The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for.

Children's Hospital of Philadelphia (CHOP) is inviting healthy individuals ages 0-21 to become part of a unique opportunity to help other kids heal: the CHOP Pediatric Fecal Microbiota Transplant (FMT) Stool Bank. This unique program is the first of its kind in the United States and offers screened stool donations from healthy children that may be used to provide life-changing treatment for children suffering from serious gut infections like recurrent C. difficile - an illness that can cause significant symptoms and complications. Contributing to this program could make a direct difference in providing safe and effective treatment options for serious gut infections in children.

This study seeks to characterize dietary intake in children with or without IBS and explore severity of symptoms and quality of life. This study uses the G-Tech wireless patch system to define patterns of gut motility in patients with or without IBS and associate these patterns with dietary intake and GI symptoms. Participants will wear the patches for 7 days as a part of the study. They can be worn under clothing and participants can continue daily activities other than swimming, bathing (although they can shower), and exercising. Stool and urine samples will also be collected to explore the gut microbiome and its association with GI symptoms, diet, and patterns of gut motility.

We are looking to partner with patients with or without a confirmed diagnosis of IBS between 8 and 18 years of age who may also be undergoing dietary modifications such as a low-FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet.

The purpose of this investigation is to evaluate the impact of non-persistent and persistent chemical exposures on autoimmunity, gene expression and the microbiome in children with and without Crohns disease. If these chemical exposures are associated with differences in the epigenome and microbiome that are known to predispose for Crohns disease, the proposed research could further support changes in dietary behaviors to limit exposure, and efforts to regulate manufacturing processes that unintentionally and intentionally add these chemicals to food.

This study was designed to measure components or metabolites of PEG 3350 in blood and urine from children who were already taking PEG 3350 and to compare these levels to measurements of the same molecules from a group of children who were not taking PEG 3350. PEG 3350 was not prescribed as part of this study. Participants completed questionnaires and provided access to their medical records.Enrollment for this study has been completed. Laboratory analysis of specimens and data analysis are being conducted. This work will be submitted for publication once all analyses have been completed. When available, study results will be accessible on https://classic.clinicaltrials.gov/ct2/show/NCT05424757.

The Childrens Hospital of Philadelphia is seekinghealthy adolescents between the ages of 12-13, who are currently in the 7^thgrade,to participate in the Sleep and Growth Study 2. The purpose of this research is to learn more about the changes in sleep and body size in adolescents as they transition from middle to high school. Participants will be asked to visit CHOP so that we can measure their bone density. Following this visit, participants will wear a sleep tracker over a 2-week period and speak to a team member by phone on three occasions about the types of food eaten in the previous 24 hours. If you and your child agree to participate, the study will involve 3 visits over approximately 2 years. All participants are compensated for their time and effort.For more information and study details, please call 215-590-2383, ext. 1, or emails_grow@chop.edu.