Maria A. Kowalska, PhD

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Maria A. Kowalska, PhD, is a member of the research faculty in the Division of Hematology at The Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Postdoctoral Fellow - Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA

Undergraduate Degree

BS in Physics - University of Lodz, Lodz, Poland 

Graduate Degree

PhD in Biochemistry - University of Lodz, Lodz, Poland 
MS in Biophysics - University of Lodz, Lodz, Poland 

Titles and Academic Titles

Senior Scientist

Departments and Services

Publications

Papers

2016

Stasiak M, Boncela J, Perreau C, Karamanou K, Chatron-Colliet A, Proult I, Przygodzka P, Chakravarti S, Maquart F-X, Kowalska MA, Wegrowski Y and Brézillon S. Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity. PLOS One March 1 2016. PLoS One 11(3):e0150226. doi: 10.1371/journal.pone.0150226, 2016.

Fuentes RE, Zaitsev S, Ahn HS, Hayes V, Kowalska M, Lambert MP, Wang Y, Siegel DL, Bougie DW, Aster RH, Myers DD, Stepanova V, Cines DB, Muzykantov VR, Poncz M. A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.
J Clin Invest. 126(2):483-94, 2016.

2015

Lambert MP, Meng R, Xiao L, Harper DC, Marks MS, Kowalska MA, Poncz M. Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules. J Thromb Haemost. 13:1888-99. 2015.

Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS. Defective release of alpha granule and lysosome contents from platelets in mouse Hermasky-Pudlak syndrome models. Blood 125:1623-32, 2015..

2014

Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB.,T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood—Proof of Concept. Clinical Chemistry. 60: 1174-82, 2014 .

Shi G, Field DJ, Ko K, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, and Morrell CN. Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. J Clin Invest. 124: 543-552, 2014.

Kowalska MA, Zhao G, Zhai L, David G, Krishnaswamy S, Poncz M. Modulation of protein C activation by histones, platelet factor 4 and heparinoids:  New insights into activated protein C formation. Arterioscler Thromb Vasc Biol. 34:120-126, 2014.

Books

Chapters

Fukami MH, Holmsen H, Kowalska MA, Niewiarowski S: Platelet Secretion. Chapter 32. In Haemostasis and Thrombosis: Basic principles and Clinical Practice. 4th edition. Edited by RW. Colman, J. Hirsh, VJ Marder, AW Clowes,  JN George. Lippincott Williams & Wilkins, 2000.

Posters and Presentations

Lectures by Invitation

2016

Kowalska MA. Seminar at the University of Reims, Champagne Ardenne, Laboratoire de Biochimie Médicale et de Biologie Moléculaire; 2016 May; Reims, France.

Awards and Honors

2009-201, Grant-in-Aid from American Heart Association “Platelet Factor 4 in Thrombosis: Intersection of Physiology and Pathology”

2007-2009, Grant-in-Aid from American Heart Association “The role of platelet-specific chemokines in inflammation”

2002-2005, Grant-in-Aid from American Heart Association “Defining the biology of PF4”

Editorial and Academic Positions

Editorial Positions

Reviewer

Blood
Journal of Thrombosis and Haemostasis
Thrombosis and Haemostasis

Leadership and Memberships

Memberships in Professional Organizations

American Society of Hematology
American Heart Association
International Society on Thrombosis and Haemostasis