S, Chilutti M, Grundmeier R, Alpern ER. Increased Risk of One-year All-cause Mortality after Pediatric Severe Sepsis. Critical Care Medicine. 2014;42(12) Suppl:A1606 [Poster Presentation at the 44th Critical Care Congress, January 2015, Phoenix, Arizona].

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS & Coffin SE. Pediatric Severe Sepsis/Septic Shock Attributable to Healthcare-associated Infections. The Society for Healthcare Epidemiology of America (SHEA) annual meeting. May 2015, Orlando, Florida.

Dziorny A, Lautz A, Densen A, O’Connor K, Weiss SL. Procalcitonin for Early Recognition of Severe Bacterial Infections in the Pediatric Intensive Care Unit. Platform presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Balamuth F, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Alpern ER, Zorc, JJ. Improved Emergency Department Recognition of Pediatric Severe Sepsis/Septic Shock with an Electronic Alert. Platform presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Balamuth F, Hayes K, Centkowski S, Gagel A, Fitzgerald JC, Weiss SL, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Decreased Organ Failure in Pediatric Sepsis Treated According to a Bundled Treatment Guideline. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 25-28, 2015, San Diego, California.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. Developing a Biomarker-driven Algorithm to Improve Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Oral presentation, IDWeek, October 9, 2015, San Diego, CA.

2014

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Chilutti M, Grundmeier R, Myers S, Lautenbach E, Alpern ER. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Platform Presentation at the Pediatric Academic Societies Annual Meeting, May 2014, Vancouver, BC, Canada.

2013

Weiss SL, Fitzgerald J, Blamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Thomas N, Nadkarni VM. Surviving Sepsis in the Hospital: Location, Location, Location! Crit Care Med. 2012;40(12) Suppl:A480. [Poster presented at 42nd Critical Care Congress, Jan 19-23, 2013, San Juan, PR]

Balamuth F, Woodford A, Weiss SL, Fitzgerald J, Chilutti M, Grundmeier R, Wein JN. Fesnak S, Lavelle J, Alpern ER. There’s an App for That: An Electronic Health Record Sepsis Registry and Clinical Protocol to Improve Quality of Care. Platform presentation. Pediatric Academic Societies’ Annual Meeting, May 2013, Washington, DC.

Grundmeier RW, Chilutti MR, Ostapenko S, Woodford AL, Wein JN, Czaplicki DJ, Schilling DM, Fitzgerald JC, Weiss SL, Balamuth FB, Alpern ER, Lavelle JM. Defining the Gold Standard: Manual Abstraction versus Automated Data Extraction for a Complex Sepsis Registry. Platform Presentation: 6th Annual Mid-Atlantic Healthcare Informatics Symposium, April 26, 2013, Philadelphia, PA.

Woodford AL, Weiss SL, Fitzgerald JC, Chilutti M, Grundmeier R, Lavelle J, Alpern ER, Balamuth F. Expedited Care and Reduced Length of Stay in Critically Ill Pediatric Patients with Sepsis Treated Using a Clinical Pathway and Electronic Order Set in the Emergency Department. Platform Presentation at American Academy of Pediatrics National Conference, October 2013, Orlando, FL.

Balamuth F, Weiss SL, Scott H, Paul R, Neuman M, Ferris R, McClead R, Hall M, Shah S, Alpern ER. For the PHIS Sepsis Research Working Group. Choice of Coding Strategies Directly Impact Estimates of the Epidemiology and Outcomes of Pediatric Severe Sepsis. Poster Presentation at American Academy of Pediatrics National Conference, October 2013, Orlando, FL.

Weiss SL, Villarroel JP, Selak MA, Tuluc F, Deutschman CS, Nadkarni VM, Becker LB. Mitochondrial Dysfunction in Circulating Immune Cells in Pediatric Septic Shock. Crit Care Med. 2013;41(12) Suppl:A17 [Oral Presentation at the 43rd Critical Care Congress, San Francisco, CA].

Fitzgerald JC, Weiss SL, Nadkarni VM, Bush J, Thomas NJ, for the SPROUT and PALISI Network Investigators. Global Epidemiology and Outcomes of Pediatric Severe Sepsis – The Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Crit Care Med. 2013;41(12) Suppl: A137 [Poster Presentation at the 43rd Critical Care Congress, San Francisco, CA].