Ran Barzilay, MD, PhD

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Ran Barzilay, MD, PhD, is a psychiatrist with the Youth Suicide Prevention, Intervention and Research Center at Children's Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Ran Barzilay, MD PhD, is an Assistant Professor of Psychiatry at Penn Medicine.  Dr. Barzilay is a child and adolescent psychiatrist with background in translational neuroscience ranging from basic molecular neuroscience to clinical studies. He studies mechanisms that drive variability in development of youth growing up under environmental stress (exposome). His research integrates multimodal data in attempt to dissect the interplay of biological and environmental factors that explain patients' susceptibility versus resilience.

Education and Training

Medical School

MD - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Graduate Degree

PhD - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Titles and Academic Titles

Attending Psychiatrist

Assistant Professor of Psychiatry, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2021

Schwartz-Lifshitz M., Ben-Dor D.H., Bustan Y., Zalsman G., Gothelf D., Weizman A., Barzilay R.: Phenotypic characterization of youth admitted to acute psychiatric inpatient unit following self-harm behavior. Archives of Suicide Research in press, 2021.

Barzilay, R., Moore, T.M., Calkins, M.E., Maliackel, L., Jones, J.D., Boyd, R.C., Warrier, V., Benton, T.D., Oquendo, M.A, Gur, R.C., Gur, R.E.: Deconstructing the role of the exposome in youth suicidal ideation: Trauma, neighborhood environment, developmental and gender effects. Neurobiology of Stress 14:100314, 2021.

Avrahami, M., Peskin, M., Moore, T.M., Drapisz, A., Taylor, J.H., Segal-Gavish, H., Balan-Moshe, L., Shachar, I., Levy, T., Weizman, A., Barzilay, R.: Body mass index increase in preschoolers with heterogeneous psychiatric diagnoses treated with risperidone. Journal of Psychopharmacology 35(9): 1134-1140, 2021.

Hertz-Palmor, N., Moore, T.M., Gothelf, D., DiDomenico, G.E., Dekel, I., Greenberg, D.M., Brown, L.A., Matalon, N., Visoki, E., White, L.K., Himes, M.H., Lifshitz-Schwartz, M., Gross, R., Gur, R.C., Gur, R.E., Pessach, I.M., Barzilay, R.: Association among income loss, financial strain and depressive symptoms during COVID-19: evidence from two longitudinal studies. Journal of Affective Disorders 291:1-8, 2021.

Shoval, G., Visoki, E., Moore, T.M., DiDomenico, G.E., Argabright, S.T., Huffnagle, N.J., Alexander-Bloch, A.F., Waller, R., Keel, L., Benton, T.D., Gur, R.E., Barzilay, R.: Evaluation of ADHD medications, externalizing symptoms, and suicidality in children. JAMA Network Open 4(6):e211342, 2021.

Alexander-Bloch, A.F., Sood, R., Shinohara, R.T., Moore, T.M., Calkins, M.E., Chertavian, C., Wolf, D.H., Gur, R.C., Satterthwaite, T.D., Gur, R.E., Barzilay, R. Connectome-wide functional connectivity abnormalities in youth with obsessive compulsive symptoms. Biological Psychiatry Cognitive Neuroscience Neuroimaging, in press, 2021.

Argabright, S.T., Visoki, E., Moore, T.M., Ryan, D.T., DiDomenico, G.E., Njoroge, W.F.M., Taylor, J.H., Guloksuz, S., Gur, R.C., Gur, R.E., Benton, T.D., Barzilay, R. Association between discrimination stress and suicidality in preadolescent children. Journal of the American Academy of Child and Adolescent Psychiatry, in press, 2021.

Daskalakis, N.P., Schultz, L.M., Visoki, E., Moore, T.M., Argabright, S.T., Harnett, N.G., DiDomenico, G.E., Warrier, V., Almasy, L., Barzilay, R. Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents. Neurobiology of Stress 15:100411, 2021.

2020

Barzilay, R., Lawrence, G.M., Berliner, A., Gur, R.E., Leventer-Roberts, M., Weizman, A., Feldman, B.: Association between prenatal exposure to a 1-month period of repeated rocket attacks and neuropsychiatric outcomes up through age 9: a retrospective cohort study. European Journal of Child and Adolescent Psychiatry 29(8):1135-1142, 2020.

Barzilay, R.: Predicting trajectories of risk and resilience in traumatized youth. Biological Psychiatry Cognitive Neuroscience Neuroimaging 5(5):473-475, 2020.

Barzilay, R., White, L.K., Moore, T.M., Calkins, M.E., Taylor, J.H., Patrick, A., Huque, Z.M., Young, J.F., Ruparel, K., Pine, D.S., Gur, R.C., Gur, R.E.: Association of anxiety phenotypes with risk of depression and suicidal ideation in community youth. Depression and Anxiety 37(9):851-861, 2020.

Barzilay, R., Rosen, A.F.G., Moore, T.M. et al. Structural brain patterns associated with Traumatic Stress Resilience and Susceptibility to Mood and Anxiety Symptoms in Youths. Adversity and Resilience Science 1: 179–190, 2020.

Barzilay, R., Moore, T. M., Greenberg, D. M., DiDomenico, G. E., Brown, L. A., White, L. K., Gur, R. C., Gur, R. E.: Resilience, COVID-19-related stress, anxiety and depression during the pandemic in a large population enriched for healthcare providers. Translational Psychiatry, 10(1), 291, 2020.

