Ulf Beier, MD, FAAP

Ulf Beier, MD, FAAP

Ulf Beier, MD, FAAP, is an attending physician in the Division of Nephrology at Children's Hospital of Philadelphia.

Areas of Expertise: Histone protein deacetylases, Molecular immunology, T-cell biology, Transplant tolerance
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Christian - Albrechts - University of Kiel, Kiel, Germany

Internship

Pediatrics - University of Illinois at Chicago, Chicago, IL

Residency

Pediatrics - University of Illinois at Chicago, Chicago, IL

Fellowship

Pediatric Nephrology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatrics

Titles and Academic Titles

Attending Physician

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Targeting sirtuin-1 to enhance foxp3+ regulatory T-cell function
HDAC9 and mitochondrial biology

Publications

Papers

2012

Beier UH, Wang L, Hancock WW. Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle. Cell Cycle. 2012 Sep 15;11(18):3351-2. doi: 10.4161/cc.21876. Epub 2012 Aug 23. Cited in PubMed; PMID 22918251. Read the abstract

Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW. Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal. 2012 Jun 19;5(229):ra45. Cited in PubMed; PMID 22715468. Read the abstract

Liu Y, Wang L, Han R, Beier UH, Hancock WW. Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One. 2012;7(1):e29035. Epub 2012 Jan 11. Cited in PubMed; PMID 22247766. Read the article

Akimova T, Beier UH, Liu Y, Wang L, Hancock WW. Histone/protein deacetylases and T cell immune responses. Blood. Epub 2012 Jan 12. Cited in PubMed; PMID 22246031. Read the abstract

2011

Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G, Hancock WW. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. Epub 2011 Jan 3. Cited in PubMed; PMID21444725. Read the article

Akimova T, Beier UH, Wang L, Levine MH, Hancock WW. Helios Expression Is a Marker of T Cell Activation and Proliferation. PLoS ONE 2011 Aug 30; 6(8): e24226. Cited in PubMed; PMID 21918685. Read the article

de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. Epub 2011 Mar 28. Cited in PubMed; PMID 21444725. Read the article

2010

Beier UH, Schmidt ML, Hast H, Kecskes S, Valentino LA. Control of disseminated intravascular coagulation in Klippel-Trenaunay-Weber syndrome using enoxaparin and recombinant activated factor VIIa: a case report. J Med Case Reports. 2010 Mar 19;4:92. Cited in PubMed; PMID 20302608. Read the article

Abstracts

2011

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Hiebert SW, et al. Loss of HDAC3 in Foxp3+ Tregs causes sustained acetylation of lysine-310 of NFKB and uncontrolled expression of NFKB-dependent pro-inflammatory genes [abstract oral presentation]. American Transplant Congress; 2011 Apr 30-May 3; Philadelphia, PA.

Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G, et al. Sirtuin-1 targeting enhances T regulatory (Treg) cell suppressive function by increasing Foxp3 and heat shock protein-70 expression and promotes Treg-dependent cardiac allograft survival [abstract oral presentation]. American Transplant Congress; 2011 Apr 30-May 3; Philadelphia, PA.

2010

Wang L, Liu Y, Ge G, Han R, Bhatti T, Larosa C, et al. DNA methyltransferase-1 (DNMT1) is indispensable for T regulatory (TREG) cell function [plenary presentation]. American Transplant Congress; 2010 May 1-5; San Diego, CA. Am J Transplant 2010,10(Suppl.4):39-40.

Beier UH, Wang L, Bhatti, TR, Liu Y, Han R, Ge G, et al. Sirtuin 1 (Sirt1) inhibition promotes the development and suppressive function of Foxp3+ T regulatory (TREG) cells and induces long-term allograft survival [abstract oral presentation]. American Transplant Congress; 2010 May 1-5; San Diego, CA. Am J Transplant 2010, 10(Suppl.4):106.

Books

2011

Beier UH, Copelovitch L. Disorders of the renal & urologic systems: congenital anomalies of the kidney & urologic system. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Amsterdam (The Netherlands): Elsevier; 2011. p. 408-13.

2006

Ruiz CE, Beier UH. Small intestinal submucosa: a new generation of valve replacement. In: Hijazi ZM, Ruiz CE, Bonhoeffer P, Feldmann L, editors. Transcatheter valve repair. London: Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books; 2006. p. 75-7.

Posters and Presentations

2011

Akimova T, Levine MH, Beier UH, Kamath B, Rand EB, Meyers KEC, et al. Contrasting effects of immunosuppression on FOXP3+ Treg biology in liver and kidney allograft recipients [poster]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

Beier U. Differential effects on foxp3+ tregs of targeting histone/protein deacetylases 6, 9 and sirtuin-1 [poster presentation]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

Akimova T, Beier UH, Hancock WW. Sexual dimorphism of Foxp3+ T-regulatory cell function is HDAC6-dependent [poster]. Kidney Week 2011, American Society of Nephrology 44th Annual Meeting; 2011 Nov 8-13; Philadelphia, PA.

Beier U. Sirtuin-1 targeting enhances T regulatory (Treg) cell suppressive function by increasing foxp3 and heat shock protein-70 expression and promotes treg-dependent cardiac allograft survival [oral presentation]. American Transplant Congress; 2011 Apr 30-May 4; Philadelphia, PA.

2010

Beier U. Sirtuin 1 (Sirt1) inhibition promotes the development and suppressive function of foxp3+ T regulatory (TREG) cells and induces long-term allograft survival. American Transplant Congress; 2010 May 1-5; San Diego, CA.

Editorial and Academic Positions

Editorial positions

Reviewer, International Journal of Cancer