LEOPARDS Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

LEOPARDS Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

Contact

 If you are interested in participating in the study or want to learn more, please contact: Contact us
This study is no longer recruiting.

Description
The study goal is to risk stratify pediatric (Acute Respiratory Distress Syndrome) ARDS patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. Specifically, the study aims to:Aim 1: Validate and refine PARDSEVERE, a published protein biomarker-based pediatric ARDS risk stratification toolAim 2: Stratify pediatric ARDS into sub-phenotypes using a known 100-gene expression-based classifier to group subjects according to shared underlying biologyAim 3: Identify de novo sub-phenotypes in pediatric ARDS using biomarkers and whole genome transcriptomics of peripheral blood

Eligibility and criteria
IRB Number:
19-016271
Eligible age range:
1 months - 17.5 years
Clinical trial phase:
N/A
Official title:
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

What to expect

Related specialties
Smiling CHOP patient holding shopping bag

We need families like you

Your time and participation make a difference in supporting the work of the Research Institute and children in our community. Learn more about opportunities to participate in our research.