John Flibotte, MD

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John Flibotte, MD, is an attending neonatologist in the Division of Neonatology, Co-medical Director of the Neonatal Neurocritical Care Program and Associate Program Director for the Neonatal-Perinatal Fellowship Program at Children's Hospital of Philadelphia.

Areas of Expertise: Infant brain injury, Neonatal neurocritical care, Neuroimaging
Locations: CHOP Newborn Care at the Hospital of the University of Pennsylvania; Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Background

Dr. John Flibotte is co-medical director of the Neonatal Neurocritical Care Program in the Neonatal/ Infant Intensive Care unit. He has a longstanding interest in the neurosciences and has been engaged in both basic science research and clinical research in the areas of neurodevelopment and hypoxic brain injury. Most recently, he has served as the local PI for clinical trials evaluating neuroprotective therapies for infants at risk for brain injury and is involved with research efforts focused on patients with hypoxic ischemic encephalopathy and hydrocephalus.

His clinical work is in the N/IICU at Children's Hospital of Philadelphia (CHOP) and includes care of infants with both medical and surgical conditions. He has strong clinical collaborations with members of the Neurology, Neurosurgery and Radiology Departments. He is involved in the Special Delivery Unit for both prenatal consults and supervision of resuscitation of infants with high risk conditions.

Dr. Flibotte is also the Associate Program Director of the Neonatal Fellowship. In addition to fellow education, he is actively engaged in the education of trainees at all levels, including nursing students, medical students, and residents. He has won numerous awards for teaching and mentoring including: Early Career Honor Roll for teaching of pediatric residents, Istvan Seri Teaching Award for teaching neonatology fellows, and the Schmidt-Kirpalani Mentoring Award for mentoring of neonatology fellows and junior faculty.

Dr. Flibotte graduated from Harvard College and Harvard Medical School and completed his residency and fellowship training at CHOP.

Education and Training

Medical School

MD - Harvard Medical School, Boston, MA

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Neonatology - The Children's Hospital of Philadelphia, Philadelphia, PA

Additional Training

Neonatology Research Fellow - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Co-Medical Director, Neonatal Neurocritical Care Program

Attending Neonatologist

Associate Program Director, Neonatal-Perinatal Fellowship Program

Associate Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Hypoxic ischemic encephalopathy
Neonatal hydrocephalus
Neonatal neurology
Communication/patient perspective

Publications

Papers

2021

Guttmann K, Flibotte J, Seitz H, Huber M, andDeMauro SB: Goals of Care Discussions and Moral Distress AmongNeonatal Intensive Care Unit Staff. J Pain Symptom Manage January 2021 Notes: [published online ahead of print]

Pouppirt NR, Martin V, Pagnotto-Hammitt L, Spittle AJ, Flibotte J, DeMauro S: The general movements assessment in neonates with hypoxic ischemic encephalopathy. Journal of Child Neurology January 2021 Notes: [published online ahead of print]

Weiss EM, Olszewski AE, Guttmann KF, Magnus BE, Li S, Shah AN, Juul SE, Wu YW, Ahmad KA, Bendel-Stenzel E, Isaza NA, Lampland AL, Mathur AM, Rao R, Riley D, Russell DG, Salih ZNI, Torr CB, Weitkamp JH, Anani UE, Chang T, Dudley J, Flibotte J, Havrilla EM, Kathen CM, O'Kane AC, Perez K, Stanley BJ, Wilfond BS, Shah SK.: Parental Factors Associated with the Decision to Participate in a Neonatal Clinical Trial. JAMA Network Open 4(1): e2032106, January 2021.

Eric S. Peeples, Rakesh Rao, Maria L.V. Dizon, Yvette R. Johnson, Priscilla Joe, John Flibotte, Tanzeema Hossain, Danielle Smith, Shannon Hamrick, Robert DiGeronimo, Girija Natarajan, Kyong-Soon Lee, Toby D. Yanowitz, Ulrike Mietzsch, Tai-Wei Wu, Nathalie L. Maitre, Eugenia K. Pallotto, Mark Speziale, Amit M. Mathur, Isabella Zaniletti, An Massaro, on behalf of the Children's Hospitals Neonatal Consortium Hypoxic-Ischemic Encephalopathy Focus Group: Predictive models of neurodevelopmental outcomes after neonatal hypoxic-ischemic encephalopathy. Pediatrics February 2021.

