Therese M. Giglia, MD, FAHA, is an attending cardiologist, Director of the Center on Cardiac Anticoagulation and Thrombosis and Director of the Infant Single Ventricle Monitoring Program at Children's Hospital of Philadelphia.
Dr. Giglia is Professor of Clinical Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and Senior Attending in Cardiology at the Children’s Hospital of Philadelphia. She is Director of CHOP’s Center on Cardiac Anticoagulation and Thrombosis, established in 2013 as a joint initiative of the Divisions of Cardiology, Hematology and Department of Nursing as one of the country’s first multidisciplinary inpatient and outpatient consultative program dedicated to the prevention, assessment and management of thrombosis in children with congenital and acquired heart disease. She is Director of the Infant Single Ventricle Monitoring Program overseeing the outpatient management of frail infants between the neonatal and second operations in staged palliation. In addition, Dr. Giglia attends frequently in the Cardiac Care Unit, the Pulmonary Hypertension Program and sees general cardiology outpatients.
Dr. Giglia’s clinical and research interests include prevention, diagnosis, treatment of thrombosis in children with heart disease and the care of critically ill infants and children with cardiovascular disease especially those with single ventricle physiology. Her research has culminated in scientific statements, peer-reviewed articles, book chapters, multicenter trials and invited lectureships in the US and abroad.
She chaired the Working Group for the American Heart Association Scientific Statement on Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease published in 2013. She has been an active participant in the NHLBI/NIH Working Group on Thrombosis in Pediatric Cardiology and Congenital Heart Disease, the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC), the Pediatric Cardiac Stroke Focus Group, the International Kawasaki Disease Registry and most recently, the Cardiac Safety Research Consortium (Duke University) on the use of direct oral anticoagulants in pediatric heart disease as an advisor to the FDA.
Dr. Giglia has been actively involved as a leader in the Pediatric Cardiology Intensive Care Society since its inception in 1996, as member of the Founding Board of Directors, PCICS Secretary for 10 years and current member of the Connections Committee focusing on national and international membership. She is a Fellow of the American Heart Association and has been active in the AHA Council on Cardiovascular Disease in the Young as Congenital Heart Defects Committee member, Liaison to the Council on Clinical Cardiology, Women in Cardiology Committee, CVDY Leadership Council member and Chair, CVDY Early Career and Mentoring Committee.
Dr. Giglia attended The Johns Hopkins University and The Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. She did residency and was Chief Resident at the Children’s Hospital of Buffalo and completed cardiology fellowship and a year as an advanced clinical fellow at The Children’s Hospital, Boston, Harvard Medical School. She was a cardiology attending at The Children’s Hospital, Boston, the Children’s National Hospital (Washington, DC) and Cohen Children’s Medical Center of New York before joining CHOP in 2009.
Education and Training
MD - The Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, NY
Children's Hospital of Buffalo, NY
Boston Children's Hospital, Boston, MA
Titles and Academic Titles
Director, Center on Cardiac Anticoagulation and Thrombosis
Director, Infant Single Ventricle Monitoring Program
Departments and Services
Giglia TM, Massicotte MP, Tweddell JS, Barst RJ, Bauman M, Erickson CC, Feltes TF, Foster E, Hinoki K, Ichord RN, Kreutzer J, McCrindle BW, Newburger JW, Tabbutt S, Todd JL, Webb CL: American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Stroke Council. Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association. Circulation 128(24): 2622-703, Dec 2013 Notes: This article is recognized as a landmark article in the field. PMID 24226806.
Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 2.
Penk JS, Reddy S, Polito A, Cisco MJ, Allan CK, Bembea M, Giglia TM, Cheng HH, Thiagarajan RR, Dalton HJ.
Pediatr Crit Care Med. 2019 Nov;20(11):1034-1039. doi: 10.1097/PCC.0000000000002104. PMID: 31517728
Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 1.
Penk JS, Reddy S, Polito A, Cisco MJ, Allan CK, Bembea MM, Giglia TM, Cheng HH, Thiagarajan RR, Dalton HJ.
Pediatr Crit Care Med. 2019 Nov;20(11):1027-1033. doi: 10.1097/PCC.0000000000002054. PMID: 31274779
Evaluating the utility of routine screening catheterisation before interstage discharge of infants with single-ventricle physiology.
Bates KE, Glatz AC, Giglia TM, Natarajan SS, Ravishankar C, Stagg A, Rome JJ.
Cardiol Young. 2019 May;29(5):660-666. doi: 10.1017/S1047951119000696. Epub 2019 May 30. PMID: 31142394
Association of a Home Monitoring Program With Interstage and Stage 2 Outcomes.
Gardner MM, Mercer-Rosa L, Faerber J, DiLorenzo MP, Bates KE, Stagg A, Natarajan SS, Szwast A, Fuller S, Mascio CE, Fleck D, Torowicz DL, Giglia TM, Rome JJ, Ravishankar C.
J Am Heart Assoc. 2019 May 21;8(10):e010783. doi: 10.1161/JAHA.118.010783. PMID: 31112448 Free PMC Article
Bleeding and Thrombosis in Pediatric Cardiac Intensive Care.
