Andrew T. Costarino Jr., MD, MSCE

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Andrew T. Costarino Jr., MD, MSCE, is Chief of the Division of Cardiac Critical Care Medicine at Children’s Hospital of Philadelphia. He holds the CHOP Endowed Chair in Cardiac Critical Care Medicine.

Outpatient Appointments: 215-590-4040
Second Opinions, Referrals and Information About Our Services: 267-426-9600

Background

Dr. Andrew T. Costarino is the Chief of the Division of Cardiac Critical Care at The Children’s Hospital of Philadelphia, he holds CHOP Endowed Chair in Cardiac Critical Care and is a Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.  A graduate of the University of Notre Dame, Dr. Costarino attended the State University of New York at Buffalo School of Medicine before coming to Philadelphia for his residency in Pediatrics.  He then completed training in Anesthesiology at the Hospital of the University of Pennsylvania and returned to CHOP for an advanced fellowship in Pediatric Anesthesiology and Pediatric Critical Care Medicine.  Dr. Costarino began his faculty career at CHOP specializing in general and pediatric anesthesia and critical care of infants and children.  He was Director of the Fellowship in Pediatric Critical Care.  His research focused on acute respiratory distress and mediators of sepsis in this population.  Dr. Costarino left CHOP to become Chairman of the Department of Anesthesiology and Critical Care Medicine at Nemours duPont Hospital for Children in Wilmington Delaware.  After 13 years in that position he was recruited to return to CHOP in his current position in the Cardiac Center in 2015.  Dr. Costarino is former member of the American Board of Pediatrics, sub board for Critical Care.

Education and Training

Medical School

MD - State University of New York at Buffalo, Buffalo, New York

Residency

Anesthesiology - The Hospital of the University of Pennsylvania, Philadelphia, PA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

<p>Pediatric Anesthesiology and Critical Care Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA<br>
Neonatology - The Children's Hospital of Philadelphia, Philadelphia, PA</p>

Board Certification

Anesthesiology
Critical Care Medicine
Pediatric Anesthesiology
Pediatrics
Pediatrics Critical Care Medicine
Pediatrics Neonatal-Perinatal Medicine

Graduate Degree

Masters in Clinical Epidemiology and Biostatistics (MSCE) - University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA

Titles and Academic Titles

Division Chief, Cardiac Critical Care Medicine

Senior Pediatric Intensivist

Endowed Chair in Cardiac Critical Care Medicine

Professor of Clinical Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2020

Spinner JA, Morris SA, Nandi D, Costarino AT, Marino B, Rossano JW, Shanszad P.: Necrotizing Enterocolitis and Associated Mortality in Neonates with Condentia; Heart Disease. Pediatric Critical Care Medicine 21: 228-234, 2020.

Lisanti AJ, Demianczyk AC, Costarino AT, Vogiatzi MG, Hoffman R, Quinn R, Chittams JL, Medoff-Cooper B.: Skin-to-Skin Care is a Safe and Effective Comfort Measure for Infants Before and After Neonatal Cardiac Surgery. Pediatric Critical Care Medicine 21(9): e834 - e841, September 2020. PMCID: 32740179

DeWitt AG, Rossano JW, Bailly DK, Bhat PN, Chanani NK, Kirkland BW, Moga MA, Owens GE, Retzloff LB, Zhang W, Banerjee M, Costarino AT, Bird GL, Gaies M.: Predicting and Surviving Prolonged Critical Illness After Congenital Heart Surgery. Critical Care Medicine 48(7): e557, July 2020.

Lisanti AJ, Demianczyk AC, Costarino AT, Vogiatzi MG, Hoffman R, Quinn R, Chittams JL, Medoff-Cooper B, : Skin to Skin Care is a Safe and Effective Comfort Measure for Infants before and after Neonatal Cardiac Surgery. Pediatric Critical Care Medicine January 2020.

2019

Shamszad, P., Costarino, A.T.: Necrotizing Enterocolitis and Associated Mortality in Neonates with Congenital Heart Disease: A Multi -Institutional Study. Pediatric Critical Care Medicine In Press, 2019.

