Pediatric residents at Children’s Hospital of Philadelphia are active participants in the institution’s research efforts. We have leaders and resident opportunities across a wide range of research types, including basic science, clinical, improvement science, medical education, health disparities, health services, and health policy research.

For examples of our broad research portfolio, visit the CHOP PolicyLab or the CHOP Research Institute.

See a sampling of resident research, including recent publications and presentations by residents:

Publications

Senter, J. P., Aisenberg, L. K., Dudley, J. W., Luan, X., Huang, J., Kenyon, C. C., & Hill, D. A. (2024). COVID19 and Asthma Onset in Children. Pediatrics, e2023064615. PMID: 38606487. 

Fahey N, Holt A, Cataltepe D, Brochier A, Stern A, Mazanec M, Courtmanche J, Wilkie T, Tan K, Lyu R, Alper E, Fowler J, Rhein L, & Garg A. Understanding barriers to well-child attendance among Black and Latinx parents. Manuscript submitted with revisions, BMC Primary Care (June 2023).

Nfonoyim B, Chandra M, Bate B, Ekotto K, Jongwane E, Ngaba L, Ngaba P, Njock V, Toledo L, Steenhoff A, Congdon M, Ekoube C. Developing and optimizing an equitable and mutually beneficial virtual global health education partnership. Int J Med Educ. 2023 Dec 22;14:193-196. doi: 10.5116/ijme.6563.1b81. PMID: 38153130.

Rana, M, Cuttin, K, Berry, GT, Torres, A. Paroxysmal hyperthermia, dysautonomia and rhabdomyolysis in a patient with Lesch-Nyhan syndrome. JIMD Reports. 2021; 62( 1): 30- 34. doi:10.1002/jmd2.12249.

Shaul E, Kennedy KV, Spergel ZC, et al. Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2024; 78: 1155-1160. doi:10.1002/jpn3.12170

Friedes BD, McRae AE, Abdul-Raheem J, Balighian E, Golden W, Pahwa AK. Medical Student Note Quality on a Pediatrics Core Clerkship Differs by Service. Cureus. 2023 Sep 5;15(9):e44740. doi: 10.7759/cureus.44740. PMID: 37809116; PMCID: PMC10557370. 2

Hakimi M, Kamsheh AM, O'Connor MJ, Loscalzo S. Shock in a 15-month-old girl after gluteal abscess incision and drainage. Pediatrics in Review (Accepted April, 2023)

Hunt AM, Uthirasamy N, Porter S, Jimenez ME. Parental Depression Screening in Pediatric Health Care Settings: A Scoping Review. Pediatrics. 2022 Jul 1;150(1):e2021055804. doi: 10.1542/peds.2021-055804

Tran Lopez K, Pumphrey K, Simmons P, Crilly C, Jones J, Kuhn E, Flynn E, Lieberman S, Abbas H, Williamson S, Juca A, Hart J, Maletsky K. A Trainee-Led Quality Improvement Project Using Change Management Theory to Improve Bedside Rounding. Hospital Pediatrics. 2023 Oct 16.

Ruiz J, Kelly RK, Aplenc R, Laetsch TW, Seif AE. Absolute neutrophil count clinical trial eligibility criteria for pediatric oncology phase I and phase I/II trials by sponsorship. Pediatr Blood Cancer. 2024; 71:e30925. https://doi.org/10.1002/pbc.30925

Chang, L, Stewart, A. M, Kester, K, Routhier, G, Michelson, K. (2023, Jun). Association of Homelessness With Emergency Department Use Among Children in New York. JAMA Pediatrics , 177(6), 637-640. Cited in PubMed; PMID: 37036731.

