Amelia J. Eisch, PhD

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Amelia J. Eisch, PhD, is a Scientist in the Department of Anesthesiology and Critical Care Medicine at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training


Postdoctoral Fellowship - Department of Psychiatry, Yale University Medical School, New Haven, CT

Undergraduate Degree

BA in Psychology - Yale University, New Haven, CT

Graduate Degree

PhD in Biological Sciences - University of California at Irvine, Irvine, CA

Titles and Academic Titles


Visiting Scientist, Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Yun S, Donovan MH, Noonan MA, Richardson DR, Reister R, Farnbauch LF, Fisher SJ, Riethmacher D, Gershenfeld HK, Lagace DC, Eisch AJ. Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice. Accepted, PLoS One. PLoS One. 2016; 11(1): e0147256. Published online 2016 Jan 21. doi: 10.1371/journal.pone.0147256. PMCID 4721672. co-corresponding authors


Petrik D, Latchney SE*, Masiulis I*, Yun S*, Zhang Z*, Wu JI, Eisch AJ. Chromatin remodeling factor Brg1 supports the early maintenance and late responsiveness of nestin-lineage adult neural stem and progenitor cells. Stem Cells. 2015 Sep 29. doi: 10.1002/stem.2215. 11pp. PMID 26418130, PMC 4713255. *equal contribution, listed alphabetically, co-corresponding authors

Latchney SE*, Jiang Y*, Petrik D, Eisch AJ, Hsieh J. Inducible knockout of Mef2A/C/D from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo. The Journal of the Federation of American Societies for Experimental Biology (The FASEB Journal). 2015 Aug 18. pii: fj.15-275651 13pp. PMID 26286136, PMC 4653059. *equal contribution, co-corresponding authors

Cho K-O, Ito N*, Lybrand Z*, Brulet R, Zhang L, Good L, Ure K, Nave K-A, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. Aberrant hippocampal neurogenesis drives epilepsy and associated cognitive decline. Nature Communications. 6:1-13 (2015). PMID 25808087, PMC 4375780. *equal contribution

Latchney SE, Jaramillo TC, Rivera PD, Espinosa-Bacerra F, Eisch AJ, Powell CM. Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neuroscience Letters. 591:86-92 (2015). PMID 25668489, PMC 4363293. co-corresponding authors




Kuhn HG, Eisch AJ, Spalding K, Peterson DA. Detection and Phenotypic Characterization of Adult Neurogenesis. In Adult Neurogenesis, 2nd Edition. Editors: Gage FH, Kempermann G, Song HJ. Cold Spring Harbor Press. Mar 1;8(3):a025981. doi: 10.1101/cshperspect.a025981 (2016).


Bulin SE, Masiulis I, Rivera PD, Eisch AJ. Addiction, Hippocampal Neurogenesis, and Neuroplasticity in the Adult Brain. In Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders. Editor PG Miller. Elsevier Inc., San Diego: Academic Press, pp. 291-303 (2013).


Bulin SE, Sankararaman A, Eisch AJ. Psychostimulants, opiates, and adult hippocampal neurogenesis. In Drug Addiction and Adult Neurogenesis. MF Olive (Ed.), Research Signpost/Transworld Research Network Publishers, Karala, India (2011).


Eisch AJ. The involvement of brain-derived neurotrophic factor in memory and depression. McGraw-Hill Education Yearbook of Science and Technology. McGraw-Hill Press, New York. (2005).

Eisch AJ and Mandyam CD. Adult neurogenesis and CNS cell cycle analysis: Novel tools for exploration of the neural causes and correlates of psychiatric disorders. In Cell Cycle in the Central Nervous System. D Janigro (Ed.), Humana Press, New York. (2005).

Posters and Presentations

Lectures by Invitation


Eisch AJ. Invited speaker. University of Richmond, Department of Psychology; 2017 Mar; Richmond, VA.

Eisch AJ. Invited speaker. Children’s Hospital of Philadelphia (CHOP) Intellectual and Developmental Disabilities Research Center; 2017 Feb; Philadelphia, PA.

Eisch AJ. Chair of session on CNS effects. NASA Human Research Program/Investigators Workshop Meeting; 2017 Jan; Galveston, TX.


Eisch AJ. Invited speaker. 3rd European Conference on Adult Neurogenesis; 2016 Jul; Bordeaux, France.

Eisch AJ. Speaker for Symposium. Resilience Redux: Better Living Through Neurobiology Research. International Behavioral Neuroscience Meeting (IBNS); 2016 Jun; Budapest, Hungary.

Eisch AJ. UT Southwestern Medical Center, Radiation Oncology Retreat; 2016 Mar; Dallas, TX.


Eisch AJ. Invited speaker. International meeting Neurogenesis: Implications for Lifelong Development and Disease; 2015 Mar; Cancun, Mexico.

Eisch AJ. Graduate Student-Nominated 2015 Seminar Speaker. Department of Biology, Drexel University; 2015 Nov; Philadelphia, PA.

Eisch AJ. Keynote Speaker. Annual retreat, NIDA-sponsored PharmacoNeuroImmunology Training Program (T32 DA007097) at University of Minnesota; 2015 Oct; St. Paul, MN.

