Education and Training

Undergraduate Degree

BS - University of Delaware, Newark, DE

Graduate Degree

MS - University of Delaware, Newark, DE

Titles and Academic Titles

Senior Mass Spectrometrist, Metabolic and Advanced Diagnostics

Departments and Services




Chen J, Li XL, Edmondson A, Meyers GD, Izumi K, Ackermann AM, Morava E, Ficicioglu C, Bennett MJ and He M. Increased Clinical Sensitivity and Specificity of Plasma Protein N-Glycan Profiling for Diagnosis Congenital Disorders of Glycosylation by Use of Flow Injection-Electrospray Ionization-Quadrupole Time-of-Flight Mass Spectrometry. Clin Chem 2019; 65:5: 653-663.


Tenopoulou M, Chen J, Bastin J, Bennett MJ, Ischiropoulos H and Doulias PT. Strategies for Correcting Very Long Chain Acyl-CoA Dehydrogenase Deficiency. Journal of Biological Chemistry 290(16) Mar 2015: 10486-10494.


Chen J, Ditewig GA and Bennett MJ. An interference-free two-step enzyme assay with UPLC–tandem mass spectrometric product measurement for the clinical diagnosis of uridine diphosphate galactose-4-epimerase deficiency. Journal of Chromatography B, 959 (2014) 5-9


Palladino A, Chen J, Kallish S, Stanley CA, and Bennett MJ. Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects. Mol Genet Metab. Dec 2012; 107(4): 679–683

Chen J, Narayan SB, Edinger AL and Bennett MJ. Flow injection tandem mass spectrometric measurement of ceramides of multiple chain lengths in biological samples. Journal of Chromatography B, 883 (2012) 136-140.


Chen J, Meng, CK, Narayan S, Luan W, Bennett MJ. The use of Deconvolution Reporting Software and backflush improves the speed and accuracy of data processing for urinary organic acid analysis. Clin Chim Acta 2009; 405:53-59.


Freeto S, Mason D, Chen J, Narayan S, Bennett, MJ. A rapid ultra performance liquid chromatography (UPLC) tandem mass spectrometric method for measuring amino acids associated with maple syrup urine disease, tyrosinemia and phenylketonuria, Ann. Clin Biochem 2007; 44:474-81.


Yager CT, Chen J, Reynolds RA, Segal, S. Galactitol and galactonate in red blood cells of galactosemic patients. Molec Genet Metab 2003; 80:283-289.


Chen J, Yager CT, Reynolds RA, Segal, S. Identification of galactitol and galactonate in red blood cells by gas chromatography/mass spectrometry. Clin Chim Acta 2002; 322:37-41.

Chen J, Yager C, Reynolds R, Palmieri M, Segal S. Erythrocyte galactose 1-phosphate quantified by isotope-dilution gas chromatography-mass spectrometry. Clin Chem 2002; 48:604-12.




Chen J and Bennett MJ. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry. Clinical Applications of Mass Spectrometry Methods and Protocols. Humana Press, 2010:365-70.

Chen J and Bennett MJ. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry. Clinical Applications of Mass Spectrometry Methods and Protocols. Humana Press, 2010:445-51.

Posters and Presentations


Chen J, Li XL, Meyers GD, Edmondson A, Bennett MJ, He M. Plasma N-glycan profiling for diagnosis of congenital disorders of glycosylation (CDG) by flow injection-ESI-QTOF. Poster presentation, American Society for Mass Spectrometry, San Antonio, TX, June 2018.

Leadership and Memberships

Memberships in Professional Organizations

2016-present, American Association for Clinical Chemistry
2005-present, American Society for Mass Spectrometry