Claudio G. Giraudo, PhD

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Claudio G. Giraudo, PhD, is a senior scientist at The Children's Hospital of Philadelphia Research Institute. His lab's focus is intracellular membrane trafficking events during the cytotoxic immune response.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Additional Training

Postdoctoral Fellow - CIQUIBIC-CONICET, Centro de Investigaciones en QuímicaBiologica, Department of Biological Chemistry, National University of Córdoba, Córdoba, Argentina

Postdoctoral Fellow - Department of Cellular Biophysics and Biochemistry, Memor

Graduate Degree

PhD in Chemical Sciences - National University of Córdoba, Córdoba, Argentina

Titles and Academic Titles

Senior Scientist

Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Intracellular membrane trafficking events during the cytotoxic immune response

Publications

Papers

2011

Shi L, Daniel K, Melia T, Coleman J, Giraudo C. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Syntaxin 1 H3 domain and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60. Read the abstract

Li F, Pincet F, Perez E, Giraudo C, Tareste D, Rothman J. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol. 2011 Jul; 24;18(8):941-6. Read the abstract

Shyam K, Daniel R, Daniel K, Giraudo C, Li F, Khandan L, et al. A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40. Read the abstract

Daniel K, Shyam K, Daniel R, Feng L, Giraudo C, Frederic P, et al. Complexin cross-link pre-fusion SNAREs into a zigzag array: a structure-based model for complexin clamping. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. Read the abstract 

2010

Quinteros CA, Giraudo CG, Villareal M, Montich G, Maccioni HJ. Identificatification of a site in Sar1 involved in the interaction with the Cts of Glycolipid Glycosyltransferases. J Biol Chem. 2010 Sept 24; 285(39): 30340–30346. Read the article

2009

Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an On-Off switch of SNARE-mediated membrane fusion. Science. 2009 Jan 23;323(5913):512-6. Read the abstract

Posters and Presentations

2010

Giraudo C, Khandam L, Coleman J, Rothman J. Novel fluorescent probes to study sphingomyelin dynamics in living cells [poster]. American Society of Biochemistry and Molecular Biology (ASMBM): Symposia Biochemistry of Membrane Traffic: secretory and endocytic pathways; 2010 Oct; Tahoe, NV.

2009

Giraudo C. A clamping mechanism for calcium regulated exocytosis [presentation]. SAIB XLV Argentinean Society for Research in Biochemistry and Molecular Biology; 2009 Nov 10-13; Tucuman, Argentina.

Giraudo C, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an on-off switch for snare-mediated membrane fusion [poster]. Molecular Membrane Biology Gordon Research Conference; 2009 Jul; Proctor Academy, NH.