Adler AC, Helman S, Field C, Steller JJ, Brown LA, Costarino AT, Yuerek M, Bender KS.: Reducing Ischemic Injury from Indwelling Peripheral Arterial Catheters in a Pediatric Cardiac ICU: A Quality Improvement Initiative. Pediatric Critical Care Medicine 19(3): 228-236, 2019.

2018

Chu DI, Tan JM, Mattei P, Simpao AF, Costarino AT, Shukia AR, Rossano JW, Tasian GE.: Outcomes of laparoscopic and open surgery in children with and without congenital heart disease. Journal of Pediatric Surgery 53(10): 1980-1988, 2018.

Adler AC; Helman S; Field C; Stellar JJ; Brown LA; Omensetter N; Costarino AT; Yuerek M; Bender KS. : Reducing Ischemic Injury From Indwelling Peripheral Arterial Catheters in a Pediatric Cardiac ICU: A Quality Improvement Initiative.  Pediatric Critical Care Medicine. Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 19(3): 228, 3 2018.

Chu DI; Tan JM; Mattei P; Simpao AF; Costarino AT; Shukla AR; Rossano JW; Tasian GE.: Outcomes of laparoscopic and open surgery in children with and without congenital heart disease. Journal of Pediatric Surgery. 53(10):1980-1988, 2018 Oct. 53(10): 1980, October 2018.

2017

Kakajiwala, A, Kim JY, Hughes JZ, Costarino AT, Ferguson, Gaynor JW, Furth SL, Blinder JJ.: Lack of Furosemide Responsiveness Predicts Acute Kidney Injury in Infants After Cardiac Surgery. Annals of Thoracic Surgery 104(4): 388-1394, 2017.

David I. Chu, Peter Mattei, MD Jonathan Tan, MD, Andrew T. Costarino, MD, Joseph W. Rossano, MD: Mortality and Morbidity after laparoscopic surgery in children with and without congenital heart disease. Journal of Pediatics 185: 88-93, 2017.

Chu DI, Tan JM, Mattei P, Costarino AT, Rossano JW, Tasian GE.: Mortality and Morbidity after Laparoscopic Surgery in Children with and without Congenital Heart Disease. J Pediatric 185: 88-93, 2017.

Aadil Kakajiwala, MBBS, Ji Y. Kim, PhD, John Z. Hughes, MPH, Andrew Costarino, MD, MSCE, John Ferguson, J. Willliam Gaynor, MD, Susan L. Furth, MD, PhD, Joshua Blinder, MD: Lack of furosemide responsiveness predicts acute kidney injury in infants following cardiac surgery. The Annals of Thoracic Surgery 2017.

2015

Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ.: OUtcomes for extremely premature infants. Anesthesia Analg 120(6): 1337-51, 2015.

Costarino AT, Dai D, Feng R, Feudtner C, Guevara JP.: Gastric Acid Suppressant Prophylaxis in Pediatric Intensive Care: Current Practice as Reflected in a Large Administrative Database. Pediatric Critical Care Medicine 15((7)): 605-12, September 2015.

Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ.: Outcomes for Extremely Premature Infants. Anesthesia Analgesia 120((6)): 1337-1351, June 2015.

2010

Theroux MC, Fisher AO, Horner L, Rodriguez ME, Costarino AT, Miller TL, Thomas L, Shaffer TH: Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model. Pediatric Anesthesia 20(4): 356-364, 2010.

2008

Theroux MC, Olivant A, Lim D, Bernardi JP, Costarino AT,. Shaffer TH: Low dose methylprednisolone prophylaxis to reduce inflammation during one lung ventilation.  Ped Anesth 18(9): 857-864, 2008.

2003

Cullen J, Lawless S, Hertzog J, Penfil S, Bradford K, Nadkarni V, Corddry D, Costarino A: A model of determining a fair market value for teaching residents: Who profits?  Pediatrics  112(1): 40-48, 2003.

2002

LoSasso A, Osterboudt K, Meier F, Costarino AT, Cullen EJ: A 16 year old boy with rapidly progressing pulmonary fibrosis.  J Pediatr  140: 270-275, 2002.

