Paroxysmal Nocturnal Hemoglobinuria

What is paroxysmal nocturnal hemoglobinuria?

Paroxysmal nocturnal hemoglobinuria is a blood disease that occurs when the red cells (oxygen-carrying blood cells) lose the flags that mark them as part of your child’s body. Instead, these cells are recognized as "strangers" and your child’s body destroys them.

When many red blood cells are destroyed, your child develops anemia, and is at risk of developing blood clots in unusual places, like the belly. Over time, your child under produces all blood cells.

Paroxysmal nocturnal hemoglobinuria is usually diagnosed based on clinical symptoms and confirmed by blood, bone marrow and molecular tests.
 


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