Mary C. Harris, MD

Medical School

MD - Dartmouth Medical School, Hanover, NH

Residency

Pediatrics - Children's Hospital Medical Center (Harvard University), Boston, MA

Fellowship

Neonatal-Perinatal Medicine - University of Pennsylvania School of Medicine, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine
Pediatrics

Papers

2020

Gordon SM, Srinivasan L, Taylor DM, Master SR, Tremoglie, MA, Hankeova A, Flannery DD, Abbasi S, Fitzgerald JC, Harris MC. Derivation of a metabolic signature associated with bacterial meningitis in infants. 2020. Pediatr Res. 88, 184–191. https://doi.org/10.1038/s41390-020-0816-7

Gordon SM, Srinivasan L and Harris MC. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. 2017. Front. Pediatr. 5:139. https://doi.org/10.3389/fped.2017.00139

Coggins S, Harris MC, Grundmeier R, Kalb E, Nawab U, Srinivasan L. Performance of Pediatric Systemic Inflammatory Response Syndrome and Organ Dysfunction Criteria in Late-Onset Sepsis in a Quaternary Neonatal Intensive Care Unit: A Case-Control Study. J Pediatr. 2020 Feb 6. pii: S0022-3476(19)31743-3. doi: 10.1016/j.jpeds.2019.12.064. PMID: 32037153

2019

Agawu A, Fahl C, Alexis D, Diaz T, Harris D, Harris MC, Aysola J, Cronholm PF, Higginbotham EJ: The Influence of Gender and Underrepresented Minority Status on Medical Student Ranking of Residency Programs. J Natl Med Assoc. 2019 Oct 23. pii: S0027-9684(18)30414-0. doi: 10.1016/j.jnma.2019.09.002. PMID: 31668360.

Schmatz M, Srinivasan L, Grundmeier RW, Elci OU, Weiss SL, Masino AJ, Tremoglie M, Ostapenko S,  Harris MC: Surviving Sepsis in a Referral Neonatal Intensive Care Unit: Association between Time to Antibiotic Administration and In-Hospital Outcomes. J. Pediatr pii: S0022-3476(19)31081-9. DOI: 10.1016/j.jpeds.2019.08.023. PMID: 31604632.

Ostapenko S, Schmatz M, Srinivasan L, Elci OU, Weiss SL, Masino AJ, Tremoglie M, Harris MC, Grundmeier RW. Neonatal sepsis registry: Time to antibiotic dataset. Data Brief. 2019 Nov 11;27:104788. doi: 10.1016/j.dib.2019.104788. eCollection 2019 Dec. PMID: 31799346 [PubMed]

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Srinivasan L, Bonafide CP, Balamuth F, Schmatz M, Grundmeier RW. Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PLoS One. 2019 Feb 22; 14(2):e0212665. doi: 10.1371/journal.pone.0212665. eCollection 2019. PMID: 30794638 

2018

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris MC: Elevations of novel cytokines in bacterial meningitis in infants. PLoS One 13(2), February 2018 Notes: e0181449. doi: 10.1371/journal.pone.0181449. eCollection 2018.

2017

Gordon SM, Srinivasan L, Harris MC. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis and Treatment with Omics. Front Pediatr. 5: 139, 2017. PMID: 28670576.

2016

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris M C: Cerebrospinal Fluid Cytokines in the Diagnosis of Bacterial Meningitis in Infants. Pediatr Res 80 (4): 566-572, 2016.

2015

Tao GZ, Liu B, Zhang R, Liu G, Abdullah F, Harris MC, Brandt ML, Ehrenkranz R A, Bowers C, Martin CR, Moss RL, Sylvester KG: Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis. Scientific reports 5: 13119, 2015.

2014

Ji J, Ling XB, Zhao Y, Hu Z, Zheng X, Xu Z, Wen Q, Kastenberg ZJ, Li P, Abdullah F, Brandt ML, Ehrenkranz RA, Harris MC, Lee TC, Simpson BJ, Bowers C, Moss RL, Sylvester KG: A data-driven algorithm integrating clinical and laboratory features for the diagnosis and prognosis of necrotizing enterocolitis. PloS one 9(2): e89860, 2014.

Padula MA, Dewan ML, Shah SS, Padula AM, Srinivasan L, McGowan KL, Mahoney KR, Harris MC: Risk factors associated with laboratory-confirmed bloodstream infections in a tertiary neonatal intensive care unit.  Pediatr Infect Dis J 33(10): 1027-1032, 2014.

Sylvester K G, Ling X B, Liu G Y, Kastenberg Z J, Ji J, Hu ZI, Peng S, Lau K, Abdullah F, Brandt M L, Ehrenkranz R A, Harris M Ce, Lee T C, Simpson J, Bowers C, Moss R L: A novel urine peptide biomarker-based algorithm for the prognosis of necrotising enterocolitis in human infants. Gut 63(8): 1284-1292, 2014.

Sylvester KG, Ling XB, Liu G, Yuen G, Kastenberg ZJ, Ji J, Hu Z, Wu S, Peng S, Abdullah F, Brandt ML, Ehrenkranz RA, Harris MC, Lee TC, Simpson BJ, Bowers C, Moss RL: Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants. J Pediatr 164(3): 607-612, 2014.

2013

Srinivasan L, Shah SS, Abbasi S, Padula MA, Harris MC: Traumatic lumbar punctures in infants hospitalized in the neonatal intensive care unit. Pediatr Infect Dis J 32(10): 1150-1152, 2013.

Books

Chapters

2016

Srinivasan L, Harris MC, Kilpatrick L.: Cytokines and Inflammatory Response in the Fetus and Neonate.  Fetal and Neonatal Physiology. Polin RA, Fox WW, Abman SH (eds.), Elsevier, Inc., 5th edition: p 1241-1254, 2016.