Kirschen MP, Smith KA, Snyder M, Zhang B, Flibotte J, Heimall L, Budzynski K, DeLeo R, Cona J,Bocage C, Hur L, Winters M, Hanna R, Mensinger JL, Huh J, Lang S, Barg FK, Shea JA, Ichord R, Berg RA, Levine JM, Nadkarni V, Topjian A: Serial Neurologic Assessment in Pediatrics (SNAP): A new tool for bedside neurological assessment of critically ill children. Pediatric Critical Care Medicine 22(5), May 2021.

Flanders TM, Lang SS, Ko TS, Andersen KN, Jahnavi J, Flibotte JJ, Licht DJ, Tasian GE, Sotardi ST, Yodh AG, Lynch JM, Kennedy BC, Storm PB, White, BR, Heur GG, Baker WB: Optical detection of intracranial pressure and perfusion changes in neonates with hydrocephalus. Journal of Pediatrics 2021 Notes: [in press]

2020

Guttmann K, Flibotte J, DeMauro SB, Seitz H: A mixed methods analysis of parental perspectives on diagnosis and prognosis of neonatal intensive care unit graduates with cerebral palsy. Journal of Child Neurology 35(5): 336-43, April 2020.

DeMauro SB, Bann C, Flibotte J, Adams-Chapman I, Hintz SR: Cranial Ultrasound and Minor Motor Abnormalities at 2 Years in Extremely LowGestational Age Infants. J Dev Behav Pediatr 41(4): 308-315, May 2020.

Flanders TM, Kimmel AC, Lang SS, Bellah R, Chuo J, Wellons JC, Flibotte JJ, Heuer GG.: Standardizing treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution with a multidisciplinary team. Childs Nerv Syst. 36(8): 1737-1744, August 2020.

Rao R, Mietzsch U, DiGeronimo R, Hamrick SE, Dizon MLV, Lee KS, Natarajan G, Yanowitz TD, Peeples ES, Flibotte J, Wu T, Zaniletti I, Mathur AM, Massaro AN : Utilization of Therapeutic Hypothermia and Neurological Injury in Neonates with Mild Hypoxic-Ischemic Encephalopathy: A Report from Children's Hospital Neonatal Consortium. American Journal of Perinatology  September 2020 Notes: [published online ahead of print]

Thom CS, Echevarria E, Osborne AD, Carr L, Rubey K, Salazar E, Callaway D, Pawlowski T, Devine M, Kleinman S, Witmer C, Flibotte J, Lambert MP.: Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients. J Thromb Haemost Page: Epub ahead of print, September 2020.

Zheng Q, Martin-Saavedra JS, Saade-Lemus S, Vossough A, Zuccoli G, Gonçalves FG, Freeman CW, Ouyang M, Singh V, Padula MA, Demauro SB, Flibotte J, Eichenwald EE, Detre JA, Sze RW, Huang H, Hwang M: Cerebral Pulsed Arterial Spin Labeling Perfusion Weighted Imaging Predicts Language and Motor Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy. Frontiers in Pediatrics 8, September 2020.

2019

Dizon M, Rakesh R, Hamrick S, Zaniletti I, DiGeronimo R, Natarajan G, Kaiser JR, Flibotte J, Lee KS, Smith D, Yanowitz T, Mathur A, Massaro A: Practice Variation in Anti-Epileptic Drug Use for Neonatal Hypoxic-Ischemic Encephalopathy Among Regional NICUs. BMC Pediatrics 19(1): 67, February 2019.

Natarajan G, Mathur A, Zaniletti I, DiGeronimo R, Lee KS, Rao R, Dizon M, Hamrick S, Rudine A, Cook N, Smith D, Flibotte J, Murthy K, Massaro A: Withdrawal of Life-Support in Neonatal Hypoxic-Ischemic Encephalopathy. Pediatric neurology 91(1): 20-26, Feb 2019.

Hwang M, Sridharan A, Darge K, Riggs B, Sehgal C, Flibotte J, Huisman T: Novel Quantitative Contrast-Enhanced Ultrasound Detection of Hypoxic Ischemic Injury in Neonates and Infants: Pilot Study 1. Journal of Ultrasound in Medicine 38(8): 2025-2038, August 2019.

2018

Lin N, Flibotte J, Licht DJ. : Neuromonitoring in the neonatal ECMO patient.  Semin Perinatol Page: pii: S0146-0005(17)30144-1, February 2018.

Guttmann K, Flibotte J, DeMauro SB: Parental Perspectives on Diagnosis and Prognosis of Neonatal Intensive Care Unit Graduates with Cerebral Palsy. The Journal of Pediatrics 203: 156-162, Dec 2018.

2014

Flibotte John J, Jablonski Angela M, Kalb Robert G: Oxygen sensing neurons and neuropeptides regulate survival after anoxia in developing C. elegans. PloS one 9(6): e101102, June 2014.

