Immune Dysregulation Program Resources for Professionals

Partnering with you to provide optimal care for patients

The Immune Dysregulation Program at Children’s Hospital of Philadelphia (CHOP) provides a single resource where clinicians can turn for advanced diagnostics of suspected immune disorders and personalized treatments targeting the unique cause of their patients’ symptoms.

Immune dysregulation encompasses a large, heterogeneous group of conditions that cause multisystem disease including autoimmunity, hyperinflammation and infections. Because of the diverse features presented, these disorders are often difficult to diagnose and treat. At CHOP, our multidisciplinary expertise, cutting-edge diagnostic and genetic testing, and comprehensive research into the many gene variants that cause immune dysregulation syndromes make us one of few centers in the world with the breadth and depth of expertise needed to address pediatric diseases of immune dysregulation.

No matter what immune dysregulation disorder your patient has — or what’s causing their inflammation — our goals remain the same: to correctly diagnose the patient and develop a customized treatment plan specifically to meet their needs. We often partner with referring physicians and managed care teams, to provide optimal care coordination and ongoing treatment for patients.

Referral and partner information

You may consider partnering with us or referring your patient to the Immune Dysregulation Program at CHOP if your patient has:

  • Objective signs/symptoms of inflammation: e.g., elevated ESR/CRP, recurrent fevers, enlarged spleen or lymph nodes, recurrent infection
  • An unclear diagnosis, or atypical presentation of diagnosis (e.g., Evans syndrome, but the patient has lung disease as well)
  • An atypical response to medication(s) that requires precision therapeutic approaches

Another reason to refer or partner with CHOP is if you desire a multidisciplinary evaluation for the patient (as opposed to a single-service consultation, e.g., rheumatology only, or immunology only)

We accept referrals from providers by phone at 215-590-6706 or via our professional contact form on our website. When referring a patient, please include the patient’s name, contact information for the patient’s parents or guardian, and a short summary of the patient’s medical history leading to your referral or inquiry. Our clinic coordinator will then reach out to the family directly to begin the intake process.

We will review each referral, including all medical records and results once obtained, in detail to determine if we are the best fit, or if another division or program at CHOP would be more appropriate. A nurse practitioner or another clinician from our team may reach out to you to discuss the referral further if more information is needed.

Virtual Collaborations: Open Office Hours

If you suspect that your patient has an immune dysregulation disorder, please request a meeting with specialists from our Immune Dysregulation team for a 30 minute discussion centered around a patient diagnosis, case review, second opinion or patient referral. Must be practicing in the the United States. Select a date and time

Online Education

CHOP’s Online Pediatric Education Network (OPEN) allows us to provide free pediatric medical education to healthcare professionals from around the world.

View Immune Dysregulation CHOP OPEN online courses.

Professional Events

We hold an annual symposium for professionals, typically in the late spring each year. We aim to be the leading meeting in the field of pediatric immune dysregulation. Stay tuned for the symposium agenda and registration details for our event in June, 2024!

Professional eNewsletters

Stay in touch with Children's Hospital of Philadelphia (CHOP). Subscribe to our various professional eNewsletters to receive updates on our research and educational opportunities for you, as well as resources for your patients, news about our clinical programs and more.

View a list of our eNewsletters

Our Publications

The Immune Dysregulation Program has an active research component as our clinicians and researchers are always searching for new clues to help patients with rare diseases and disorders. We publish extensively related to the functions of immune cells, genetic causes for immune dysregulation disorders and novel treatments for patients who may not respond to current treatments.

See our Research Publications