Michael Chorny, PhD

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Michael Chorny, PhD, is a researcher with Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Undergraduate Degree

BPharm in Pharmaceutical Sciences - The Hebrew University of Jerusalem, Israel

Graduate Degree

PhD in Pharmaceutical Sciences - The Hebrew University of Jerusalem, Israel
MS in Pharmaceutical Sciences - The Hebrew University of Jerusalem, Israel

Titles and Academic Titles

Researcher

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Publications

Papers

2015

R. Iyer, J. L. Croucher, M. Chorny, J. L. Mangino, I. S. Alferiev, R. J. Levy, V. Kolla, G. M. Brodeur, Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Lett 360, 205-212 (2015).

I. S. Alferiev, R. Iyer, J. L. Croucher, R. F. Adamo, K. Zhang, J. L. Mangino, V. Kolla, I. Fishbein, G. M. Brodeur, R. J. Levy, M. Chorny, Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51, 22-29 (2015).

2014

J. E. Tengood, I. S. Alferiev, K. Zhang, I. Fishbein, R. J. Levy, M. Chorny, Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A 111, 4245-4250 (2014).

2013

M. Chorny, I. Fishbein, J. E. Tengood, R. F. Adamo, I. S. Alferiev, R. J. Levy, Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB J 27, 2198-2206 (2013).

2012

M. Chorny, I. S. Alferiev, I. Fishbein, J. E. Tengood, Z. Folchman-Wagner, S. P. Forbes, R. J. Levy, Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharm Res 29, 1232-1241 (2012).

Books

Chapters

2014

I. Fishbein, M. Chorny, I.S. Alferiev, R.F. Adamo, R.J. Levy: Prevention of restenosis with stent-based vascular gene delivery: gene-eluting stents. Coronary artery restenosis: causes, treatment and clinical outcomes. Amir S. Lotfi (eds.). Nova Science Publishers, New York, Page: 239-261, 2014.

J.E. Tengood, I. Fishbein, R.J. Levy, M. Chorny: Nanomedicines for Restenosis Therapy. Frontiers in Nanobiomedical Research: Volume 3. Handbook of Nanobiomedical Research (Fundamentals, Applications and Recent Developments, v2: Applications in Therapy). V. Torchilin (eds.). World Scientific Publishing, London, 2: 39-87, Oct 2014 Notes: ISBN: 978-981-4520-64-5.

2012

I. Fishbein, M. Chorny, I.S. Alferiev, R.J. Levy: Site Specific Controlled Release for Cardiovascular Disease - Translational Directions. Fundamentals and Applications of Controlled Release Drug Delivery. J. Siepmann, R.A. Siegel, M.J. Rathbone (eds.). Springer, New York, Page: 445-492, 2012.

2006

E. Cohen-Sela, M. Chorny, G. Golomb: Nanoparticles for the treatment of restenosis. Nanoparticles for Pharmaceutical Applications. A.J. Domb, Y. Tabata, M.N.V.R. Kumar, S. Farber (eds.). ASP, Stevenson Ranch, CA, Page: 123-134, 2006.

2003

M. Chorny, H. Cohen-Sacks, I. Fishbein, H.D. Danenberg, G. Golomb: Biodegradable nanoparticles as drug delivery systems for parenteral administration. Tissue Engineering and Novel Delivery Systems. M.J. Yaszemski, D.J. Trantolo, K. Lewandrowski, V. Hasirci, D.E. Altobelli, D.L. Wise (eds.). Marcel Dekker, New York, Page: 393-422, 2003.

2000

I. Fishbein, M. Chorny, I. Gati, L. Rabinovich, G. Golomb: Drug delivery systems for the treatment of restenosis. Biomaterials and Bioengineering Handbook. D.L. Wise (eds.). Marcel Dekker, New York, Page: pp. 313-335, 2000.

Posters and Presentations

2015

R. Iyer, J.L. Croucher, M. Chorny, J.L. Mangino, I. Alferiev, R.J. Levy, V. Kolla, G.M. Brodeur: Nanoparticle delivery of an SN38 conjugate is more effective than Irinotecan in a mouse model of Neuroblastoma. American Association for Cancer Research Annual Meeting 2015, April 18-22, 2015, Philadelphia, PA 2015.

2014

I. Fishbein, R.F. Adamo, M. Chorny, I.S. Alferiev, R.J. Levy: Induction of pro-healing macrophages through the reprogramming of invading monocytes: a new antirestenotic strategy. 3rd International Conference on Translational Medicine, November 3-5, 2014, Las Vegas, NV 2014.

R. Iyer, J.L. Croucher, M. Chorny, J.L. Mangino, I. Alferiev, R.J. Levy, V. Kolla, G.M. Brodeur: Biodegradable Nanoparticles Loaded with a Rapidly Activatable SN38 Prodrug Effectively Inhibit Growth of Neuroblastoma (NB) Xenografts. Advances in Neuroblastoma Research 2014 Conference, May 13-16, 2014, Cologne, Germany 2014.

P.C. Naha, A.A. Zaki, E. Hecht, M. Chorny, P. Chhour, W. Witschey, H.I. Litt, A. Tsourkas, D.P. Cormode: Dextran coated bismuth-iron oxide nanoparticle as a novel contrast agent for both computed tomography and magnetic resonance imaging. ACS 2014 Colloid & Surface Science Symposium, June 22-25, 2014, Philadelphia, PA 2014.

