Epilepsy Neurogenetics Initiative (ENGIN)

Epilepsy is a common brain disease defined by the presence of seizures. For many children, the cause of epilepsy is genetic. Until recently, little has been known about the genes that cause the condition, so treatment has been imprecise and not targeted toward the underlying cause. Many families spend years searching for answers to alleviate their child’s suffering.

The Epilepsy Neurogenetics Initiative (ENGIN) at Children’s Hospital of Philadelphia (CHOP) integrates genetic testing into the diagnosis and treatment of children with difficult-to-treat or unexplained epilepsies, and provides access to expert care for children with genetic epilepsy syndromes and other genetic neurodevelopmental disorders. We combine cutting-edge clinical care and advanced genetic testing with innovative research to identify the genetic variants causing a child’s epilepsy and develop an individualized approach to treatment and management.

Families come to our Epilepsy Neurogenetics Initiative clinic from all over the world due to our unparalleled access to genetic tests, our expertise in the interpretation of genetic testing results, our in-depth knowledge regarding a wide range of genetic causes of epilepsy, and our efforts to quickly turn discoveries into effective treatments. Through ENGIN, your child will have access to a full range of epilepsy therapies, including medication, dietary treatment and epilepsy surgery.

Researchers from ENGIN at CHOP Show How Variants in RNA Editing Can Cause Epilepsy

Why Choose Us?

The Epilepsy Neurogenetics Initiative (ENGIN) at Children’s Hospital of Philadelphia is committed to providing comprehensive and individualized care for children with epilepsy. We are leaders in the field of epilepsy genetics and offer every child seen in our program unparalleled access to diagnostic genetic testing, an individualized treatment plan, and enrollment in our innovative research studies.

Who We Treat

Any child with epilepsy may be eligible for referral to our program. Your path will depend primarily on whether or not the child already has a diagnosis in hand. No matter what, we are here to help and guide you to the right place.

Our Team

When your child is seen in our ENGIN clinic, their core care team will include an attending pediatric neurologist and genetic counselor who specialize in genetic epilepsies and neurogenetic disorders, as well as physical and occupational therapists. Depending on your child’s personalized treatment plan, they may also see neurosurgeons, research coordinators, cardiologists, gastroenterologists, neuro-ophthalmologists social workers, psychologists and other specialists, all of whom have experience treating children with genetic epilepsies.