Ran Barzilay, MD, PhD

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Ran Barzilay, MD, PhD, is a psychiatrist with the Youth Suicide Prevention, Intervention and Research Center at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Ran Barzilay, MD PhD, is a Research Associate at the Lifespan Brain Institute at Children’s Hospital of Philadelphia & UPenn Medicine. Dr. Barzilay is a child and adolescent psychiatrist with background in translational neuroscience ranging from basic molecular neuroscience to clinical studies. He studies a broad range of brain mechanisms that affect developmental psychopathology.Specifically, his work focuses on the effects of developmental stress on psychopathology, attempting to dissect the interplay of host and environmental factors in underpinning patient’s susceptibility versus resilience. Dr. Barzilay is also interested in studying developmental trajectories of brain disorders that involve social cognition deficits like Autism and Schizophrenia.

Education and Training

Medical School

MD - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Graduate Degree

PhD - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Titles and Academic Titles

Attending Psychiatrist

Departments and Services

Publications

Papers

2017

Segal-Gavish H., Barzilay R., Rimoni O., Offen D. Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders. World J Biol Psychiatry. 2019 Mar;20(3):243-252. doi: 10.1080/15622975.2017.1323118. Epub 2017 Jun 8.

Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Henry Hornfeld S, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R. BDNF Overexpression Prevents Cognitive Deficit Elicited by Adolescent Cannabis Exposure and Host Susceptibility Interaction. Human Molecular Genetics. 2017; 26: 2462-2471.

Perets N., Segal-Gavish H., Gothelf Y., Barzilay R., Barhum Y., Abramov N., Hertz S., Morozov D., London M., Offen D. Long Term Beneficial Effect of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Transplantation in the BTBR Mouse Model of Autism. Behavior Brain Research. 2017; 331:254-260.

Avrahami M., Barzilay R., HarGil M., Weizman A., Watemberg N. Serum Ferritin Levels Are Lower in Children With Tic Disorders Compared with Children Without Tics: A Cross-Sectional Study. J Child Adolescent Psychopharmacology. 2017; 27:192-195.

2016

Barzilay R., Ventorp F.,  Segal H., Aharoni I., Bieber A., Dar S., Vescan M., Globus R., Weizman A., Naor D., Lipton J., Janelidze S., Brundin L., Offen D. CD44 deficiency is associated with increased susceptibility to stress-induced anxiety-like behavior in mice. Journal of Molecular Neuroscience. 2016; 60:548-558.

Zalsman G., Weller A., Shbiro L., Barzilay R., Gutman A., Weizman A., Mann J.J., Wasserman J., Wasserman D. Brain Fiber Tract Analysis Using Diffusion Tensor Imaging Reveals Aberrant Connectivity in a Rat Model of Depression. World Journal Biological Psychiatry. 2016. In press.

Zalsman G., Hawton K., Wasserman D., Van Heeringen K., Arensman E., Sarchiapone M., Carli V., Hoschl C., Barzilay R., Balzas J., Purebl G., Kahn J.P., Saiz P.A., Lipsicas C.B., Bobes J., Cozman D., Hegerl U., Zohar J. Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry. 2016; 3: 646-659.

Barzilay R., Shalit N., Shoval G., Shlosberg D., Mor N., Zweigenhaft N., Weizman A., Krivoy R. Characteristics of Synthetic Cannabinoid and Natural Cannabis Users Admitted to a Psychiatric Hospital: A Comparative study. Journal of Clinical Psychiatry. 2016; 77:e989-e995.

Zalsman G., Siman Tov Y., Tzuriel D., Shoval G., Barzilay R., Tiech Fire N., Sherf M., Mann J.J. Psychological Autopsy of Seventy High School Suicides: Combined Qualitative/Quantitative Approach. European Psychiatry. 2016; 6: 8-14.

Barzilay R., Ventorp F, Erhardt S, Samuelsson M, Träskman-Bendz L, Janelidze S, Weizman A, Offen D, Brundin L. The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Journal of Affective Disorders. 2016; 193:349-54.