DeOliveira, M., Feeney, C., Leahy, C., Nystrom, S., Howell, D. N., Farouk, S. S., Wu, M., Olabisi, O. A., & Sparks, M. A. (2021). Collapsing Glomerulopathy in Identical Twins With Lupus and High-Risk Apolipoprotein L1 (APOL1) Genotype. Kidney international reports, 6(9), 2501-2504. (PMID: 34514214)

Howard, J., Herold, B., Major, S., Leahy, C., Ramseur, K., 2nd, Franz, L., Deaver, M., Vermeer, S., Carpenter, K. L., Murias, M., Huang, W. A., & Dawson, G. (2023). Associations between executive function and attention abilities and language and social communication skills in young autistic children. Autism: the international journal of research and practice, 27(7), 2135-2144. (PMID: 36802865)

Loerinc LB, Scheel AM, Thompson AB, Wall KM, Gillespie SE, McCallum ME, Flowers L, CamachoGonzalez AF. Factors Associated With Anal High-Grade Intraepithelial Lesions and Carcinoma Among Young Men Who Have Sex With Men and Transgender Women With HIV in Atlanta. J Low Genit Tract Dis. 2023 Jan 1;27(1):71-77. doi: 10.1097/LGT.0000000000000714. Epub 2022 Oct 28. PMID: 36305912.

Gombolay G, Morris M, Loerinc L, Blackwell L, Howarth R. Sleep Characteristics in Pediatric Anti-Nmethyl-d-aspartate (NMDA) Receptor Encephalitis: A Retrospective Cohort Study. J Child Neurol. 2023 Apr;38(5):298-306. doi: 10.1177/08830738231173603. Epub 2023 May 18. PMID: 37203168; PMCID: PMC10524468.

Steinhardt LC, Kc A, Tiffany A, Quincer EM, Loerinc L, Laramee N, Large A, Lindblade KA. Reactive Case Detection and Treatment and Reactive Drug Administration for Reducing Malaria Transmission: A Systematic Review and Meta-Analysis. Am J Trop Med Hyg. 2023 Dec 20;110(4_Suppl):82-93. doi: 10.4269/ajtmh.22-0720. PMID: 38118166; PMCID: PMC10993791. 3

Puthumana, J., Egilman, A. C., Ramachandran, R., Naushad, N., Shah, N., & Ross, J. (2021). Early experience with the FDA's regulatory review of novel gene therapies. BMJ Evidence-Based Medicine.

Obsekov V, Ghassabian A, Mukhopadhyay S, Trasande L. Manganese and thyroid function in the national health and nutrition examination survey, 2011-2012. Environ Res. 2023 Apr 1;222:115371. doi: 10.1016/j.envres.2023.115371. Epub 2023 Jan 26. PMID: 36709872. 4

Trasande L, Krithivasan R, Park K, Obsekov V, Belliveau M. Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the United States. J Endocr Soc. 2024 Jan 11;8(2):bvad163. doi: 10.1210/jendso/bvad163. Erratum in: J Endocr Soc. 2024 Feb 14;8(3):bvae019. PMID: 38213907; PMCID: PMC10783259.

Obsekov V, Teng C, Balmer DF. EKG Acquisition Curriculum for Pediatric Trainees. J Med Educ Curric Dev. 2023 Oct 9;10:23821205231204758. doi: 10.1177/23821205231204758. PMID: 37822779; PMCID: PMC10563494.

Obsekov V, Kahn LG, Trasande L. Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States. Expo Health. 2023;15(2):373-394. doi: 10.1007/s12403-022-00496-y. Epub 2022 Jul 26. PMID: 37213870; PMCID: PMC10198842.

Regan-Fendt KE, Izumi K. Nuclear speckleopathies: developmental disorders caused by variants in genes encoding nuclear speckle proteins. Hum Genet. 2023 Mar 16. doi: 10.1007/s00439-023-02540-6. PMID: 36929417.

Regan-Fendt KE, Rippert AL, Medne L, Skraban CM, DeJesse J, Gray C, Reichert SL, Staropoli NP, Santos FJR, Krantz ID, Murrell JR, Izumi K. Retrospective identification of patients with SRRM2-related neurodevelopmental disorder in a single tertiary children's hospital. Am J Med Genet A. 2023 Aug;191(8):2149-2155. PMID: 37212523.

Revak S, Shaker M, Sun D. Balancing early detection of adenosine deaminase deficiency with overdiagnosis risk. Ann Allergy Asthma Immunol. 2022 Dec;129(6):665-666. doi: 10.1016/j.anai.2022.09.013. PMID: 36464395.

