Janet Kwiatkowski, MD, MSCE

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Janet Kwiatkowski, MD, MSCE, is the Director of the Thalassemia Center at Children's Hospital of Philadelphia.

Areas of Expertise: Thalassemias, Sickle cell disease, Anemia, Iron deficiency anemia, Transfusional iron overload, General pediatric hematology
Locations: Main Campus

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Columbia University College of Physicians and Surgeons, New York, NY

Internship

Pediatrics - Johns Hopkins University Hospital, Baltimore, MD

Residency

Pediatrics - Johns Hopkins University Hospital, Baltimore, MD

Fellowship

Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology/Oncology

Titles and Academic Titles

Director, Thalassemia Program

Attending Physician

Principal Investigators

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2016

Stanley HM, Friedman D, Webb J, Kwiatkowski, JL.  Transfusional Iron Overload in a Cohort of Children with Sickle Cell Disease: Impact of Magnetic Resonance Imaging, Transfusion Method, and Chelation. Pediatr Blood Cancer. 2016 Apr 21. doi: 10.1002/pbc.26017. [Epub ahead of print].

Nabavizadeh SA, Vossough A, Ichord RN, Kwiatkowski J, Pukenas BA, Smith MJ, Storm PB, Zager EL, Hurst RW. Intracranial Aneurysms in sickle cell anemia: clinical and imaging findings. J Neurointerv Surg. 2016 Apr;8(4):434-40. doi: 10.1136/neurintsurg-2014-011572. Epub 2015 Mar 19.

Luchtman-Jones L, Pressel S, Hilliard L, Brown RC, Kwiatkowski JL, Davis BR, Ware RE. Effects of hydroxyurea treatment for patients with hemoglobin SC disease. Am J Hematol. 2016 Feb;91(2):238-42. doi: 10.1002/ajh.24255.

Ware RE, Davis BR…Kwiatkowski JL, Jackson S…Pressel S, Adams RJ.  Hydroxycarbamide versus chronic transfusion for maintenance of transcranial Doppler flow velocities in children with sickle cell anaemia-TCD with Transfusions Changing to Hydroxyurea (TWiTCH): a multicenter, open-label, phase 3, non-inferiority trial. Lancet. 2016 Feb 13;387(10019):661-70. doi: 10.1016/S0140-6736(15)01041-7. Epub 2015 Dec 6.

2015

Wood JC, Pressel S, Rogers ZR, Odame I, Kwiatkowski JL, Lee MT, Owen WC, Cohen AR, St. Pierre T, Heeney MM, Schultz WH, Davis BR, Ware RE for the TWiTCH Investigators. Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial. Am J Hematol. 2015 Sep;90(9):806-10. doi: 10.1002/ajh.24089.

Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA for the Thalassemia Clinical Research Network. Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassemia. Br J Haematol. 2015 Jun;169(6):887-98. doi: 10.1111/bjh.13452. Epub 2015 Apr 24.

Belmont AP, Nossair F, Brambilla D, Friedman M, Boswinkel J, Bradford AB, and Kwiatkowski JL. Safety of deep sedation in young children with sickle cell disease: a retrospective cohort study. J Pediatr. 2015 May;166(5):1226-32. doi: 10.1016/j.jpeds.2015.01.054.

Tubman VN, Fung EB, Vogiatzi M, Thompson AA, Rogers ZR, Neufeld EJ, Kwiatkowski JL, for the Thalassemia Clinical Research Network. Guidelines for the Standard Monitoring of Patients with Thalassemia: Report of the Thalassemia Longitudinal Cohort. J Pediatr Hematol Oncol. 2015 Apr;37(3):e162-9. doi: 10.1097/MPH.0000000000000307.

Aygun B, Mortier NA, Kesler K, Lockhart A, Schultz WH, Cohen Ar, Alvarez O, Rogers ZR, Kwiatkowski JL, Miller ST, Sylvestre P, Iyer R, Lane PA, Ware RE and the Stroke with Transfusions Changing to Hydroxyurea Trial Investigators. Therapeutic phlebotomy is safe in children with sickle cell anemia and can be effective treatment for transfusional iron overload. Br J Haematol. 2015 Apr;169(2):262-6. doi: 10.1111/bjh.13280. Epub 2015 Jan 22.

2014

King AA, Rodeghier MJ, Panepinto JA, Strouse JJ, Casella JF, Quinn C, Dowling M…Kwiatkowski JL, Howard TH… DeBaun MR.  Silent cerebral infarction, income and grade retention among students with sickle cell. Am J Hematol. 2014 Oct;89(10):E188-92. doi: 10.1002/ajh.23805. Epub 2014 Aug 4.

DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ…Kwiatkowski JL, King AA, …Casella JF.  Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. N Engl J Med. 2014 Aug 21;371(8):699-710. doi: 10.1056/NEJMoa1401731.

Green ST, Martin MB, Haines D, Carson S, Coates T, Oliveros O, Gerstenberger E, Trachtenberg F, Kwiatkowski JL for the Thalassemia Clinical Research Network. Variance of pain prevalence and associated severity during the transfusion cycle of adult thalassemia patients. Br J Haematol. 2014 Sep;166(5):797-800. doi: 10.1111/bjh.12903. Epub 2014 May 8.

Arkuszewski M, Krejza J, Chen R, Ichord R, Kwiatkowski JL, Bilello M, Zimmerman R, Ohene-Frempong K, Melhem ER.  Sickle cell anemia: intracranial stenosis and silent cerebral infarcts in children with low risk of stroke. Adv Med Sci. 2014 Mar;59(1):108-13. doi: 10.1016/j.advms.2013.09.001. Epub 2014 Mar 27.

