Eugene Khandros, MD, PhD

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Eugene Khandros, MD, PhD, is an attending physician with the Division of Hematology at the Children's Hospital of Philadelphia.

Locations: Main Campus

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania, Philadelphia, PA

Residency

Pediatrics - Morgan Stanley Children’s Hospital of New York, Columbia University, New York, NY

Fellowship

Pediatric Hematology/Oncology - University of Pennsylvania, Philadelphia, PA

Board Certification

Pediatrics

Graduate Degree

PhD in Cell and Molecular Biology - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Instructor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2020

Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine BM, Qin K, Abdulmalik O, Hardison R, Shi J, Blobel GA. HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood 2020 epub Apr 16. PMID: 32299090.

Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine B, Zhang Z, Keller CA, Hardison RC, Blobel GA. Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F- and A-erythroblasts.Blood. 2020 May 28;135(22):1957-1968. PMID: 32268371.

2019

Lechauve C, Keith J, Khandros E, Fowler S, Mayberry K, Freiwan A, Thom CS, Delbini P, Romero EB, Zhang J, Motta I, Tillman H, Cappellini MD, Kundu M, Weiss MJ. The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia. Science Translational Medicine 2019 11(506). PMID: 31434755.

Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.  Blood Advances 2019 3(10):1586-1597. PMID: 31126914.

Khandros E and Kwiatkowski J. Beta thalassemia: Monitoring and new treatment approaches. Hematology Oncology Clinics of North America 2019 33(3): 339-353. PMID 31030806.

2014

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ. Trim58 degrades dynein and regulates terminal erythropoiesis. Developmental Cell 2014 30(6):688-700. PMID 25241935.

2013

Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood 2013 121(16):3228-3236. PMID 23426945.

2012

Khandros E, Thom CS, D'Souza J, Weiss MJ. Integrated protein quality control pathways regulate free α globin in murine β-thalassemia. Blood 2012 119(22):5265-75. PMID 22427201.

Mollan TL, Khandros E, Weiss MJ, Olson JS. The kinetics of alpha-globin binding to alpha hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of a hemichrome folding intermediate. Journal of Biological Chemistry 2012 287(14):11338-11352. PMID 22298770.

Khandros E, Mollan TL, Yu X, Wang X, Yao Y, D'Souza J, Gell DA, Olson JS, Weiss MJ. Insights into hemoglobin assembly through in vivo mutagenesis of alpha-hemoglobin stabilizing protein. Journal of Biological Chemistry 2012 287(14):11325-11337. PMID 22287545.

2011

Kirino Y, Vourekas A, Khandros E, Mourelatos Z. Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods in Molecular Biology 2011 725:281-293. PMID 21528460.

2010

Nasimuzzaman M*, Khandros E*, Wang X, Kong Y, Zhao H, Weiss D, Rivella S, Weiss MJ, Persons DA. Analysis of alpha hemoglobin stabilizing protein overexpression in murine -thalassemia. American Journal of Hematology 2010 85(10):820-822. PMID 20815047.

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes and Development 2010 24(15):1620-33. PMID 20679398.

2009

Chou ST, Khandros E, Bailey C, Nichols KE, Vakoc C, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.  Blood 2009 114(5):983-94. PMID 19491391.

Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chlorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nature Cell Biology 2009 11(5), 652-658. PMID 19377467.

2008

Puthanveettil SV, Monje FJ, Miniaci MC, Choi YB, Karl KA, Khandros E, Gawinowicz MA, Sheetz MP, Kandel ER. A new component in synaptic plasticity: upregulation of kinesin in the neurons of the gill-withdrawal reflex. Cell 2008 135(5): 960-73. PMID 19041756.

2001

Jacob T, Ascher E, Hingorani A, Khandros Y, Tsemekhin B, Zeien L, Gunduz Y. Differential proteolytic activity and induction of apoptosis in fibrous versus atheromatous plaques in carotid atherosclerotic disease. Journal of Vascular Surgery 2001 33(3): 614-20. PMID 11241135.

Awards and Honors

2012, Alpha Omega Alpha
2012, Adolph J. Creskoff Prize, University of Pennsylvania School of Medicine
2009-2012, NHLBI Medical Scientist Training Program Competitive Grant
2008-2009, Predoctoral Training Grant in Genetics, University of Pennsylvania School of Medicine
2008, Emily and Francis Botelho Prize for Excellence in Basic Science, University of Pennsylvania School of Medicine