Ran Barzilay, MD PhD, is an Assistant Professor of Psychiatry at Penn Medicine. Dr. Barzilay is a child and adolescent psychiatrist with background in translational neuroscience ranging from basic molecular neuroscience to clinical studies. He studies mechanisms that drive variability in development of youth growing up under environmental stress (exposome). His research integrates multimodal data in attempt to dissect the interplay of biological and environmental factors that explain patients' susceptibility versus resilience.
Education and Training
MD - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Medicine - Beilinson Hospital, Rabin Medical Center, Israel
Child and Adolescent Psychiatry - Geha Mental Health Center, Israel
PhD in Neuroscience - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Titles and Academic Titles
Director, BarziLab at the lifespan Brain Institute (LiBI)
Assistant Professor of Psychiatry, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Argabright, S.T., Visoki, E., Moore, T.M., Ryan, D.T., DiDomenico, G.E., Njoroge, W.F.M., Taylor, J.H., Guloksuz, S., Gur, R.C., Gur, R.E., Benton, T.D., Barzilay, R. Association between discrimination stress and suicidality in preadolescent children. Journal of the American Academy of Child and Adolescent Psychiatry 61(5):686-697, 2022.
Birnbaum, R., Barzilay, R., Brusilov, M., Wolman, I., Malinger, G.: The normal cavum veli interpositi at 14-17 weeks: three-dimensional and Doppler transvaginal neurosonographic study. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology in press, 2021.
Gur R.E., White L.K., Waller R., Barzilay R., Moore T.M., Kornfield S., Njoroge W.F.M., Duncan A.F., Chaiyachati B.H., Parish-Morris J., Maayan L., Himes M.M., Laney N., Simonette K., Riis V., Elovitz M.A.: The disproportionate burden of the COVID-19 pandemic among pregnant black women. Psychiatry Research 293:113475, 2021.
Schwartz-Lifshitz M., Ben-Dor D.H., Bustan Y., Zalsman G., Gothelf D., Weizman A., Barzilay R.: Phenotypic characterization of youth admitted to acute psychiatric inpatient unit following self-harm behavior. Archives of Suicide Research in press, 2021.
Waller R., Powell T., Rodriguez Y., Corbett N., Perlstein S., White L.K., Barzilay R., Wagner N.J.: The impact of the COVID-19 pandemic on children's conduct problems and callous-unemotional traits. Child Psychiatry Human Development in press, 2021.
Barzilay, R., Moore, T.M., Calkins, M.E., Maliackel, L., Jones, J.D., Boyd, R.C., Warrier, V., Benton, T.D., Oquendo, M.A, Gur, R.C., Gur, R.E.: Deconstructing the role of the exposome in youth suicidal ideation: Trauma, neighborhood environment, developmental and gender effects. Neurobiology of Stress 14:100314, 2021.
Warrier V., Kwong A.S.F., Luo M., Dalvie S., Croft J., Sallis H.M., Baldwin J., Munafò M.R., Nievergelt C.M., Grant A.J., Burgess S., Moore T.M., Barzilay R., McIntosh A., van IJzendoorn M.H., Cecil C.A.M.: Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach. Lancet Psychiatry 8(5):373-386, 2021.
Avrahami, M., Peskin, M., Moore, T.M., Drapisz, A., Taylor, J.H., Segal-Gavish, H., Balan-Moshe, L., Shachar, I., Levy, T., Weizman, A., Barzilay, R.: Body mass index increase in preschoolers with heterogeneous psychiatric diagnoses treated with risperidone. Journal of Psychopharmacology 35(9): 1134-1140, 2021.
Gur, R.E., White, L.K., Shani, S., Barzilay, R., Moore, T.M., Emanuel, B.S., Zackai, E.H., McDonald-McGinn, D.M., Matalon, N., Weinberger, R., Gur, R.C., Gothelf, D.: A binational study assessing risk and resilience factors in 22q11.2 deletion syndrome. Journal of Psychiatric Research 138:319-325, 2021.
Hertz-Palmor, N., Moore, T.M., Gothelf, D., DiDomenico, G.E., Dekel, I., Greenberg, D.M., Brown, L.A., Matalon, N., Visoki, E., White, L.K., Himes, M.H., Lifshitz-Schwartz, M., Gross, R., Gur, R.C., Gur, R.E., Pessach, I.M., Barzilay, R.: Association among income loss, financial strain and depressive symptoms during COVID-19: evidence from two longitudinal studies. Journal of Affective Disorders 291:1-8, 2021.
Shoval, G., Visoki, E., Moore, T.M., DiDomenico, G.E., Argabright, S.T., Huffnagle, N.J., Alexander-Bloch, A.F., Waller, R., Keel, L., Benton, T.D., Gur, R.E., Barzilay, R.: Evaluation of ADHD medications, externalizing symptoms, and suicidality in children. JAMA Network Open 4(6):e211342, 2021.
