Jérôme Clatot, PhD

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Jérôme Clatot, PhD, is the Director of the ENGIN Ion Channel/Electrophysiology Core with the Epilepsy Neurogenetics Initiative at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training


​Post-Doctoral Fellow in Cellular Cardiac Electrophysiology - Lankenau Institute for Medical Research, Wynnewood, PA
Post-Doctoral Fellow in Cellular Cardiac Electrophysiology - Case Western Reserve University, Cleveland, OH

Graduate Degree

PhD in Cellular Cardiac Electrophysiology - Paris University, Paris, France
MS in Physiology Biotechnology - Pontoise University, Pontoise, France

Titles and Academic Titles

Director, ENGIN Ion Channel/Electrophysiology Core

Departments and Services




Clatot J, Marionneau C, Deschênes I. Voltage-gated sodium mutations can exert dominant negative suppression by coupled gating deficiency or trafficking deficiency. “American Journal of Physiology, 2018 ”

Chatterjee S., Vyas R., Chalamalasetti S., Sahu I.D., Clatot J., Wan X., Lorigan G.A., Deschênes I., Chakrapani S. The Voltage-Gated Sodium Channel Pore exhibits Conformational Flexibility during Slow Inactivation. Journal of General Physiology, 2018


Clatot J., Hoshi M, Wan X., Liu H, Jain A., Shinlapawittayatorn K., Marionneau C., Ficker E., Ha T., Deschenes I. Voltage-Gated Sodium Channels Assemble and Gate as Dimers. Nature Communications 2017.


Ziyadeh-Isleem A*, Clatot J.*, Duchatelet S, Gandjbakhch E, Denjoy I, Hidden-Lucet F, Hatem S, Deschênes I, Coulombe A, Neyroud N, Guicheney P. *Both authors contributed equally to this work. A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. Heart Rhythm Journal 2014 Jun;11(6):1015-23


Clatot J., Ziyadeh-Isleem A., Maugenre S., Denjoy I., Liu H., Dilanian G., Hatem S.N., Deschênes I., Coulombe A., Guicheney P., and Neyroud N. Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 alpha-subunits. Cardiovascular Research 2012 96: 53-63



Neyroud N, Cox R, Antzelevitch C, Clatot J. Interaction between Nav1.5 and Kv4.3 regulates the balance between INa and Ito, unveiling a major mechanism for Brugada Syndrome. Channelopathy meeting, 24-26 June 2018, Chicago, USA.

Clatot J, Burashnikov E, Juang J, Hasdemir C, Antzelevitch C. KCNE4 a new susceptibly gene in Brugada Syndrome. Biophysical Society meeting, 17-21 February 2018. San Francisco, California, USA.


Clatot J, Liu H, Girardeau A, Marioneau C, Deschênes I. Voltage-gated sodium mutations can exert dominant negative suppression by coupled gating deficiency or trafficking deficiency. Biophysical Society meeting, 11-15 February 2017. New Orleans, Louisiana, USA.



Clatot J. Book: “Le complexe du canal sodique cardiaque Nav1.5”, Editions universitaires europeennes 2016. ISBN: 978-3-8417-2917-0

Posters and Presentations

Invited Lectures


Invited Grand Round lecturer, Academic Medical Center, Amsterdam, Netherlands. 2017.

Invited Grand Round lecturer, Hôptial Pitié Salpetrière, Paris, France. 2017.

Invited Grand Round lecturer, Bern Universitaat, Bern, Switzerland. 2017.

Awards and Honors

2015, AHA meeting Travel award 2015
2014, Hearth Rhythm Society clinical research fellowship award
2012, PhD in Electrophysiology, Very Honorable
2012, Biophysical society meeting Travel award
2011, Denis Escandes Award of Excellence Laureate
2009, CODDIM Fellowship (French Governmental Pre-Doctoral Fellowship grant)
2006, Biotechnology/Cellular Pathology Master II, Honors Distinction
2005, Biochemistry Master I, Honors Distinction
2003, DEUG SVN Honors Distinction

Leadership and Memberships

American Heart Association
Biophysical Society
Heart Rhythm Society