Education and Training
PhD in Chemical Sciences - National University of Córdoba, Córdoba, Argentina
Postdoctoral Fellow - CIQUIBIC-CONICET, Centro de Investigaciones en QuímicaBiologica, Department of Biological Chemistry, National University of Córdoba, Córdoba, Argentina
Postdoctoral Fellow - Department of Cellular Biophysics and Biochemistry, Memor
Titles and Academic Titles
Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Intracellular membrane trafficking events during the cytotoxic immune response
Shi L, Daniel K, Melia T, Coleman J, Giraudo C. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Syntaxin 1 H3 domain and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60.
Li F, Pincet F, Perez E, Giraudo C, Tareste D, Rothman J. Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol. 2011 Jul; 24;18(8):941-6.
Shyam K, Daniel R, Daniel K, Giraudo C, Li F, Khandan L, et al. A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol. 2011 Jul 24;18(8):934-40.
Daniel K, Shyam K, Daniel R, Feng L, Giraudo C, Frederic P, et al. Complexin cross-link pre-fusion SNAREs into a zigzag array: a structure-based model for complexin clamping. Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33.
Quinteros CA, Giraudo CG, Villareal M, Montich G, Maccioni HJ. Identificatification of a site in Sar1 involved in the interaction with the Cts of Glycolipid Glycosyltransferases. J Biol Chem. 2010 Sept 24; 285(39): 30340–30346.
Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an On-Off switch of SNARE-mediated membrane fusion. Science. 2009 Jan 23;323(5913):512-6.
Posters and Presentations
Giraudo C, Khandam L, Coleman J, Rothman J. Novel fluorescent probes to study sphingomyelin dynamics in living cells [poster]. American Society of Biochemistry and Molecular Biology (ASMBM): Symposia Biochemistry of Membrane Traffic: secretory and endocytic pathways; 2010 Oct; Tahoe, NV.
Giraudo C. A clamping mechanism for calcium regulated exocytosis [presentation]. SAIB XLV Argentinean Society for Research in Biochemistry and Molecular Biology; 2009 Nov 10-13; Tucuman, Argentina.
Giraudo C, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson W, Melia TJ, et al. Alternative zippering as an on-off switch for snare-mediated membrane fusion [poster]. Molecular Membrane Biology Gordon Research Conference; 2009 Jul; Proctor Academy, NH.
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