2001

Schultz TR, Costarino AT, Durning SM, Napoli LA, Schears G, Godinez RI, Priestley M, Dominguez T, Lin R. Helfaer M: Airway pressure release ventilation in pediatrics.  Pediatr Crit Care Med 3: 243-246, 2001.

Schears GS, Liebig C, Frey AM, Chiavacci R, Harris K, Ford N, Mohan A, Lin RJ, Costarino AT and Helfaer MA.: Comparison of two securement techniques for peripherally inserted central venous catheters (PICCs).  Solutions Conference & Awards Presentation, Compendium of Best Clinical Practices, JCAHO  1, 2001.

Dominguez TD, Chalom R, Costarino AT. : The severity and cost of child abuse in the Pediatric Intensive Care Unit.  Journal of Intensive Care Medicine 16: 35-41, 2001.

Dominguez T, Chalom R, Costarino A: The impact of adverse patient occurrences on hospital costs.  Crit Care Med  29: 169-175, 2001.

Arens R, McDonough JM, Costarino AT, Tayag-Kier CE, Mahboubi S, Maislin G, Schwab RJ, Pack AL: Magnetic resonance imaging of the upper airway structure of children with obstructive sleep apnea syndrome. Amer J. Resp Crit Care Med August 164(4): 698-703, 2001.

1999

Chalom R, Costarino AT, Raphaely RC: Hospital costs of pediatric intensive care.  Crit Care Med 27(10): 2079-2085, 1999.

1998

Koogler T, Costarino AT: The potential benefits of the pediatric non-heart beating organ donors.  Pediatrics  101(6): 1049-1052, 1998.

1996

Orsini AJ, Leef KH, Costarino AT, Dettorre MD, Stefano JL: Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome.  J Pediatr  129: 140-145, 1996.

Hertzog J, Costarino AT: Nasal mask positive pressure ventilation in paediatric patients with type II respiratory failure.  Ped Anesth 6: 219-224, 1996.

Durbin DR, Giardino AP, Costarino, AT: Residents on the transport team: Balancing service and education.  Arch Pediatr Adol Med  1996.

1995

Sutton LN, Wang Z, Duhaime C, Costarino AT, Sauter R, Zimmerman R: Tissue lactate in pediatric head trauma: A clinical study using 1HNMR Spectroscopy.  Pediatr Neurosurg  22: 81-87, 1995.

Lavelle J, Costarino AT, Ludwig S: Recognition and management of the ill child.  Comprehensive Therapy  21: 711-718, 1995.

Dulkerian SJ, Kilpatrick L, Costarino AT, McCawley L, Fein J, Corcoran L, Zirin S, Harris MC: Cytokine elevations in infants with bacterial and aseptic meningitis. J  Pediatr 1995;  126(6):872--‐876. 126(6): 872-876, 1995.

1994

Marshall BE, Clarke WR, Costarino AT, Chen L, Miller F, Marshall C: The dose--‐ response relationship for hypoxic pulmonary vasoconstriction.  Respir Physiol  96: 231-247, 1994.

Harris MC, Costarino AT, Sullivan JS, Dulkerian S, Kilpatrick L: Cytokine elevations in critically ill infants with sepsis and necrotizing enterocolitis.  J Pediatr  124(1): 105-111, 1994.

1993

Davis S, Furman D, Costarino AT: Adult respiratory distress syndrome in children: Associated disease, clinical course, and predictors of mortality.  J Pediatr  123: 35-45, 1993.

1992

Sullivan JS, Kilpatrick L, Costarino AT, Lee SC, Harris MC: Correlation of plasma cytokine elevations with mortality rate in children with sepsis.  J Pediatr  120: 510-515, 1992.

Jardine D, Costarino AT: Negative pressure ventilation for infants with respiratory failure after cardiac surgery.  Paediatr Anaes  2: 45-50, 1992.

DiCarlo JV, Raphaely RC, Steven JM, Norwood WI, Costarino AT: Pulmonary mechanics in infants after cardiac surgery.  Crit Care Med  20: 22-27, 1992.

