Eugene Khandros, MD, PhD
Locations: Main Building, Buerger Center for Advanced Pediatric Care
About Eugene Khandros, MD, PhD
Titles
Attending Physician
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatrics – American Board of Pediatrics
Awards and Honors
2025, The American Society for Clinical Investigation (ASCI) Young Physician-Scientist Award
2022, Distinguished Teaching Award for Hematology, Pediatric Hematology-Oncology Fellowship Program, Children's Hospital of Philadelphia
2012, Alpha Omega Alpha
2012, Adolph J. Creskoff Prize, University of Pennsylvania School of Medicine
2009-2012, NHLBI Medical Scientist Training Program Competitive Grant
2008-2009, Predoctoral Training Grant in Genetics, University of Pennsylvania School of Medicine
2008, Emily and Francis Botelho Prize for Excellence in Basic Science, University of Pennsylvania School of Medicine
Leadership and Memberships
2016-present, American Society of Hematology
Education & training
Undergraduate Degree
BA in Biochemistry - Columbia University, New York, NY
Graduate Degree
PhD in Cell and Molecular Biology - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Medical Degree
MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Residency
Pediatrics - Morgan Stanley Children’s Hospital of New York, Columbia University, New York, NY
Fellowship
Pediatric Hematology/Oncology - Children's Hospital of Philadelphia, Philadelphia, PA
Publications
PubMed
Publications
2026
Bagchi A, Billakanti S, Shehu V, Farrell KM, Cotteta SA, Godfrey BN, Alpert M, Flores Zeranski J, Budinich KA, Geng Z, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Shi J, Khandros E: Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex. Blood 147(6): 675-688, Feb 2026.
Traxler EA, Hotan Q, Shao Y, Komar C, Chen Q, Saari MS, Thrasher AJ, Yang S, Qin K, Wang M, Peslak SA, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Minn AJ, Khandros E, Shi J, Blobel GA: Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing. Blood Jan 2026.
2025
Gibson NM, Khandros E, Elgarten CW, Worster E, Monos DS, Thompson AA, Kwiatkowski JL, Olson T: Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia. Blood 145(22): 2666-2670, May 2025.
2024
Huang P, Peslak SA, Shehu V, Keller CA, Giardine BM, Shi J, Hardison RC, Blobel GA, Khandros E: Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood 143(19): 1980-1991, May 2024.
Khandros E, Blobel GA: Elevating fetal hemoglobin - recently discovered regulators and mechanisms. Blood 144(8): 845-852, Aug 2024.
2021
Khandros E and Blobel G.: Heterogeneity of fetal hemoglobin production in adult red blood cells. Current Opinion in Hematology 28(3): 164-170, May 2021.
2020
Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. : HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Advances 4(18): 4560-4572, Sep 2020.
Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalk O, Giardine B, Zhang Z, Keller CA, Hardison RC, Blobel GA: Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F- and A-erythroblasts. Blood 135(22): 1957- 1968, May 2020.
2019
Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA.: The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Advances 3(10): 1586-1597, May 2019.
Khandros E, Kwiatkowski JL: Beta thalassemia: Monitoring and new treatment approaches. Hematology/Oncology Clinics of North America 33(3): 339-353, Jun 2019.
2012
Khandros E, Thom C, D'Souza J, Weiss MJ: Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood 119(22): 5265-75, May 2012.
Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ: Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein. The Journal of Biological Chemistry 287(14): 11325-37, Mar 2012.
2010
Khandros E, Weiss MJ: Protein quality control during erythropoiesis and hemoglobin synthesis. Hematology/Oncology Clinics of North America 24(6): 1071-88, Dec 2010.