Sickle Cell and Red Cell Disorders Curative Therapy Center (CuRED) News

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First Patients at CHOP Begin Newly Approved Sickle Cell Gene Therapies

Sep 25, 2024

CHOP announced that its first patients outside of clinical trials have begun the treatment process for the newly FDA approved sickle cell gene therapies.

The Late Dr. Kwaku Ohene-Frempong Portrait Unveiling

Jul 1, 2024

The life and legacy of the late Dr. Kwaku Ohene-Frempong was celebrated by family, friends and colleagues at his portrait unveiling ceremony on CHOP’s campus on June 20.

Cure Sickle Cell Walk & Family Fun Day Presented by West Pharmaceutical Services Raises More Than $256,000 for Sickle Cell Disease Research and Care

Jun 20, 2024

Earlier this month, Children’s Hospital of Philadelphia (CHOP) hosted the Cure Sickle Cell Walk & Family Fun Day presented by West Pharmaceutical Services at Citizens Bank Park raising more than $256,000 (and counting!) to support sickle cell warriors.

Researchers Publish Final Results of Key Clinical Trial for Gene Therapy for Sickle Cell Disease

Apr 24, 2024

In a landmark study, an international consortium led by researchers at CHOP published the final results of a key clinical trial of the gene therapy CASGEVY for the treatment of sickle cell disease.

FDA Approves Two Gene Therapies for Sickle Cell Disease

Dec 8, 2023

The Food and Drug Administration (FDA) has approved CASGEVY™ (exagamglogene autotemcel) and LYFGENIA™ (lovotibeglogene autotemcel), the first two gene therapies for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

Researchers Develop “In Vivo” Gene Editing Model for Blood Disorders

Jul 27, 2023

CHOP and Penn researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders directly within the body.

Dr. Alexis Thompson Discusses Early Successes of Gene Therapy for Sickle Cell Disease

Sep 29, 2022

In a short documentary by the New England Journal of Medicine, Dr. Alexis Thompson discusses the early successes of gene therapy, as well as its risks and benefits.

FDA Approves First Potentially Curative Gene Therapy for Beta Thalassemia

Aug 24, 2022

A leading study site for nearly a decade, CHOP will be part of a network of treatment centers in the country offering the therapy to patients who require regular blood transfusions.

New Data Show Benefits of CRISPR-edited Gene Therapy for Blood Disorders in a Larger Patient Group with Longer-Term Follow-Up

Jun 14, 2022

A group of researchers that includes CHOP presented new data on CRISPR-edited gene therapy for blood disorders at an international meeting.

CHOP Researchers Develop Proof-of-Concept Treatment that Elevates Both Adult and Fetal Hemoglobin

Jun 1, 2021

CHOP researchers have developed a proof-of-concept treatment for blood disorders like sickle cell disease that elevates both fetal and adult hemoglobin.

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