Karl Degenhardt, MD, PhD

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Karl Degenhardt, MD, PhD, is an attending cardiologist with the Cardiac Center and Fetal Heart Program at Children's Hospital of Philadelphia.

Locations: Main Hospital

Phone: 215-590-4040


Karl Degenhardt, MD, PhD, is an attending cardiologist with the Cardiac Center and Fetal Heart Program at Children's Hospital of Philadelphia.

Despite having many responsibilities, Dr. Degenhardt says that, ultimately, he has two primary jobs. “One is to make an accurate assessment of the patient’s conditions and come up with the best plan for management. The second is to be sure that the patient and family understand what I am thinking and why I am making my recommendations.”

His decision to pursue pediatric cardiology was made at the Mount Sinai School of Medicine, where he completed his MD and PhD. He explains, “I know it sounds nerdy, but for me, the relationship between the anatomy of the heart and its function in the patient’s overall cardiovascular system just had a logical appeal.”

Looking to the future, Dr. Degenhardt talked about the role patient feedback is playing in the evolution of pediatric cardiology. “The population of patients surviving with congenital heart disease is growing exponentially,” he says. “These patients are teaching us what to expect and how to help the next generation.”

Education and Training

Medical School

MD - Mount Sinai School of Medicine, New York, NY


Pediatrics - Schneider Children’s Hospital, New Hyde Park, NY


Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Cardiology

Graduate Degree

PhD - Mount Sinai School of Medicine, New York, NY

Titles and Academic Titles

Attending Cardiologist

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T. Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship or prognostic indicator? Pediatr Radiol. 2016 Apr;46(4):483-9. doi: 10.1007/s00247-015-3514-6. Epub 2015 Dec 21.


Patel MR, Pandya KG, Lau-Cam CA, Singh S, Pino MA, Billack B, et al. Design and synthesis of N-substituted indazole-3-carboxamides as poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(†). Chem Biol Drug Des. 2012 Apr;79(4):488-96. doi: 10.1111/j.1747-0285.2011.01302.x. Epub 2012 Jan 30. Cited in PubMed; PMID 22177599.

Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, et al. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13;22(3):639-50. Cited in PubMed; PMID 22421048.


Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging. 2010 May;3(3):314-22. Epub 2010 Feb 27. Cited in PubMed; PMID 20190279.

Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, et al. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15;339(2):519-27. Epub 2010 Jan 4. Cited in PubMed; PMCID: PMC2830354.


Degenhardt K, Singh MK, Massera D, Wang Q, Li J, Lu M, et al. Anomalous pulmonary venous connections result from disruption of sema3D [abstract]. Weinstein Cardiovascular Development Conference; 2011 May 5-7; Cincinnati, OH.


Degenhardt K.  Embryology of the cardiovascular system. In: Rychik J, Tian Z, editors. Fetal cardiovascular imaging: a disease based approach. Philadelphia: Elsevier; 2011. p. 10-16.