Kathryn E. Hamilton, PhD

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Kathryn E. Hamilton, PhD, is a researcher in the Center for Pediatric Inflammatory Bowel Disease (IBD) at Children’s Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Postdoctoral Fellow - University of Pennsylvania, Philadelphia, PA

Undergraduate Degree

BA in Biology with concentration in Biotechnology - Assumption College, Worcester, MA

Graduate Degree

PhD in Cell and Molecular Physiology - University of North Carolina, Chapel Hill, NC

Titles and Academic Titles

Researcher

Assistant Professor Pediatrics, Division of Gastroenterology, Liver, and Nutrition, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2019

Priya Chatterji, Patrick A. Williams, Kelly A. Whelan, Fernando C. Samper, Sarah F. Andres, Lauren A. Simon, Louis R Parham, Rei Mizuno, Emma T. Lundsmith, David S.M. Lee, Shun Liang, H.R. Sagara Wijeratne; Stefanie Marti, Lillian Chau, Veronique Giroux, Benjamin J. Wilkins, Gary D. Wu, Premal Shah, Gian G. Tartaglia, and Kathryn E. Hamilton: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Reports 20(6): e47074, June 2019.

Sarah F. Andres, Kathy N. Williams, Rei Mizuno, Jeff Headd, Priya Chatterji, Kathryn E. Hamilton, Anil K. Rustgi: IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer. Carcinogenesis 40(4): 569-579, June 2019.

2018

Yuta Kasagia, Prasanna M. Chandramouleeswarana, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muirb, Hiroshi Nakagawa: The esophageal organoid system reveals functional interplay between Notch and cytokines in reactive epithelial changes. Cell and Molecular Gastroenterology 5(3): 333-352, January 2018.

Rei Mizuno, Priya Chatterji, Sarah F. Andres, Kathryn E. Hamilton, Lauren A. Simon, Shawn Foley, Arjun Jeganathan, Brian Gregory, Blair B. Madison, and Anil K. Rustgi: Differential regulation of LET-7 by LIN28B isoform-specific functions. Molecular Cancer Research 16(3): 403-416, March 2018.

Véronique Giroux, Julien Stephan, Priya Chatterji, Ben Rhoades, Andres J. Klein-Szanto, Christopher J. Lengner, Kathryn E. Hamilton, Anil K. Rustgi: Mouse intestinal krt15+ crypt cells are radio-resistant and tumor-initiating. Stem Cell Reports 10(6): 1947-1958, June 2018.

Priya Chatterji*, Kathryn E. Hamilton*, Shun Liang, Sarah F. Andres, H. R. Sagara Wijeratne, Rei Mizuno, Lauren A. Simon, Philip D. Hicks, Shawn W. Foley, Jason R. Pitarresi, Andres J. Klein-Szanto, Amanda T. Mah, Laurianne Van Landeghem, Brian D. Gregory, Christopher J. Lengner, Blair B. Madison, Premal Shah, and Anil K. Rustgi *co-first author: The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.  Genes and Development 32(15-16): 1020-1034, August 2018.

2017

Giroux V, Lento AA, Islam M, Kharbanda A, Pitaressi JR, Hamilton KE, Whelan KA, Long A, Rhoades B, Tang Q, Nakagawa H, Lengner CJ, Bass AJ, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK Novel long-lived esophageal progenitor cells contribute to homeostasis and regeneration. Journal of Clinical Investigation. 2017, Jun 1;127(6):2378-2391.

Almohazey D, Lo Y, Vossler C, Simmons A, Hsieh J, Bucar E, Schumacher M, Hamilton KE, Lau K, Shroyer N, Frey M. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death and Differentiation. 2017, May;24(5):855- 865.

Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Chang S, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang ML, Furuta GT, Falk GW, Spergel JM and Nakagawa H: Autophagy mediates epithelial cytoprotection and redox homeostasis in Eosinophilic Esophagitis. Gut, 2017 Jul;66(7):1197-1207.

2015

Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Stromal loss of mRNA-binding protein Imp1 promotes a tumorigenic microenvironment in the colon. Molecular Cancer Research, 2015, Nov;13(11):1478-86.

Amaravadi RK, Hamilton KE, Ma X, Piao S, Del Portillo A, Nathanson KL, Carlino MS, Georgina V. Long GV, Puzanov I, Xu X, Morrissette JD, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clinical Cancer Research, 2015, Dec 1;21(23):5215-21.

Long A, Giroux V, Whelan KA, Hamilton KE, Tetreault MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa H, Rustgi AK. WNT10A promotes an invasive and self-renewing phenotype in espophageal squamous cell carcinoma. Carcinogenesis, 2015 May;36(5)598-606.

2013

Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumorinitiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis, 2013, Nov;34(11):2647-54.

2011

Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Molecular Cancer Research, 2011 Dec;9(12):1718-31.

2010

Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO. Suppressor of Cytokine Signaling 3 (SOCS3) Is Not an Independent Biomarker of Colorectal Adenoma Risk. BMC Research Notes, 2010, May 25;3:144.

2006

Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, and Colgan SP. Selective induction of Mucin-3 by hypoxia in intestinal epithelia. Journal of Cellular Biochemistry, 2006, Dec 15;99(6):1616-27.