2015

Raab E, Apenteng T, Handzel J M, Harris MC: Neonatology. The Philadelphia Guide: Inpatient Pediatrics. Frank G, Shah SS, Catalozzi MC, Zaoutis LB (eds.), Lippincott, Williams & Williams, Inc. 2nd edition: p 327-343, 2015.

2012

Srinivasan L, Harris MC, Shah SS: Lumbar puncture in the neonate: challenges in decision-making and interpretation. Semin Perinatol 36(6): 445-453, 2012.

Srinivasan L, Harris MC: New technologies for the rapid diagnosis of neonatal sepsis. Curr Opin Pediatr 24(2): 165-171, 2012.

Posters and Presentations

2019

Karavite D, Muthu N, Shaeffer G, Balamuth F, Harris MC, Grundmeier, R. Lessons Learned from Knowledge Elicitation in Complex Clinical Environments: Iteration is not just for Design. Workshop presentation, Human Factors and Ergonomic Society (HFES) Healthcare Symposium. Chicago, Illinois, March, 2019.

Finnegan L, Harris M, Coggins S, Schmatz M, Tremoglie-Barkowski M, Srinivasan S. Suspected Sepsis in the NICU: Leveraging Staff Perceptions of Delays in Antibiotic Administration to Drive Improvement. ESPR (podium presentation), SPR (poster) 2019. Platform presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Sivakumar N, Srinivasan L, Grundmeier R, Schmatz M, Harris MC. Demystifying “Culture- negative sepsis”: Reasons for prolonged antibiotic administration in the NICU. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

Coggins S, Harris MC, Grundmeier R, Nawab U, Srinivasan L. Pediatric SIRS and organ dysfunction criteria in late-onset sepsis in a quaternary NICU: a case-control study. Poster presentation, Eastern Society Pediatric Research, Philadelphia, PA March 2019. Poster presentation, Society for Pediatric Research, Baltimore, MD May 2019.

2018

Masino AJ, Harris MC, Forsyth D, Ostapenko S, Grundmeier RW. Machine Learning Models for Infant Sepsis Prediction. Podium presentation, AMIA Annual Symposium. San Francisco, CA November, 2018.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Society for Pediatric Research at the Pediatric Academic Society Annual Meeting, Toronto, Ontario, Canada May 2018.

Schmatz M, Srinivasan L, Grundmeier R, Ostapenko S, Chilluti M, Harris MC: Surviving Sepsis in the NICU: Delayed Antimicrobial Therapy Worsens Outcomes in Late Onset Sepsis. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Kalb E, Coggins S, Harris MC, Nawab U, Grundmeier R, Srinivasan L: Applicability of systemic inflammatory response syndrome (SIRS) and severe sepsis definitions to late onset infections in a quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

Coggins S, Kalb, E, Harris MC, Nawab U, Grudmeier R, Srinivasan L: Factors Associated with Delayed Recognition of Sepsis in a Quaternary NICU. Poster presentation, Eastern Society for Pediatric Research, Philadelphia, PA March 2018.

2017

Skraban C, Herrick H, Medne L, Harris MC, Santani A, Zackai E: Acinar Dysplasia, Tbx4 and Lung Branching Morphogenesis. Platform presentation by collaborator, poster presentation, 38th Annual David W. Smith Workshop on Malformations and Morphogenesis, Stowe, VT August 2017.

Schmatz M, Srinivasan L, Davis D, Grundmeier G, Ostapenko S, Chilutti M, Harris M C: Culture Negative Sepsis in the NICU: What Drives the Decision to Extend Antibiotics? Society for Pediatric Research 2017 (Poster presentation at the SPR Meeting, San Francisco, CA and the ESPR Meeting, Philadelphia, PA 2017).

Flannery D, Srinivasan L, Davis D, Schmatz M, Harris M C.: Challenges in Early recognition of Neonatal Fungal Sepsis. Society for Pediatric Research 2017 (Poster presentation at the SPR Meeting, San Francisco, CA and the ESPR Meeting, Philadelphia, PA 2017).

2016

Schmatz M, Srinivasan L, Tremoglie M, Grundmeier R, Perez A, Ostapenko S, Chilutti M, and Harris MC: Improvements in Timing of Antibiotic Administration in a Quaternary Care NICU: A One Year Perspective. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 at the ESPR Meeting, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Grundmeier R, Tremoglie M, Perez A, Chilutti M, Ostapenko S and Harris MC: Antibiotic Use in the NICU: Do Comorbidities Matter? Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 and at the ESPR Meeting, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Grundmeier R, Tremoglie M, Perez A, Chilutti M, Ostapenko S and Harris MC: Antibiotic Use in the NICU: Do Comorbidities Matter? CHOP Quality and Patient Safety Day 2016 (Poster presentation).

Pai VV, Srinivasan V, Perez A, Grundmeier RW, Harris MC: Glucose Dysregulation and Bacterial Infection in Neonates. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 and at the ESPR Meeting, Philadelphia PA 2016). 

Neonatal Sepsis QI Group: Improving time to antibiotic administration during sepsis evaluations in the NICU: adopting a culture of urgency.  CHOP Quality and Patient Safety Day 2016 (Podium and poster presentation).

Gordon SM, Srinivasan L, Abbasi S, Perez A, Tremoglie M and Harris MC: Analysis of Cerebrospinal Fluid Reveals Derangement of Metabolism in Infants with Bacterial Meningitis. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Washington, DC 2016 and the Eastern SPR Meeting, Philadelphia, PA 2016). 

Invited Lectures

2018

Harris MC. “Neonatal Sepsis: Improving Early Detection and Outcomes” - Symposium participation via video conference, ABC Hospital, Mexico, Nov 16, 2018