Slovin, Ariella, et al. "Meaningful Work, Career Fit, and Professional Well-Being of Pediatric Academicians in the United States." Hospital Pediatrics (2024): e2022007080. PMID: 8596849 

Miller C, MD MPH; Rothstein R, MD MPH; Jones JM, MD; Zorc JJ, MD MSCE. High Flow Nasal Cannula and Bronchiolitis: Reducing Admissions to Intensive Care by Optimizing Respiratory Support in the Emergency Department and General Inpatient Units. Journal of Pediatrics, (2024). 

Rothstein R, BS MPH; DeAngelo N, BS; Grant CN, MD; Martin KL, MD; Mechanisms of Cervical Spine Injury in Rural Children: A Single Institution Longitudinal Study. Journal of Pediatric Surgery, (2021). 

Rothstein R, BS MPH; Rideout L, FNP PhD; Chwals WJ, MD. Fall-Related Injury Prevention Among Young Children: A Systematic Review. International Journal of Injury Control and Safety Promotion, (2021).

Rothstein R, BS MPH; Ritchie M, BS MPH; Rideout L, FNP PhD; Chwals WJ, MD. Fall-Related Injury in Infants and Toddlers: A Single Institution Study. The Journal of Trauma and Acute Care Surgery, (2020).

Su KW, Cetinbas M, Martin VM, Virkud YV, Seay H, et al. Early infancy dysbiosis in food protein-induced enterocolitis syndrome: A prospective cohort study. Allergy. 2023; 78(6):1595-1604.

Seay HL, Martin VM, Virkud YV, Marget M, Shreffler WG, Yuan Q. Prospective associations between acid suppressive therapy and food allergy in early childhood. Clin Exp Allergy. 2022; 52(5):711-714.

Martin VM, Virkud YV, Dahan E, Seay HL, et al. Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis. Microbiome. 2022; 10(1):154.

Trivedi M, Hoque S, Shillan H, Seay H, et al. CENTER-IT: a novel methodology for adapting multi-level interventions using the Consolidated Framework for Implementation Research-a case example of a school-supervised asthma intervention. Implement Sci Commun. 2022; 3(1):33.

Arenas JA, Becker S, Seay H, Frisard C, Hoque S, Spano M, Lindenauer P, Sadasivam R, Pbert L, Trivedi M. A response to COVID-19 school closures: The Feasibility of a school-linked text message intervention as an adaption to school-supervised asthma therapy. Pedi Pulm. 2022; 57(5):1214-1222.

Trivedi M, Hoque S, Luther J, Spano M, Shillan H, Pearl H, Seay H, et al. Incorporating systems-level stakeholder perspectives into the clinical trial design of school-supervised asthma therapy. Contemp Clin Trials. 2021; 108:106510.

Seay H, Perman M, Treat J, Ahmed F, Brown-Whitehorn T, Spergel J, Heimall J. MMR and Varicella Immunization Rate during Dupilumab Therapy. J. Allergy Clin Immunology. 2024; 153(2): AB28.

Seay H, Yazdani M, Wanamaker S, Pumphrey K, Kenyon C. Implementation Strategies for Adoption of Single Maintenance and Reliever Therapy among Primary Care Physicians. J. Allergy Clin Immunology. 2024; 153(2): AB183.

Marget M, Martin V, Virkud Y, Seay H, Rosow R, Yuan Q, Shreffler W. Impact of the LEAP study on age at introduction of peanut in a suburban U.S. cohort. J. Allergy Clin Immunology. 2022; 149(2): AB105.

Trivedi M, Hoque S, Luther J, Shillan H, Pearl H, Seay H, et al. Engagement of systems-level stakeholders in the clinical trial design of school- supervised asthma therapy. Am J Respir Crit Care Med. 2021; 203: A1617.

Schuelke MR, Bassiri H, Behrens EM, Canna S, Croy C, DiNofia A, Gollomp K, Grupp S, Lambert M, Lambrix A, Maude SL, Myers R, Newman H, Petrosa W, Seif A, Sullivan KE, Teachey DT, Diorio C. Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients. Blood Adv. 2023 Sep 26;7(18):5603-5607. doi: 10.1182/bloodadvances.2023010712. Erratum in: Blood Adv. 2023 Nov 28;7(22):6829. PMID: 37721859; PMCID: PMC10514204. 6

Shannon MM, Burris HH, Graham DA. Variation in NICU Head CT Utilization Among U.S. Children's Hospitals. Hosp Pediatr. 2023 Feb 1;13(2):106-141. doi:10.1542/hpeds.2021-006322. PMID: 36617983.

