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Infant Malnutrition (FTT) — Differential diagnosis — Clinical Pathway: Inpatient

Infant Malnutrition/Failure to Thrive (FTT) Clinical Pathway — Inpatient

Differential Diagnosis

The majority of patients with infant malnutrition (failure to thrive) in General Pediatrics will fall under the inadequate intake category.
It is important to consider a broad differential diagnosis of potential underlying organic etiologies.

Etiology Symptoms Recommendations
Inadequate Intake
  • Long intervals between feeds (Sleep > 3 hrs when < 2 months old)
  • Falling asleep during feeds
  • Limited number and volume of feedings per day
  • Improper mixing of formula
  • Lactation problems: poor supply, difficulty with latching
  • Limited urine diapers (< 1 wet diaper per 8 hrs)
  • Food insecurity/inability to access food resources (i.e., WIC or SNAP)
  • Excessive vomiting/spitting up/reflux
  • Increased hunger cues/caregiver isn’t recognizing cues
  • Symptoms of maternal depression
  • Birth weight not regained in 2 weeks
  • Signs of oral motor dysfunction
Continue following Inadequate Intake Section
Malabsorption
  • High volume, extremely loose stools
  • Clay colored stools
  • Greasy or significantly foul smelling stools
  • Chronic diarrhea
  • Abdominal distention, gassiness with diarrhea
  • Blood in stools
  • Verify newborn screen negative for cystic fibrosis
  • Quantify and qualify stools
  • If abnormal stools, consider initial malabsorption workup
    • Labs: CBC, CMP, GGT, CRP, Prealbumin, ESR
    • Stool Studies: hemoccult, reducing substances and stool pH, Fecal elastase
  • GI consult as clinically indicated
Increased Metabolic Demands
  • Cardiac: heart murmur, tachypnea, sweating or cyanosis with feeds, feeding fatigue
  • Respiratory: noisy breathing, tachypnea, difficulty breathing with feeds, nasal obstruction
  • Neurologic: increased or decreased tone, abnormal movements
  • Neuro-oncologic: diencephalic tumor causing nystagmus, strabismus, macrocephaly, papilledema, vomiting/lethargy
  • Metabolic/genetic: abnormal newborn screen, dysmorphic features
  • Renal: urologic abnormalities, renal tubular acidosis
  • Endocrinology: tachycardia, diaphoresis
Testing and consultation based on clinical assessment

 

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