2004

Flibotte JJ, Lee KE, Koroshetz WJ, Rosand J, McDonald CT: Continuous antibiotic prophylaxis and cerebral spinal fluid infection in patients with intracranial pressure monitors. Neurocrit Care 1(1): 61-68, March 2004.

Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J: Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 63(6): 1059-1064, Sep 2004.

Abstracts

2019

Baker WB, Flanders TM, Balu R, He L, Heye K, Gabrielli EM, Flibotte JJ, Licht DJ, Heuer GG, Yodh AG, Kofke WA: Non-invasive optical assessment of intracranial pressure: pilot results in human patients. Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740F July  2019.

Books

Chapters

2019

Parga-Belinkie J, Foglia EF, Flibotte J: Caveats of Cooling: Available Evidence and Ongoing Investigations of Therapeutic Hypothermia. Neoreviews 20(9): 513e-519e, September 2019.

Sheppard S, Herrick H, Ahrens-Nicklas R, Cohen J, Flibotte J, Pyle L: Case 2: Severe Hyperammonemia in a Neonate:  An Alternate Ending. Neoreviews 20(2): e90-e92, February 2019.

Coughlin K, Flibotte J, Cahill AM, Osterhoudt K, Hedrick H, Vrecenak J: Methemoglobinemia in an Infant After Sclerotherapy With High-Dose Doxycycline. Pediatrics 143(2): e20181642, February 2019.

2018

Flanders T, Billinghurst L, Flibotte J, Heuer G: Neonatal Hydrocephalus. Neoreviews 19(8), August 2018.

2017

Flibotte J & Gokulakrishnan G: Chapter 46: Examination of the Newborn Infant. Rudolph's Pediatrics, 23rd Edition  2017.

Robinson A, Flibotte J, Kaplan SL, DeMauro SB: Lenticulostriate Vasculopathy and Neurodevelopmental Outcomes in Preterm Infants: A Systematic Review. American Journal of Perinatology  34(8): 780-786, July 2017.

Handley SC, Ebbert RP, Edwards TM, Flibotte J: A Newborn Infant with Giant Omphalocele and Peeling Skin. NeoReviews 18(4): e253-e257, April 2017.

2013

Flibotte JJ, Lee GE, Buser GL, Feja KN, Kreiswirth BN, McSherry GD, Nolan SM, Tolan RW Jr, Zhang H: Infertility, in vitro fertilization and congenital tuberculosis J. Perinatol 33(7): 565-568, July 2013.

Flibotte J: Disorders of the Gastrointestinal System. Netter's Pediatrics. Florin T, Ludwig S (eds.). Oxford: Elsevier, Page: 652-657, 2011 Notes: Chapter 103.

Posters and Presentations

2021

Natarajan G, Hamrick SE, Zaniletti I, DiGeronimo R, Dizon ML, Flibotte J, Lee K, Mietzsch U, Murthy K, Peeples ES, Joe P, Smith DL, Wu T, Yanowitz TD, Massaro AN, Rao R_: Opioid Exposure and Short-term Outcomes in Hypoxic Ischemic Encephalopathy: Is there an association? Pediatric Academic Societies, Virtual Meeting May 2021 Notes: [poster presentation by collaborator]

2020

Callahan KP, Hoffman C, Martin A, Flibotte J: Communicating Neurologic Information to Shocked Parents in the Neonatal Intensive Care Unit. [Poster Presentation], Eastern Society of Pediatric Research 32nd Annual Scientific Meeting, Philadelphia, PA March 2020 Notes: Due to Covid-19 related conference cancellation, this peer-reviewed abstract was disseminated on 1/April2020 to ESPR 2020 Meeting Program Guide.

Callahan KP, Hoffman C, Martin A, Flibotte J: Communicating Neurologic Information to Shocked Parents in the Neonatal Intensive Care Unit. [Poster Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Due to COVID-19 related conference cancellation, this peer-reviewed abstract was disseminated in PAS 2020 Meeting Program Guide.

Carr L, Devine M, Flibotte J, Nawab U, Shelov E, Padula M: Leveraging the EHR for Quality Improvement: Use of Novel CDS. [Poster Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Due to COVID-19 related conference cancellation, this peer-reviewed abstract was disseminated in PAS 2020 Meeting Program Guide.

Carr L, Padula M, O'Connor T, Flibotte J, Cunningham M, Chuo J, Thomas B, Nawab U: Improving Utilization of a NICU Rounding Checklist through Low- and High-technology Tests of Change. [Platform Presentation], 10th Annual Academic Pediatric Association Conference, Philadelphia, PA May  2020 Notes: Oral presentation given by collaborator. Due to COVID-19 related conference cancellation, this peer-reviewed abstract and presentation was disseminated in Meeting Program Guide.