2005

Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schonfeld C, Loffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. Journal of Experimental Medicine, 2005, Dec 5;202(11):1493-505.

Louis NA, Hamilton KE, Kong T, and Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB Journal, 2005 Jun 1: 19: 950-959.

Posters and Presentations

2019

Louis R. Parham, Maiah H. Dent, Patrick A. Williams, Lauren A. Simon, Xianghui Ma, Kathryn E. Hamilton: Investigating the role of IGF2 mRNA-binding protein 1 (IMP1) in regulating intestinal regeneration in response to DNA damage (poster presentation by trainee) FASEB Gastrointestinal Tract XVIII Conference, Steamboat Springs, CO 2019.

Louis R. Parham, Maiah H. Dent, Patrick A. Williams, Lauren A. Simon, Xianghui Ma, Kathryn E. Hamilton: Evaluating intestinal stem cell responses to inflammation (poster presentation by trainee). 2019 UPenn Institute for Regenerative Medicine Symposium, Philadelphia, PA 2019.

Patrick A. Williams, Lauren A. Simon, Louis R. Parham, Xianghui Ma, Maiah H. Dent, Kathryn E. Hamilton: Role of Autophagy in Calorie Restriction and Intestinal Regeneration (poster presentation by trainee). 2019 UPenn Institute for Regenerative Medicine Symposium, Philadelphia, PA 2019.

Patrick A. Williams, Lauren A. Simon, Louis R. Parham, Xianghui Ma, Maiah H. Dent, Kathryn E. Hamilton: Role of the RNA-binding protein IMP1 in autophagy regulation in the intestinal epithelium (podium presentation/E-poster oral presentation by trainee). FASEB Gastrointestinal Tract XVIII Conference, Steamboat Springs, CO 2019.

2018

Judith R. Kelsen, Jodie Ouahed, Waldo Spessott, Kameron Kooshesh, Maria Sanmillan, Noor Dawany, Kathleen E. Sullivan, Kathryn E. Hamilton, Voyteck Slowik, Sergey Nejentsev, João Farela Neves, Helena Flores, Wendy Chung, Ashley Wilson, Kwame Anyane Yeboa, Karen Wou, Preti Jain, Sophia Tollefson, Jonathan S. Evans, Neil E. Warner, Aleixo Muise, Agnes Toth-Petroczy, Dana Vuzman, Nikkola Carmichael, Corneliu Bodea, Christopher Cassa, Marcella Devoto, Richard Mass, Edward Behrens, Scott B. Snapper, Claudio Giraudo: Mutations in STXBP3 contribute to very early onset of ibd immunodeficieny and hearing loss (podium presentation presented by a colleague) Digestive Diseases Week, Washington, DC 2018.

Judith R. Kelsen, Maire A. Conrad, Noor Dawany, Audrey Merz, Rawan Shraim, Trusha Patel, Kathleen E. Sullivan, Marcella Devoto, Kathryn E. Hamilton: Understanding phenotypic distinctions in sub-populations of very early-onset inflammatory bowel disease (poster presentation) Digestive Diseases Week, Washington, DC 2018.

Lillian Chau, Sarah A. Smith, Sayaka A. Ogawa, Kelly A. Whelan, Kathryn E. Hamilton, Jie Chen, Sue A. Keilbaugh, Franz Fogt, Meenakshi Bewtra, Barry Slaff, Aalim Weljie, Michael J. Bennett, Hiroshi Nakagawa, Gary D. Wu: Inflammation-induced alterations in colonic epithelial mitochondria function revealed by fatty acid oxidation (podium presentation presented by a colleague) Digestive Diseases Week, Washington, DC 2018.

Priya Chatterji, Kathryn E. Hamilton, Shun Liang, Sarah F. Andres, H. R. Sagara Wijeratne, Rei Mizuno, Lauren Simon, Philip D. Hicks, Shawn Foley, Jason Pitarresi, Andres Klein-Szanto, Amanda Mah, Laurianne Van Landeghem, Brian Gregory, Christopher Lengner, Blair Madison, Premal Shah, Anil K. Rustgi: The LIN28B-IMP1 axis directs a post-transcriptional regulon of oncogenic signaling in the intestine (poster presentation by trainee) Digestive Diseases Week, Washington, DC 2018.

Priya Chatterji, Lauren Simon, Sarah F. Andres, Rei Mizuno, Emma Lundsmith, Lillian Chau, Veronique Giroux, Amanda Mah, Laurianne Van Landeghem, Gary D. Wu, Kelly A. Whelan, Anil K. Rustgi, Kathryn E. Hamilton: Unraveling post-transcriptional regulation of intestinal response to acute challenge by the rna binding protein IMP1 (poster presentation by trainee) Digestive Diseases Week, Washington, DC 2018.

Sarah F. Andres, Kathy N. Williams, Kathryn E. Hamilton, Rei Mizuno, Jeff Headd, Priya Chatterji, Anil K. Rustgi: The RNA binding protein IMP1 enhances colon cancer metastasis via promotion of a pro-metastatic gene expression program (podium presentation presented by a colleague) Digestive Diseases Week, Washington, DC 2018.

