Alyssa Baccarella, MD

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Alyssa Baccarella, MD, is a fellow with the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of California, San Francisco, CA


Pediatrics - New York- Presbyterian Morgan Stanley Children’s Hospital, Columbia University Medical Center, New York, NY


Pediatric Gastroenterology - Children’s Hospital of Philadelphia, Philadelphia, PA

Titles and Academic Titles


Departments and Services




Aschbacher, K., Cole, S., Hagan, M., Rivera, L., Baccarella, A., Wolkowitz, O.M., Lieberman, A.F., and Bush, N.R. (2022). An immunogenomic phenotype predicting behavioral treatment response: Toward precision psychiatry for mothers and children with trauma exposure. Brain. Behav. Immun. 99, 350–362.


Aschbacher, K., Hagan, M., Steine, I.M., Rivera, L., Cole, S., Baccarella, A., Epel, E.S., Lieberman, A., and Bush, N.R. (2021). Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence. Transl. Psychiatry 2021 111 11, 1–9. Available at: [Accessed February 12, 2022].

Baccarella, A., Linder, A., Spencer, R., Jonokuchi, A.J., King, P.B., Maldonado-Soto, A., Boneparth, A., Hooe, B.S., Schweickert, A.J., Carlin, R.F., et al. (2021). Increased Intracranial Pressure in the Setting of Multisystem Inflammatory Syndrome in Children, Associated With COVID-19. Pediatr. Neurol. 115, 48–49. Available at: [Accessed February 12, 2022].


Kim, C.C., Baccarella, A.M., Bayat, A., Pepper, M., and Fontana, M.F. (2019). FCRL5+ Memory B Cells Exhibit Robust Recall Responses. Cell Rep. 27, 1446. Available at: [Accessed June 12, 2020].

Baccarella, A., Williams, C.R., Parrish, J.Z., and Kim, C.C. (2018). Empirical assessment of the impact of sample number and read depth on RNA-Seq analysis workflow performance. BMC Bioinformatics 19. Available at: [Accessed June 12, 2020].


Williams, C.R. ϯ, Baccarella, A. ϯ, Parrish, J.Z., and Kim, C.C. (2017). Empirical assessment of analysis workflows for differential expression analysis of human samples using RNA-Seq. BMC Bioinformatics 18, 38. Available at: [Accessed April 27, 2017].


Fontana, M.F., Baccarella, A., Craft, J.F., Boyle, M.J., McIntyre, T.I., Wood, M.D., Thorn, K.S., Anidi, C., Bayat, A., Chung, M.R., et al. (2016). A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection. PLoS One 11, e0162132. Available at: [Accessed April 27, 2017].

Williams, C.R., Baccarella, A., Parrish, J.Z., and Kim, C.C. (2016). Trimming of sequence reads alters RNA-Seq gene expression estimates. BMC Bioinformatics 17, 103. Available at: [Accessed July 7, 2016].


Fontana, M.F., Baccarella, A., Kellar, D., Oniskey, T.K., Terinate, P., Rosenberg, S.D., Huang, E.J., Herbert, D.R., and Kim, C.C. (2015). Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol. 37, 470–8. Available at: [Accessed July 7, 2016].

Fontana, M.F., Baccarella, A., Pancholi, N., Pufall, M.A., Herbert, D.R., and Kim, C.C. (2015). JUNB is a key transcriptional modulator of macrophage activation. J. Immunol. 194, 177–86. Available at: [Accessed July 7, 2016].


Baccarella, A., Huang, B.W., Fontana, M.F., and Kim, C.C. (2014). Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria. Malar. J. 13, 354. Available at: [Accessed February 24, 2015].


Baccarella, A. ϯ, Fontana, M.F. ϯ, Chen, E.C., and Kim, C.C. (2013). Toll-like receptor 7 mediates early innate immune responses to malaria. Infect. Immun. 81, 4431–4442.

Soda, T., Frank, C., Ishizuka, K., Baccarella, A., Park, Y.-U., Flood, Z., Park, S.K., Sawa, A., and Tsai, L.-H. (2013). DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Mol. Psychiatry 18, 898–908. Available at:

Posters and Presentations


A. Baccarella, H. Bloomhardt, T. Yang, “Policing and Pediatrics: How systemic racism and the current system affects our patients, and what can be done about it”. Legislative Advocacy Noon Conference, Columbia Pediatrics, June 18th, 2020


Baccarella, H Bloomhardt, H. Tredway, T. Yang, “Clearing the Air: Vaping and e-cigarettes”. Adolescent Medicine Division Meeting, Columbia Pediatrics, October 14th, 2019

Awards and Honors

2022-present, T32 NRSA Grant Awardee
2015, Alameda Contra Costa County Medical Association Summer Scholarship
2014, UCSF Pathways Explore Grant
2011, Walle J. H. Nauta Award for Outstanding Research