Carr L, Padula M, O'Connor T, Flibotte J, Cunningham M, Chuo J, Thomas B, Nawab U: Improving Utilization of a NICU Rounding Checklist through Low- and High-technology Tests of Change. [Platform Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Oral presentation by collaborator. Due to COVID-19 related conference cancellation, this peer-reviewed abstract and presentation was disseminated in PAS 2020 Meeting Program Guide.

Cotten CM, Fisher KA, Malcolm W, Gustafson K, Kurtzberg J, Bates SV, El-Dib M, Flibotte J, Salas AA, Shankaran S, Weiss MD, Das A: Phase II Clinical Trial of Autologous Cord Blood Cells for Neonates with Hypoxic-Ischemic Encephalopathy. [Platform Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Oral presentation by collaborator. Due to COVID-19 related conference cancellation, this peer-reviewed abstract and presentation was disseminated in PAS 2020 Meeting Program Guide.

Goodman A, Redline R, Comstock B, Juul S, Chang T, Mayock D, Chalak L, Lampland A, Riley D, Mathur A, Rao R, Maitre N, Van Meurs K, Gonzalez F, Flibotte J, Yanowitz T, Mietzsch U, Sokol G, Wu T, Ahmad K, Weitkamp H, Baserga M, Poindexter B, Wu Y: Placental abnormalities in a large cohort of neonatal hypoxic-ischemic encephalopathy (HIE). [Poster Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Due to COVID-19 related conference cancellation, this peer-reviewed abstract was disseminated in PAS 2020 Meeting Program Guide.

Weiss EM, Guttmann K, Olszewski A, Magnus B, Li S, Shah AN, Juul SE, Ahmad KA, Bendel-Stenzel E, Isaza NA, Lampland A, Mathur A, Rao R, Riley D, Russell D, Salih Z, Torr C, Weitkamp JH, Wu Y, Anani UE, Chang T, Dudley J, Flibotte J, Havrilla EM, O'Kane AC, Perez K, Stanley BJ, Shah SK, Wilfond BS: Influence of the Engagement between Research Team Members and Parents on the Decision to Enroll in a Neonatal Clinical Trial. [Poster Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Due to COVID-19 related conference cancellation, this peer-reviewed abstract was disseminated in PAS 2020 Meeting Program Guide.

Weiss EM, Olszewski A, Guttmann K, Magnus B, Li S, Shah AN, Juul SE, Ahmad KA, Bendel-Stenzel E, Isaza NA, Lampland A, Mathur A, Rao R, Riley D, Russell D, Salih Z, Torr C, Weitkamp JH, Wu Y, Anani UE, Chang T, Dudley J, Flibotte J, Havrilla EM, Kathen CM, O'Kane AC, Perez K, Stanley BJ, Wilfond BS, Shah SK: Influence of Parental Factors and Perception of Illness on the Decision to Enroll in a Neonatal Clinical Trial. [Platform Presentation], Pediatric Academic Societies Annual Meeting, Philadelphia, PA May 2020 Notes: Oral presentation given by collaborator. Due to COVID-19 related conference cancellation, this peer-reviewed abstract and presentation was disseminated in PAS 2020 Meeting Program Guide.

Weiss EM, Olszewski A, Guttmann K, Magnus B, Li S, Shah AN, Juul SE, Ahmad KA, Bendel-Stenzel E, Isaza NA, Lampland A, Mathur A, Rao R, Riley D, Russell D, Salih Z, Torr C, Weitkamp JH, Wu Y, Anani UE, Chang T, Dudley J, Flibotte J, Havrilla EM, Kathen CM, O'Kane AC, Perez K, Stanley BJ, Wilfond BS, Shah SK.: Influence of Parental Factors and Perception of Illness on the Decision to Enroll in a Neonatal Clinical Trial. [Platform presentation], University of Washington Center for Clinical and Translational Research Science Day, Seattle, WA May 2020 Notes: Virtual oral presentation by collaborator.

2019

Carr L, Padula M, O'Connor T, Flibotte J, Cunningham M, Chuo J, Thomas B, Nawab U: Compliance with Initiating a NICU Checklist Markedly Improved Following a Human Factors-Based, Low-Technology Test of Change. [Poster Presentation], Vermont Oxford Network, Annual Quality Congress, Chicago, IL  October 2019.

