Mary C. Harris, MD

Mary C. Harris, MD

Dr. Mary Cay Harris is a professor of pediatrics, a specialist in neonatal-perinatal medicine, and a senior attending physician in the Division of Neonatology at Children's Hospital of Philadelphia.

Areas of Expertise: Neonatal sepsis, Biomarkers, Transcriptomics and metabolomics of sepsis, Early sepsis recognition and therapy
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Mary Cay Harris, MD, is Professor of Pediatrics at the University of Pennsylvania and an attending physician in the Division of Neonatology and in the Newborn Intensive Care unit at CHOP.  Dr. Harris attended medical school at Dartmouth Medical School, completed her residency training at the Children’s Hospital Medical Center, Harvard University, and received her fellowship training in Neonatal-Perinatal Medicine at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Harris is a specialist in Neonatal-Perinatal Medicine at the Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine. She has had a long standing interest in neonatal infectious diseases/inflammation, specifically the role of biomarkers in the diagnosis of sepsis, meningitis, and necrotizing enterocolitis. These studies have investigated the role of cytokines in the immune response and recently the utility of proteomics, transcriptomics and metabolomics as diagnostic markers of disease, involving successful mentorships and collaborations. Her studies have identified biomarkers that may predict pathophysiology or clinical condition in infected infants, but none has yet been found to have sufficient diagnostic accuracy to be employed in clinical practice.

Through her work over the years, however, Dr. Harris has become aware of the critical need to improve sepsis outcomes by developing methods to accurately and rapidly identify infected infants. At the same time she has also developed an interest in the use of new technology and the Electronic Health Record (EHR) to improve patient outcomes. In conjunction with investigators in the PICU (Weiss) and the Department of Biomedical and Health Informatics, she has worked collaboratively to establish a sepsis registry in the NICU using an automated data abstraction process from the EHR. This project investigates the time from sepsis recognition to the administration of antibiotics in order to improve the efficiency of medication administration in infants suspected of sepsis. Most recently Drs. Harris and Grundmeier have received grant funding from the Institute for Biomedical Informatics at the University of Pennsylvania to use the automated registry to develop an early warning system in order to improve best practices related to sepsis management, and improve sepsis related outcomes.

Education and Training

Medical School

MD - Dartmouth Medical School, Hanover, NH

Residency

Pediatrics - Children's Hospital Medical Center (Harvard University), Boston, MA

Fellowship

Neonatal-Perinatal Medicine - University of Pennsylvania School of Medicine, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine
Pediatrics

Titles and Academic Titles

Attending Neonatologist

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Publications

Papers

2016

Srinivasan L, Kilpatrick L, Shah SS, Abbasi S, Harris M C: Cerebrospinal Fluid Cytokines in the Diagnosis of Bacterial Meningitis in Infants. Pediatr Res 80 (4): 566-572, 2016.

2015

Tao GZ, Liu B, Zhang R, Liu G, Abdullah F, Harris MC, Brandt ML, Ehrenkranz R A, Bowers C, Martin CR, Moss RL, Sylvester KG: Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis. Scientific reports 5: 13119, 2015.

2014

Ji J, Ling XB, Zhao Y, Hu Z, Zheng X, Xu Z, Wen Q, Kastenberg ZJ, Li P, Abdullah F, Brandt ML, Ehrenkranz RA, Harris MC, Lee TC, Simpson BJ, Bowers C, Moss RL, Sylvester KG: A data-driven algorithm integrating clinical and laboratory features for the diagnosis and prognosis of necrotizing enterocolitis. PloS one 9(2): e89860, 2014.

Padula MA, Dewan ML, Shah SS, Padula AM, Srinivasan L, McGowan KL, Mahoney KR, Harris MC: Risk factors associated with laboratory-confirmed bloodstream infections in a tertiary neonatal intensive care unit.  Pediatr Infect Dis J 33(10): 1027-1032, 2014.

Sylvester K G, Ling X B, Liu G Y, Kastenberg Z J, Ji J, Hu ZI, Peng S, Lau K, Abdullah F, Brandt M L, Ehrenkranz R A, Harris M Ce, Lee T C, Simpson J, Bowers C, Moss R L: A novel urine peptide biomarker-based algorithm for the prognosis of necrotising enterocolitis in human infants. Gut 63(8): 1284-1292, 2014.

Sylvester KG, Ling XB, Liu G, Yuen G, Kastenberg ZJ, Ji J, Hu Z, Wu S, Peng S, Abdullah F, Brandt ML, Ehrenkranz RA, Harris MC, Lee TC, Simpson BJ, Bowers C, Moss RL: Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants. J Pediatr 164(3): 607-612, 2014.

2013

Srinivasan L, Shah SS, Abbasi S, Padula MA, Harris MC: Traumatic lumbar punctures in infants hospitalized in the neonatal intensive care unit. Pediatr Infect Dis J 32(10): 1150-1152, 2013.

Books

Chapters

2016

Srinivasan L, Harris MC, Kilpatrick L.: Cytokines and Inflammatory Response in the Fetus and Neonate.  Fetal and Neonatal Physiology. Polin RA, Fox WW, Abman SH (eds.), Elsevier, Inc., 5th edition: p 1241-1254, 2016.