Costarino, AT, Gruskay JA, Corcoran L, Polin RA, Baumgart S: Sodium restriction versus daily maintenance replacement in very low birth weight premature neonates: A randomized and blinded therapeutic trial.   J Pediatr  120: 99-106, 1992.

1990

Sherbotie JR, Costarino AT, DiCarlo JV, et al: Toxic shock syndrome with staphylococcus aureus exit site infection in a patient on peritoneal dialysis.  Am J Kidney Dis XV(1): 80-83, 1990.

DiCarlo JV, Dudley TE, Sherbotie JR, Kaplan BS, Costarino AT: Continuous arteriovenous hemofiltration/dialysis (CAVH/D) improves pulmonary gas exchange in children with multiple organ system failure.  Crit Care Med 18: 822-826, 1990.

1989

Gruskay JA, Harris MC, Costarino AT, Polin RA, Baumgart S: Neonatal staphylococcus epidermidis meningitis with unremarkable CSF examination results.  Am J Dis Child 143: 580-582, 1989.

1988

Gruskay JA, Costarino AT, Polin RA, Baumgart S: Non-oliguric hyperkalemia in the premature infant weighing less than 1,000 grams.  J Pediatr 113: 381-386, 1988.

1987

Ennever JF, Costarino AT, Polin RA, Speck WT: Rapid clearance of a structural isomer of bilirubin during phototherapy.  J Clin Invest 79: 1674-1678, 1987.

Costarino AT, Davis D, Keon TP: Falsely normal saturation reading with the pulse oximeter.  Anesthesiology 67: 830-831, 1987.

1985

Curtis--Cohen M, Stahl GE, Costarino AT, Polin RA: Randomized trial of prophylactic phototherapy in the infant with very low birth weight.  J Pediatr 107: 121-124, 1985.

Costarino AT, Ennever JF, Baumgart S, Spect WT, Polin RA: The effect of spectral distribution on isomerization of bilirubin in vivo.  J Pediatr 107: 125-128, 1985.

Costarino AT, Ennever JF, Baumgart S, Paul M, Speck WT, Polin RA: Bilirubin IXa photoisomerization in premature neonates under low and high dose phototherapy. Pediatrics 75: 519-522, 1985.

Books

Costarino AT. Pediatric Anesthesiology. Anesthesiology Clinics of North America. In Brenn BR (eds.). W.B. Saunders, Philadelphia, PA. 23(4), 2005.

Chapters

2019

Levenbrown, Y. Costarino, AT: Edema. Nephrology and Fluid/Electrolyte Physiology - Neonatal Questions and Controversies. Oh, Guignard, Baumgart, Polin (eds.). Elsevier, 87 (Part C): 271-290, 2019.

2009

Slamon N, Theroux MT, Costarino AT: Neuromuscular blockade   Pediatric Critical Care Medicine Basic Science and Clinical Evidence  Wheeler DS, Wong HR, Shanley TP, eds. (eds.). Springer, New York, NY, Page: 1674-1684, 2009.

2008

Boyd CD, Costarino AT: Edema.  Polin R: Nephrology and Fluid/Electrolyte Physiology - Neonatal Questions and Controversies. Oh, Guignard, Baumgart (eds.). Elsevier, Philadelphia, PA  12: 196-207, 2008.

2006

Costarino AT, Brenn BR: Preoperative management. Pediatrics On Call  Pohl CA, Callahan CA, Gartner JC, Bradford KK (eds.). Lange Medical Books/McGraw Hill, Philadelphia, PA  Page: 567-579, 2006.

2005

Costarino AT, Downes JJ: Pediatric anesthesia historical perspective.  Anesthesiology Clin of North America   (eds.). W.B. Saunders, Philadelphia, PA, 23(4): 573-595, 2005.

Costarino AT, Deshpande JK: Pediatric anesthesiology: Thoughts on the future.  Anesthesiology Clin of North America  W. B. Saunders, Philadelphia, PA, 23(4): 861, 2005.