Dong, F., Calkins, M.E., Compton, P., Medoff-Cooper, B., Barzilay, R., Taylor, J.H., Moore, T.M., Gur, R.C., Gur, R.E., Hodgson, N.A.: Association between traumatic stressful events and schizotypal symptoms among a community-based sample of adolescents: A 2-year longitudinal study. Schizophrenia Research 233: 44-52, 2021.
Taliaz, D., Spinrad, A., Barzilay, R., Barnett-Itzhaki, Z., Averbuch, D., Teltsh, O., Schurr, R., Darki-Morag, S., Lerer, B. Optimizing prediction of response to antidepressant medications using machine learning and integrated genetic, clinical, and demographic data. Translational Psychiatry 11(1):381, 2021.
Alexander-Bloch, A.F., Sood, R., Shinohara, R.T., Moore, T.M., Calkins, M.E., Chertavian, C., Wolf, D.H., Gur, R.C., Satterthwaite, T.D., Gur, R.E., Barzilay, R. Connectome-wide functional connectivity abnormalities in youth with obsessive compulsive symptoms. Biological Psychiatry Cognitive Neuroscience Neuroimaging, in press, 2021.
Kornfield, S.L., White, L.K., Waller, R., Njoroge, W., Barzilay, R., Chaiyachati, B.H., Himes, M.M., Rodriguez, Y., Riis, V., Simonette, K., Elovitz, M.A., Gur, R.E. Risk And Resilience Factors Influencing Postpartum Depression And Mother-Infant Bonding During COVID-19. Health Aff (Millwood) 40(10):1566-1574, 2021.
Daskalakis, N.P., Schultz, L.M., Visoki, E., Moore, T.M., Argabright, S.T., Harnett, N.G., DiDomenico, G.E., Warrier, V., Almasy, L., Barzilay, R. Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents. Neurobiology of Stress 15:100411, 2021.
Barzilay, R., Lawrence, G.M., Berliner, A., Gur, R.E., Leventer-Roberts, M., Weizman, A., Feldman, B.: Association between prenatal exposure to a 1-month period of repeated rocket attacks and neuropsychiatric outcomes up through age 9: a retrospective cohort study. European Journal of Child and Adolescent Psychiatry 29(8):1135-1142, 2020.
Barzilay, R.: Predicting trajectories of risk and resilience in traumatized youth. Biological Psychiatry Cognitive Neuroscience Neuroimaging 5(5):473-475, 2020.
Barzilay, R., White, L.K., Moore, T.M., Calkins, M.E., Taylor, J.H., Patrick, A., Huque, Z.M., Young, J.F., Ruparel, K., Pine, D.S., Gur, R.C., Gur, R.E.: Association of anxiety phenotypes with risk of depression and suicidal ideation in community youth. Depression and Anxiety 37(9):851-861, 2020.
Barzilay, R., Rosen, A.F.G., Moore, T.M. et al. Structural brain patterns associated with Traumatic Stress Resilience and Susceptibility to Mood and Anxiety Symptoms in Youths. Adversity and Resilience Science 1: 179–190, 2020.
Barzilay, R., Moore, T. M., Greenberg, D. M., DiDomenico, G. E., Brown, L. A., White, L. K., Gur, R. C., Gur, R. E.: Resilience, COVID-19-related stress, anxiety and depression during the pandemic in a large population enriched for healthcare providers. Translational Psychiatry, 10(1), 291, 2020.
Barzilay, R., Calkins, M.E., Moore, T.M., Wolf, D.H., Satterthwaite, T.D., Scott, J.C., Jones, J.D., Benton, T.D., Gur, R.C., Gur, R.E.: Association between traumatic stress load, psychopathology and cognition in the Philadelphia Neurodevelopmental Cohort. Psychological Medicine 49(2): 325-334, 2019.
Barzilay, R., Calkins, M.E., Moore, T.M., Boyd, R.C., Jones, J.D., Benton, T.D., Oquendo, M.A., Gur, R.C., Gur, R.E.: Neurocognitive functioning in community youth with suicidal ideation: Sex and pubertal effects. The British Journal of Psychiatry 215(3):552-558, 2019
Barzilay, R., Patrick, A.M., Calkins, M.E., Moore, T.M., Gur, R.C., Gur, R.E.: Association between early-life trauma and obsessive compulsive symptoms in community youth. Depression and Anxiety 36(7):586-595, 2019.
Barzilay, R., Patrick, A.M., Calkins, M.E., Moore, T.M., Wolf, D.H., Benton, T.D., Leckman, J.F., Gur, R.C., Gur, R.E.: Obsessive-Compulsive Symptomatology in Community Youth: Typical Development or a Red Flag for Psychopathology? Journal of the American Academy of Child & Adolescent Psychiatry 58(2): 277-286, 2019.
