Matthew M. Demczko, MD

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Matthew M. Demczko, MD, is an attending physician and the Education Director with Mitochondrial Medicine at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Jefferson Medical College, Philadelphia, PA

Internship

Pediatrics - Sidney Kimmel Medical College/Nemours A.I. duPont Hospital For Children, Philadelphia, PA

Residency

Pediatrics - Sidney Kimmel Medical College/Nemours A.I. duPont Hospital For Children, Philadelphia, PA (Chief Resident)

Fellowship

Biochemical Genetics - Clinic for Special Children, Strasburg, PA

Board Certification

Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Education Director

Attending Physician

Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2020

Aluri J., Bach A., Kitcharoensakkul M., Putnam C.D., Shinawi M., Saucier N., Ritter M., Abraham S.M., Powell J., Jones S.M., Scurlock A.M., Schuettpelz L.G.,  Kaviany S., Paracatu L.C., Walkiewicz M.A., Harmon M.T., Keppel, M.P., Similuk, M.,   Kulm E., Joyce M., de Jesus A.A., Goldbach-Mansky R., Lee Y., Cella M., Dinauer M., Bednarski J.J., Bemrich-Stolz C., Canna S.W., Demczko M.M., De Ravin S.S., Bleesing J.J., Connelly J.A.,  Rao K., Cooper M.A. Mosaic and Germline Gain-of-function Variants in TLR8 Lead to Primary Immunodeficiency with Lymphoproliferation and Bone Marrow Failure. Blood. Accepted Dec. 2020.

Kavey, R.E.W., Manlhiot, C., Runeckles, K., Collins, T., Gidding, S.S., Demczko, M.M., Clauss, S., Harahsheh, A.S., Mietus-Syder, M., Khoury, M., Madsen, N., McCrindle, B.W. Effectiveness and Safety of Statin Therapy in Children: A Real-World Clinical Practice Experience. CJC Open. (2020).

2019

Demczko, M.M. Inherited Disorders of Metabolism. Merck Manuals, Professional and Consumer Editions. 20th ed. 2019.

Williams K.B., Brigatti K.W., Puffenberger E.G., Gonzaga-Jauregui C., Griffin L.B.,  Martinez E.D., Wenger O.K., Mark Yoder M., Kandula V.,  Fox M.D., Demczko M.M., Poskitt L., Furuya K.N., Reid J.G., Overton J.D., Baras A., Miles L., Radhakrishnan K., Carson V.J., Antonellis A., Jinks R.N., Strauss K.A. Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease. Human Molecular Genetics. 28(4):525-38. 2019.

2013

Mackenzie W.G., Dhawale A.A., Demczko M.M., Ditro C., Rogers K.J., Bober M.B., Campbell J.W., Grissom L.E. Flexion-Extension Cervical Spine MRI in Children with Skeletal Dysplasia: Is It Safe and Effective? J Pediatr Orthop. 33(1): 91-8. 2013.

2009

Kelly E., Demczko M.M., Moore C.S. The Effect of Gene Dosage Imbalance and NFATc1 Localization on Endocardial Cushion Development in the Ts65Dn Mouse Model for Down Syndrome. Develop Biol. 331(2):489. 2009.

Posters and Presentations

2020

Demczko, M.M., Livingston, F. COVID-19 in Children with Asthma, Medical Complexity. Presented at Nemours Monthly Lecture Series, August 19, 2020 (Virtual).

Demczko M.M. Bringing Precision Medicine to Lower Delaware: Use of a Novel Next Generation Sequencing Panel in an Isolated Amish Founder Population. Presented at the 7th Annual DE-CTR ACCEL Annual Advisory Meeting, February 24, 2020, Charleston, SC.

2019

Khair A., Kaur G.,Ganganna S., Jain B., Salvucci A., Pazzuto T., Obeid R., Polavarapu A., Elia J., Cellucci M., Demczko M.M., Falchek S. Refractory Pediatric Catatonia in Children with Anti NMDAR Autoimmune Encephalitis. Presented at the 13th Annual Pediatric Neurology Society Congress, September 17, 2019, Athens, Greece.

