Lacramioara Ivanciu, PhD

Lacramioara Ivanciu, PhD

Lacramioara Ivanciu, PhD,  is a researcher in the Division of Hematology at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Undergraduate Degree

BA in Biology - University of Bucharest, Bucharest, Romania

Graduate Degree

PhD in Biology - University of Bucharest, Bucharest, Romania
MS in Biology - University of Bucharest, Bucharest, Romania

Titles and Academic Titles

Researcher

Research Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2015

Hui DJ, Edmonson SC, Podsakoff GM, Pien GC, Ivanciu Lacramioara, Camire RM, Ertl H, Mingozzi F, High KA, Basner-Tschakarjan E.: AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. Mol Ther Methods Clin Dev.  30(2): 15029, September 2015.

Ivanciu L, Camire RM. Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity. Blood 126(1): 94-102, July 2015.

Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, Milstein S, Charisse K, Kuchimanchi S, Maier MA, Nechev L, Kandasamy P, Kel'in AV, Nair JK, Rajeev KG, Manoharan M, Meyers R, Sorensen B, Simon AR, Dargaud Y, Negrier C, Camire RM, Akinc A.: An RNAi therapeutic antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nature Medicine 21(5): 492-7, May 2015.

2014

Ivanciu Lacramioara, Krishnaswamy Sriram, Camire Rodney M: New insights into the spatiotemporal localization of prothrombinase in vivo. Blood 124(11): 1705-14, Sep 2014.

Pavani Giulia, Ivanciu Lacramioara, Faella Armida, Marcos-Contreras Oscar A, Margaritis Paris: The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo. Blood 124(7): 1157-65, Aug 2014.

Abstracts

2015

Nabil K. Thalji, Lacramioara Ivanciu, Sriram Krishnaswamy, Rodney M. Camire: The mechanism of rivaroxaban reversal by FXa reveals a paradoxical property of direct FXa inhibitors. FASEB meeting "Proteases in Hemostasis and Vascular Biology"  June 2015.

2014

Pavani Giulia, Ivanciu Lacramioara, Faella Armida, Marcos-Contreras Oscar O, Margaritis Paris : Binding of FVIIa to the endothelial protein C receptor enhances its hemostatic function in hemophilic mice. Thrombosis and Hemostasis Summit of North America April 2014.

Posters and Presentations

Posters

2015

Pavani, Lacramioara Ivanciu, Katherine A. Stafford and Paris Margaritis: A single amino acid in the Gla domain mouse FVIIa allows its binding to the endothelial protein C receptor and enhances its coagulant activity in vivo. 57th American Society of Hematology Annual Meeting (poster) December 2015.

Lectures by Invitation

Ivanciu L. Modulating Factor V levels in vivo. Novo Nordisk Inc.; 2015 Jun; Copenhagen, Denmark.

Awards and Honors

2015, 2015 GRIFOLS Martin Villar Haemostasis Award, "The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo" paper

2014, Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corp

2012, Martin Villar Haemostasis Award, (1st Prize)

2012,  Poster Award, 22nd Children's Hospital of Philadelphia Research Poster Day

2012, 2012 GRIFOLS Martin Villar Haemostasis Award, "In vivo genome editing restores haemostasis in a mouse model of haemophilia" manuscript 

2011, Travel Award, 53th Annual Meeting of American Society of Hematology

2010-2012, Recipient of the Judith Graham Pool Postdoctoral Research Fellowship, National Hemophilia Foundation

2010, Travel Award, 52th Annual Meeting of American Society of Hematology

2008-2010, Ruth L. Kirschstein National Research Service Award (T32)

2008, Travel Award, 50th Annual Meeting of American Society of Hematology

Editorial and Academic Positions

Ad-hoc Reviewer

2015-present, PLOS One
2015-present, Journal of Thrombosis and Haemostasis

Leadership and Memberships

Memberships in Professional Organizations

International

2011-present, International Society of Thrombosis and Haemostasis
2014-present, World Federation of Hemophilia

National

2013-Present North American Society on Thrombosis and Hemostasis (NASTH)