Gur, R.E., Moore, T.M., Rosen, A.F.G., Barzilay, R., Roalf, D.R., Calkins, M.E., Ruparel, K., Scott, J.C., Almasy, L., Satterthwaite, T.D., Shinohara, R.T., Gur, R.C.: Burden of environmental adversity associated with psychopathology, maturation and brain-behavior parameters in youth. JAMA Psychiatry 76 (9):966-975, 2019.
Bustan, Y., Drapisz, A., Ben-Dor, D.H., Avrahami, M., Schwartz-Lifschitz, M., Weizmann, A., Barzilay, R.: Elevated neutrophil to lymphocyte ratio in non-affective psychotic adolescent inpatients: Evidence for early association between inflammation and psychosis. Psychiatry Research 262: 149-153, 2018.
Barzilay, R., White, L.K., Calkins, M.E., Moore, T.M., Young, J.F., Wolf, D.H., Satterthwaite, T.D., Gur, R.C., Gur, R.E.: Sex-specific association between high traumatic stress exposure and social cognitive functioning in youth. Biological Psychiatry Cognitive Neuroscience Neuroimaging 3(10): 860-867, 2018.
Zohar, N., Hochman, E., Katz, N., Krivoy, A., Weizman, A., Barzilay, R.: Association between elevated C-reactive Protein and manic polarity in acute psychiatric inpatients with affective symptomatology. Neuropsychobiology 76(3): 166-170, 2018.
Segal-Gavish, H., Gazit, N., Barhum, Y., Ben-Zur, T., Taler, M., Henry Hornfeld, S., Gil-Ad, I., Weizman, A., Slutsky, I., Niwa, M., Kamiya, A., Sawa, A., Offen, D., Barzilay, R.: BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction. Human Molecular Genetics 26(13): 2462-2471, 2017.
Zalsman, G., Hawton, K., Wasserman, D., Van Heeringen, K., Arensman, E., Sarchiapone, M., Carli, V., Hoschl, C., Barzilay, R., Balzas, J., Purebl, G., Kahn, J.P., Saiz, P.A., Lipsicas, C.B., Bobes, J., Cozman, D., Hegerl, U., Zohar, J.: Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 3(7): 646-659, 2016.
Barzilay, R., Kaminitz, A., Sega,l H., Taler, M., Offen, D., Gil-Ad, I., Mechoulam, R., Weizman, A.: Dominant negative DISC1 mutant mice display specific social behavior deficits and aberration in BDNF and cannabinoid receptor expression. World Journal Biological Psychiatry 15(1): 76-82, 2014.
Barzilay, R., Lobel, T., Krivoy, R., Shlosberg, D., Weizman, A., Katz, N.: Elevated C-reactive protein levels in schizophrenia inpatients is associated with aggressive behavior. European Psychiatry 31: 8-12, January 2016.
Barzilay, R., Ventorp, F., Segal, H., Aharoni, I., Bieber, A., Dar, S., Vescan, M., Globus, R., Weizman, A., Naor, D., Lipton, J., Janelidze, S., Brundin, L., Offen, D.: CD44 deficiency is associated with increased susceptibility to stress-induced anxiety-like behavior in mice. Journal of Molecular Neuroscience 60(4): 548-558, December 2016.
Barzilay, R., Shalit, N., Shoval, G., Shlosberg, D., Mor, N., Zweigenhaft, N., Weizman, A., Krivoy, R.: Characteristics of synthetic cannabinoid and natural cannabis users admitted to a psychiatric hospital: A comparative study. Journal of Clinical Psychiatry 77(8): e989-e995, 2016.
Barzilay, R., Ventorp, F., Erhardt, S., Samuelsson, M., Träskman-Bendz, L., Janelidze, S., Weizman, A., Offen, D., Brundin, L.: The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Journal of Affective Disorders 193: 349-354, March 2016.
Laor, N., Nagel-Edelstein, T., Barzilay, R., Golan, O.: Israel and Autism. Encyclopedia of Autism Spectrum Disorders. Volkmar F.R. (eds.). Springer, 2018.
Barzilay R.; Bone Marrow Stem Cells for Neural Rescue: Prospects of Cellular Therapy. Book Chapter in "The Molecular Basis of Neurodegenerative Diseases" Offen D. and Lev N. (Eds.), Research Signpost. 2008.
Posters and Presentations
Barzilay R. “Association of childhood suicidality with genetic stress susceptibility and clinical indicators of inflammation”, Society of Biological Psychiatry SOBP, New Orleans. Apr 2022.
Barzilay R. “The exposome framework: a key to parse variability from risk to resilience in youth“, Neuroscience Seminar Series, McLean Hospital, Harvard Medical School (virtual meeting). Apr 2022.
