Stella T. Chou, MD

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Stella T. Chou, MD is Chief of the Division of Transfusion Medicine and an attending physician in the Division of Hematology at Children's Hospital of Philadelphia.

Areas of Expertise: General pediatric hematology, Transfusion medicine, Sickle cell disease and alloimmunization, Apheresis
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Background

Stella T. Chou, MD, is board certified in Blood Banking/Transfusion Medicine and Pediatric Hematology/Oncology and is an attending physician in the Divisions of Hematology and Transfusion Medicine at the Children's Hospital of Philadelphia. She specializes in caring for children with sickle cell disease, those who make antibodies against red cell transfusions (alloimmunization), and those requiring apheresis. Her research interests are focused on improving red blood cell matching for patients through the use of innovative tools.

Dr. Chou earned her medical degree from New York Medical College in Valhalla, New York. She completed her internship and residency in pediatrics at CHOP, as well as a fellowship in pediatric hematology/oncology. She also completed a fellowship in transfusion medicine at Hospital of The University of Pennsylvania in Philadelphia.

In addition to her clinical work, Dr. Chou serves as an Associate Professor of Pediatrics at the Perelman School of Medicine, University of Pennsylvania.

Dr. Chou’s laboratory research efforts are centered on investigating the mechanisms of normal hematopoietic development and how these become disrupted in hematologic diseases. Her research interests also include alloimmunization in patients with sickle cell disease. Her current research in this area focuses on improving red blood cell matching using innovative tools. Her work has demonstrated that inheritance of variant blood group antigens in patients with sickle cell disease contributes to their high rate of red cell antibody formation. Her research laboratory uses induced pluripotent stem cells (iPSCs) and primary human cells to model blood diseases and study their underlying pathophysiology. Ongoing work focuses on genetic matching of red cells and creating customized iPSCs with rare blood group antigen combinations as renewable sources of red cell reagents to improve antibody identification and donor red cell matching. Since transfusion therapy remains a critical treatment for hemoglobinopathies, her goal is to identify new approaches to minimize alloimmunization, reduce complications and improve therapy. For her innovative research, she is a recipient of the National Blood Foundation Hall of Fame award.

“Because transfusion therapy remains a critical treatment for hemoglobinopathies, my goal is to identify new approaches to minimize alloimmunization, reduce complications and improve therapy,” she says.

Education and Training

Medical School

MD - New York Medical College, Valhalla, NY

Internship

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Hematology/Oncology - Children's Hospital of Philadelphia, Philadelphia, PA
Transfusion Medicine - Hospital of The University of Pennsylvania, Philadelphia, PA

Board Certification

Blood Banking and Transfusion Medicine
Hematology/Oncology
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

Chief, Division of Transfusion Medicine

Distinguished Chair in Pediatrics

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2022

Zhang Z, An HH, Vege S, Hu T, Zhang S, Mosbruger T, Jayaraman P, Monos D, Westhoff CM, Chou ST.: Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion. Am J Hum Genet 109: 180-191, Jan 2022.

2021

Uter S, An HH, Linder GE, Kadauke S, Sesok-Pizzini D, Kim HC, Friedman DF, Chou ST.: Measures to reduce red cell use in patients with sickle cell disease requiring red cell exchange during a blood shortage. Blood Adv 5: 2586-2592, Jun 2021.

Waldis SJ, Uter S, Kavitsky D, Flickinger C, Vege S, Friedman DF, Westhoff CM, Chou ST: Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K-matched transfusions. Blood Adv 5(3): 737-744, Feb 2021.

2020

Liu Y, Zhong H, Bao W, Mendelson A, An X, Shi P, Chou ST, Manwani D, Yazdanbakhsh K: Patrolling monocytes scavenge endothelial adherent sickle RBC: a novel mechanism of inhibition of vaso-occlusion in SCD. Blood 134(7): 579-590, Aug 2019.

