Center for Pediatric Eosinophilic Disorders
Eosinophilic disorders were unknown a generation ago. Today, eosinophilic esophagitis (EoE) is one of the most common chronic inflammatory diseases of the esophagus.
Eosinophils, a type of white blood cell, are an important part of the immune system and help fight parasites. However, when too many eosinophils appear in areas other than the blood and intestine, they can cause problems. In the nose, they cause seasonal allergies; in the lungs, they cause asthma; in the esophagus, they cause EoE.
CHOP's Center for Pediatric Eosinophilic Disorders cares for more than 1,500 children with EoE – the largest clinical population in the world.
We provide:
- A team of specialists from gastroenterology, allergy, nutrition and pathology
- A coordinated approach to diagnosis and treatment
- Psychology and social work resources
Conditions we treat
This program treats children with eosinophilic disorders, chronic inflammatory diseases of the esophagitis and gastrointestinal system.
Meet your team
Our team of pediatric specialists come from gastroenterology, allergy, nutrition and pathology (doctors who examine tissue samples to help find a diagnosis). These specialists work with skilled nurses, psychologists and dietitians to support your family.
Our locations
You can see specialists from the Center for Pediatric Eosinophilic Disorders at various convenient locations
Our EoE research
Part of our mission is to advance comprehensive research that fosters collaboration and bridges the gap between discovery and bedside care. Through ongoing studies — including research exploring how cell signaling drives tissue remodeling in eosinophilic esophagitis — we are working to deepen understanding of eosinophilic disorders and improve how they are evaluated and treated.
Eosinophilic disorders resources for families
We have created resources to help you get answers to questions about skin patch testing, optimal home management of your child’s symptoms, food allergies and more.
Patient stories
Preparing for your appointment
Before your child’s appointment, please have copies of all previous records and previous biopsies sent to us so our pathology department can review the slides. Mail records to: Center for Pediatric Eosinophilic Disorders, 3500 Civic Center Blvd., Philadelphia, PA 19104; Attn: Michele Shuker, Allergy and Immunology
Please arrive at the Allergy and Immunology office at least 15 minutes before your child's appointment so staff can check you in. At your appointment, you’ll meet the staff — allergists/immunologists, gastroenterologists and nutritionists — who will evaluate your child.
Your child's visit and future visits may include:
- A complete history and physical exam
- Review of previous work-up
- Future appointment scheduling, as needed for allergy skin and patch testing, and endoscopy of the upper GI tract and other types of endoscopy
Transforming Personalized Care for Children with EoE
CHOP’s Transforming EoE Frontier Program is redefining how eosinophilic esophagitis is diagnosed and treated through minimally invasive testing and cutting-edge molecular tools. By tailoring care to each child’s unique biology, the team is making EoE management safer, more precise, and truly personalized.
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