Books

Chapters
2012

Kwiatkowski, JL. Thalassemia Minor”and “Beta Thalassemia Major. In: Gulati GL, Filicko-O’Hara J, Krause JR, editors. Case Studies in Hematology and Coagulation. Chicago (IL): American Society for Clinical Pathology Press; 2012.

2011

Kwiatkowski JL. Hemoglobinopathies. In: Lanzkowsky, et al., editors. Manual of Pediatric Hematology and Oncology. 5th ed. London (UK): Elsevier, London; 2011. pp. 200-246.

2009

Kwiatkowski JL, Porter J. Transfusion and Iron Chelation Therapy in Thalassemia and Sickle Cell Disease. In: Steinberg MH, Forget BG, Higgs DR, Weatherall DJ, editors. Disorders of Hemoglobin. 2nd ed. Cambridge University Press; 2009.

2008

Kwiatkowski JL. Iron Deficiency Anemia. In Schwartz, et al., editors. The Five-Minute Pediatric Consult. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp. 466-7.

Kwiatkowski JL. Microcytic Anemia. In Schwartz, et al., editors. The Five-Minute Pediatric Consult. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp. 536-7.

Kwiatkowski JL. Aplastic Anemia. In Schwartz, et al., editors. The Five-Minute Pediatric Consult. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp. 54-5.

Kwiatkowski JL. Thalassemia. In Schwartz, et al., editors. The Five-Minute Pediatric Consult. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp. 846-7.

2005

Kwiatkowski JL.  Section Editor. Clinical Management of Patients with Thalassemia. In: Perspectives on the Treatment of Transfusion-Dependent Hematologic Disorders. Health Science Center for Continuing Medical Education; 2005.

Kwiatkowski JL. Iron Deficiency Anemia. In: The Five-Minute Pediatric Consult. 4th Ed. Schwartz, et al., editors. Philadelphia (PA): Lippincott Williams & Wilkins; 2005. pp. 500-501.

Kwiatkowski JL, Shusterman S. Microcytic Anemia. In: The Five-Minute Pediatric Consult. 4th Ed. Schwartz, et al., editors. Philadelphia (PA): Lippincott Williams & Wilkins; 2005. pp. 62-63.

Kwiatkowski JL, Minturn J. Aplastic Anemia. In: The Five-Minute Pediatric Consult. 4th Ed. Schwartz, et al., editors. Philadelphia (PA): Lippincott Williams & Wilkins; 2005. pp. 134-35.

Bickert B, Kwiatkowski JL. Coagulation Disorders. In: Depiro, et al, editors Pharmacotherapy: A Pathophysiologic Approach. 6th ed. McGraw-Hill; 2005. pp. 1833-1854.

2004

Kwiatkowski JL, Ohene-Frempong K. Stroke in sickle cell disease. In: Okpala I, editor. Practical Management of Haemoglobinopathies. Malden (MA): Blackwell Publishing, Ltd.; 2004. pp. 134-144.

2002

Bickert B, Kwiatkowski JL. Coagulation Disorders. In: Depiro JT, et al, editors. Pharmacotherapy: A Pathophysiologic Approach. 5th ed., McGraw-Hill Companies, Inc.; 2002. pp. 1747-1768.

Posters and Presentations

2015

Kwiatkowski JL. Mentoring Lunch for Women, Underrepresented Minorities, and Early Career Investigators. New York Academy of Sciences, Tenth Cooley’s Anemia Symposium; 2015 Oct 20; Chicago, IL.  

Kwiatkowski JL. Current Recommendations for Chelation Therapy in Transfusion-Dependent Thalassemia. New York Academy of Sciences, Tenth Cooley’s Anemia Symposium; 2015 Oct 20; Chicago, IL.  

Kwiatkowski JL. The Role of Zinc in Thalassaemia. 8th Annual Advanced Sickle Cell And Thalassaemia Course. Guys and St. Thomas NHS Foundation Trust; 2015 Oct 2; London, UK.

Kwiatkowski JL. Optimizing TCD Screening and Treatment Protocols. 8th Annual Advanced Sickle Cell And Thalassaemia Course. Guys and St. Thomas NHS Foundation Trust; 2015 Oct 2; London, UK.

2014

Kwiatkowski JL. Iron Assessment and Chelation Options.  Cooley’s Anemia Foundation Patient-Family Conference; 2015 Jun 21; Chicago, IL.

Awards and Honors

2001, Ethel Brown Foerderer Fund Fellow



1998, Hematology/Oncology Research Competition Award, Managing Cancer Chemotherapy Toxicities; The Philadelphia-Delaware Valley Association of Hematology/Oncology Fellows



1998, Young Investigator Award; American Society of Clinical Oncology: Role of Schwann Cells in Neuroblastoma Differentiation



1997, Selected participant, American Association for Cancer Research Workshop, Molecular Biology in Clinical Oncology; The Given Institute, Aspen, CO



1992, Charles E. Hamilton Prize

1992, Janet M. Glasgow Memorial Achievement Citation for Scholastic Excellence

1991, Alpha Omega Alpha

1987, Phi Beta Kappa

1985, Phi Eta Sigma

Editorial and Academic Positions

Academic and Institutional Committees

2008-present, Member, Fellowship Committee, University of Pennsylvania
2003-present, Member, Committee for the Protection of Human Subjects, University of Pennsylvania
2006-present, Member, Cooley’s Anemia Foundation Medical Advisory Board

Leadership and Memberships

Memberships in Professional Organizations

CHOP Clinical Trials Research Affinity Group, Advisory committee member

American Society of Hematology

American Society of Pediatric Hematology/Oncology