Chang Ti-Cheng, Haupfear Kelly M, Yu Jing, Rampersaud Evadnie, Sheehan Vivien A, Flanagan Jonathan M, Hankins Jane S, Weiss Mitchell J, Wu Gang, Vege Sunitha, Westhoff Connie M, Chou Stella T, and Zheng Yan: A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data. Blood Advances 4(18):4347-4357, Sept 2020. PMCID: PMC7509869

Chou Stella T, Alsawas Mouaz, Fasano Ross M, Field Joshua J, Hendrickson Jeanne E, Howard Jo, Kameka Michelle, Kwiatkowski Janet, Pirenne France, Shi Patricia A, Stowell Sean R, Thein Swee Lay, Westhoff Connie M, Wong Trisha E, Akl Elie A: American Society of Hematology 2020 Guidelines for sickle cell disease: transfusion support. Blood Advances 4(2): 327-355, Jan 2020. PMCID: PMC6988392

Pagano Monica B, Allen Elizabeth S, Chou Stella T, Dunbar Nancy M, Gniadek Thomas, Goel Ruchika, Harm Sarah K, Hopkins Courtney K, Jacobson Jessica, Lokhandwala Parvez M, Metcalf Ryan A, Raval Jay S, Schwartz Joseph, Shan Hua, Spinella Phillip C, Storch Emily, Cohn Claudia S: Current advances in transfusion medicine: a 2019 review of selected topics from the AABB Clinical Transfusion Medicine Committee. Transfusion 60(7): 1614-1623, July 2020.

Waldis SJ, Uter S, Kavitsky D, Flickinger C, Vege S, Friedman DF, Westhoff CM, Chou ST: Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K-matched transfusions. Blood Adv 5(3): 737-744, Feb 2021.

2019

Hassan Murad M, Liem Robert I, Lang Eddy S, Akl Elie A, Meerpohl Joerg J, DeBaun Michael, Tisdale John F, Brandow Amanda M, Lanzkron Sophie M, Chou Stella T, Webb Starr, Mustafa Reem A: 2019 sickle cell disease guidelines by the American Society of Hematology: methodology, challenges and innovations Blood Advances 3(23): 3945-3950, Dec 2019. PMCID: PMC6963245

Chonat Satheesh, Risinger Mary, Sakthivel Haripriya, Niss Omar, Rothman Jennifer A, Hsieh Loan, Chou Stella T, Kwiatkowski Janet L, Khandros Eugene, Gorman Matthew F, Wells Donald T, Maghathe Tamara, Dagaonkar Neha, Seu Katie G, Zhang Kekian, Zhang Wenying, Kalfa Theodosia A: The spectrum of SPTA1-associated hereditary spherocytosis. Frontiers in Physiology 10; 815, July 2019. PMCID: PMC6617536

Yunfeng Liu, Hui Zhong, Weili Bao, Avital Mendelson, Xiuli An, Patricia Shi, Stella T Chou, Deepa Manwani, and Karina Yazdanbakhsh : Patrolling Monocytes Scavenge Endothelial Adherent Sickle RBC: A Novel Mechanism of Inhibition of Vaso-occlusion in SCD. Blood. 2019 May 10. pii: blood.2019000172. doi: 10.1182/blood.2019000172. [Epub ahead of print]

Coleman Sarita, Westhoff Connie M, Friedman David F, Chou Stella T: Alloimmunization in patients with sickle cell disease and underrecognition of accompanying delayed hemolytic transfusion reactions. Transfusion Apr 2019.

Tasian Sarah K, Casas Jessica A, Posocco David, Gandre-Babbe Shilpa, Gagne Alyssa L, Liang Ge, Loh Mignon L, Weiss Mitchell J, French Deborah L, Chou Stella T: Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells. Leukemia 33(1): 181-190, Jan 2019. PMCID: PMC6286697

2018

Gagne Alyssa L, Maguire Jean Ann, Gandre-Babbe Shilpa, Chou Stella T, Tasian Sarah K, Loh Mignon L, Weiss Mitchell J, Gadue Paul, French Deborah L: Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL. Stem cell research 31: 157-160, 08 2018.