P.C. Naha, A.A. Zaki, E. Hecht, M. Chorny, P. Chhour, W. Witschey, H.I. Litt, A. Tsourkas, D.P. Cormode: Dextran coated bismuth-iron oxide nanohybrid contrast agent for computed tomography and magnetic resonance imaging. World Molecular Imaging Congress 2014, September 17-20, 2014, Seoul, Korea 2014.

2013

S.P. Forbes, I.S. Alferiev, R.F. Adamo, M. Chorny, R.J. Levy, I. Fishbein: Prevention of Restenosis through Ad-iNOS Gene Therapy Combined with Supplementation of Tetrahydrobiopterin and Arginine. 16th Annual Meeting of the American Society of Gene & Cell Therapy, May 15-18, 2013, Salt Lake City, UT. 2013.

M. Chorny: Magnetically targeted drug delivery to stented blood vessels. 3rd International Conference on Pharmaceutics and Novel Drug Delivery Systems, April 8-10, 2013, Chicago, IL. 2013.

J.E. Tengood, I.S. Alferiev, R.J. Levy, M. Chorny: Functionalization of endothelial cells with biodegradable magnetic nanoparticles for targeted delivery. The TERMIS-Americas 2013 Annual Conference & Exposition, November 10-13, 2013, Atlanta, GA 2013.

J.E. Tengood, I.S. Alferiev, I. Fishbein, R.J. Levy, M. Chorny: Measuring Intracellular Degradation of Polylactide-Based Magnetic Nanoparticles Using FRET 16th Annual Meeting of the American Society of Gene & Cell Therapy, May 15-18, 2013, Salt Lake City, UT. 2013.

I. Fishbein, R.F. Adamo, J.M. Connolly, S. Redlich, K.A. Clark, R.A. Corrales, M. Chorny, S.P. Forbes, R.J. Levy: Ex-Vivo Transduced Monocytes as Gene Delivery Vehicles to Restenotic Arteries. 16th Annual Meeting of the American Society of Gene & Cell Therapy, May 15-18, 2013, Salt Lake City, UT. 2013.

Invited Lectures

2015

"Nanoparticles for site-specific delivery of small-molecule drugs and biotherapeutics to injured vasculature", 5th International Conference on Clinical & Experimental Cardiology, Philadelphia, PA, USA, April 2015.

"Monitoring disassembly of biodegradable nanoparticles designed for targeted delivery", 5th International Conference on Clinical & Experimental Cardiology, Philadelphia, PA, USA, April 2015.

"SN-38 prodrug-loaded nanoparticles for neuroblastoma therapy", International Conference on Significant Advances in Biomedical Engineering, Philadelphia, PA, USA, April 2015.

2014

"Real-time analysis of nanoparticle disassembly in vascular cells and biomimetic media using Foerster Resonance Energy Transfer", Symposium on Nanoparticles for Biomedical Applications: Improving Performance and Design Through Mechanistic Studies, Ben-Gurion University of the Negev, Beer-Sheva, Israel, October 2014.

2013

"Magnetic targeting for site-specific delivery of genes and cells to stented blood vessels", Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel, October 2013.

"Magnetically targeted drug delivery to stented blood vessels", 3rd International Conference on Pharmaceutics and Novel Drug Delivery Systems, Chicago, IL, USA, April 2013.

Awards and Honors

2011, Certificate of Research Excellence from the American Heart Association in recognition of outstanding dedication and achievement in heart disease and stroke research
2009, New Investigator Award from the Ethel Brown Foerderer Fund for Excellence
2006, Outstanding presentation in basic research, The Children's Hospital of Philadelphia/The Joseph Stokes, Jr. Research Institute
2001, Superpharm Ph.D. student distinction award
1997, Goldhaber Family prize for academic achievements

Editorial and Academic Positions

Editorial Positions

2013-present, Journal of Nanotechnology in Diagnosis and Treatment, Editorial board member

Reviewer

2015-present, Journal of Microencapsulation
2014-present, Journal of Biomedical Nanotechnology
2013-present, ACS Nano
2012-present, Expert Opinion on Drug Delivery
2012-present, Molecular Therapy
2012-present, Molecular Pharmaceutics
2012-present, Joint research project proposals for the Institute for Drug Research, the Hebrew University of Jerusalem (Israel) and the Fraunhofer-Gesellschaft Institute (Germany)
2011-present, Grant applications for The Henry Smith Charity, London, UK
2011-present, Pharmaceutical Research
2011-present, Acta Biomaterialia
2011-present, Drug Development & Industrial Pharmacy
2009-present, Nanomedicine
2009-present, International Journal of Nanomedicine
2009-present, Current Cancer Drug Targets
2006-present, Biomaterials
2005-present, Langmuir Archives of Medical Research
2003-present, Journal of Pharmaceutical Sciences

Academic and Institutional Committees

2013-present, Pediatric Cardiology Scholarship Oversight Committee
2012-present, Center for Targeted Therapeutics and Translational Nanomedicine, reviewer of pilot grant applications
2012-present, Reviewer of T32 applications for the Division of Cardiology
2011-present, Bioengineering Graduate Group

Leadership and Memberships

Memberships in Professional Organizations

International

2010-present, Controlled Release Society
2009-present, American Society of Gene and Cell Therapy
2008-present, American Heart Association