Study of Rifampin as a Treatment for Elevated Calcium Levels in Patients with Genetic Vitamin D Excess
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Description
You are invited to take part in a voluntary research trial because you have a genetic defect in vitamin D metabolism that causes elevated blood and/or urine levels of calcium and you are between the ages of 6 months and 65 years. You will be given a rifampin, which is an antibiotic drug that has been approved in the US by the FDA for treatment of many infections. Rifampin has not been approved for use in disorders of vitamin D metabolism. If you meet all criteria, you will be asked to come to CHOP for study visits and have phone calls for a total of approximately 48 weeks. Besides administration of the study product, the study procedures include: review of medical records, physical exam, ultrasound of the kidneys, blood and urine tests, tests of intestinal calcium absorption and nutritional assessment. Participants aged 3 years or older will also have a DXA scan performed. You will be compensated for your time and reimbursed for travel.
Eligibility and criteria
What to expect
This study will take approximately 36 weeks(up to 48 weeks) and include 6 research study visits to The Childrens Hospital of Philadelphia and an additional 5 blood and urine tests.
We need families like you
Your time and participation make a difference in supporting the work of the Research Institute and children in our community. Learn more about opportunities to participate in our research.