Babushok Daria V, Stanley Natasha L, Morrissette Jennifer J D, Lieberman David B, Olson Timothy S, Chou Stella T, Hexner Elizabeth O: Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32. Leukemia 32(12): 2720-2723, Dec 2018. PMCID: PMC6301065

Dong Ha Bhang, Bang-Jin Kim, Byung Gak Kim, Keri Schadler, Kwan-Hyuck Baek, Yong-Hee Kim, Wayland Hsiao, Bi-Sen Ding, Shahin Rafii, Mitchell Weiss, Stella Chou, Thomas Kolon, Jill Ginsberg, Buom-Yong Ryu, and Sandra Ryeom: Testicular endothelial cells are a critical population in the germline stem cell niche. Nature Communications 9(1): 4379, October 2018. PMCID: PMC6197186

Grevet Jeremy D, Lan Xianjiang, Hamagami Nicole, Edwards Christopher R, Sankaranarayanan Laavanya, Ji Xinjun, Bhardwaj Saurabh K, Face Carolyne J, Posocco David F, Abdulmalik Osheiza, Keller Cheryl A, Giardine Belinda, Sidoli Simone, Garcia Ben A, Chou Stella T, Liebhaber Stephen A, Hardison Ross C, Shi Junwei, Blobel Gerd A: Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science 361(6399): 285-290, July 2018. PMCID: PMC6257981

Chou Stella T, Evans Perry, Vege Sunitha, Coleman Sarita L, Friedman David F, Keller Margaret, Westhoff Connie M. : RH genotype matching for transfusion support in sickle cell disease. Blood Page: 10.1182/blood-2018-05-851360, July 2018 Notes: *featured article.

Hankins Jane S, Estepp Jeremie H, Hodges Jason R, Villavicencio Martha A, Robison Leslie L, Weiss Mitchell J, Kang Guolian, Schreiber Jane E, Porter Jerlym S, Kaste Sue C, Saving Kay L, Bryant Paulette C, Deyo Jeffrey E, Nottage Kerri A, King Allison A, Brandow Amanda M, Lebensburger Jeffrey D, Adesina Oyebimpe, Chou Stella T, Zemel Babette S, Smeltzer Matthew P, Wang Winfred C, Gurney James G: Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood. Pediatric blood & cancer Page: e27228, May 2018.

Liu Yunfeng, Jing Fangmiao, Yi Woelsung, Mendelson Avital, Shi Patricia, Walsh Ronald, Friedman David F, Minniti Caterina, Manwani Deepa, Chou Stella T, Yazdanbakhsh Karina: HO-1 patrolling monocytes protect against vaso-occlusion in sickle cell disease. Blood 131(14): 1600-1610, Apr 2018. PMCID: PMC5887768

2017

Daria Babushok, Jamie Duke, Hongbo Xie, Natasha Stanley, Jamie Atienza, Nieves Perdigones, Peter Nicholas, Deborah Ferriola, Yimei Li, Hugh Huang, Wenda Ye, Jennifer JD Morrissette, Jane Kearns, David L. Porter, Gregory M Podsakoff, Laurence Eisenlohr, Jaclyn Biegel, Stella T. Chou, Dimitrios Monos, Monica Bessler, and Timothy S Olson: Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications. Blood Advances 1(22): 1900-1910, October 2017. PMCID: 5621748

Chou Stella T, Flanagan Jonathan M, Vege Sunitha, Luban Naomi L.C., Brown R. Clark, Ware Russell E, Westhoff Connie M.: Whole exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia. Blood Advances 1(18): 1414-1421, August 2017. PMCID: PMC5727856

2016

Godefroy Emmanuelle, Liu Yunfeng, Shi Patricia, Mitchell W Beau, Cohen Devin, Chou Stella T, Manwani Deepa, Yazdanbakhsh Karina: Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization. Haematologica 101(9): 1028-38, Sep 2016. PMCID: 5060019

Cohen Devin, Hartung Helge, Evans Perry, Friedman David F, Chou Stella T: Red blood cell alloimmunization in transfused patients with bone marrow failure syndromes. Transfusion 56(6): 1314-9, Jun 2016.