Giglia TM, Witmer C.
Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S287-95. doi: 10.1097/PCC.0000000000000814. Review. PMID: 27490612
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Anticoagulation and Thrombolysis.
Giglia TM, Witmer C, Procaccini DE, Byrnes JW. Pediatr Crit Care Med. 2016 Mar;17(3 Suppl 1):S77-88. doi: 10.1097/PCC.0000000000000623. Review.
Stroke in children with cardiac disease: report from the International Pediatric Stroke Study Group Symposium.
Sinclair AJ, Fox CK, Ichord RN, Almond CS, Bernard TJ, Beslow LA, Chan AK, Cheung M, deVeber G, Dowling MM, Friedman N, Giglia TM, Guilliams KP, Humpl T, Licht DJ, Mackay MT, Jordan LC.
Pediatr Neurol. 2015 Jan;52(1):5-15. doi: 10.1016/j.pediatrneurol.2014.09.016. Epub 2014 Oct 5. Review. PMID: 25532775 Free PMC Article
Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.
McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR.
Circulation. 2014 Sep 30;130(14):1192-203. doi: 10.1161/CIRCULATIONAHA.113.008428. PMID: 25266860
Outcomes using a clinical practice pathway for the management of pulse loss following pediatric cardiac catheterization.
Glatz AC, Keashen R, Chang J, Balsama LA, Dori Y, Gillespie MJ, Giglia TM, Raffini L, Rome JJ.
Catheter Cardiovasc Interv. 2015 Jan 1;85(1):111-7. doi: 10.1002/ccd.25686. Epub 2014 Oct 7. PMID: 25257828
Bleeding and thrombotic emergencies in pediatric cardiac intensive care: unchecked balances.
Giglia TM, Dinardo J, Ghanayem NS, Ichord R, Niebler RA, Odegard KC, Massicotte MP, Yates AR, Laussen PC, Tweddell JS.
World J Pediatr Congenit Heart Surg. 2012 Oct 1;3(4):470-91. doi: 10.1177/2150135112460866. PMID: 23804911
Preoperative pulmonary hemodynamics and assessment of operability: is there a pulmonary vascular resistance that precludes cardiac operation?
Giglia TM, Humpl T. Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S57-69. doi: 10.1097/PCC.0b013e3181d10cce. Review. PMID: 20216166
Critical treatment strategies for acute pulmonary hypertension in infants and children: Pediatric Cardiac Intensive Care Society Scientific Statement.
Giglia TM, Bronicki R, Checchia PA, Laussen PC.
Pediatr Crit Care Med. 2010 Mar;11(2 Suppl):S3. doi: 10.1097/PCC.0b013e3181d10d87. No abstract available. PMID: 20216159
ACCF/AHA/AAP recommendations for training in pediatric cardiology. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence (ACC/AHA/AAP Writing Committee to Develop Training Recommendations for Pediatric Cardiology).
Graham TP Jr, Beekman RH 3rd, Allen HD, Bricker JT, Freed MD, Hurwitz RA, McQuinn TC, Schieken RM, Strong WB, Zahka KG, Sanders SP, Colan SD, Cordes TM, Donofrio MT, Ensing GJ, Geva T, Kimball TR, Sahn DJ, Silverman NH, Sklansky MS, Weinberg PM, Hellenbrand WE, Lloyd TR, Lock JE, Mullins CE, Romes JJ, Teitel DF, Vetter VL, Silka MJ, Van Hare GF, Walsh EP, Kulik T, Giglia TM, Kocis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL, Murphy D Jr, Foster E, Benson DW Jr, Baldwin HS, Hirshfeld JW Jr, Kugler JD, Moskowitz WB, Creager MA, Lorell BH, Merli G, Rodgers GP, Rutherford JD, Tracy CM, Weitz HH; American College of Cardiology Foundation; American Heart Association; American College of Physicians Task Force on Clinical Competence; Writing Committee to Develop Training Recommendations for Pediatric Cardiology.Circulation. 2005 Oct 18;112(16):2555-80.
Right ventricular decompression and left ventricular function in pulmonary atresia with intact ventricular septum. The influence of less extensive coronary anomalies.
Gentles TL, Colan SD, Giglia TM, Mandell VS, Mayer JE Jr, Sanders SP.
Circulation. 1993 Nov;88(5 Pt 2):II183-8. PMID: 8222152
Influence of right heart size on outcome in pulmonary atresia with intact ventricular septum.
Giglia TM, Jenkins KJ, Matitiau A, Mandell VS, Sanders SP, Mayer JE Jr, Lock JE. Circulation. 1993 Nov;88(5 Pt 1):2248-56. PMID: 8222119
Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.
Wessel DL, Adatia I, Giglia TM, Thompson JE, Kulik TJ. Circulation. 1993 Nov;88(5 Pt 1):2128-38. PMID: 8222107
Diagnosis and management of right ventricle-dependent coronary circulation in pulmonary atresia with intact ventricular septum.
Giglia TM, Mandell VS, Connor AR, Mayer JE Jr, Lock JE. Circulation. 1992 Nov;86(5):1516-28. PMID: 1423965
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