Kathryn E. Hamilton, PhD Kathryn E. Hamilton, PhD, is a researcher in the Center for Pediatric Inflammatory Bowel Disease (IBD) at Children’s Hospital of Philadelphia. Locations: Main Campus Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467) Education and Training FellowshipPostdoctoral Fellow - University of Pennsylvania, Philadelphia, PA Undergraduate DegreeBA in Biology with concentration in Biotechnology - Assumption College, Worcester, MA Graduate DegreePhD in Cell and Molecular Physiology - University of North Carolina, Chapel Hill, NC Titles and Academic Titles ResearcherAssistant Professor Pediatrics, Division of Gastroenterology, Liver, and Nutrition, Perelman School of Medicine at the University of Pennsylvania Departments and Services Division of Gastroenterology, Hepatology and Nutrition Publications Papers2017 Giroux V, Lento AA, Islam M, Kharbanda A, Pitaressi JR, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK Novel long-lived esophageal progenitor cells contribute to homeostasis and regeneration. Journal of Clinical Investigation. 2017, Jun 1;127(6):2378-2391. Almohazey D, Lo Y, Vossler C, Simmons A, Hsieh J, Bucar E, Schumacher M, Hamilton KE, Lau K, Shroyer N, Frey M. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death and Differentiation. 2017, May;24(5):855- 865. Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Chang S, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM and Nakagawa H: Autophagy mediates epithelial cytoprotection and redox homeostasis in Eosinophilic Esophagitis. Gut, 2017 Jul;66(7):1197-1207. 2015 Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Stromal loss of mRNA-binding protein Imp1 promotes a tumorigenic microenvironment in the colon. Molecular Cancer Research, 2015, Nov;13(11):1478-86. Amaravadi RK, Hamilton KE, Ma X, Piao S, Del Portillo A, Nathanson KL, Carlino MS, Georgina V. Long GV, Puzanov I, Xu X, Morrissette JD, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clinical Cancer Research, 2015, Dec 1;21(23):5215-21. Long A, Giroux V, Whelan KA, Hamilton KE, Tetreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in espophageal squamous cell carcinoma. Carcinogenesis, 2015 May;36(5)598-606. 2013 Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumorinitiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis, 2013, Nov;34(11):2647-54. 2011 Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Molecular Cancer Research, 2011 Dec;9(12):1718-31. 2010 Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO. Suppressor of Cytokine Signaling 3 (SOCS3) Is Not an Independent Biomarker of Colorectal Adenoma Risk. BMC Research Notes, 2010, May 25;3:144. 2006 Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, and Colgan SP. Selective induction of Mucin-3 by hypoxia in intestinal epithelia. Journal of Cellular Biochemistry, 2006, Dec 15;99(6):1616-27. 2005 Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schonfeld C, Loffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. Journal of Experimental Medicine, 2005, Dec 5;202(11):1493-505. Louis NA, Hamilton KE, Kong T, and Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB Journal, 2005 Jun 1: 19: 950-959. Posters and Presentations2017 Hamilton KE. Digestive Diseases Week (DDW) 2017, Chicago, IL. Poster Presentation 2016 Hamilton KE. Digestive Diseases Week (DDW) 2016, San Diego, CA. Poster Presentation 2015 Hamilton KE. Advances in Inflammatory Bowel Disease 2015 (CCFA), Orlando, FL. Oral Presentation Hamilton KE. Experimental Biology 2015, Boston, MA. Oral Presentation 2014 Hamilton KE. Advances in Inflammatory Bowel Disease 2014 (CCFA), Orlando, FL. Poster Presentation Hamilton KE. Experimental Biology 2014, San Diego, CA. Oral Presentation Invited Lectures 2017 Hamilton, KE. Invited Speaker, Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics, and Beyond, Children’s Hospital of Philadelphia, June 2017, Philadelphia, PA Hamilton, KE. Invited Speaker, Committee-Sponsored Symposium, Digestive Diseases Week (DDW) 2017, Chicago, IL Hamilton, KE. Invited Research Symposium Speaker, Experimental Biology 2017, Chicago, IL Hamilton, KE. University of North Carolina Chapel Hill (October 2017) Center for Gastrointestinal Biology and Disease. “Post-transcriptional control of autophagy in intestinal repair and inflammation” Hamilton, KE. Duke University (February 2017) Department of Molecular Genetics and Microbiology. ”IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer” Hamilton, KE. Vanderbilt University (April 2017). Center for Digestive Disease Research. “Role of mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer” Hamilton, KE. Rutgers University (March 2017). Center for Inflammation and Immunity. “IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer” 2015 Hamilton, KE. Fox Chase Cancer Center (December 2015). Center for Translational Research. “Post-transcriptional regulation of intestinal homeostasis and colorectal cancer” Hamilton, KE. Rutgers University (October 2015). Cell and Molecular Biology, Department of Biological Sciences. “Novel regulation of autophagy and intestinal homeostasis via IMP1” Awards and Honors 2016, American Gastroenterological Association (AGA) Women’s Leadership Conference, Dallas, TX 2015, American Society for Investigative Pathology (ASIP) Research Travel Award, Experimental Biology Meeting, Boston, MA 2014, American Physiological Society GI & Liver Section Takeda Travel Award, Experimental Biology Meeting, San Diego, CA 2014, American Gastroenterological Association/American Association for the Study of Liver Diseases Academic Skills Workshop, San Diego, CA 2012, American Gastroenterological Association Research Foundation Horizon Pharma Fellow Abstract Prize Recipient, Freston Conference, Chicago, IL 2010, University of North Carolina Graduate Education Advancement Board Impact Award, Chapel Hill, NC 2009, American Physiological Society GI & Liver Section Research Recognition Award, Experimental Biology Meeting, New Orleans, LA 2009, American Physiological Society GI & Liver Section Graduate Student Poster Competition Award, Experimental Biology Meeting, New Orleans, LA Editorial and Academic Positions Editorial Positions 2012-present, American Journal of Physiology: Gastrointestinal and Liver Physiology, Editorial Board Member Academic and Institutional Committees 2011-present, Undergraduate Student Scholars Program (USSP) Committee, University of Pennsylvania Division of Gastroenterology 2010-present, Women in GI Committee, University of Pennsylvania Division of Gastroenterology Leadership and Memberships Memberships in Professional Organizations 2014-present, Crohn’s and Colitis Foundation of America - 2016, Committee Member and Faculty Panelist 2014-present, American Society for Investigative Pathology (ASIP) - 2015, Mini-Symposium Co-Chair, Experimental Biology 2013-present, American Association of Cancer Research (AACR) 2012-present, American Gastroenterological Association - 2018, Digestive Diseases Week, Session Chair - 2018, Digestive Diseases Week, Abstract Reviewer 2009-present, American Physiological Society - 2017-present, Programming Committee, GI and Liver Section Patient Experience Ratings About the Patient Experience Rating System The Patient Experience Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question. Responses are measured on a scale of 1 to 5 with 5 being the best score. The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.