Giani Felix C, Fiorini Claudia, Wakabayashi Aoi, Ludwig Leif S, Salem Rany M, Jobaliya Chintan D, Regan Stephanie N, Ulirsch Jacob C, Liang Ge, Steinberg-Shemer Orna, Guo Michael H, Esko Tõnu, Tong Wei, Brugnara Carlo, Hirschhorn Joel N, Weiss Mitchell J, Zon Leonard I, Chou Stella T, French Deborah L, Musunuru Kiran, Sankaran Vijay G: Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell 18(1): 73- Jan 2016. PMCID: PMC4707983

2015

Zhang H , Xue C , Shah R , Bermingham K , Hinkle CC , Li W , Rodrigues A , Tabita-Martinez J , Millar JS , Cuchel M , Pashos EE , Liu Y , Yan R , Yang W, Gosai SJ , VanDorn D , Chou ST , Gregory BD , Morrisey EE , Li M , Rader DJ , Reilly MP. Functional Analysis and Transcriptome Profiling of iPSC-derived Macrophages and their Application in Modeling Mendelian Disease. Circ Res. 2015 Jun 19;117(1):17-28.

Westhoff CM, Vege S, Halter Hipsky C, Horn T, Hue-Roye K, Keller J, Velliquette R, Lomas-Francis C, Chou ST, Reid ME. RHCE*ceAG (254C>G, 85Gly) is prevalent in Blacks, encodes a partial ce-phenotype, and is associated with discordant RHD zygosity. Transfusion. 2015 Nov;55(11):2624-32.

Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest. 2015 Jun;125(6):2369-74.

Wang Yuhuan, Hayes Vincent, Jarocha Danuta, Sim Xiuli, Harper Dawn C, Fuentes Rudy, Sullivan Spencer K, Gadue Paul, Chou Stella T, Torok-Storb Beverly J, Marks Michael S, French Deborah L, Poncz Mortimer: Comparative analysis of human ex vivo-generated platelets vs. megakaryocyte-generated platelets in mice: A cautionary tale. Blood Apr 2015.

Casas Jessica, Friedman David F, Jackson Tannoa, Vege Sunitha, Westhoff Connie M, Chou Stella T: Changing practice: red blood cell typing by molecular methods for patients with sickle cell disease. Transfusion Jan 2015.

Byrska-Bishop Marta, VanDorn Daniel, Campbell Amy E, Betensky Marisol, Arca Philip R, Yao Yu, Gadue Paul, Costa Fernando F, Nemiroff Richard L, Blobel Gerd A, French Deborah L, Hardison Ross C, Weiss Mitchell J, Chou Stella T: Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus. The Journal of clinical investigation 125(3): 993-1005, Jan 2015. PMCID: PMC4362246

2014

Shaham Lital, Vendramini Elena, Ge Yubin, Goren Yaron, Birger Yehudit, Tijssen Marloes R, McNulty Maureen, Geron Ifat, Schwartzman Omer, Goldberg Liat, Chou Stella T, Pitman Holly, Weiss Mitchell J, Michaeli Shulamit, Sredni Benjamin, Göttgens Berthold, Crispino John D, Taub Jeffrey W, Izraeli Shai: MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome. Blood 125(8): 1292-301, Dec 2014. PMCID: PMC4335082

2013

Malinge Sébastien, Chlon Tim, Doré Louis C, Kettering Rhett P, Tallman Martin S, Paietta Elisabeth, Gamis Alan S, Taub Jeffrey W, Chou Stella T, Weiss Mitchell J, Crispino John D, Figueroa Maria E: Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood 122(14): e33-43, Oct 2013. PMCID: PMC3790517

Chou Stella T, Jackson Tannoa, Vege Sunitha, Smith-Whitley Kim, Friedman David F, Westhoff Connie M: High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors. Blood 122(6): 1062-71, May 2013.

