This research is studying a vaccine against Mpox (formerly known as monkeypox) that is FDA approved for adults but not yet approved for children. The goal of the study is to determine if the vaccine protects children just as well as it protects adults. The study is also looking at the safety of the vaccine. This study is open to healthy adolescents, ages 12-17. In addition, adolescents with certain immunodeficiency diseases or other conditions, that are well controlled, are eligible to participate.

Although we know a lot about returning to sports, exercise, and school after concussion, we know very little about returning to drive after a concussion. Our Driving after Concussion study needs the help of both healthy and recently concussed teen partners in our research to understand how concussion affects driving behaviors in teens.We are looking for healthy (have not had a concussion in the last year) and recently concussed teens who are 16.5-18 years old with a drivers license and their own smartphone.Our teen research partners may be asked to complete surveys about themselves and download smartphone applications that track symptoms associated with concussion and/or observe real-world driving behaviors. They may also be asked to come to CHOP's Driving Simulator Lab to complete a 3-hour session that includes surveys, clinical testing, and device testing along with a simulated driving assessment to observe driving behavior.All teens who participate will be compensated for their time and effort.

The Center for Injury Research & Prevention is seeking teens age 16-19 and a parent to participate in a research study about distracted driving. Both teens and parents must be licensed drivers and use smartphones. The purpose of this research study is to figure out if a new smartphone app impacts distracted driving, and to learn parent and teen perspectives on the app. Participants will be asked to complete occasional surveys and use a smartphone app for up to 3 weeks. The entire study can be completed remotely, and no visits to CHOP are required. Families are compensated for their time in the study.

Conversations are important for getting along in everyday life, but we don't really know what makes them successful. This study aims to find out what factors help make conversations better. By looking at different talking styles and techniques, we want to learn how to have more effective and enjoyable conversations. We are seeking volunteers between 12-15 years old both with and without autism and their families to partner with us.

Researchers at CHOP are trying to improve outcomes in the treatment of adolescents with anorexia nervosa. Eligible families will receive Family Based Treatment for anorexia nervosa. Some adolescents with anorexia nervosa will also receive Cognitive Remediation Therapy (a treatment that increases flexible thinking). Both parents are required to participate and any siblings living at home are asked to come to the first four treatment sessions. Families will receive treatment for approximately 6 months and will be asked to complete number of assessments during treatment and at two time points after treatment ends.