Demczko M.M. Preemptive Genomics: Characterizing and Mitigating Genetic Risk Through Next Generation Sequencing in the Dover Plain Community. Presented at the ACCEL Innovative Discoveries Series, May 17, 2019, Newark, DE.

Demczko M.M. Bringing Precision Medicine to Lower Delaware: A Modern Medical Home for the Amish Children of Dover. Presented at the Annual Wilmington New Castle Pediatric Association Spring Dinner Meeting, May 1, 2019, New Castle, DE.

Demczko M.M., Bowser L., Lee S., Crowgey E. Characterizing Genetic Risk Through Next Generation Sequencing in the Dover Amish Community. Presented at the 6th Annual DE-CTR ACCEL Meeting, March 18, 2019, Newark, DE.

Crowgey E., Demczko M.M. Translational Medicine and the Use of Next Generation Sequencing Panels. Presented at the Nemours Research in Progress Series, February 14, 2019, Wilmington, DE.

Demczko M.M., Brescia, A.M., Leffler, M. Takayasu Artertis: The Varied Presentations of the Large Vessel Vasculitis. Presented at Nemours/A.I. duPont Hospital for Children Pediatric Grand Rounds, January 16, 2019, Wilmington, DE.

Awards and Honors

2021, Sidney Kimmel Medical College Dean’s Award for Excellence in Education
2019, DE-CTR ACCEL Best Poster Award
2018, Faculty Educator of the Month, Nemours/A.I. Dupont Hospital for Children
2015, Recipient of the Bambi Taylor, M.D. Pediatric Emergency Medicine Award, Nemours/A.I. Dupont Hospital for Children
2015, Recipient of the Pediatric Critical Care Award, Nemours/A.I. Dupont Hospital for Children
2014, Medelita National “Honoring Excellent Resident Observations” Award Nominee, Nemours/A.I. Dupont Hospital for Children
2014, Member, Alpha Omega Alpha Medical Honor Society, Nemours/A.I. Dupont Hospital for Children
2013, Arnold P. Gold Foundation Humanism and Excellence in Teaching Award, Nemours/A.I. Dupont Hospital for Children
2012, Recipient of the Dean Marie Banes Memorial Prize in Pediatrics, Jefferson Medical College
2011, George McClellan Surgical Honor Society, Jefferson Medical College
2011, Gold Humanism Honor Society, Jefferson Medical College
2008, Magna Cum Laude, Franklin & Marhsall College
2008, Phi Beta Kappa Honor Society, Franklin and Marshall College
2008, Biology Senior Award, Franklin & Marhsall College
2008, Sigma Xi Scientific Research Society Prize in Biology, Franklin & Marhsall College
2008, Charles D. Spotts Award in Religious Studies, Franklin & Marhsall College
2008, Morgan D. Person and Frederick C. Schiffman Prizes in Health Professions Studies, Franklin & Marhsall College
2008, Theodore E. Woodward, M.D. Healing Arts Prize, Franklin & Marhsall College
2007, Black Pyramid Senior Honor Society, Franklin & Marhsall College
2007, Isaac E. Roberts Prize in Biology, Franklin & Marhsall College
2007, Bradford S. Kline Memorial Prize for Pre-Medical Biology Student, Franklin & Marhsall College
2006, Benjamin Rush Honor Society of Healing Arts Professionals, Franklin & Marhsall College
2004-2008, John Marshall Scholar, Franklin & Marhsall College

Leadership and Memberships

Memberships in Professional Organizations

2013-present, Alpha Omega Alpha
2012-present, American Academy of Pediatrics
2011-present, Arnold P. Gold Humanism Honor Society
2008-present, Phi Beta Kappa
2008-present, Sigma Xi