Zaslavsky Alexander, Chou Stella T*, Schadler Keri, Lieberman Allyson, Pimkin Maxim, Kim Yeo Jung, Baek Kwan-Hyuck, Aird William C, Weiss Mitchell J, Ryeom Sandra: The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood 121(16): 3205-15, Apr 2013. PMCID: PMC3630833, *co-first author

Gandre-Babbe Shilpa, Paluru Prasuna, Aribeana Chiaka, Chou Stella T, Bresolin Silvia, Lu Lin, Sullivan Spencer K, Tasian Sarah K, Weng Julie, Favre Helene, Choi John K, French Deborah L, Loh Mignon L, Weiss Mitchell J.: Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. Blood 121(24): 4925-9, April 2013.

2012

Roy Anindita, Cowan Gillian, Mead Adam J, Filippi Sarah, Bohn Georg, Chaidos Aristeidis, Tunstall Oliver, Chan Jerry K Y, Choolani Mahesh, Bennett Phillip, Kumar Sailesh, Atkinson Deborah, Wyatt-Ashmead Josephine, Hu Ming, Stumpf Michael P H, Goudevenou Katerina, O'Connor David, Chou Stella T, Weiss Mitchell J, Karadimitris Anastasios, Jacobsen Sten Eirik, Vyas Paresh, Roberts Irene: Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proceedings of the National Academy of Sciences of the United States of America 109(43): 17579-84, Oct 2012. PMCID: 3491522

Chou Stella T, Byrska-Bishop Marta, Tober Joanna M, Yao Yu, Vandorn Daniel, Opalinska Joanna B, Mills Jason A, Choi John Kim, Speck Nancy A, Gadue Paul, Hardison Ross C, Nemiroff Richard L, French Deborah L, Weiss Mitchell J: Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 109(43): 17573-8, Oct 2012. PMCID: 3491490

2009

Chou Stella T, Khandros Eugene, Bailey L Charles, Nichols Kim E, Vakoc Christopher R, Yao Yu, Huang Zan, Crispino John D, Hardison Ross C, Blobel Gerd A, Weiss Mitchell J: Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood 114(5): 983-94, Jul 2009. PMCID: PMC2721792

2008

Chou Stella T, Opalinska Joanna B, Yao Yu, Fernandes Myriam A, Kalota Anna, Brooks John S J, Choi John K, Gewirtz Alan M, Danet-Desnoyers Gwenn-ael, Nemiroff Richard L, Weiss Mitchell J: Trisomy 21 enhances human fetal erythro-megakaryocytic development. Blood 112(12): 4503-6, Dec 2008. PMCID: PMC2597125

2006

Stachura David L, Chou Stella T, Weiss Mitchell J: Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood 107(1): 87-97, Jan 2006. PMCID: PMC1895362

2004

Chou Stella T, Shah Samir S, Hodinka Richard L, Cohen Alan R: Positive heterophile antibody test and massive splenomegaly in an adolescent with previously unsuspected Gaucher disease. Pediatric emergency care 20(3): 181-4, Mar 2004.

2002

Sandoval C, Dong S (maiden name), Visintainer P, Ozkayanak MF, Jayabose S.: The clinical and laboratory features of 178 children with recurrent epistaxis.   Journal of Pediatric Hematology/Oncology. 24: 47-49, 2002. PMCID: PMC11902740

Abstracts

2018

Tasian SK, Casas JA, Posocco D, Gandre-Babbe S, Gagne A, Liang G, Loh ML, Weiss MJ, French DL, Chou ST: Mutation-specific signaling profiles and therapeutic vulnerabilities of induced pluripotent stem cell models of juvenile myelomonocytic leukemia. Blood 130: 1678, Dec 2018.

2017

Liu Y, Jing F, Yi W, Mendelson A, Shi P, Walsh R, Friedman DF, Minniti C, Manwani D, Chou ST, Yazdanbakhsh K: Protective role of HO-1 expressing CD16+ patrolling monocytes against hemolysis-induced endothelial damage and vaso-occlusive crisis in sickle cell disease. Blood 130: 767, Dec 2017.

Books

Chapters

2020

Chou ST: Development of the hematopoietic system. Nelson Textbook of Pediatrics, 21st Edition. Kliegman RM, Stanton B, St. Geme J, Schor NF (eds.). Elsevier, Page: 2500-2505, 2020.