Eisch AJ. Department of Neuroscience, University of Connecticut Health Center; 2015 Jul; Farmington, CT.

Eisch AJ. Symposium Co-organizer and speaker. A Disrupted Gliogenic/Neurogenic Equilibrium Is Essential for the Injury Response of Adult Neural Stem Cells. XII European Meeting on Glial Cells in Health and Disease (Euroglia); 2015 Jul; Bilbao, Spain.

Eisch AJ. Symposium speaker. Adult neurogenesis: from circuit to function. 9th IBRO World Congress; 2015 Jul; Rio de Janeiro, Brazil (

Eisch AJ. UT Southwestern Medical Center, Seminar speaker for Student Undergraduate Research Fellowship (SURF) Program; 2015 Jun; Dallas, TX.

Eisch AJ. University of Pennsylvania/Children’s Hospital of Philadelphia, Department of Anesthesiology and Critical Care; 2015 Apr; Philadelphia, PA.

Eisch AJ. University of Valencia, Invited speaker for First Joint Meeting University of Valencia and UT

Eisch AJ. Southwestern Medical Center; 2015 Mar; Valencia, Spain.

Eisch AJ. Cajal Institute, CSIC; 2015 Mar; Madrid, Spain.

Eisch AJ. Department seminar speaker, University of Alabama, Birmingham, Department of Neurobiology; 2015 Jan; Birmingham, AL.

Eisch AJ. Speaker, Session on: Adult Hippocampal Neurogenesis: Behavioral Functions at the Intersection of Cognition and Emotion. Thirty-Ninth Annual Winter Conference on The Neurobiology of Learning & Memory, 2015 Jan; Park City, UT.

Awards and Honors

2015, Graduate Student-Nominated 2015 Seminar Speaker, Department of Biology, Drexel University, Philadelphia, PA

2013, Second place nomination, 2013 Minnie Stevens Piper Foundation Professorship, UT Southwestern Medical Center

2012, Finalist, 2012 Award for Excellence in Postdoctoral Mentoring, UT Southwestern Medical Center

2011, Nominated by UTSW to apply for ELAM program (Executive Leadership in Academic Medicine)

2011, Selected as inaugural Seymour Benzer Lecturer, National Academy of Sciences

2010, Selected as inaugural Seymour Benzer Lecturer, National Academy of Sciences, Kavli Frontiers of Science/National Academy of Sciences annual meeting, Irvine, CA

2010, Kavli Frontiers of Science Fellow, National Academy of Sciences, USA

2009, Nominated for The University of Texas Academy of Health Science Education

2008, Chapter Program Award for UT Southwestern Chapter of Sigma Xi (AJ Eisch, President)

2006, Educator of Distinction, Joseph B. Whitehead Foundation, Atlanta, GA

2005, 2007, Nominated as Outstanding Teacher of the Year, Department of Psychiatry, UT Southwestern Medical Center

2004-2006, Young Investigator Award, National Alliance for Research on Schizophrenia and Depression

2004, Co-Chair of inaugural mini-symposium at annual meeting of Society for Neuroscience

2004, Travel Fellowship for Society for Neuroscience Meeting, National Institute on Drug Abuse/National Institutes of Health

2003, Featured Young Investigator, National Alliance for Research on Schizophrenia and Depression

2002-2004, Young Investigator Award, National Alliance for Research on Schizophrenia and Depression

1997-1999, National Research Service Award, Institutional Postdoctoral Fellowship

1996, Travel Fellowship for Meeting of the College on Problems of Drug Dependence

1995-1997, National Research Service Award, Individual Predoctoral Fellowship NIH/NIDA F31 DA005647

1993-1995, National Research Service Award, Institutional Predoctoral Fellowship

1993, California Reagents Fellowship, University of California, Irvine, CA

1991, Steinhaus Award for Excellence in Teaching, University of California, Irvine, CA

1990-1991, California Reagents Tuition Fellowship, University of California, Irvine, CA

1990, Summer Research Fellowship, National Science Foundation

1990, Honors Conferred for undergraduate research thesis, Yale University, New Haven, CT

1990, Graduate cum laude, Yale University, New Haven, CT


Editorial and Academic Positions

Editorial Positions

Co-Editor (with HG Kuhn), Neural Stem Cells in Development, Adulthood, and Disease. Volume in the Series: Stem Cell Biology and Regenerative Medicine. Series editor: Kursad Turksen. Springer Scientific, New York: Humana Press (2015).

Guest Editor, Behavioural Brain Research special issue “Adult neurogenesis and behavior”, 227: 2 (2012).

2015-2021, Editorial Board, THREE (The Health Risks of Extraterrestrial Environments)

2013-present, Editorial Board, Brain Plasticity

2011-present, European Journal of Neurodegenerative Diseases

Ad-hoc Reviewer, 60+ journals

2009-present, Associate Editor, Neuroscience Letters


Leadership and Memberships

2015-present, International College of Neuropsychopharmacology (CINP)

2013-present, Member, Radiation Research Society

2012-present, International Society of Neurochemistry

1991-present, Member, Society for Neuroscience