2015

Raab E, Apenteng T, Handzel J M, Harris MC: Neonatology. The Philadelphia Guide: Inpatient Pediatrics. Frank G, Shah SS, Catalozzi MC, Zaoutis LB (eds.), Lippincott, Williams & Williams, Inc. 2nd edition: p 327-343, 2015.

2012

Srinivasan L, Harris MC, Shah SS: Lumbar puncture in the neonate: challenges in decision-making and interpretation. Semin Perinatol 36(6): 445-453, 2012.

Srinivasan L, Harris MC: New technologies for the rapid diagnosis of neonatal sepsis. Curr Opin Pediatr 24(2): 165-171, 2012.

Posters and Presentations

2017

Schmatz M, Srinivasan L, Davis D, Grundmeier G, Ostapenko S, Chilutti M, Harris M C: Culture Negative Sepsis in the NICU: What Drives the Decision to Extend Antibiotics? Society for Pediatric Research 2017 (Poster presentation at the SPR Meeting, San Francisco, CA and the ESPR Meeting, Philadelphia, PA 2017).

Flannery D, Srinivasan L, Davis D, Schmatz M, Harris M C.: Challenges in Early recognition of Neonatal Fungal Sepsis. Society for Pediatric Research 2017 (Poster presentation at the SPR Meeting, San Francisco, CA and the ESPR Meeting, Philadelphia, PA 2017).

2016

Schmatz M, Srinivasan L, Tremoglie M, Grundmeier R, Perez A, Ostapenko S, Chilutti M, and Harris MC: Improvements in Timing of Antibiotic Administration in a Quaternary Care NICU: A One Year Perspective. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 at the ESPR Meeting, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Grundmeier R, Tremoglie M, Perez A, Chilutti M, Ostapenko S and Harris MC: Antibiotic Use in the NICU: Do Comorbidities Matter? Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 and at the ESPR Meeting, Philadelphia, PA 2016).

Schmatz M, Srinivasan L, Grundmeier R, Tremoglie M, Perez A, Chilutti M, Ostapenko S and Harris MC: Antibiotic Use in the NICU: Do Comorbidities Matter? CHOP Quality and Patient Safety Day 2016 (Poster presentation).

Pai VV, Srinivasan V, Perez A, Grundmeier RW, Harris MC: Glucose Dysregulation and Bacterial Infection in Neonates. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Baltimore, MD 2016 and at the ESPR Meeting, Philadelphia PA 2016). 

Neonatal Sepsis QI Group: Improving time to antibiotic administration during sepsis evaluations in the NICU: adopting a culture of urgency.  CHOP Quality and Patient Safety Day 2016 (Podium and poster presentation).

Gordon SM, Srinivasan L, Abbasi S, Perez A, Tremoglie M and Harris MC: Analysis of Cerebrospinal Fluid Reveals Derangement of Metabolism in Infants with Bacterial Meningitis. Society for Pediatric Research 2016 (Poster presentation at the SPR Meeting, Washington, DC 2016 and the Eastern SPR Meeting, Philadelphia, PA 2016). 

2015

Schmatz M, Srinivasan L, Grundmeier R, Chilutti M, Monk H, Ostapenko S, Perez A, Tremoglie M, Harris MC: Automated Neonatal Sepsis Registry: A Novel Approach to Understand Clinical Practice and Sepsis Related Outcomes. Society for Pediatric Research 2015.

Awards and Honors

2016, Best in Healthcare Award, American Health Council

2014, Outstanding Achievement Award, Intern Selection Committee, Pediatric Residency Program, The Children's Hospital of Philadelphia

2013, Faculty Mentor Award, The Children's Hospital of Philadelphia

2011, Top Physician, Neonatal-Perinatal Medicine, South Jersey Magazine

2009-2011, 2013, 2015, Faculty Honor Roll, The Children's Hospital of Philadelphia

2002, 2007, 2010, 2011, 2016, 2017, The Best Doctors in America

1972, Phi Beta Kappa, Vassar College

Editorial and Academic Positions

Editorial Positions

2013-present, Review Editorial Board, Frontiers in Neonatology

Peer Reviewer

Pediatrics
Pediatric Research
Journal of Clinical Microbiology
Journal of Pediatrics
Critical Care Medicine
Pediatric Emergency Care
Clinical Immunology and Immunopathology
Blood
Archives of Pediatrics and Adolescent Medicine
Clinical & Diagnostic Laboratory Immunology

Academic and Institutional Committees

2014-present, Member, NICU QI Sepsis Committee
2014-present, Member, Fellowship Selection Committee, Division of  Neonatology
2003-present, Member, Steering Committee, Neonatal Sepsis Club

Leadership and Memberships

Memberships in Professional Organizations

International

2005-present, European Society for Pediatric Research
1993-present, Society for Pediatric Research

National

2017-present, 1861 Society, Vassar College
2008-present, Eastern Society for Pediatric Research
2008-present, American Pediatric Society
2007-present, Children's Hospital Boston Alumni Association
2002-present, American Academy of Pediatrics
1998-present, Infectious Disease Society of America
1972-present, Phi Beta Kappa