2019

Stella T. Chou: Development of the Hematopoietic System. Nelson Textbook of Pediatrics, 21st Edition. Robert M. Kliegman, Bonita M.D. Stanton, Joseph St. Geme, Nina F Schor (eds.). Elsevier, 2019.

2014

Chou ST, Schreiber AD: Autoimmune Hemolytic Anemia. Nathan and Oski's Hematology of Infancy and Childhood. Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux S. (eds.). Elsevier, 2014.

2011

Chou ST, Westhoff CM. : The Rh System.  The American Association of Blood Banks Technical Manual.  Roback JD, Combs MR, Grossman BJ, Hillyer CD (Eds).  (eds.). AABB: Bethesda. 2011.

2007

Chou ST, Weiss MJ.: Nonimmune Hemolytic Anemia.  Conn's Current Therapy. Rakel R, Bope E (Eds).  (eds.). WB Saunders, 2007.

Chou Stella T, Weiss Mitchell J: Diseased red blood cells topple iron balance. Nature medicine 13(9): 1020-1, Sep 2007.

Posters and Presentations

2018

Hyun H. An, Judith Aeschlimann, David F. Posocco, Jean Ann Maguire, Paul Gadue, Deborah L. French, Connie M. Westhoff, Stella T. Chou: Induced pluripotent stem cell-derived red cells for use as reagents to resolve Rh specificities. Transfusion October 2018 Notes: American Association of Blood Banks Annual Meeting, Boston MA (Oral presentation).

Invited Lectures

2022

"New tools for prevention and management of alloimmunization," University of Washington Hematology Grand Rounds, Seattle, WA (virtual). Jan 2022.

2021

Chou ST. "Alloimmunization in patients with sickle cell disease: risk factors, prevention, and management," Vanderbilt Haploidentical Transplant Global Learning Collaborative (virtual). Dec 2021.

Chou ST. "RH genotyping and red cell matching in sickle cell disease," Education Session for the Association for Advancement of Blood and Biotherapies Annual Meeting (virtual). Oct 2021.

Chou ST. "Red cell transfusion for sickle cell disease: role and best practices," NIH Immunohematology and Blood Symposium Annual Meeting, Bethesda, MD (virtual). Sept 2021.

Chou ST. "New insights to molecular red cell typing for sickle cell disease," University of Alabama, Birmingham, AL (virtual). Feb 2021.

Chou ST. "2020 American Society of Hematology clinical guidelines on transfusion support in sickle cell disease," South Thames Sickle Cell and Thalassemia Network, London, UK (virtual). Feb 2021.

Chou ST. "Sickle cell disease: alloimmunization prevention and management with genetic tools," University of Toronto Transfusion Medicine Grand Rounds, Toronto, Canada (virtual). Jan 2021.

2020

Chou ST. "Universal platelets and red cells," presented at the Presidential Symposium at the American Society of Hematology Annual Meeting, Virtual (San Diego). Dec 2020.

Chou ST. "Erythrocyte disorders and anemia," Reading Hospital Pediatric Grand Rounds, Reading, PA. June 2020.

Chou ST. "The 2020 American Society of Hematology guidelines on transfusion support for patients with sickle cell disease," Cincinnati Children's Hospital, Cincinnati, OH. June 2020.

Chou ST. "Alloimmunization and delayed hemolytic transfusion reactions in patients with SCD," Duke University, Durham, NC. May 2020.

Chou ST. "Highlights of ASH: transfusion medicine," The American Society of Hematology 2020 Highlights of ASH in North America, Washington, DC. Jan 2020.

2019

Chou ST. "RH genotype matching for transfusion in sickle cell disease," Annual Academy for Sickle Cell and Thalassemia Conference, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Oct 2019.

Chou ST. "Changing practice in blood transfusion: molecular red cell typing," 2nd King's College London Bone Marrow Failure/Aplastic Anemia Meeting, London, UK. Oct 2019.