2019

Barzilay, R., Calkins, M.E., Moore, T.M., Wolf, D.H., Satterthwaite, T.D., Scott, J.C., Jones, J.D., Benton, T.D., Gur, R.C., Gur, R.E.: Association between traumatic stress load, psychopathology and cognition in the Philadelphia Neurodevelopmental Cohort. Psychological Medicine 49(2): 325-334, 2019.

Barzilay, R., Calkins, M.E., Moore, T.M., Boyd, R.C., Jones, J.D., Benton, T.D., Oquendo, M.A., Gur, R.C., Gur, R.E.: Neurocognitive functioning in community youth with suicidal ideation: Sex and pubertal effects. The British Journal of Psychiatry 215(3):552-558, 2019

Barzilay, R., Patrick, A.M., Calkins, M.E., Moore, T.M., Gur, R.C., Gur, R.E.: Association between early-life trauma and obsessive compulsive symptoms in community youth. Depression and Anxiety 36(7):586-595, 2019.

Barzilay, R., Patrick, A.M., Calkins, M.E., Moore, T.M., Wolf, D.H., Benton, T.D., Leckman, J.F., Gur, R.C., Gur, R.E.: Obsessive-Compulsive Symptomatology in Community Youth: Typical Development or a Red Flag for Psychopathology? Journal of the American Academy of Child & Adolescent Psychiatry 58(2): 277-286, 2019.

Gur, R.E., Moore, T.M., Rosen, A.F.G., Barzilay, R., Roalf, D.R., Calkins, M.E., Ruparel, K., Scott, J.C., Almasy, L., Satterthwaite, T.D., Shinohara, R.T., Gur, R.C.: Burden of environmental adversity associated with psychopathology, maturation and brain-behavior parameters in youth. JAMA Psychiatry 76 (9):966-975, 2019.

2018

Bustan, Y., Drapisz, A., Ben-Dor, D.H., Avrahami, M., Schwartz-Lifschitz, M., Weizmann, A., Barzilay, R.: Elevated neutrophil to lymphocyte ratio in non-affective psychotic adolescent inpatients: Evidence for early association between inflammation and psychosis. Psychiatry Research 262: 149-153, 2018.

Barzilay, R., White, L.K., Calkins, M.E., Moore, T.M., Young, J.F., Wolf, D.H., Satterthwaite, T.D., Gur, R.C., Gur, R.E.: Sex-specific association between high traumatic stress exposure and social cognitive functioning in youth. Biological Psychiatry Cognitive Neuroscience Neuroimaging 3(10): 860-867, 2018.

Zohar, N., Hochman, E., Katz, N., Krivoy, A., Weizman, A., Barzilay, R.: Association between elevated C-reactive Protein and manic polarity in acute psychiatric inpatients with affective symptomatology. Neuropsychobiology 76(3): 166-170, 2018.

2017

Segal-Gavish, H., Gazit, N., Barhum, Y., Ben-Zur, T., Taler, M., Henry Hornfeld, S., Gil-Ad, I., Weizman, A., Slutsky, I., Niwa, M., Kamiya, A., Sawa, A., Offen, D., Barzilay, R.: BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction. Human Molecular Genetics 26(13): 2462-2471, 2017.

2016

Zalsman, G., Hawton, K., Wasserman, D., Van Heeringen, K., Arensman, E., Sarchiapone, M., Carli, V., Hoschl, C., Barzilay, R., Balzas, J., Purebl, G., Kahn, J.P., Saiz, P.A., Lipsicas, C.B., Bobes, J., Cozman, D., Hegerl, U., Zohar, J.: Suicide prevention strategies revisited: 10-year systematic review. Lancet Psychiatry 3(7): 646-659, 2016.

Barzilay, R., Kaminitz, A., Sega,l H., Taler, M., Offen, D., Gil-Ad, I., Mechoulam, R., Weizman, A.: Dominant negative DISC1 mutant mice display specific social behavior deficits and aberration in BDNF and cannabinoid receptor expression. World Journal Biological Psychiatry 15(1): 76-82, 2014.

Barzilay, R., Lobel, T., Krivoy, R., Shlosberg, D., Weizman, A., Katz, N.: Elevated C-reactive protein levels in schizophrenia inpatients is associated with aggressive behavior. European Psychiatry 31: 8-12, January 2016.

Barzilay, R., Ventorp, F., Segal, H., Aharoni, I., Bieber, A., Dar, S., Vescan, M., Globus, R., Weizman, A., Naor, D., Lipton, J., Janelidze, S., Brundin, L., Offen, D.: CD44 deficiency is associated with increased susceptibility to stress-induced anxiety-like behavior in mice. Journal of Molecular Neuroscience 60(4): 548-558, December 2016.

Barzilay, R., Shalit, N., Shoval, G., Shlosberg, D., Mor, N., Zweigenhaft, N., Weizman, A., Krivoy, R.: Characteristics of synthetic cannabinoid and natural cannabis users admitted to a psychiatric hospital: A comparative study. Journal of Clinical Psychiatry 77(8): e989-e995, 2016.

Barzilay, R., Ventorp, F., Erhardt, S., Samuelsson, M., Träskman-Bendz, L., Janelidze, S., Weizman, A., Offen, D., Brundin, L.: The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Journal of Affective Disorders 193: 349-354, March 2016.

Books

Chapters

2008

Barzilay R.; Bone Marrow Stem Cells for Neural Rescue: Prospects of Cellular Therapy. Book Chapter in "The Molecular Basis of Neurodegenerative Diseases" Offen D. and Lev N. (Eds.), Research Signpost. 2008.