Boyd CD, Costarino AT : Acute respiratory distress syndrome.  Gellis and Kagan's Current Pediatric Therapy, 18th edition  Burg FD, Jingelfinger MD, Polin RA, Gershon A, eds. (eds.). W.B. Saunders, Philadelphia, PA, Page: 465-469, 2005.

2002

Schultz SE, Costarino AT: Assessment for successful extubation. Clinical Guidelines for Mechanical Ventilation; 1st Edition, Chapter 26. Handbooks in Health Care Co., Newtown, PA, Page: 346-353, 2002.

2001

Lin RJ, Costarino AT: Neonatal pain management. Fetal and Neonatal Secrets. Polin RA, Spitzer AR, eds. (eds.). Hanley-Belfus Publishing Company, Philadelphia, PA, Page: 341-348, 2001.

2000

Baumgart S, Costarino AT: Water and electrolyte metabolism of the micropremie. Clinics in Perinatology. Cowett F, ed. (eds.). W.B. Saunders, Philadelphia, PA, 27(1): 45, 2000.

1999

Lavelle JM, Costarino AT: Care of the pediatric patient.  Pediatric Otolaryngology: Principles and Practice Pathways. Wetmore R, Muntz H, McGill T, eds. (eds.). Thieme, NY, 1999.

Costarino AT, Brans YW: Fetal and neonatal body fluid composition with reference to growth and development. Fetal and Neonatal Physiology - Chapter 162, Second Edition. Polin RA, and Fox W (eds.). W.B. Saunders, Philadelphia, PA, 1999.

1998

Kasemsri T, Costarino AT: Acute respiratory distress syndrome.  Current Pediatric Therapy - Chapter 6. Burg F, Ingelfinger J, Wald E, Polin R, eds.,  (eds.). W.B. Saunders, Philadelphia, PA  Page: 557-564, 1998.

Costarino AT, Baumgart S : Neonatal water and electrolyte metabolism.  Principles of Perinatal--Neonatal Metabolism - Chapter 46, Second Edition,  Cowett R, ed. (eds.). Springer Verlag, New York, 1998.

Baumgart S, Costarino AT: Fluid and electrolyte therapeutics.  Current Pediatric Therapy - Chapter 3. Burg F, Ingelfinger J, Wald E, Polin R, eds.,  (eds.). W.B. Saunders, Philadelphia, PA, Page: 283-289, 1998.

1996

Baumgart S, Costarino AT: Fluid and electrolyte therapeutics.  Current Pediatric Therapy. Burg F, Wald E, Ingelfinger J, Polin R (eds.). W.B. Saunders, Philadelphia, PA, 1996.

1995

Lavelle J, Costarino AT: Central venous access.  Textbook of Pediatric Emergency Procedures. Henretig FM, King C (eds.). Williams & Wilkins, Philadelphia, PA, 1995.

1994

Costarino AT, Froese N: Sedation and pain relief in the ICU.   Illustrated Textbook of Pediatric Emergency and Critical Care Procedures  Dieckmann R, Fiser D, Selbst S (eds.). Mosby, Philadelphia, PA, 1994.

1992

Baumgart S, Costarino AT: Commonly encountered fluid and electrolyte problems in the preterm newborn infant.  Workbook in Practical Neonatology ,  R.A. Polin, ed. (eds.). W.B. Saunders Company, Philadelphia, PA, 1992.

1991

Costarino AT, Marshall B: Ventilation distribution and pulmonary gas exchange.  Manual of Thoracic Anesthesia. E. Cohen, ed. (eds.). Lippincott Company, Philadelphia, PA, 1991.

Costarino AT, Baumgart S: Water metabolism in the neonate.  Principles of  Perinatal and Neonatal Metabolism. R. Cowett, ed. (eds.). Springer Verlag, New York, 1991, 1991.

1988

Costarino AT, Baumgart S: Controversies in fluid and electrolyte therapy for the premature infant.  In Clinics in Perinatology  R. Kliegman ed. 15: 863, 1988 Notes: W. B. Saunders, Philadelphia, PA.

1987

Costarino AT, Polin RA : Neuromuscular relaxants in the neonate.  Clinics in Perinatology  j. Arana Ed. (eds.). W.B. Saunders, Philadelphia, PA, 14: 965-989, 1987.

