Claudio G. Giraudo, PhD
About Claudio G. Giraudo
Titles
Senior Scientist
Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Research Interests
Intracellular membrane trafficking events during the cytotoxic immune response
Education & training
Graduate Degree
PhD in Chemical Sciences - National University of Córdoba, Córdoba, Argentina
Additional Training
Postdoctoral Fellow - CIQUIBIC-CONICET, Centro de Investigaciones en QuímicaBiologica, Department of Biological Chemistry, National University of Córdoba, Córdoba, Argentina
Postdoctoral Fellow - Department of Cellular Biophysics and Biochemistry, Memor
Publications
Publications
2011
Shi L, Daniel K, Melia T, Coleman J, Giraudo C. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Syntaxin 1 H3 domain and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60.
Li F, Pincet F, Perez E, Giraudo C, Tareste D, Rothman J. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol. 2011 Jul; 24;18(8):941-6.
Shyam K, Daniel R, Daniel K, Giraudo C, Li F, Khandan L, et al. A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40.
Daniel K, Shyam K, Daniel R, Feng L, Giraudo C, Frederic P, et al. Complexin cross-link pre-fusion SNAREs into a zigzag array: a structure-based model for complexin clamping. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33.
2010
Quinteros CA, Giraudo CG, Villareal M, Montich G, Maccioni HJ. Identificatification of a site in Sar1 involved in the interaction with the Cts of Glycolipid Glycosyltransferases. J Biol Chem. 2010 Sept 24; 285(39): 30340–30346.
2009
Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an On-Off switch of SNARE-mediated membrane fusion. Science. 2009 Jan 23;323(5913):512-6.