The goal of this study is to increase our understanding of how the brain is affected in infants with and without Down Syndrome. This may in turn provide clues that could eventually help identify therapeutic targets for intervention for individuals with Down Syndrome. We are enrolling infants with Down Syndrome between the ages of birth to 12 months old, and infants with typical development between the ages of birth to 6 months old. Expectant parents are encouraged to contact us. 

Participants will be asked to make 3 visits to CHOP over time to complete cognitive and behavioral testing and a non-invasive MRI.

Participants will be compensated for their time and receive a written feedback report.