Costarino AT: Review: Hatch DJ and Summer E; Neonatal anesthesia and perioperative care -second edition, vol. 5; Current topics in anesthesia. Anesth Analg 66: 287-292, 1987.

1986

Costarino AT, Baumgart S: Modern fluid and electrolyte management of the critically ill premature infant.  Pediatric Clinics of North America. R. Polin and W. Fox eds. (eds.). W.B. Saunders, Philadelphia, PA, 33: 153-178, 1986.

Posters and Presentations

2020

Naim MY, Putt M, Abend MS, Mastropietro CW, Frank DU, Costarino AT, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Nicolson SC, Roeser ME, Smith CJ, Kimmel SE: Development and Validation of a Seizure Prediction Model in Neonates Following Cardiac Surgery. Society of Thoracic Surgeon 2020 Notes 2020 Notes: Poster Presentation.

Naim MY, Massey S, Costarino AT, Fuller S, Gaynor JW, Kimmel SE, Licht DJ, Mascio CE, Nicolson SC, Putt M, Abend NS: Predictors for Seizures in Neonates Following Surgery with Cardiopulmonary Bypass. American Heart Association Scientific Sessions 2020.

Maryam Y. Naim, Shavonne Massey, Andrew T. Costarino, Stephanie Fuller, J. William Gaynor, Stephen E. Kimmel, Daniel J. Licht, Christopher E. Mascio, Susan C. Nicolson, Mary Putt and Nicholas S. Abend: Predictors for Seizures in Neonates Following Surgery with Cardiopulmonary Bypass. American Heart Association 2020.

Brown N, Chen JM, Costarino AT, Dori Y, Natarajan SS, Ravishankar C, Rome JJ, Stewart MT, Naim MY: Cardiac Intensivists, Cardiologists and Cardiac Surgeons Partner to Change the Culture of a Meeting in a Cardiac Intensive Care Unit  Cardiology 2020 Notes February 2020 Notes: Poster Presentation.

2019

Brown N., Chen JM, Costarino AT, Dori Y, Natarajan SS, Ravishankar C, Rome JJ, Stewart MT, Naim MY: Cardiac Intensivisits, Joseph A. Spinner, Shaine A. Morris, Deipanjan, Intensive Care Unit Centile conference notes. Poster Presentation. Poster Presenation October 2019.

2018

Naim Y.M., Licht D., Fuller S., Mascio C.E., Xiao R., Gaynor W., Mastropietro C.W., Smith C.J., Frank D., Costarino A.T., Massey S.L., Wilhelm M.: Risk Factors for Electroencephalographic Seizures in Neonates Following Surgery with Cardiopulmonary Bypass: A Multicenter Study. PCICS 2018 Notes: Oral Presentation at the 14th Annual International Meeting of the Pediatric Cardiac Intensive Care Society (PCICS), December 13-16, 2018.

Lectures by invitations

2019

Costarino AT. Mechanical Ventilation in the Cardiac Neonate, Cardiology 2019 - 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease, Huntington Beach, CA. Feb 2019.

Awards and Honors

2006, Anesthesia History Association, David M. Little Prize Honorable Mention for: Costarino AT Jr., Downes JJ. Pediatric anesthesia historical perspective. Anesthesiology Clinics of North America. 23(4):573-95, vii, 2005 December

Editorial and Academic Positions

Editorial positions

Reviewer

1991-present, Clinical Intensive Care: International Journal of Critical and Coronary Care Medicine
1991-present, Journal of Pediatrics
1990-present, Journal of Critical Care Medicine
1988-present, Pediatric Emergency Care

Leadership and Memberships

Memberships in Professional Organizations

International

1985-present, International Anesthesia Research Society

National

2016, Pediatric Cardiac Intensive Care Society
1997-present, Society for Pediatric Anesthesiology
1991-present American College of Chest Physicians, Fellow
1988-present, Society of Critical Care Medicine
1987-present, American Medical Association
1984-presentm, American Academy of Pediatrics, Fellow