Giordano T, Durkin A, Simi A, Shannon M, Dailey J, Facey H, Ballester L, Wetmore RF, Germiller JA. HighDose Celecoxib for Pain After Pediatric Tonsillectomy: A Randomized Controlled Trial. Otolaryngol Head Neck Surg. 2023 Feb;168(2):218-226. doi: 10.1177/01945998221091695. PMID: 35412873.

Nguemeni Tiako MJ, South E, Shannon MM, McCarthy C, Meisel ZF, Elovitz MA, Burris HH. Urban residential tree canopy and perceived stress among pregnant women. Environ Res. 2021 Oct;201:111620. doi: 10.1016/j.envres.2021.111620. Epub 2021 Jul 1. PMID: 34216611; PMCID: PMC8485251. 

Shannon MM, Clougherty JE, McCarthy C, Elovitz MA, Nguemeni Tiako MJ, Melly SJ, Burris HH. Neighborhood Violent Crime and Perceived Stress in Pregnancy. Int J Environ Res Public Health. 2020;17(15). doi:10.3390/ijerph17155585

Pumphrey K, Tran Lopez K, Simmons P, Jones J, Crilly C. et. Al. "A Trainee-Led Quality Improvement Project Using Change Management Theory to Improve Bedside Rounding." Hospital Pediatrics. Published October 2023 Simmons

Gold JI, Gold NB, Strong A, Tully E, Xiao R, Schwartz LA, Ficicioglu C. (2022) The current state of adult metabolic medicine in the United States: Results of a nationwide survey. Genet Med. 2022 May 10:S1098-3600(22)00747-X.

Walker, J.T., Saunders, D.C., Rai, V. et al. Genetic risk converges on regulatory networks mediating early type 2 diabetes. Nature 624, 621–629 (2023). https://doi.org/10.1038/s41586-023-06693-2

Richardson, T. M., Pettway, Y. D., Walker, J. T., Nelson, H. A., Ishahak, M., Poffenberger, G., Aramandla, R., Reihsmann, C., Agarwal, A., Powers, A. C., Brissova, M. Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles. J. Vis. Exp. (201), e65259, doi:10.3791/65259 (2023). Jelinek SK, Gzesh AS, Whelihan JT Jr. Queer-Affirming Mentorship: A Catalyst for Change and a Challenge to Power Structures. Acad Med. 2023 Oct 30. doi: 10.1097/ACM.0000000000005536. Epub ahead of print. PMID: 37903343. 7

Whelihan JT, Novak M. Pre-exposure Prophylaxis-Preventing HIV in Adolescents. JAMA Pediatr. Published online October 25, 2021. doi:10.1001/jamapediatrics.2021.3274

Stuard, W., Oduguwa, E., Whelihan, J., et. al. Corneal Transplant, Not All the Rules Prevent Blindness. International Journal of Eye Banking. Vol. 9 No. 3. Fall 2021.

Edelson JB, Wooster L, Huang J, Wang Z, Connelly J, Rossano J, O'Connor M, Mavroudis CD, Eichner JR, Gaynor JW, Dewitt A, Evans SH, Edwards J, Wittlieb-Weber C, Lin K, Lane-Fall M, Maeda K. Pediatric Patients on Veno-Arterial Extracorporeal Membrane Oxygenation Undergoing Cardiac Rehabilitation Have Better Outcomes. JHLT Open. May 2024. 10.1016/j.jhlto.2024.100057.

Hardin KM, Giverts I, Campain J, Farrell R, Cunningham T, Brooks L, Christ A, Wooster L, Bailey CS, Schoenike M, Sbarbaro J, Baggish A, Nayor M, Ho JE, Malhotra R, Shah R, Lewis GD. Systemic Arterial Oxygen Levels Differentiate Pre- and Post-capillary Predominant Hemodynamic Abnormalities During Exercise in Undifferentiated Dyspnea on Exertion. J Card Fail. 2024 Jan;30(1):39-47. doi: 10.1016/j.cardfail.2023.05.023. Epub 2023 Jul 17. PMID: 37467924.