Chou ST. "Expanding our toolbox to improve red cell matching," Transfusion Medicine Grand Rounds, Harvard Medical School, Boston, MA. Sept 2019.

Chou ST. "Transfusion therapy for sickle cell disease: new approaches for old challenges," Distinguished Hematologist Seminar Series, Yale School of Medicine, New Haven, CT. June 2019.

Chou ST. "Transfusion therapy for patients with sickle cell disease: new approaches for old challenges," National Institutes of Health, NHLBI, Bethesda, MD. May 2019.

Chou ST. "Innovations in transfusion management of patients with sickle cell disease," British Society of Hematology Annual Meeting Education Session, Glasgow, Scotland. Apr, 2019.

2018

Chou ST. "ASH clinical practice guidelines on sickle cell disease: transfusion medicine," The American Society of Hematology, San Diego, CA. Dec, 2018.

Chou ST. "A new approach to transfusion for sickle cell disease: time for personalized therapy," St. Jude Research Hospital, Memphis, TN. Nov, 2018.

Chou ST. "Antigen matching for patients with sickle cell disease: experience in the United States," Education Session at the American Association of Blood Banks Annual Meeting, Boston, MA. Oct, 2018.

Chou ST. "Personalized and Precision Medicine in Pediatric Transfusion Medicine," Education Session at the American Association of Blood Banks Annual Meeting, Boston, MA. Oct, 2018.

Chou ST. "Customized induced pluripotent stem cell-derived red cell reagents," American Society of Pediatric Hematology Oncology Annual Meeting Education Session, Pittsburgh, PA. May, 2018.

Chou ST. "Highlights of the 59th American Society of Hematology Annual Meeting, Transfusion Medicine," Highlights of ASH in Latin America, Rio de Janiero, Brazil. Apr, 2018.

Chou ST. "Genomic applications to improve transfusion therapy for sickle cell disease," Texas Children's Hematology and Oncology Center Research Seminar Series, Houston, TX. Feb, 2018.

Awards and Honors

2021, Distinguished Chair in Pediatrics, Children's Hospital of Philadelphia
2018, The National Blood Foundation Hall of Fame
2015, Scholar Award of The National Blood Foundation
2011, National Blood Foundation Young Investigator Scholarship
1997, New York Medical College Trustees' Scholarship for top 30 students
1997, Joseph Collins Foundation Scholarship for academic excellence
1995, Dean's List with Distinction, Duke University
1994, Dean's List, Duke University

Editorial and Academic Positions

Editorial Positions

2019-2021, Hematology: American Society of Hematology Education Program Book, Associate Editor
2018-present, Haematologica, reviewer
2017-present, Blood Advances, reviewer
2015-present, Proceedings of National Academy of Science, reviewer
2011-present, British Journal of Hematology, reviewer
2011-present, Transfusion, reviewer
2010-present, Blood, reviewer

Academic and Institutional Committees

2020-2021, Search Committee for CHOP Blood Bank Medical Director, Chair
2019-present, Faculty Research Advisory Committee, Department of Pediatrics
 - 2020-present, Co-chair
2016-present, Hematology-Oncology Fellowship, Department of Pediatrics
2014-present, Hematology Mentorship Committee, Department of Pediatrics
2010-present, Transfusion Committee, Department of Pathology

Leadership and Memberships

Memberships in Professional Organizations

International

2008-present, Association for Advancement of Blood and Biotherapies
 - 2014-present, Clinical Transfusion Medicine Committee
2004-present, American Society of Hematology
 - 2016-2020, Chair, Transfusion Panel for the ASH Sickle Cell Disease Guideline Panel
 - 2014-2020, Scientific Committee on Transfusion Medicine
 - 2020, Scientific Committee on Transfusion Medicine, Chair

National

2022-present, National Institutes of Health State of the Science in Transfusion Medicine
 - 2022-present, Donor and Blood Recipient Health Disparities in Transfusion Medicine Working Group
2017-present, American Society for Apheresis
2016-present, National Blood Foundation
 - 2016-present, Grant Review Committee
2005-present, American Society of Pediatric Hematology/Oncology