Karl Degenhardt, MD, PhD

Karl Degenhardt, MD, PhD

Karl Degenhardt, MD, PhD, is an attending cardiologist with the Cardiac Center and Fetal Heart Program at Children's Hospital of Philadelphia.

Locations: Main Campus
Phone: 215-590-4040

Education and Training

Medical School

MD - Mount Sinai School of Medicine, New York, NY


Pediatrics - Schneider Children’s Hospital, New Hyde Park, NY


Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Cardiology

Graduate Degree

PhD - Mount Sinai School of Medicine, New York, NY

Titles and Academic Titles

Attending Cardiologist

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T. Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship or prognostic indicator? Pediatr Radiol. 2016 Apr;46(4):483-9. doi: 10.1007/s00247-015-3514-6. Epub 2015 Dec 21. Read the abstract.


Patel MR, Pandya KG, Lau-Cam CA, Singh S, Pino MA, Billack B, et al. Design and synthesis of N-substituted indazole-3-carboxamides as poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(†). Chem Biol Drug Des. 2012 Apr;79(4):488-96. doi: 10.1111/j.1747-0285.2011.01302.x. Epub 2012 Jan 30. Cited in PubMed; PMID 22177599. Read the abstract  

Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, et al. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13;22(3):639-50. Cited in PubMed; PMID 22421048. Read the abstract


Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging. 2010 May;3(3):314-22. Epub 2010 Feb 27. Cited in PubMed; PMID 20190279. Read the article

Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, et al. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15;339(2):519-27. Epub 2010 Jan 4. Cited in PubMed; PMCID: PMC2830354. Read the article


Degenhardt K, Singh MK, Massera D, Wang Q, Li J, Lu M, et al. Anomalous pulmonary venous connections result from disruption of sema3D [abstract]. Weinstein Cardiovascular Development Conference; 2011 May 5-7; Cincinnati, OH.


Degenhardt K.  Embryology of the cardiovascular system. In: Rychik J, Tian Z, editors. Fetal cardiovascular imaging: a disease based approach. Philadelphia: Elsevier; 2011. p. 10-16.