Barzilay R. “Common and Unique Genomic and Environmental Contributions to Suicidality in Black American Preadolescents”, International Summit on Suicide Research 2021 (virtual meeting). Oct 2021.
Barzilay R. “Obsessive and compulsive symptoms in youths as early markers of clinical risk”, Society of Biological Psychiatry SOBP (virtual meeting). May 2021.
Barzilay R. “A multidimensional evaluation of resilience and its contribution to understanding mental health during COVID-19 pandemic outbreak”, virtual meeting of the Anxiety and Depression Association of America ADAA (virtual meeting). Mar 2021.
Barzilay R. “The Contribution of Stress and Resilience to Mental Health during the COVID-19 Pandemic: Results from a Binational Cohort”, Israel Society of Biological Psychiatry symposium on mental health aspects of COVID-19 (virtual meeting). Nov 2020.
Barzilay R. “Risk for and Resilience to Psychopathology in 22q11.2 Deletion Syndrome”, annual meeting of the Anxiety and Depression Association of America (virtual meeting). Oct 2020.
Barzilay R. “Stress, resilience and their contribution to mental health during the COVID-19 pandemic”, Penn Psychiatry Grand Rounds. Sept 2020.
Barzilay R. “A multidimensional evaluation of resilience and its contribution to understanding mental health during COVID-19 pandemic outbreak”, 6th international symposium on resilience research (virtual meeting). Sept 2020.
Barzilay R. “Stress, resilience and mental health during COVID19 outbreak: Findings from a crowdsourcing research website”, Digital Innovation in Mental Health (DIMH) meeting (virtual meeting). Aug 2020.
Barzilay R. “Stress, resilience and mental health during COVID19 outbreak: Findings from a crowdsourcing research website”, CHOP Department of Child & Adolescent Psychiatry Town Hall Meeting. May 2020.
Barzilay R. “The exposome in psychiatry: Using environmental data to study developmental psychopathology”, NIMH. Mar 2020.
Barzilay R. “The exposome in psychiatry: Using environmental data to study developmental psychopathology”, 1st Computational Psychiatry meeting, Geha Mental Health Center, Israel. Jan 2020.
Barzilay R. “The exposome in psychiatry: Using environmental data to study suicidal behavior in youth”, University of Cambridge, Cambridge UK. Jan 2020.
Awards and Honors
2019, Selected to participate in the 2019 Research Colloquium (for early career psychiatrists) of the American Psychiatric Association
2018, The American College of Neuropsychopharmacology (ACNP) annual meeting Travel Award,
2016, Schizophrenia International Research Society (SIRS) Conference Travel Award for 2016
2016, The European College of Neuropsychopharmacology (ECNP) meeting Poster Award
2015, Selected to participate in the ECNP Workshop on Neuropsychopharmacology for Junior Scientists in Europe
2014, The European College of Neuropsychopharmacology (ECNP) 2014 Fellowship Award for excellent junior scientists
2013, Society of Biological Psychiatry (SOBP) International Travel Fellowship Award
2013, Israel Society for Biological Psychiatry annual meeting Poster Award
2012, Accepted to the "Research Leadership Program" for residents in psychiatry in the Israeli Association for Biological Psychiatry
2012, The Israel Society for Biological Psychiatry Award for excellent basic research study in psychiatry
2011, Young Scientist Award in the 10th World Congress of Biological Psychiatry, Prague, Czech Republic
2011, Young Investigator Award in the 13th International Congress of Schizophrenia Research
2011, The Constantiner Travel Scholarship for research in Molecular Genetics
2011. Young Investigator Award in the 4th Israeli Stem Cell Society annual meeting
2009-2011, Foulkes Foundation Fellowship for M.D. Ph.D. students
Editorial and Academic Positions
2022-present, JAMA Pediatrics
2021-present, Lancet Psychiatry
2021-present, Neurobiology of Stress
2020-present, JAMA Network Open
2020-present, British Journal of Psychiatry
2020-present, Translational Psychiatry
2020-present, JAMA Psychiatry
2020-present, Biological Psychiatry
2020-present, Journal of Child Psychology and Psychiatry
2019-present, Biological Psychiatry Cognitive Neuroscience Neuroimaging
2019-present, Depression and Anxiety
2018-present, Psychological Medicine
2018-present, Journal of Child and Adolescent Psychiatry
2018-present, Journal of Psychiatric Research
2016-present, Schizophrenia Bulletin
2016-present, Journal of Affective Disorders
2016-present, Psychiatry Research
2016-present, European Psychiatry
2013-present, Schizophrenia Research
Leadership and Memberships
Memberships in Professional Organizations
2013-present, Israel Society for Child and Adolescent Psychiatry
2012-present, Israel Medical Association
2010-present, Israel Society for Biological Psychiatry
2018-present, Society of Biological Psychiatry
Patient Experience Ratings
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