David F. Friedman, MD

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David F. Friedman, MD, is associate medical director of the Transfusion Service and Apheresis Program, and medical director of the Phlebotomy Service at The Children's Hospital of Philadelphia.

Areas of Expertise: Apheresis, Blood banking, Pediatric hematology, Transfusion medicine
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Clinical interests

Blood banking and transfusion medicine
Pediatric therapeutic apheresis
Pediatric hematology
Biomedical informatics

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA


Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA


Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA
Bloodbanking and Transfusion Medicine - Hospital of the University of Pennsylvania, Philadelphia, PA
Senior Fellow, Divisions of Hematology and Pathology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Undergraduate Degree

BA in Physics - Yale University, New Haven, CT

Titles and Academic Titles

Medical Director, Phlebotomy Service

Associate Medical Director, Apheresis Program

Associate Medical Director, Transfusion Service

Departments and Services




Fieldston ES, Fakeye OA, Friedman DF.   Repeat Laboratory Testing in the Pediatric Emergency Department: How Often and How Important?   Pediatr Emerg Care. 2019 Mar;35(3):190-193. PMID: 30211834

Wang KY, Friedman DF, DaVeiga SP.   Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis.   Transfusion. 2019 Feb 13.   PMID: 30758852


Chou,  Stella T. , Evans,  Perry, Vege,  Sunitha , Coleman Sarita L. , Friedman, David F. , Keller,  Margaret  and Westhoff, Connie M.  RH genotype matching for transfusion support in sickle cell disease.   Blood 2018 132:1198-1207; doi: https://doi.org/10.1182/blood-2018-05-851360 PMID: 30026182

Zubrow ME, Thomas NJ, Friedman DF, Yehya N.    RBC Transfusions Are Associated With Prolonged Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2018 Feb;19(2):e88-e96.    PMID: 29194281

Leibowitz M, Wolfe H, Flynn A, Waanders A, Burlingame C, Aumaier B, Friedman D, Lambert MP.   Standardization of prophylactic platelet transfusion dosing in a pediatric oncology population: a quality improvement project.   Transfusion. 2018 Dec;58(12):2836-2840.    PMID: 30264395


Prince SD, Winestone LE, Nance SJ, Friedman DF.  Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report.   Transfusion. 2017 Jun;57(6):1401-1406. Epub 2017 Mar 31.    Includes cover photograph.   PMID:  28369934


Cohen D, Hartung H, Evans P, Friedman DF, Chou ST. Red blood cell alloimmunization in transfused patients with bone marrow failure syndromes. Transfusion. 2016 Jun;56(6):1314-9. PMID:27080340

Stanley HM, Friedman DF, Webb J, Kwiatkowski JL. Transfusional Iron Overload in a Cohort of Children with Sickle Cell Disease: Impact of Magnetic Resonance Imaging, Transfusion Method, and Chelation.   Pediatr Blood Cancer. 2016 Aug;63(8):1414-8.   PMID: 27100139


Casas J, Friedman DF, Jackson T, Vege S, Westhoff CM, Chou ST.    Changing practice: red blood cell typing by molecular methods for patients with sickle cell disease.   Transfusion. 2015 Jun;55(6 Pt 2):1388-93. Epub 2015 Jan 9    PMID:  25573464

Lancaster D, Friedman DF, Chiotos K, and Sullivan KV.   Blood Volume Required for Detection of Low-Levels and Ultra Low-Levels of Organisms Responsible for Neonatal Bacteremia Using BACTEC Peds Plus/F, Plus Aerobic/F Media, and the BD BACTEC FX System: an In Vitro Study.   Journal of Clinical Microbiology  53(11) 3609-13, 2015.   PMID 26292299

Jobes DR, Sesok-Pizzini D, Friedman DF.  Reduced transfusion requirement with use of fresh whole blood in pediatric cardiac surgical procedures .  Ann Thorac Surg 99(5):1706-11,  2015.  PMID 25818574.


Gálvez JA, Ahumada L, Simpao AF, Lin EE, Bonafide CP, Choudhry D, England WR, Jawad AF, Friedman D, Sesok-Pizzini DA, Rehman MA.   Visual analytical tool for evaluation of 10-year perioperative transfusion practice at a children's hospital.   J Am Med Inform Assoc. 2014 May-Jun;21(3):529-34.   PMID: 24363319

Tina S. Ipe, MD,* Jennifer J. Wilkes, MD, Helge D. Hartung, MD, Connie M. Westhoff, PhD, Stella T. Chou, MD, David F. Friedman, MD Severe Hemolytic Transfusion Reaction Due to Anti-D in a D + Patient With Sickle Cell Disease   J Pediatr Hematol Oncol   2014   PMID: 25171447


Chou ST, Jackson T, Vege S, Smith-Whitley K, Friedman DF, Westhoff CM. High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors   Blood. 2013 Aug 8;122(6):1062-71.  PMID: 23723452

Sullivan KV, Turner NN, Lancaster DP, Shah AR, Chandler LJ, Friedman DF, Blecker-Shelly DL. Superior sensitivity and decreased time to detection with the Bactec Peds Plus/F system compared to the BacT/Alert Pediatric FAN blood culture system   J Clin Microbiol. 2013 Dec;51(12):4083-6.   PMID: 24088854


Weiss, PF, Klink, AJ, Friedman, DF, Feudtner, C,  Pediatric therapeutic plasma exchange indications and patterns of use in us children's hospitals,  Journal of Clinical Apheresis Volume 27, Issue 6, pages 287–294, 2012.  PMID: 22811262

Chou ST, Friedman DF.   Transfusion practices for patients with sickle cell disease at the Children's Hospital of Philadelphia.    Immunohematology. 2012;28(1):27-30. PMID: 22646148


Stricker, P.A.,  Shaw, T. L.,, Desouza, D.G., Hernandez, S.A.,  Bartlett, S.P., Friedman DF, Sesok-Pizzini, DA,  Jobes, D.R. Blood Loss, Replacement, and Associated Morbidity in Infants and Children Undergoing Craniofacial Surgery, Pediatric Anesthesia 20: 150 – 159.  2010  PMID: 20078812


Sesok-Pizzini DA, Friedman DF. Neonatal and infant platelet transfusions. Immunohematology 24:1 15-19, 2008.


Shelat SG, Friedman DF, Meny GM, Smith-Whitley K, Carlow D, Norris, R. False-positive pregnancy test after passive transfusion of B-human chorionic gonadotropin from donor red blood cells during erythrocytapheresis. Transfusion. 47:788-91 2007.


Borgna-Pignatti C, Ventola M, Friedman DF, Cohen AR, Origa R, Galanello R, Lindeman R, Francis S, Reverberi R, Volpato S. Seasonal Variation of Pre-transfusion Hemoglobin Levels in Patients with Thalassemia Major. Blood 107:355-357, 2006.

Sesok-Pizzini DA, Friedman DF, Smith-Whitley K, Nance, SJ. Transfusion support of patients with Sickle Cell Disease at the Children's Hospital of Philadelphia. Immunohematology 22:3 121-125, 2006.


Elia J, Dell ML, Friedman DF, Zimmerman RA, Balamuth N, Ahmed A, Pati S. PANDAS with Catatonia: Response to lorazepam and plasmapheresis. Journal of the American Academy of Child and Adolescent Psychiatry 44:11 p. 1145-1150.