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New Study Explores Placental Malperfusion’s Impact on Fetal Health and Development in Congenital Heart Disease

Nov 3, 2025

Researchers at Children’s Hospital of Philadelphia (CHOP) discovered that placental malperfusion (PMP), a condition that disrupts blood flow in the placenta, is common in fetuses with congenital heart disease (CHD) and is linked to poor fetal growth, longer hospital stays and potentially increased mortality. The study also highlights that genetic changes in key pathways for placental and cardiac development may underlie PMP in CHD.

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