Kathryn E. Hamilton, PhD

Kathryn E. Hamilton, PhD

Kathryn E. Hamilton, PhD, is a researcher in the Center for Pediatric Inflammatory Bowel Disease (IBD) at Children’s Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Postdoctoral Fellow - University of Pennsylvania, Philadelphia, PA

Undergraduate Degree

BA in Biology with concentration in Biotechnology - Assumption College, Worcester, MA

Graduate Degree

PhD in Cell and Molecular Physiology - University of North Carolina, Chapel Hill, NC

Titles and Academic Titles

Researcher

Assistant Professor Pediatrics, Division of Gastroenterology, Liver, and Nutrition, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2017

Giroux V, Lento AA, Islam M, Kharbanda A, Pitaressi JR, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK Novel long-lived esophageal progenitor cells contribute to homeostasis and regeneration. Journal of Clinical Investigation. 2017, Jun 1;127(6):2378-2391.

Almohazey D, Lo Y, Vossler C, Simmons A, Hsieh J, Bucar E, Schumacher M, Hamilton KE, Lau K, Shroyer N, Frey M. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death and Differentiation. 2017, May;24(5):855- 865.

Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Chang S, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM and Nakagawa H: Autophagy mediates epithelial cytoprotection and redox homeostasis in Eosinophilic Esophagitis. Gut, 2017 Jul;66(7):1197-1207.

2015

Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Stromal loss of mRNA-binding protein Imp1 promotes a tumorigenic microenvironment in the colon. Molecular Cancer Research, 2015, Nov;13(11):1478-86.

Amaravadi RK, Hamilton KE, Ma X, Piao S, Del Portillo A, Nathanson KL, Carlino MS, Georgina V. Long GV, Puzanov I, Xu X, Morrissette JD, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clinical Cancer Research, 2015, Dec 1;21(23):5215-21.

Long A, Giroux V, Whelan KA, Hamilton KE, Tetreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in espophageal squamous cell carcinoma. Carcinogenesis, 2015 May;36(5)598-606.

2013

Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumorinitiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis, 2013, Nov;34(11):2647-54.

2011

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Molecular Cancer Research, 2011 Dec;9(12):1718-31.

2010

Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO. Suppressor of Cytokine Signaling 3 (SOCS3) Is Not an Independent Biomarker of Colorectal Adenoma Risk. BMC Research Notes, 2010, May 25;3:144.

2006

Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, and Colgan SP. Selective induction of Mucin-3 by hypoxia in intestinal epithelia. Journal of Cellular Biochemistry, 2006, Dec 15;99(6):1616-27.

2005

Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schonfeld C, Loffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. Journal of Experimental Medicine, 2005, Dec 5;202(11):1493-505.

Louis NA, Hamilton KE, Kong T, and Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB Journal, 2005 Jun 1: 19: 950-959.

Posters and Presentations

2017

Hamilton KE. Digestive Diseases Week (DDW) 2017, Chicago, IL. Poster Presentation

2016

Hamilton KE. Digestive Diseases Week (DDW) 2016, San Diego, CA. Poster Presentation

2015

Hamilton KE. Advances in Inflammatory Bowel Disease 2015 (CCFA), Orlando, FL. Oral Presentation

Hamilton KE. Experimental Biology 2015, Boston, MA. Oral Presentation

2014

Hamilton KE. Advances in Inflammatory Bowel Disease 2014 (CCFA), Orlando, FL. Poster Presentation

Hamilton KE. Experimental Biology 2014, San Diego, CA. Oral Presentation

Invited Lectures

2017

Hamilton, KE. Invited Speaker, Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics, and Beyond, Children’s Hospital of Philadelphia, June 2017, Philadelphia, PA

Hamilton, KE. Invited Speaker, Committee-Sponsored Symposium, Digestive Diseases Week (DDW) 2017, Chicago, IL

Hamilton, KE. Invited Research Symposium Speaker, Experimental Biology 2017, Chicago, IL

Hamilton, KE. University of North Carolina Chapel Hill (October 2017) Center for Gastrointestinal Biology and Disease. “Post-transcriptional control of autophagy in intestinal repair and inflammation”

Hamilton, KE. Duke University (February 2017) Department of Molecular Genetics and Microbiology. ”IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

Hamilton, KE. Vanderbilt University (April 2017). Center for Digestive Disease Research. “Role of mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

Hamilton, KE. Rutgers University (March 2017). Center for Inflammation and Immunity. “IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

2015

Hamilton, KE. Fox Chase Cancer Center (December 2015). Center for Translational Research. “Post-transcriptional regulation of intestinal homeostasis and colorectal cancer”

Hamilton, KE. Rutgers University (October 2015). Cell and Molecular Biology, Department of Biological Sciences. “Novel regulation of autophagy and intestinal homeostasis via IMP1”

Awards and Honors

2016, American Gastroenterological Association (AGA) Women’s Leadership Conference, Dallas, TX

2015, American Society for Investigative Pathology (ASIP) Research Travel Award, Experimental Biology Meeting, Boston, MA

2014, American Physiological Society GI & Liver Section Takeda Travel Award, Experimental Biology Meeting, San Diego, CA

2014, American Gastroenterological Association/American Association for the Study of Liver Diseases Academic Skills Workshop, San Diego, CA

2012, American Gastroenterological Association Research Foundation Horizon Pharma Fellow Abstract Prize Recipient, Freston Conference, Chicago, IL

2010, University of North Carolina Graduate Education Advancement Board Impact Award, Chapel Hill, NC

2009, American Physiological Society GI & Liver Section Research Recognition Award, Experimental Biology Meeting, New Orleans, LA

2009, American Physiological Society GI & Liver Section Graduate Student Poster Competition Award, Experimental Biology Meeting, New Orleans, LA

Editorial and Academic Positions

Editorial Positions

2012-present, American Journal of Physiology: Gastrointestinal and Liver Physiology, Editorial Board Member

Academic and Institutional Committees

2011-present, Undergraduate Student Scholars Program (USSP) Committee, University of Pennsylvania Division of Gastroenterology

2010-present, Women in GI Committee, University of Pennsylvania Division of Gastroenterology

Leadership and Memberships

Memberships in Professional Organizations

2014-present, Crohn’s and Colitis Foundation of America
 - 2016, Committee Member and Faculty Panelist

2014-present, American Society for Investigative Pathology (ASIP)
 - 2015, Mini-Symposium Co-Chair, Experimental Biology

2013-present, American Association of Cancer Research (AACR)

2012-present, American Gastroenterological Association
 - 2018, Digestive Diseases Week, Session Chair
 - 2018, Digestive Diseases Week, Abstract Reviewer

2009-present, American Physiological Society
 - 2017-present, Programming Committee, GI and Liver Section