2017

Priya Chatterji, Kathryn E. Hamilton, Sarah Andres, Shawn Foley, Rei Mizuno, , Antoni Castells, Miriam Cuatrecasas, Lauren Simon, Brian Gregory, Blair B. Madison and Anil K. Rustgi: IMP1 plays a protective role in LIN28B-associated intestinal tumorigenesis by regulating ER stress and cell junction assembly  (oral presentation presented by colleague). Experimental Biology April 2017 Notes: Chicago, IL.



Williams KN, Andres SF, Preet R, Hamilton KE, Chatterji P, Mizuno R, Dixon DA, Rustgi AK: Reciprocal roles for mRNA binding protein IMP1 in exosome secretion and colorectal cancer cell tumor growth (oral presentation presented by colleague). The American Association of Physicians/American Society for Clinical Investigation Joint Meeting April 2017 Notes: Chicago, IL.



Kelsen JR, Conrad MA, Simon LA, Williams KN, Mizuno R, Chatterji P, Dawany N, Giraudo C, Behrens EM, Sullivan KE, Devoto M, Hamilton KE: Using functional assays in patient-derived enteroids to understand genotype-phenotype interactions in Very Early Onset Inflammatory Bowel Disease (VEO-IBD) (Poster Presentation) Digestive Diseases Week May 2017 Notes: Chicago, IL.



Williams KN, Andres SF, Preet R, Hamilton KE, Chatterji P, Mizuno R, Dixon DA, Rustgi AK: Insulin-like growth factor 2 mRNA binding protein 1 (IMP1) enhances exosome generation in colorectal cancer (oral presentation presented by colleague). Digestive Diseases Week May 2017 Notes: Chicago IL.

Invited Lectures

2017

Hamilton, KE. Invited Speaker, Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics, and Beyond, Children’s Hospital of Philadelphia, June 2017, Philadelphia, PA

Hamilton, KE. Invited Speaker, Committee-Sponsored Symposium, Digestive Diseases Week (DDW) 2017, Chicago, IL

Hamilton, KE. Invited Research Symposium Speaker, Experimental Biology 2017, Chicago, IL

Hamilton, KE. University of North Carolina Chapel Hill (October 2017) Center for Gastrointestinal Biology and Disease. “Post-transcriptional control of autophagy in intestinal repair and inflammation”

Hamilton, KE. Duke University (February 2017) Department of Molecular Genetics and Microbiology. ”IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

Hamilton, KE. Vanderbilt University (April 2017). Center for Digestive Disease Research. “Role of mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

Hamilton, KE. Rutgers University (March 2017). Center for Inflammation and Immunity. “IMPlicating mRNA binding protein IMP1 in Inflammatory Bowel Disease and Colorectal Cancer”

2015

Hamilton, KE. Fox Chase Cancer Center (December 2015). Center for Translational Research. “Post-transcriptional regulation of intestinal homeostasis and colorectal cancer”

Hamilton, KE. Rutgers University (October 2015). Cell and Molecular Biology, Department of Biological Sciences. “Novel regulation of autophagy and intestinal homeostasis via IMP1”

Awards and Honors

2016, American Gastroenterological Association (AGA) Women’s Leadership Conference, Dallas, TX

2015, American Society for Investigative Pathology (ASIP) Research Travel Award, Experimental Biology Meeting, Boston, MA

2014, American Physiological Society GI & Liver Section Takeda Travel Award, Experimental Biology Meeting, San Diego, CA

2014, American Gastroenterological Association/American Association for the Study of Liver Diseases Academic Skills Workshop, San Diego, CA

2012, American Gastroenterological Association Research Foundation Horizon Pharma Fellow Abstract Prize Recipient, Freston Conference, Chicago, IL

2010, University of North Carolina Graduate Education Advancement Board Impact Award, Chapel Hill, NC

2009, American Physiological Society GI & Liver Section Research Recognition Award, Experimental Biology Meeting, New Orleans, LA

2009, American Physiological Society GI & Liver Section Graduate Student Poster Competition Award, Experimental Biology Meeting, New Orleans, LA

Editorial and Academic Positions

Editorial Positions

2012-present, American Journal of Physiology: Gastrointestinal and Liver Physiology, Editorial Board Member

Academic and Institutional Committees

2011-present, Undergraduate Student Scholars Program (USSP) Committee, University of Pennsylvania Division of Gastroenterology

2010-present, Women in GI Committee, University of Pennsylvania Division of Gastroenterology

Leadership and Memberships

Memberships in Professional Organizations

2014-present, Crohn’s and Colitis Foundation of America

 - 2016, Committee Member and Faculty Panelist

2014-present, American Society for Investigative Pathology (ASIP)

 - 2015, Mini-Symposium Co-Chair, Experimental Biology

2013-present, American Association of Cancer Research (AACR)

2012-present, American Gastroenterological Association

 - 2018, Digestive Diseases Week, Session Chair

 - 2018, Digestive Diseases Week, Abstract Reviewer

2009-present, American Physiological Society

 - 2017-present, Programming Committee, GI and Liver Section