Flanders TM, Baker WB, Flibotte JJ, Licht DJ, Linna KA, Tasian GE,  Su YS, Kennedy BC, Storm PB, Lang S, Heuer GG: Changes in intracranial pressure in neonatal hydrocephalus as measured by diffuse correlation spectroscopy. [Poster Presentation], International Society for Pediatric Neurosurgery 47th Annual Meeting; Birmingham, UK October 2019.

Flanders TM, Kimmel AC, Lang S, Bellah RD, Chuo J, Wellons JC, Flibotte JJ, Heuer GG: Standardized treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution. [Poster Presentation], International Society for Pediatric Neurosurgery, 47th Annual Meeting, Birmingham, UK  October 2019.

Flanders TM, Kimmel AC, Lang S, Bellah RD, Chuo J, Wellons JC, Flibotte JJ, Heuer GG: Standardized treatment of preterm infants with post-hemorrhagic hydrocephalus at a single institution. [Poster Presentation], International Society for Pediatric Neurosurgery 47th Annual Meeting, Birmingham, UK     October 2019.

Guttmann K, DeMauro S, Flibotte J, Seitz H: A content analysis of parental perspectives on diagnosis and prognosis of NICU graduates with cerebral palsy. [Podium Presentation], Pediatric Academic Society Annual Meeting, Baltimore, MD April 2019 Notes: Oral presentation given by collaborator.

Rao R, Hamrick S, DiGeronimo R, Dizon M, Lee KS, Natarajan G, Yanowitz T, Peeples E, Flibotte J, Smith D, Mietzsch U, Wu TW, Zaniletti I, Mathur A, Massaro A: Antecedents of Neurological Injury in nNeonates with Mild Hypoxic-Ischemic Encephalopathy (mHIE). [Poster Presentation], Pediatric Academic Society Annual Meeting, Baltimore, MD April 2019.

Zheng Q, Ouyang M, Martin-Saavedra JS, Saade-Lemus S, Yu Q, Wang Sze R, Flibotte J, Detre J, Huang H, Hwang M: Altered brain perfusion in neonatal hypoxic ischemic injury with negative reading of DWI, T1/T2-weighted images: Implications of perfusion MRI for reperfusion response monitoring and prognostication. [Poster Presentation], International Society for Magnetic Resonance in Medicine 27th Annual Meeting and Exhibition, Montreal, Canada May 2019.

2018

Coughlin K, Flibotte J, Cahill AM, Hedrick H, Osterhoudt K, Vrecenak J: Methemoglobinemia in a Neonate. [Poster Presentation], Eastern Society for Pediatric Research Annual Meeting, Case Competition, Philadelphia, PA March 2018.

Coughlin K, Flibotte J, O'Connor T, Harris, C, Kreger J, Nawab U: Identifying Waste in the NICU MRI Process. [Poster Presentation], Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA March 2018.

Hwang,M, Sridharan,A, Darge,K, Riggs,B, Sehgal,C, Flibotte,J, Huisman,T: Novel Quantitative Contrast-Enhanced Ultrasound Detection of Hypoxic Ischemic Injury in Neonates and Infants: Pilot Study I. [Poster Presentation], Radiological Society of North America 2018 Scientific Assembly and Annual Meeting, Chicago, IL April 2018.

Editorial and Academic Positions

Academic and institutional committees

Resident Lecture Committee
Neonatology-Perinatology Fellowship Improvement Committee
Improving Rates of Developmental Follow-Up for Preterm Infants, Quality Improvement Committee
Member, Neonatal Fellowship Clinical Competency Committee
Neonatology Divisional Quality Improvement Committee on Central Line Associated Blood Stream Infections (CLABSI)
Neonatology Fellowship Selection Committee
Neonatology MRI Safety Committee
Management of Post-Hemorrhagic Hydrocephalus, Quality Improvement Committee
Sedation Committee
Minimizing Sedation for Neonatal Brain MRI Acquisition
Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Data Safety Monitoring Board, Fluid Filled Lung Oxygenation Trial for Severe Bronchopulmonary Dysplasia
Data Safety Monitoring Board, Janus Kinase inhibitor (Baricitinib) for Aicardi Goutières Syndrome
Physician Partner, Neonatal Intensive Care Unit
Neonatology Scholarship Oversight Committee for Fellows' Research

Editorial Positions

Ad hoc reviewer, Bentham Science Publishing
Ad hoc reviewer, Pediatric Emergency Care
Ad hoc reviewer, Journal of Perinatal Medicine
Ad hoc reviewer, Journal of Pediatrics
Ad hoc reviewer, Pediatric Neurology
Ad hoc reviewer, Scientific Reports
Ad hoc reviewer, Archives of Disease in Childhood: Fetal & Neonatal