Barzilay R., Lobel T., Krivoy R., Shlosberg D., Weizman A., Katz N. Elevated C-reactive Protein Levels in Schizophrenia Inpatients is Associated with Aggressive Behavior. European Psychiatry. 2016; 31:8-12

Segal-Gavish H., Karvat G., Barak N., Barzilay R., Ganz J., Edry L., Aharony I., Offen D., Kimchi T. Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice. Journal of Autism Research. 2016; 9: 17-32.

2014

Barzilay R., Kaminitz A., Segal H., Taler M., Offen D., Gil-Ad I., Mechoulam R., Weizman A. Dominant negative DISC1 mutant mice display specific social behavior deficits and aberration in BDNF and cannabinoid receptor expression. World Journal Biological Psychiatry 2014; 15:76-82.

2013

Barzilay R., Ganz J., Sadan O., Ben-Zur T., Bren Z., Hinden N., Taler M. Lev N., Gil-Ad I., Weizman A., Offen D. Mesenchymal stem cells protect against phencyclidine induced insult in vivo and counter-act changes in astrocyte gene expression in vitro. European Neuropsychopharmacology. 2013; 23:1115-1123.

2012

Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D. Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: A potential therapy for Huntington's disease. Experimental Neurology. 2012; 234:417-427.

Yust-Katz S., Fisher-Shoval Y., Barhum Y., Ben-Zur T., Barzilay R., Lev N., Hod M., Melamed E., Offen D. Placental mesenchymal stromal cells induced into neurotrophic factor-producing cells protect neuronal cells from hypoxia and oxidative stress. Cytotherapy. 2012;14:45-55.

2011

Barzilay R., Ben-Zur T., Sadan O., Bren Z., Tarasenko I., Taler M., Lev N., Uzan R., Gil-Ad I., Melamed E., Weizman A., Offen D. Intra-cerebral human adult stem cells transplantation increases BDNF levels and protects against phencyclidine-induced social deficit in mice. Translational Psychiatry 2011; 1: e61.

2010

Barhum Y., Gai Castro S., Bahat-Stromza M., Barzilay R., Melamed E., Offen D. Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of Multiple Sclerosis. Journal of Molecular Neuroscience. 2010; 41:129-137.

2009

Barzilay R., Sadan O., Melamed E., Offen D. Comparative characterization of bone marrow derived mesenchymal stem cells from four different rat strains. Cytotherapy.2009;11:435-442.

Barzilay R., Ben Zur T., Bulvik S., Melamed E., Offen D. Lentiviral delivery of LMX1a into enhances dopaminergic phenotype in differentiated human bone marrow  mesenchymal stem cells. Stem Cells and Development. 2009; 18: 591-601.

2008

Sadan O., Shemesh N., Barzilay R., Bahat-Stromza M., Melamed E., Cohen Y., Offen D. Migration of neurotrophic factors-secreting mesenchymal stem cells towards a quinolinic acid lesion as viewed by MRI. Stem Cells. 2008; 26: 2542-2551.

Barzilay R., Kan I, Ben Zur T., Bulvik S.,  Melamed E., Offen D. Induction of Human Mesenchymal Stem Cells into Dopamine-Producing Cells with Different Differentiation Protocols. Stem Cells and Development. 2008;17: 547-554.

Levy Y.S., Bahat Stromza M., Barzilay R., Burshtein A., Bulvik S., Barhum Y., Panet H., Melamed E., Offen D. Regenerative effect of neural induced mesenchymal stem cells in rat models of Parkinson’s disease. Cytotherapy. 2008; 10: 340-352.

2006

Blondheim NR, Levy YS, Ben-Zur T, Burshtein A, Cherlow T, Kan I, Barzilai R, Bahat-Stromza M, Barhum Y, Bulvik S, Melamed E, Offen D. Human mesenchymal stem cells express neural genes, suggesting a neural predisposition. Stem Cells and Development. 2006;15: 141-164.

Books

Chapters

2008

Barzilay R.; Bone Marrow Stem Cells for Neural Rescue: Prospects of Cellular Therapy. Book Chapter in "The Molecular Basis of Neurodegenerative Diseases" Offen D. and Lev N. (Eds.), Research Signpost. 2008.